Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | huntingtin | Starlite/ChEMBL | No references |
Homo sapiens | microtubule-associated protein tau | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0159 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0361 | 0.3886 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.1546 | 0.1546 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.0159 | 0.0159 |
Echinococcus granulosus | acetylcholinesterase | 0.0361 | 0.3886 | 0.3886 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.1546 | 0.1546 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0361 | 0.3886 | 0.3886 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0833 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0361 | 0.3886 | 0.3886 |
Loa Loa (eye worm) | hypothetical protein | 0.0361 | 0.3886 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.1126 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.0159 | 0.0159 |
Onchocerca volvulus | Huntingtin homolog | 0.0148 | 0.1126 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0361 | 0.3886 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0061 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0361 | 0.3886 | 0.3886 |
Loa Loa (eye worm) | carboxylesterase | 0.0361 | 0.3886 | 1 |
Brugia malayi | hypothetical protein | 0.0148 | 0.1126 | 0.2897 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0159 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.1546 | 0.3978 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.1546 | 0.1546 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1126 | 0.2897 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.1546 | 0.3978 |
Echinococcus granulosus | acetylcholinesterase | 0.0361 | 0.3886 | 0.3886 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0159 | 0.0159 |
Brugia malayi | Carboxylesterase family protein | 0.0361 | 0.3886 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.1546 | 0.3978 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.1126 | 0.2897 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.0159 | 0.0159 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0061 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0361 | 0.3886 | 0.3886 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0833 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.0159 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.0159 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0361 | 0.3886 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.0159 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.0159 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0361 | 0.3886 | 0.3886 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.6535 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (binding) | 17.7828 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.