Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0019 | 0.0208 | 0.0476 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0015 | 0.013 | 0.0297 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0125 | 0.0286 |
Onchocerca volvulus | 0.0029 | 0.0437 | 0.0871 | |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0015 | 0.013 | 0.037 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0026 | 0.0375 | 0.086 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0125 | 0.0125 |
Brugia malayi | hypothetical protein | 0.0146 | 0.3117 | 0.7121 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0026 | 0.0375 | 0.0857 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.014 | 0.2979 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0026 | 0.0375 | 0.0375 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0125 | 0.0286 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.0375 | 0.3201 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0125 | 0.0286 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.0375 | 0.3201 |
Echinococcus granulosus | cathepsin l1 | 0.0026 | 0.0375 | 0.0375 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.3117 | 0.7121 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0026 | 0.0375 | 0.086 |
Onchocerca volvulus | 0.0026 | 0.0375 | 0.0749 | |
Onchocerca volvulus | 0.0026 | 0.0375 | 0.0749 | |
Entamoeba histolytica | cysteine protease, putative | 0.0026 | 0.0375 | 1 |
Echinococcus granulosus | geminin | 0.0164 | 0.3523 | 0.3523 |
Loa Loa (eye worm) | fibroinase | 0.0026 | 0.0375 | 0.0857 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.014 | 0.2979 | 0.8457 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.0375 | 0.3201 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0026 | 0.0375 | 0.0375 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0879 | 0.2007 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.0375 | 0.3201 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0437 | 0.1239 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0015 | 0.013 | 0.013 |
Echinococcus multilocularis | cathepsin b | 0.014 | 0.2979 | 0.2979 |
Echinococcus granulosus | cathepsin b | 0.014 | 0.2979 | 0.2979 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0019 | 0.0208 | 0.0274 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.0375 | 0.3201 |
Onchocerca volvulus | Cathepsin L homolog | 0.0026 | 0.0375 | 0.0749 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0208 | 0.0476 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0049 | 0.0896 | 0.2543 |
Loa Loa (eye worm) | cathepsin B | 0.0049 | 0.0896 | 0.2046 |
Echinococcus multilocularis | geminin | 0.0164 | 0.3523 | 0.3523 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.0375 | 0.3201 |
Echinococcus granulosus | cathepsin l1 | 0.0019 | 0.0208 | 0.0208 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0026 | 0.0375 | 0.0375 |
Echinococcus multilocularis | cysteine protease | 0.0026 | 0.0375 | 0.0375 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Onchocerca volvulus | 0.0026 | 0.0375 | 0.0749 | |
Echinococcus multilocularis | cathepsin L | 0.0015 | 0.013 | 0.013 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0437 | 0.1239 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.0375 | 0.0857 |
Onchocerca volvulus | 0.0026 | 0.0375 | 0.0749 | |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.0375 | 0.0857 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0208 | 0.016 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0049 | 0.0896 | 1 |
Echinococcus granulosus | cathepsin b | 0.014 | 0.2979 | 0.2979 |
Onchocerca volvulus | 0.0026 | 0.0375 | 0.0749 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0019 | 0.0208 | 0.0591 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0125 | 0.0286 |
Brugia malayi | Pre-SET motif family protein | 0.0201 | 0.4378 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0229 | 0.5013 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.3523 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0125 | 0.0356 |
Onchocerca volvulus | 0.0019 | 0.0208 | 0.0415 | |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0412 | 0.0412 |
Echinococcus granulosus | GPCR family 2 | 0.0015 | 0.0125 | 0.0125 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.3523 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0375 | 0.0857 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0015 | 0.013 | 0.037 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0026 | 0.0375 | 0.1065 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.0375 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Plasmodium vivax | vivapain-2 | 0.0026 | 0.0375 | 0.8001 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.014 | 0.2979 | 0.6805 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.053 | 0.1211 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.0375 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0437 | 0.0437 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Echinococcus granulosus | cathepsin L | 0.0015 | 0.013 | 0.013 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0437 | 0.1239 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0208 | 0.0476 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0049 | 0.0896 | 0.1568 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.0437 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0201 | 0.4378 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0026 | 0.0375 | 1 |
Onchocerca volvulus | 0.0026 | 0.0375 | 0.0749 | |
Giardia lamblia | Cathepsin B precursor | 0.0049 | 0.0896 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0115 | 0.2416 | 0.5519 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.0375 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Giardia lamblia | Cathepsin B precursor | 0.0049 | 0.0896 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0026 | 0.0375 | 0.086 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.0375 | 0.0857 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0026 | 0.0375 | 0.0375 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0015 | 0.013 | 0.0297 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.053 | 0.1504 |
Onchocerca volvulus | Cathepsin F homolog | 0.0026 | 0.0375 | 0.0749 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0879 | 0.2007 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0879 | 0.2007 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0437 | 0.1239 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0026 | 0.0375 | 0.0375 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0026 | 0.0375 | 0.086 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.014 | 0.2979 | 0.8457 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0437 | 0.0997 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0015 | 0.013 | 0.037 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0125 | 0.0356 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0125 | 0.0356 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0437 | 0.0437 |
