TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 409.476 | Formula: C27H23NO3
H donors: 1 H acceptors: 2 LogP: 6.03 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: O=Cc1[nH]c(c(c1Cc1ccccc1)Cc1ccccc1)C(=O)OCc1ccccc1
InChi: 1S/C27H23NO3/c29-18-25-23(16-20-10-4-1-5-11-20)24(17-21-12-6-2-7-13-21)26(28-25)27(30)31-19-22-14-8-3-9-15-22/h1-15,18,28H,16-17,19H2
InChiKey: YMNXQSFLXVQYBZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	fused histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium ulcerans	imidazoleglycerol-phosphate dehydratase	Get druggable targets OG5_129258	All targets in OG5_129258
Mycobacterium tuberculosis	Probable imidazole glycerol-phosphate dehydratase HisB	Get druggable targets OG5_129258	All targets in OG5_129258
Mycobacterium leprae	Probable imidazole glycerol-phosphate dehydratase HisB	Get druggable targets OG5_129258	All targets in OG5_129258
Candida albicans	Imidazole glycerol phosphate dehydratase	Get druggable targets OG5_129258	All targets in OG5_129258
Candida albicans	Imidazole glycerol phosphate dehydratase	Get druggable targets OG5_129258	All targets in OG5_129258

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0038	0.0185	0.0178
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0038	0.0185	0.0178
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0038	0.0185	0.0178
Schistosoma mansoni	hypothetical protein	0.0109	0.0834	0.0834
Echinococcus granulosus	sodium channel protein	0.0038	0.0185	0.0178
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0038	0.0185	0.0185
Brugia malayi	olfactory channel protein osm-9	0.0038	0.0185	0.0185
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0038	0.0185	0.0178
Echinococcus granulosus	voltage gated potassium channel	0.0038	0.0185	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0166	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0185	0.0185
Loa Loa (eye worm)	TAR-binding protein	0.013	0.1022	0.1022
Schistosoma mansoni	hypothetical protein	0.0044	0.0235	0.0235
Treponema pallidum	nicotinate phosphoribosyltransferase	0.0206	0.1719	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0284	0.0284
Schistosoma mansoni	nicotinate phosphoribosyltransferase related pre-B cell enhancing factor	0.0206	0.1719	0.1719
Echinococcus granulosus	microtubule associated protein 2	0.0672	0.5986	0.5983
Brugia malayi	AMP-binding enzyme family protein	0.0049	0.0278	0.0278
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0045	0.025	0.025
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0185	0.0185
Echinococcus granulosus	hypothetical protein	0.0038	0.0185	0.0178
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0038	0.0185	0.0178
Mycobacterium ulcerans	acyl-CoA synthetase	0.0049	0.0278	0.0293
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0049	0.0278	0.0293
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.0038	0.0185	0.1041
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0109	0.0834	0.0828
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0038	0.0185	0.0178
Mycobacterium ulcerans	hypothetical protein	0.0049	0.0278	0.0293
Schistosoma mansoni	hypothetical protein	0.0038	0.0185	0.0185
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.0038	0.0185	0.1041
Echinococcus multilocularis	transient receptor potential cation channel	0.0038	0.0185	0.0178
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0038	0.0185	0.0178
Entamoeba histolytica	nicotinate phosphoribosyltransferase, putative	0.0206	0.1719	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.0324	0.0324
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0038	0.0185	0.0178
Schistosoma mansoni	voltage-gated potassium channel	0.0038	0.0185	0.0185
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0049	0.0278	0.0339
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0038	0.0185	0.063
Schistosoma mansoni	voltage-gated potassium channel	0.0038	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0166	0.0166
Brugia malayi	voltage-dependent calcium channel	0.0038	0.0185	0.0185
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0038	0.0185	0.0185
Brugia malayi	cation channel family protein	0.0038	0.0185	0.0185
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0038	0.0185	0.0178
Toxoplasma gondii	transporter, cation channel family protein	0.0038	0.0185	1
Loa Loa (eye worm)	voltage-gated potassium channel	0.0038	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0185	0.0185
