Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0177 | 0.2679 | 1 |
Trypanosoma brucei | endonuclease G, putative | 0.0106 | 0.0157 | 0.5 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0177 | 0.2679 | 0.2563 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0177 | 0.2679 | 1 |
Trypanosoma cruzi | endonuclease G, putative | 0.0106 | 0.0157 | 0.5 |
Schistosoma mansoni | integrin alpha | 0.0185 | 0.2957 | 0.2845 |
Trypanosoma cruzi | endonuclease G, putative | 0.0106 | 0.0157 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.0106 | 0.0157 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0177 | 0.2679 | 1 |
Leishmania major | endonuclease G, putative | 0.0106 | 0.0157 | 0.5 |
Echinococcus granulosus | ectonucleotide | 0.0149 | 0.1685 | 0.6061 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0177 | 0.2679 | 0.2563 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.135 | 0.135 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0177 | 0.2679 | 0.2563 |
Schistosoma mansoni | hypothetical protein | 0.0382 | 1 | 1 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0106 | 0.0157 | 0.5 |
Trypanosoma brucei | endonuclease G, putative | 0.0106 | 0.0157 | 0.5 |
Onchocerca volvulus | 0.0382 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.154 | 0.154 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0285 | 0.6529 | 0.6529 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0185 | 0.2957 | 0.2845 |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0382 | 1 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0177 | 0.2679 | 1 |
Toxoplasma gondii | DNA/RNA non-specific endonuclease | 0.0106 | 0.0157 | 0.5 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0149 | 0.1685 | 0.6061 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0177 | 0.2679 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0177 | 0.2679 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0177 | 0.2679 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.2679 | 0.2679 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0149 | 0.1685 | 0.6061 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.2679 | 0.2679 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0177 | 0.2679 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0177 | 0.2679 | 0.2563 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0177 | 0.2679 | 1 |
Echinococcus granulosus | integrin alpha 3 | 0.0142 | 0.1417 | 0.4998 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.014 | 0.135 | 0.1213 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.2679 | 0.2679 |
Echinococcus multilocularis | integrin alpha 3 | 0.0142 | 0.1417 | 0.4998 |
Loa Loa (eye worm) | hypothetical protein | 0.0149 | 0.1685 | 0.1685 |
Leishmania major | DNA/RNA non-specific endonuclease-like protein | 0.0106 | 0.0157 | 0.5 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0177 | 0.2679 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0177 | 0.2679 | 1 |
Trypanosoma cruzi | DNA/RNA non-specific endonuclease protein-like, putative | 0.0106 | 0.0157 | 0.5 |
Echinococcus multilocularis | ectonucleotide | 0.0149 | 0.1685 | 0.6061 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0177 | 0.2679 | 0.2563 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 5 uM | Inhibition of fibrinogen binding to activated human platelets | ChEMBL. | No reference |
IC50 (functional) | = 5 uM | Inhibition of fibrinogen binding to activated human platelets | ChEMBL. | No reference |
IC50 (functional) | = 6.6 uM | Inhibition of human platelet aggregation | ChEMBL. | No reference |
IC50 (functional) | = 6.6 uM | Inhibition of human platelet aggregation | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.