Detailed information for compound 754843

Basic information

Technical information
  • TDR Targets ID: 754843
  • Name: 2-[4-[5-[(3-methylphenoxy)methyl]-1,2,4-oxadi azol-3-yl]phenoxy]acetamide
  • MW: 339.345 | Formula: C18H17N3O4
  • H donors: 1 H acceptors: 3 LogP: 2.58 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)COc1ccc(cc1)c1noc(n1)COc1cccc(c1)C
  • InChi: 1S/C18H17N3O4/c1-12-3-2-4-15(9-12)24-11-17-20-18(21-25-17)13-5-7-14(8-6-13)23-10-16(19)22/h2-9H,10-11H2,1H3,(H2,19,22)
  • InChiKey: ZSVQKRPJTGGTGG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-[5-[(3-methylphenoxy)methyl]-1,2,4-oxadiazol-3-yl]phenoxy]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans hypothetical protein 0.0016 0.3119 0.5
Loa Loa (eye worm) hypothetical protein 0.0015 0.3056 0.3056
Onchocerca volvulus Kinesin light chain homolog 0.0001 0.0029 0.4528
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.3056 0.3717
Trypanosoma cruzi stress-inducible protein STI1-like, putative 0.0001 0 0.0047
Echinococcus multilocularis GPCR, family 2 0.0015 0.3056 0.3717
Schistosoma mansoni hypothetical protein 0.0015 0.3056 0.3717
Leishmania major hypothetical protein, conserved 0.0001 0.0064 1
Entamoeba histolytica TPR repeat protein 0.0001 0 0.0047
Trypanosoma brucei stress-induced protein sti1, putative 0.0001 0.0064 1
Schistosoma mansoni DNAj homolog subfamily C member 0.0001 0.0064 0.0078
Trichomonas vaginalis chaperone binding protein, putative 0.0001 0 0.0047
Plasmodium falciparum Hsp70/Hsp90 organizing protein 0.0001 0.0064 1
Brugia malayi hypothetical protein 0.0001 0.0029 0.0029
Brugia malayi Latrophilin receptor protein 2 0.0015 0.3056 0.3056
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.3056 0.3056
Schistosoma mansoni hypothetical protein 0.0033 0.6786 0.8254
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 1 1
Loa Loa (eye worm) TPR domain-containing protein 0.0001 0.0093 0.0093
Trichomonas vaginalis chaperone binding protein, putative 0.0001 0.0064 1
Toxoplasma gondii O-linked N-acetylglucosamine transferase 0.004 0.8128 1
Trichomonas vaginalis O-linked N-acetylglucosamine transferase, ogt, putative 0.0001 0.0064 0.9953
Schistosoma mansoni o-linked n-acetylglucosamine transferase ogt 0.004 0.8221 1
Trypanosoma cruzi small glutamine-rich tetratricopeptide repeat protein, putative 0.0001 0 0.0047
Entamoeba histolytica TPR repeat protein 0.0001 0.0064 1
Echinococcus granulosus stress induced phosphoprotein 1 0.0001 0.0093 0.0113
Leishmania major small glutamine-rich tetratricopeptide repeat protein, putative 0.0001 0 0.0047
Trypanosoma brucei stress-inducible protein STI1-like, putative 0.0001 0 0.0047
Treponema pallidum hypothetical protein 0.0016 0.3119 0.9999
Giardia lamblia O-linked GlcNAc transferase 0.004 0.8128 1
Echinococcus multilocularis small glutamine rich tetratricopeptide 0.0001 0.0064 0.0078
Trypanosoma cruzi stress-inducible protein STI1-like, putative 0.0001 0 0.0047
Treponema pallidum hypothetical protein 0.0016 0.3119 1
Schistosoma mansoni heat shock protein 70 0.0001 0.0064 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.0001 0 0.0047
Giardia lamblia O-linked GlcNAc transferase 0.0023 0.4692 0.5772
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.3056 0.3717
Schistosoma mansoni hypothetical protein 0.0015 0.3056 0.3717
Echinococcus multilocularis O glycosyltransferase 0.004 0.8221 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 1 1
Treponema pallidum hypothetical protein 0.0016 0.3119 0.9999
Treponema pallidum hypothetical protein 0.0016 0.3119 0.9999
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.3056 0.3717
Trypanosoma brucei stress-inducible protein STI1-like, putative 0.0001 0 0.0047
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.6786 0.6786
Trypanosoma cruzi hypothetical protein, conserved 0.0001 0.0064 1
Schistosoma mansoni hypothetical protein 0.0015 0.3056 0.3717
Loa Loa (eye worm) UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 0.004 0.8192 0.8192
Loa Loa (eye worm) hypothetical protein 0.0049 1 1
Echinococcus granulosus GPCR family 2 0.0015 0.3056 0.3717
Echinococcus granulosus small glutamine rich tetratricopeptide 0.0001 0.0064 0.0078
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.3056 0.3717
Trypanosoma cruzi hypothetical protein, conserved 0.0001 0.0064 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.3056 0.3056
Wolbachia endosymbiont of Brugia malayi hypothetical protein 0.0016 0.3119 1
Brugia malayi UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 0.004 0.8192 0.8192
Schistosoma mansoni hypothetical protein 0.0015 0.3056 0.3717
Chlamydia trachomatis hypothetical protein 0.0016 0.3119 0.5
Trypanosoma brucei stress-inducible protein STI1-like, putative 0.0001 0 0.0047
Onchocerca volvulus 0.0001 0.0064 1
Trypanosoma brucei small glutamine-rich tetratricopeptide repeat protein, putative 0.0001 0 0.0047
Plasmodium vivax Hsp70/Hsp90 organizing protein, putative 0.0001 0.0064 1
Leishmania major stress-induced protein sti1 0.0001 0.0029 0.4528
Echinococcus multilocularis stress induced phosphoprotein 1 0.0001 0.0093 0.0113
Trichomonas vaginalis chaperone binding protein, putative 0.0001 0.0064 0.9953
Schistosoma mansoni heat shock protein 70 0.0001 0.0064 0.0078
Loa Loa (eye worm) hypothetical protein 0.0033 0.6786 0.6786
Echinococcus granulosus O glycosyltransferase 0.004 0.8221 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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