Schistosoma mansoni	calcium-activated potassium channel	0.0038	0.0185	0.0185
Brugia malayi	Transient-receptor-potential like protein	0.0038	0.0185	0.0185
Brugia malayi	AMP-binding enzyme family protein	0.0049	0.0278	0.0278
Schistosoma mansoni	voltage-gated potassium channel	0.0038	0.0185	0.0185
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0036	0.0166	0.0047
Schistosoma mansoni	transcription factor LCR-F1	0.0109	0.0834	0.0834
Schistosoma mansoni	microtubule-associated protein tau	0.0672	0.5986	0.5986
Schistosoma mansoni	voltage-gated ion channel	0.0038	0.0185	0.0185
Echinococcus granulosus	TRP transient receptor potential channel	0.0038	0.0185	0.0178
Schistosoma mansoni	tar DNA-binding protein	0.013	0.1022	0.1022
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0038	0.0185	0.0178
Schistosoma mansoni	voltage-gated potassium channel	0.0038	0.0185	0.0185
Trypanosoma brucei	PAB1-binding protein , putative	0.0027	0.0082	0.0438
Loa Loa (eye worm)	voltage-gated calcium channel	0.0038	0.0185	0.0185
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.025	0.0422
Echinococcus granulosus	transient receptor potential cation channel	0.0038	0.0185	0.0178
Echinococcus multilocularis	voltage dependent calcium channel	0.0038	0.0185	0.0178
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0038	0.0185	0.0185
Echinococcus multilocularis	voltage gated potassium channel	0.0038	0.0185	0.0178
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0038	0.0185	0.0185
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0038	0.0185	0.0178
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0038	0.0185	0.0178
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0038	0.0185	0.0185
Mycobacterium tuberculosis	Nicotinic acid phosphoribosyltransferase PncB1	0.0206	0.1719	0.4079
Echinococcus granulosus	sterol regulatory element binding protein	0.0045	0.025	0.0243
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0038	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0185	0.0185
Echinococcus granulosus	potassium voltage gated channel protein	0.0038	0.0185	0.0178
Schistosoma mansoni	voltage-gated potassium channel	0.0038	0.0185	0.0185
Schistosoma mansoni	voltage-gated potassium channel	0.0038	0.0185	0.0185
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0038	0.0185	0.0185
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0038	0.0185	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0185	0.0185
Echinococcus multilocularis	transient receptor potential cation channel	0.0038	0.0185	0.0178
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0038	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0185	0.0185
Echinococcus multilocularis	potassium voltage gated channel protein	0.0038	0.0185	0.0178
Echinococcus multilocularis	potassium large conductance calcium activated	0.0038	0.0185	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0185	0.0185
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0284	0.0284
Schistosoma mansoni	nicotinate phosphoribosyltransferase related pre-B cell enhancing factor	0.1111	1	1
Schistosoma mansoni	voltage-gated potassium channel	0.0038	0.0185	0.0185
Echinococcus multilocularis	voltage dependent calcium channel	0.0038	0.0185	0.0178
Brugia malayi	hypothetical protein	0.0109	0.0834	0.0834
Schistosoma mansoni	voltage-gated potassium channel	0.0038	0.0185	0.0185
Entamoeba histolytica	hypothetical protein	0.0109	0.0834	0.4833
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0284	0.0278
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0038	0.0185	0.0185
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0036	0.0166	0.5
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0324	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0185	0.0185
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0284	0.0284
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0278	0.0278
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0038	0.0185	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0185	0.0185
Echinococcus multilocularis	protein dispatched 1	0.0052	0.0308	0.0302
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0038	0.0185	0.0185
Entamoeba histolytica	hypothetical protein	0.0109	0.0834	0.4833
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0169	0.0169
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0038	0.0185	0.0178
Mycobacterium ulcerans	imidazoleglycerol-phosphate dehydratase	0.0455	0.4	1
Schistosoma mansoni	tar DNA-binding protein	0.013	0.1022	0.1022