Onchocerca volvulus | 0.0146 | 0.3117 | 0.6218 | |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0026 | 0.0375 | 0.0857 |
Toxoplasma gondii | cathepsin B | 0.0049 | 0.0896 | 1 |
Plasmodium vivax | vivapain-2 | 0.0026 | 0.0375 | 0.8001 |
Giardia lamblia | Cathepsin B precursor | 0.0049 | 0.0896 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Onchocerca volvulus | Cathepsin L homolog | 0.0026 | 0.0375 | 0.0749 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0015 | 0.0125 | 0.0125 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0879 | 0.2007 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0026 | 0.0375 | 0.0857 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0437 | 0.1176 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0026 | 0.0375 | 0.1065 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0026 | 0.0375 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.2979 | 0.6805 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0026 | 0.0375 | 0.086 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0125 | 0.0125 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0208 | 0.0476 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0447 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0026 | 0.0375 | 0.0375 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.014 | 0.2979 | 0.8457 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0447 | 1 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0447 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0026 | 0.0375 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.0375 | 0.3201 |
Onchocerca volvulus | 0.0229 | 0.5013 | 1 | |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0049 | 0.0896 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0026 | 0.0375 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.053 | 0.1211 |
Onchocerca volvulus | 0.0026 | 0.0375 | 0.0749 | |
Brugia malayi | cathepsin L-like precursor | 0.0019 | 0.0208 | 0.0476 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0115 | 0.2416 | 0.5519 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.0375 | 0.0857 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.0375 | 0.0857 |
Echinococcus multilocularis | cathepsin b | 0.014 | 0.2979 | 0.2979 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0015 | 0.0125 | 0.0125 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0208 | 0.0476 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0026 | 0.0375 | 0.0375 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0437 | 0.0437 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0026 | 0.0375 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0019 | 0.0208 | 0.3182 |
Brugia malayi | Cathepsin L-like precursor | 0.0019 | 0.0208 | 0.0476 |
Loa Loa (eye worm) | cysteine protease | 0.0026 | 0.0375 | 0.0857 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0019 | 0.0208 | 0.016 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.014 | 0.2979 | 0.8457 |
Brugia malayi | Cathepsin L-like precursor | 0.0026 | 0.0375 | 0.0857 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0026 | 0.0375 | 0.0502 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0026 | 0.0375 | 0.3201 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0437 | 0.0997 |
Loa Loa (eye worm) | ctsf protein | 0.0026 | 0.0375 | 0.0857 |
Brugia malayi | MH2 domain containing protein | 0.0115 | 0.2416 | 0.5519 |
Echinococcus multilocularis | GPCR, family 2 | 0.0015 | 0.0125 | 0.0125 |
Schistosoma mansoni | hypothetical protein | 0.0015 | 0.0125 | 0.0356 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0049 | 0.0896 | 0.2688 |
Echinococcus granulosus | cysteine protease | 0.0015 | 0.013 | 0.013 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 5.3 uL/min/10^6cells | Intrinsic clearance in human hepatocytes from chimeric mouse with humanized liver assessed per 10'6 cells at 10 uM after 0.25 to 2 hrs by LC-MS/MS method | ChEMBL. | 22048522 |
Concentration (functional) | = 1 uM | Concentration of 2-Amino-9-(4-hydroxy-3-hydroxymethyl)but-1-yl)purine in blood of mice after 3 hours upon oral administration | ChEMBL. | 2754699 |
Concentration (functional) | = 1 uM | Concentration of 2-Amino-9-(4-hydroxy-3-hydroxymethyl)but-1-yl)purine in blood of mice after 3 hours upon oral administration | ChEMBL. | 2754699 |
Concentration (functional) | = 3.2 uM | Concentration of 9-[4-Hydroxy-3-(hydroxymethyl)but-1-yl)guanine in blood of mice after 3 hours upon oral administration | ChEMBL. | 2754699 |
Concentration (functional) | = 3.2 uM | Concentration of 9-[4-Hydroxy-3-(hydroxymethyl)but-1-yl)guanine in blood of mice after 3 hours upon oral administration | ChEMBL. | 2754699 |
Concentration (functional) | = 4 uM | Concentration of 2-Amino-9-(4-hydroxy-3-hydroxymethyl)but-1-yl)purine in blood of mice after 1 hour upon oral administration | ChEMBL. | 2754699 |
Concentration (functional) | = 4 uM | Concentration of 2-Amino-9-(4-hydroxy-3-hydroxymethyl)but-1-yl)purine in blood of mice after 1 hour upon oral administration | ChEMBL. | 2754699 |
Concentration (functional) | = 8 uM | Concentration of 2-Amino-9-(4-hydroxy-3-hydroxymethyl)but-1-yl)purine in blood of mice after 0.25 hours upon oral administration | ChEMBL. | 2754699 |
Concentration (functional) | = 8 uM | Concentration of 2-Amino-9-(4-hydroxy-3-hydroxymethyl)but-1-yl)purine in blood of mice after 0.25 hours upon oral administration | ChEMBL. | 2754699 |
Concentration (functional) | = 13 uM | Concentration of 9-[4-Hydroxy-3-(hydroxymethyl)but-1-yl)guanine in blood of mice after 1 hour upon oral administration | ChEMBL. | 2754699 |
Concentration (functional) | = 13 uM | Concentration of 9-[4-Hydroxy-3-(hydroxymethyl)but-1-yl)guanine in blood of mice after 1 hour upon oral administration | ChEMBL. | 2754699 |
Concentration (functional) | = 16 uM | Concentration of 9-[4-Hydroxy-3-(hydroxymethyl)but-1-yl)guanine in blood of mice after 0.25 hours upon oral administration | ChEMBL. | 2754699 |
Concentration (functional) | = 16 uM | Concentration of 9-[4-Hydroxy-3-(hydroxymethyl)but-1-yl)guanine in blood of mice after 0.25 hours upon oral administration | ChEMBL. | 2754699 |
S | = 120 mg ml-1 | Aqueous solubility of the compound at 25 degrees centigrade | ChEMBL. | 2754699 |
T1/2 (ADMET) | = 0.1 hr | Elimination half life in chimeric mouse with humanized liver at 3 mg/kg, iv by LC-MS/MS method | ChEMBL. | 22048522 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.