Detailed information for compound 729324

Basic information

Technical information
  • TDR Targets ID: 729324
  • Name: N-(4-acetylphenyl)-2-[(3-chlorophenyl)-(4-met hylphenyl)sulfonylamino]acetamide
  • MW: 456.942 | Formula: C23H21ClN2O4S
  • H donors: 1 H acceptors: 4 LogP: 4.21 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN(S(=O)(=O)c1ccc(cc1)C)c1cccc(c1)Cl)Nc1ccc(cc1)C(=O)C
  • InChi: 1S/C23H21ClN2O4S/c1-16-6-12-22(13-7-16)31(29,30)26(21-5-3-4-19(24)14-21)15-23(28)25-20-10-8-18(9-11-20)17(2)27/h3-14H,15H2,1-2H3,(H,25,28)
  • InChiKey: RMIUSAJLPPDORE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-acetylphenyl)-2-[(3-chlorophenyl)-(4-methylphenyl)sulfonyl-amino]acetamide
  • 2-[(3-chlorophenyl)-(4-methylphenyl)sulfonyl-amino]-N-(4-ethanoylphenyl)ethanamide
  • ZINC02916105

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase isozyme 0.02 0.3741 0.4679
Schistosoma mansoni tar DNA-binding protein 0.0193 0.3573 0.9553
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.1682 0.4496
Brugia malayi beta-lactamase 0.0075 0.0909 0.2429
Entamoeba histolytica hypothetical protein 0.0066 0.0704 1
Echinococcus granulosus tumor protein p63 0.0389 0.7995 1
Schistosoma mansoni ubiquitinyl hydrolase-UCH37 (C12 family) 0.0066 0.0704 0.1881
Brugia malayi beta-lactamase family protein 0.0075 0.0909 0.2429
Echinococcus multilocularis tumor protein p63 0.0389 0.7995 1
Schistosoma mansoni family C12 unassigned peptidase (C12 family) 0.02 0.3741 1
Schistosoma mansoni tar DNA-binding protein 0.0193 0.3573 0.9553
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase UCHL3 0.02 0.3741 1
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase isozyme L3 0.02 0.3741 1
Loa Loa (eye worm) hypothetical protein 0.02 0.3741 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase, family 1 protein 0.02 0.3741 1
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0909 0.5
Loa Loa (eye worm) RNA binding protein 0.0193 0.3573 0.9553
Mycobacterium ulcerans lipase LipD 0.0075 0.0909 0.5
Onchocerca volvulus 0.0075 0.0909 0.1526
Schistosoma mansoni tar DNA-binding protein 0.0193 0.3573 0.9553
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.02 0.3741 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0909 0.5
Toxoplasma gondii ABC1 family protein 0.0075 0.0909 0.0674
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0903 0.2415
Loa Loa (eye worm) hypothetical protein 0.0075 0.0909 0.2429
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0909 0.2429
Schistosoma mansoni family C12 unassigned peptidase (C12 family) 0.02 0.3741 1
Brugia malayi ubiquitin C-terminal hydrolase UCH-L5 0.0066 0.0704 0.1881
Loa Loa (eye worm) hypothetical protein 0.0075 0.0903 0.2415
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase BAP1 0.0066 0.0704 0.088
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0045 0.0121
Mycobacterium ulcerans beta-lactamase 0.0075 0.0909 0.5
Brugia malayi RNA binding protein 0.0193 0.3573 0.9553
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0909 0.0674
Schistosoma mansoni tar DNA-binding protein 0.0193 0.3573 0.9553
Schistosoma mansoni ubiquitinyl hydrolase-UCH37 (C12 family) 0.0066 0.0704 0.1881
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0506 0.1352
Onchocerca volvulus 0.0075 0.0909 0.1526
Brugia malayi TAR-binding protein 0.0193 0.3573 0.9553
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase, putative 0.0066 0.0704 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.1682 0.4496
Schistosoma mansoni family C12 unassigned peptidase (C12 family) 0.02 0.3741 1
Echinococcus multilocularis tar DNA binding protein 0.0193 0.3573 0.4469
Loa Loa (eye worm) hypothetical protein 0.0075 0.0909 0.2429
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0909 0.0674
Brugia malayi RNA recognition motif domain containing protein 0.0193 0.3573 0.9553
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase isozyme 0.0066 0.0704 0.088
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0045 0.0057
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.02 0.3741 1
Brugia malayi hypothetical protein 0.0174 0.3145 0.8408
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase isozyme 0.0066 0.0704 0.088
Loa Loa (eye worm) TAR-binding protein 0.0193 0.3573 0.9553
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase isozyme 0.0066 0.0704 0.088
Schistosoma mansoni hypothetical protein 0.0075 0.0903 0.2415
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0909 0.0674
Brugia malayi beta-lactamase family protein 0.0075 0.0909 0.2429
Onchocerca volvulus 0.0075 0.0909 0.1526
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0909 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0909 0.2429
Trichomonas vaginalis Clan CA, family C12, ubiquitin hydrolase-like cysteine peptidase 0.02 0.3741 1
Loa Loa (eye worm) beta-lactamase 0.0075 0.0909 0.2429
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase BAP1 0.0066 0.0704 0.088
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0045 0.0057
Loa Loa (eye worm) ubiquitin C-terminal hydrolase UCH-L5 0.0066 0.0704 0.1881
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0193 0.3573 0.9553
Schistosoma mansoni hypothetical protein 0.0037 0.0045 0.0121
Trichomonas vaginalis Clan CA, family C12, ubiquitin hydrolase-like cysteine peptidase 0.02 0.3741 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0909 0.2429
Loa Loa (eye worm) hypothetical protein 0.0075 0.0909 0.2429
Echinococcus granulosus tar DNA binding protein 0.0193 0.3573 0.4469
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0909 0.1136
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0909 0.2429
Schistosoma mansoni tar DNA-binding protein 0.0193 0.3573 0.9553
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase isozyme L3, putative 0.02 0.3741 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.1682 0.4496
Onchocerca volvulus 0.0174 0.3145 1
Brugia malayi hypothetical protein 0.0037 0.0045 0.0121
Leishmania major ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C12, putative 0.02 0.3741 1
Loa Loa (eye worm) hypothetical protein 0.0075 0.0909 0.2429
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.1682 0.4496
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0909 0.1136
Loa Loa (eye worm) hypothetical protein 0.0174 0.3145 0.8408
Leishmania major hypothetical protein, conserved 0.0075 0.0909 0.0674
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase isozyme 0.02 0.3741 0.4679
Mycobacterium leprae Probable lipase LipE 0.0075 0.0909 0.5
Mycobacterium ulcerans hypothetical protein 0.0075 0.0909 0.5
Loa Loa (eye worm) hypothetical protein 0.0075 0.0909 0.2429
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0909 0.2429
Schistosoma mansoni ubiquitinyl hydrolase-BAP1 (C12 family) 0.0066 0.0704 0.1881
Loa Loa (eye worm) hypothetical protein 0.0057 0.0506 0.1352
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0909 0.0674

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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