Echinococcus granulosus	transient receptor potential cation channel	0.0038	0.0185	0.0178
Brugia malayi	TAR-binding protein	0.013	0.1022	0.1022
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0108	0.0818	0.0818
Echinococcus granulosus	transient receptor potential cation channel	0.0038	0.0185	0.0178
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0038	0.0185	0.0185
Schistosoma mansoni	transient receptor potential channel	0.0038	0.0185	0.0185
Schistosoma mansoni	transient receptor potential channel	0.0038	0.0185	0.0185
Loa Loa (eye worm)	pre-B cell enhancing factor	0.1111	1	1
Plasmodium vivax	ataxin-2 like protein, putative	0.0027	0.0082	0.4714
Schistosoma mansoni	tar DNA-binding protein	0.013	0.1022	0.1022
Plasmodium falciparum	bifunctional polynucleotide phosphatase/kinase	0.0019	0.0007	0.0000015993
Echinococcus granulosus	sodium leak channel non selective protein	0.0038	0.0185	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0343	0.0343
Echinococcus granulosus	hyperpolarization activated cyclic	0.0038	0.0185	0.0178
Echinococcus granulosus	calcium activated potassium channel	0.0038	0.0185	0.0178
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0284	0.0278
Toxoplasma gondii	transporter, cation channel family protein	0.0038	0.0185	1
Schistosoma mansoni	vesicular amine transporter	0.0038	0.0185	0.0185
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0038	0.0185	0.0185
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0026	0.0072	0.0072
Brugia malayi	ion channel NompC	0.0038	0.0185	0.0185
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0049	0.0278	0.0339
Schistosoma mansoni	ryanodine receptor related	0.0038	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0185	0.0185
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0038	0.0185	0.0178
Brugia malayi	CHE-14 protein	0.0045	0.025	0.025
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.0324	0.0324
Echinococcus granulosus	transient receptor potential cation channel	0.0038	0.0185	0.0178
Echinococcus granulosus	voltage dependent calcium channel	0.0038	0.0185	0.0178
Echinococcus multilocularis	transient receptor potential cation channel	0.0038	0.0185	0.0178
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0082	0.0438
Plasmodium falciparum	nicotinate phosphoribosyltransferase, putative	0.0206	0.1719	1
Schistosoma mansoni	hypothetical protein	0.0044	0.0235	0.0235
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0185	0.0185
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0106	0.0803	0.4652
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0762	0.0762
Echinococcus multilocularis	short transient receptor potential channel 6	0.0038	0.0185	0.0178
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0038	0.0185	0.0185
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0038	0.0185	0.0185
Schistosoma mansoni	transient receptor potential channel	0.0038	0.0185	0.0185
Schistosoma mansoni	nicotinate phosphoribosyltransferase	0.0206	0.1719	0.1719
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0038	0.0185	0.0185
Entamoeba histolytica	hypothetical protein	0.0109	0.0834	0.4833
Echinococcus granulosus	Protein patched homolog 1	0.0045	0.025	0.0243
Echinococcus granulosus	hyperpolarization activated cyclic	0.0038	0.0185	0.0178
Echinococcus multilocularis	tumor protein p63	0.0693	0.6175	0.6172
Echinococcus multilocularis	aryl hydrocarbon receptor	0.0026	0.0072	0.0065
Schistosoma mansoni	voltage-gated potassium channel	0.0038	0.0185	0.0185
Entamoeba histolytica	acyl-coA synthetase, putative	0.0049	0.0278	0.1586
Echinococcus granulosus	potassium voltage gated channel protein	0.0038	0.0185	0.0178
Schistosoma mansoni	voltage-gated potassium channel	0.0038	0.0185	0.0185
Trypanosoma cruzi	nicotinate phosphoribosyltransferase, putative	0.0206	0.1719	1
Brugia malayi	hypothetical protein	0.0026	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0185	0.0185
Schistosoma mansoni	voltage-gated potassium channel	0.0038	0.0185	0.0185
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0038	0.0185	0.0178
Echinococcus granulosus	potassium voltage gated channel protein	0.0038	0.0185	0.0178
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0038	0.0185	0.0178
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0038	0.0185	1
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0038	0.0185	0.0178
Leishmania major	4-coumarate:coa ligase-like protein	0.0049	0.0278	0.1201
Echinococcus multilocularis	calcium activated potassium channel	0.0038	0.0185	0.0178
