Detailed information for compound 731789

Basic information

Technical information
  • TDR Targets ID: 731789
  • Name: 2,4-dichloro-N'-(4-methoxybenzoyl)benzohydraz ide
  • MW: 339.173 | Formula: C15H12Cl2N2O3
  • H donors: 2 H acceptors: 2 LogP: 3.59 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(=O)NNC(=O)c1ccc(cc1Cl)Cl
  • InChi: 1S/C15H12Cl2N2O3/c1-22-11-5-2-9(3-6-11)14(20)18-19-15(21)12-7-4-10(16)8-13(12)17/h2-8H,1H3,(H,18,20)(H,19,21)
  • InChiKey: XPYLAQWWVONFRH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2,4-dichloro-N'-[(4-methoxyphenyl)-oxomethyl]benzohydrazide
  • 2,4-dichloro-N'-(4-methoxyphenyl)carbonyl-benzohydrazide
  • ZINC00054858
  • ST002158

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.7995 0.7995
Loa Loa (eye worm) hypothetical protein 0.0036 0.0307 0.0307
Loa Loa (eye worm) hypothetical protein 0.0036 0.0307 0.0307
Brugia malayi Latrophilin receptor protein 2 0.0064 0.1606 0.1606
Plasmodium falciparum phd finger protein, putative 0.0029 0 0.5
Leishmania major hypothetical protein, conserved 0.0036 0.0307 0.5
Brugia malayi beta-lactamase 0.0036 0.0307 0.0307
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.5038 0.5038
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0307 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.1439 0.1439
Schistosoma mansoni tar DNA-binding protein 0.013 0.4672 0.7113
Onchocerca volvulus 0.0036 0.0307 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0965 0.0965
Echinococcus multilocularis geminin 0.0171 0.6568 1
Brugia malayi RNA binding protein 0.013 0.4672 0.4672
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0307 1
Loa Loa (eye worm) RNA binding protein 0.013 0.4672 0.4672
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.1606 0.1606
Echinococcus multilocularis tar DNA binding protein 0.013 0.4672 0.7113
Schistosoma mansoni tar DNA-binding protein 0.013 0.4672 0.7113
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0307 0.0467
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.1606 0.1606
Mycobacterium ulcerans hypothetical protein 0.0036 0.0307 0.5
Mycobacterium leprae Probable lipase LipE 0.0036 0.0307 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0307 0.0307
Echinococcus multilocularis GPCR, family 2 0.0064 0.1606 0.2445
Loa Loa (eye worm) MH2 domain-containing protein 0.0244 1 1
Mycobacterium ulcerans lipase LipD 0.0036 0.0307 0.5
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0307 0.0467
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.3074 0.4681
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0307 0.0307
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0307 0.5
Schistosoma mansoni hypothetical protein 0.0064 0.1606 0.2445
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0307 0.5
Loa Loa (eye worm) hypothetical protein 0.0138 0.5038 0.5038
Brugia malayi TAR-binding protein 0.013 0.4672 0.4672
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.1606 0.2445
Brugia malayi beta-lactamase family protein 0.0036 0.0307 0.0307
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0307 0.0467
Echinococcus granulosus GPCR family 2 0.0064 0.1606 0.2445
Mycobacterium ulcerans beta-lactamase 0.0036 0.0307 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0284 0.0433
Schistosoma mansoni hypothetical protein 0.0138 0.5038 0.767
Brugia malayi jmjC domain containing protein 0.0035 0.0284 0.0284
Brugia malayi beta-lactamase family protein 0.0036 0.0307 0.0307
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0307 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.7995 0.7995
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0307 0.5
Onchocerca volvulus 0.0036 0.0307 1
Schistosoma mansoni hypothetical protein 0.0171 0.6568 1
Loa Loa (eye worm) transcription factor SMAD2 0.0244 1 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.3074 0.4681
Schistosoma mansoni tar DNA-binding protein 0.013 0.4672 0.7113
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0307 0.0467
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.013 0.4672 0.4672
Echinococcus granulosus geminin 0.0171 0.6568 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.1606 0.2445
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0307 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0307 0.0307
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.0201 0.7995 0.7995
Loa Loa (eye worm) hypothetical protein 0.0064 0.1606 0.1606
Schistosoma mansoni hypothetical protein 0.0064 0.1606 0.2445
Schistosoma mansoni hypothetical protein 0.0064 0.1606 0.2445
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0307 0.5
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.9242 1
Schistosoma mansoni tar DNA-binding protein 0.013 0.4672 0.7113
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0284 0.0433
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.1606 0.2445
Schistosoma mansoni jumonji domain containing protein 0.0076 0.2165 0.3296
Loa Loa (eye worm) hypothetical protein 0.0036 0.0307 0.0307
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0307 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0307 0.0307
Toxoplasma gondii ABC1 family protein 0.0036 0.0307 1
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0529 0.0806
Schistosoma mansoni hypothetical protein 0.0064 0.1606 0.2445
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0307 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0284 0.0433
Brugia malayi RNA recognition motif domain containing protein 0.013 0.4672 0.4672
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0284 0.0433
Loa Loa (eye worm) beta-lactamase 0.0036 0.0307 0.0307
Schistosoma mansoni tar DNA-binding protein 0.013 0.4672 0.7113
Schistosoma mansoni hypothetical protein 0.0171 0.6568 1
Brugia malayi jmjC domain containing protein 0.0095 0.3074 0.3074
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0307 0.5
Giardia lamblia PHD finger protein 15 0.0029 0 0.5
Loa Loa (eye worm) TAR-binding protein 0.013 0.4672 0.4672
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.7995 0.7995
Echinococcus granulosus tar DNA binding protein 0.013 0.4672 0.7113
Onchocerca volvulus 0.0036 0.0307 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0307 0.0307
Trichomonas vaginalis esterase, putative 0.0036 0.0307 0.5
Echinococcus granulosus jumonji domain containing protein 0.004 0.0529 0.0806
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.1606 0.2445
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0307 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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