Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Cholesterol esterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Cholesterol esterase | 597 aa | 587 aa | 25.6 % | |
Schistosoma mansoni | gliotactin | Cholesterol esterase | 597 aa | 581 aa | 30.1 % |
Brugia malayi | Carboxylesterase family protein | Cholesterol esterase | 597 aa | 546 aa | 26.7 % |
Loa Loa (eye worm) | hypothetical protein | Cholesterol esterase | 597 aa | 550 aa | 27.5 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Cholesterol esterase | 597 aa | 536 aa | 27.1 % |
Echinococcus granulosus | acetylcholinesterase | Cholesterol esterase | 597 aa | 511 aa | 32.5 % |
Onchocerca volvulus | Cholesterol esterase | 597 aa | 555 aa | 27.4 % | |
Echinococcus multilocularis | BC026374 protein (S09 family) | Cholesterol esterase | 597 aa | 643 aa | 26.0 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Cholesterol esterase | 597 aa | 657 aa | 23.7 % |
Echinococcus multilocularis | acetylcholinesterase | Cholesterol esterase | 597 aa | 517 aa | 32.7 % |
Brugia malayi | Carboxylesterase family protein | Cholesterol esterase | 597 aa | 481 aa | 24.3 % |
Loa Loa (eye worm) | hypothetical protein | Cholesterol esterase | 597 aa | 478 aa | 24.9 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Cholesterol esterase | 597 aa | 570 aa | 28.4 % |
Echinococcus granulosus | BC026374 protein S09 family | Cholesterol esterase | 597 aa | 664 aa | 25.9 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Cholesterol esterase | 597 aa | 607 aa | 28.2 % |
Loa Loa (eye worm) | acetylcholinesterase 1 | Cholesterol esterase | 597 aa | 561 aa | 31.2 % |
Onchocerca volvulus | Putative nuclear protein | Cholesterol esterase | 597 aa | 557 aa | 30.2 % |
Echinococcus multilocularis | acetylcholinesterase | Cholesterol esterase | 597 aa | 663 aa | 28.2 % |
Brugia malayi | Carboxylesterase family protein | Cholesterol esterase | 597 aa | 554 aa | 28.7 % |
Brugia malayi | Carboxylesterase family protein | Cholesterol esterase | 597 aa | 545 aa | 27.5 % |
Echinococcus granulosus | acetylcholinesterase | Cholesterol esterase | 597 aa | 645 aa | 28.1 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Cholesterol esterase | 597 aa | 540 aa | 30.6 % |
Onchocerca volvulus | Cholesterol esterase | 597 aa | 495 aa | 27.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Tolloid protein 1 | 0.0519 | 1 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0519 | 1 | 1 |
Echinococcus multilocularis | laminin | 0.0519 | 1 | 1 |
Brugia malayi | Fibulin-1 precursor | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0519 | 1 | 1 |
Onchocerca volvulus | Arrow homolog | 0.0519 | 1 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0519 | 1 | 1 |
Echinococcus granulosus | Tolloid protein 1 | 0.0519 | 1 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0519 | 1 | 1 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0519 | 1 | 1 |
Schistosoma mansoni | egf-like domain protein | 0.0519 | 1 | 1 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0519 | 1 | 1 |
Echinococcus granulosus | laminin | 0.0519 | 1 | 1 |
Giardia lamblia | High cysteine protein | 0.0198 | 0 | 0.5 |
Echinococcus multilocularis | fibrillin 1 | 0.0519 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 50 uM | Inhibitory activity AChE from Electrophorus electricus using ATCh substrate and DTNB by spectrophotometry | ChEMBL. | 16366609 |
IC50 (binding) | > 50 uM | Inhibitory activity AChE from Electrophorus electricus using ATCh substrate and DTNB by spectrophotometry | ChEMBL. | 16366609 |
Ki (binding) | = 0 nM | Steady state inhibition constant for Human Leukocyte Elastase inhibition | ChEMBL. | 9572899 |
Ki (binding) | = 5.7 uM | Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometry | ChEMBL. | 16366609 |
Ki (binding) | = 5.7 uM | Inhibitory activity against bovine pancreatic CEase in presence of pNPB chromogenic substrate by spectrophotometry | ChEMBL. | 16366609 |
kOH- (ADMET) | = 0.083 M-1 s-1 | Alakaline hydrolysis rate (k-OH) | ChEMBL. | 9572899 |
kon (binding) | < 0.8 10e3* M-1 s-1 | Second order rate constant for enzyme-inhibitor complex Human Leukocyte Elastase inhibition was determined | ChEMBL. | 9572899 |
kon (binding) | < 0.8 10e3* M-1 s-1 | Second order rate constant for enzyme-inhibitor complex Human Leukocyte Elastase inhibition was determined | ChEMBL. | 9572899 |
Log kOH- (ADMET) | = 1.08 | Alkaline hydrolysis rate (logk-OH) | ChEMBL. | 9572899 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.