Schistosoma mansoni	transient receptor potential channel 4	0.0038	0.0185	0.0185
Mycobacterium ulcerans	acyl-CoA synthetase	0.0049	0.0278	0.0293
Echinococcus granulosus	nicotinamide phosphoribosyltransferase	0.1111	1	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0106	0.0803	0.0797
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0038	0.0185	0.0185
Schistosoma mansoni	voltage-dependent calcium channel	0.0038	0.0185	0.0185
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0038	0.0185	0.2428
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0038	0.0185	0.0185
Plasmodium vivax	acyl-CoA synthetase, putative	0.0036	0.0166	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0049	0.0278	0.0293
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0038	0.0185	0.0178
Toxoplasma gondii	hypothetical protein	0.0038	0.0185	1
Echinococcus multilocularis	conserved hypothetical protein	0.0038	0.0185	0.0178
Schistosoma mansoni	voltage-gated potassium channel	0.0038	0.0185	0.0185
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0284	0.0284
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0038	0.0185	0.0178
Schistosoma mansoni	cellular tumor antigen P53	0.0101	0.0762	0.0762
Brugia malayi	Niemann-Pick C1 protein precursor	0.0106	0.0803	0.0803
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0038	0.0185	0.0178
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0038	0.0185	0.0185
Echinococcus granulosus	tar DNA binding protein	0.013	0.1022	0.1016
Echinococcus multilocularis	sodium leak channel non selective protein	0.0038	0.0185	0.0178
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0109	0.0834	0.0828
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0038	0.0185	0.0185
Schistosoma mansoni	two-pore calcium channel	0.0038	0.0185	0.0185
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0038	0.0185	0.0178
Echinococcus granulosus	potassium large conductance calcium activated	0.0038	0.0185	0.0178
Echinococcus multilocularis	Niemann Pick C1 protein	0.0151	0.1219	0.1214
Echinococcus multilocularis	tar DNA binding protein	0.013	0.1022	0.1016
Echinococcus granulosus	potassium voltage gated channel protein	0.0038	0.0185	0.0178
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0038	0.0185	0.1041
Mycobacterium ulcerans	acyl-CoA synthetase	0.0049	0.0278	0.0293
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0038	0.0185	0.2428
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0038	0.0185	0.0178
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0049	0.0278	0.0293
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0049	0.0278	0.1586
Leishmania major	nicotinate phosphoribosyltransferase, putative	0.0206	0.1719	1
Echinococcus multilocularis	two pore calcium channel protein 2	0.0038	0.0185	0.0178
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0038	0.0185	0.0185
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0038	0.0185	0.0185
Schistosoma mansoni	voltage-gated potassium channel	0.0038	0.0185	0.0185
Brugia malayi	hypothetical protein	0.0027	0.0082	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0082	0.0082
Brugia malayi	cation channel family protein	0.0038	0.0185	0.0185
Onchocerca volvulus	Bifunctional polynucleotide phosphatase\/kinase homolog	0.0019	0.0007	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0185	0.0185
Onchocerca volvulus		0.0038	0.0185	0.2428
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0038	0.0185	0.0185
Schistosoma mansoni	voltage-gated potassium channel	0.0038	0.0185	0.0185
Loa Loa (eye worm)	RNA binding protein	0.013	0.1022	0.1022
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0082	0.0438
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0038	0.0185	0.0178
Trichomonas vaginalis	nicotinate phosphoribosyltransferase, putative	0.0206	0.1719	1
Echinococcus multilocularis	sterol regulatory element binding protein	0.0045	0.025	0.0243
Echinococcus multilocularis	expressed conserved protein	0.01	0.0744	0.0738
Schistosoma mansoni	polynucleotide kinase-3'-phosphatase	0.0019	0.0007	0.0007
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0038	0.0185	0.1041
Echinococcus granulosus	Niemann Pick C1 protein	0.0151	0.1219	0.1214
Echinococcus multilocularis	short transient receptor potential channel 6	0.0038	0.0185	0.0178
Loa Loa (eye worm)	ion channel NompC	0.0038	0.0185	0.0185
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0038	0.0185	0.0185
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0038	0.0185	0.0185
Schistosoma mansoni	hypothetical protein	0.0044	0.0235	0.0235
Schistosoma mansoni	hypothetical protein	0.0044	0.0235	0.0235
Mycobacterium tuberculosis	Nicotinic acid phosphoribosyltransferase PncB2	0.0206	0.1719	0.4079
Echinococcus granulosus	shaker cognate	0.0038	0.0185	0.0178
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0049	0.0278	0.0293
Schistosoma mansoni	tar DNA-binding protein	0.013	0.1022	0.1022
Echinococcus granulosus	two pore calcium channel protein 1	0.0038	0.0185	0.0178
Echinococcus multilocularis	transient receptor potential cation channel	0.0038	0.0185	0.0178
Brugia malayi	DNA 3'-phosphatase family protein	0.0019	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0037	0.0169	0.0169
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0185	0.0185
Echinococcus granulosus	expressed conserved protein	0.01	0.0744	0.0738
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0166	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0072	0.0072
Echinococcus multilocularis	microtubule associated protein 2	0.0672	0.5986	0.5983
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0038	0.0185	0.0185
Schistosoma mansoni	60S ribosomal protein L21	0.0038	0.0185	0.0185
Echinococcus multilocularis	nicotinamide phosphoribosyltransferase	0.1111	1	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0038	0.0185	0.0185
Echinococcus granulosus	tumor protein p63	0.0693	0.6175	0.6172
Echinococcus granulosus	aryl hydrocarbon receptor	0.0026	0.0072	0.0065
Echinococcus granulosus	transient receptor potential cation channel	0.0038	0.0185	0.0178
Echinococcus multilocularis	ryanodine receptor 44f	0.0038	0.0185	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0166	0.0166
Echinococcus granulosus	short transient receptor potential channel 6	0.0038	0.0185	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0278	0.0278
Echinococcus multilocularis	sodium channel protein	0.0038	0.0185	0.0178
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0038	0.0185	0.0185
Brugia malayi	RNA recognition motif domain containing protein	0.013	0.1022	0.1022
Echinococcus multilocularis	shaker cognate	0.0038	0.0185	0.0178
Echinococcus multilocularis	potassium voltage gated channel protein	0.0038	0.0185	0.0178
Echinococcus multilocularis	potassium voltage gated channel protein	0.0038	0.0185	0.0178
Echinococcus granulosus	voltage gated potassium channel	0.0038	0.0185	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0007	0.0007
Schistosoma mansoni	voltage-gated potassium channel	0.0038	0.0185	0.0185
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0038	0.0185	0.0178
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.0324	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0045	0.025	0.025
Onchocerca volvulus		0.0101	0.0762	1
Echinococcus multilocularis	transient receptor potential cation channel	0.0038	0.0185	0.0178
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0038	0.0185	0.0185
Schistosoma mansoni	voltage-gated potassium channel	0.0038	0.0185	0.0185
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0169	0.0169
Mycobacterium leprae	Probable imidazole glycerol-phosphate dehydratase HisB	0.0225	0.1888	1
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0038	0.0185	0.0185
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0038	0.0185	0.0178
Echinococcus multilocularis	potassium voltage gated channel protein	0.0038	0.0185	0.0178
Echinococcus multilocularis	two pore calcium channel protein 1	0.0038	0.0185	0.0178
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0038	0.0185	0.0185
Brugia malayi	RNA binding protein	0.013	0.1022	0.1022
Plasmodium falciparum	acyl-CoA synthetase	0.0036	0.0166	0.0929
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0185	0.0185
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0038	0.0185	0.0185
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0038	0.0185	0.0185
Loa Loa (eye worm)	voltage-gated potassium channel	0.0038	0.0185	0.0185
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0873	0.7822	0.7821
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0284	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0166	0.0166
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0038	0.0185	0.0178
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0038	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0185	0.0185
Loa Loa (eye worm)	calcium channel	0.0038	0.0185	0.0185
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0038	0.0185	0.0185
Echinococcus granulosus	short transient receptor potential channel 6	0.0038	0.0185	0.0178
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0038	0.0185	0.0178
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0284	0.0278
Trypanosoma cruzi	PAB1-binding protein , putative	0.0027	0.0082	0.0438
Leishmania major	hypothetical protein, unknown function	0.0038	0.0185	0.063
Echinococcus multilocularis	voltage gated potassium channel	0.0038	0.0185	0.0178
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0038	0.0185	0.0178
Loa Loa (eye worm)	ryanodine receptor	0.0038	0.0185	0.0185
Echinococcus multilocularis	transient receptor potential cation channel	0.0038	0.0185	0.0178
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0038	0.0185	0.0185
Brugia malayi	hypothetical protein	0.0038	0.0185	0.0185
Schistosoma mansoni	patched 1	0.0045	0.025	0.025
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0185	0.0185
Echinococcus granulosus	two pore calcium channel protein 2	0.0038	0.0185	0.0178
Echinococcus multilocularis	transient receptor potential gamma protein	0.0038	0.0185	0.0178
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0038	0.0185	0.0178
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0038	0.0185	0.0178
Schistosoma mansoni	voltage-gated cation channel	0.0038	0.0185	0.0185
Toxoplasma gondii	hypothetical protein	0.0038	0.0185	1
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0038	0.0185	0.0178
Toxoplasma gondii	transporter, cation channel family protein	0.0038	0.0185	1
Echinococcus granulosus	transient receptor potential gamma protein	0.0038	0.0185	0.0178
Brugia malayi	AMP-binding enzyme family protein	0.0049	0.0278	0.0278
Entamoeba histolytica	hypothetical protein	0.0109	0.0834	0.4833
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0278	0.0278
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0038	0.0185	0.0178
Echinococcus granulosus	ryanodine receptor 44f	0.0038	0.0185	0.0178
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0038	0.0185	0.0178
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0803	0.0803
Echinococcus granulosus	voltage dependent calcium channel	0.0038	0.0185	0.0178
Echinococcus granulosus	potassium voltage gated channel protein	0.0038	0.0185	0.0178
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0038	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0185	0.0185
Onchocerca volvulus		0.0049	0.0278	0.3654
Echinococcus multilocularis	transfer RNA-Gly	0.0038	0.0185	0.0178
Leishmania major	hypothetical protein, conserved	0.0038	0.0185	0.063
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0038	0.0185	0.0178
Echinococcus granulosus	transient receptor potential cation channel	0.0038	0.0185	0.0178
Plasmodium falciparum	ataxin-2 like protein, putative	0.0027	0.0082	0.0438
Schistosoma mansoni	tar DNA-binding protein	0.013	0.1022	0.1022
Mycobacterium tuberculosis	Probable imidazole glycerol-phosphate dehydratase HisB	0.0455	0.4	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0106	0.0803	0.0797
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0038	0.0185	0.0178
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0049	0.0278	0.1586
Leishmania major	4-coumarate:coa ligase-like protein	0.0049	0.0278	0.1201
Onchocerca volvulus		0.0026	0.0072	0.0939
Schistosoma mansoni	voltage-gated potassium channel	0.0038	0.0185	0.0185
Schistosoma mansoni	voltage-gated potassium channel	0.0038	0.0185	0.0185
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0038	0.0185	0.0178
Echinococcus multilocularis	protein patched	0.0045	0.025	0.0243
Leishmania major	4-coumarate:coa ligase-like protein	0.0049	0.0278	0.1201
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.013	0.1022	0.1022
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0038	0.0185	0.0185
Trypanosoma brucei	nicotinate phosphoribosyltransferase, putative	0.0206	0.1719	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0284	0.0284

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4 uM	Compound was evaluated in the imidazole glycerol phosphate dehydratase (IGPD) endpoint assay for inhibition of the IGPD enzyme	Starlite.	12067551
IC50 (binding)	= 4 uM	Inhibition of Escherichia coli imidazoleglycerol phosphate dehydratase using imidazole glycerol phosphate as substrate incubated for 30 min prior to substrate addition measured for 16 min by spectrophotometric analysis	ChEMBL.	12067551

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 72926