TDR Targets

Basic information

Technical information

TDR Targets ID: 763345
Name: 6-[[4-(tert-butylamino)-6-chloro-1,3,5-triazi n-2-yl]oxy]-2-methylpyridazin-3-one
MW: 310.74 | Formula: C12H15ClN6O2
H donors: 1 H acceptors: 4 LogP: 2.07 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1nc(nc(n1)NC(C)(C)C)Oc1ccc(=O)n(n1)C
InChi: 1S/C12H15ClN6O2/c1-12(2,3)17-10-14-9(13)15-11(16-10)21-7-5-6-8(20)19(4)18-7/h5-6H,1-4H3,(H,14,15,16,17)
InChiKey: MWUFYLROHQHXOW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-[[4-(tert-butylamino)-6-chloro-1,3,5-triazin-2-yl]oxy]-2-methyl-pyridazin-3-one
6-[[4-(tert-butylamino)-6-chloro-1,3,5-triazin-2-yl]oxy]-2-methyl-3-pyridazinone
6-[[4-(tert-butylamino)-6-chloro-s-triazin-2-yl]oxy]-2-methyl-pyridazin-3-one
STOCK3S-34367
ZINC00529429

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	geminin	0.0529	0.7735	0.7735
Giardia lamblia	Pyruvate kinase	0.0034	0.0214	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.146	0.1626
Chlamydia trachomatis	pyruvate kinase	0.0034	0.0214	0.5
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0435	0.0485
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0246	0.0758
Loa Loa (eye worm)	pyruvate kinase	0.0034	0.0214	0.0238
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.0673	0.1552
Leishmania major	pyruvate kinase	0.0034	0.0214	0.0491
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0063	0.0142
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0255	0.3575	0.398
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0246	1
Leishmania major	pyruvate kinase	0.0034	0.0214	0.0491
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0149	0.1953	0.1953
Echinococcus granulosus	pyruvate kinase	0.0034	0.0214	0.0214
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0246	0.0273
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0149	0.1953	0.1953
Mycobacterium ulcerans	lipase LipD	0.0036	0.0246	0.1145
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0246	0.1145
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0074	0.0813	0.0813
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0246	0.0758
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0034	0.0214	0.0238
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0246	1
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.0673	0.1552
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0246	0.0273
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0246	0.0758
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0043	0.0345	0.0794
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0074	0.0813	0.0813
Echinococcus multilocularis	transcription factor Dp 1	0.0037	0.026	0.026
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0305	0.4332	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0435	0.0485
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0043	0.0345	0.0794
Trichomonas vaginalis	esterase, putative	0.0036	0.0246	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0246	0.0273
Entamoeba histolytica	hypothetical protein	0.0074	0.0813	1
Leishmania major	hypothetical protein, conserved	0.0024	0.0063	0.0142
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0232	0.3226	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0435	0.0485
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0144	0.1888	0.4357
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0034	0.0214	0.0491
Toxoplasma gondii	LsmAD domain-containing protein	0.0024	0.0063	0.14
Loa Loa (eye worm)	pyruvate kinase	0.0034	0.0214	0.0238
Trichomonas vaginalis	pyruvate kinase, putative	0.0034	0.0214	0.8693
Brugia malayi	beta-lactamase	0.0036	0.0246	0.0273
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0149	0.1953	0.1953
Schistosoma mansoni	tar DNA-binding protein	0.0255	0.3575	0.4622
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0043	0.0345	0.0794
Leishmania major	mitochondrial DNA polymerase beta	0.0305	0.4332	1
Loa Loa (eye worm)	hypothetical protein	0.0611	0.8983	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0149	0.1953	0.2174
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0246	1
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0246	1
Leishmania major	hypothetical protein, conserved	0.0036	0.0246	0.0565
Onchocerca volvulus		0.0036	0.0246	0.2045
Trichomonas vaginalis	pyruvate kinase, putative	0.0034	0.0214	0.8693
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0246	0.0318
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0246	0.1145
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0149	0.1953	0.2525
Onchocerca volvulus	Pyruvate kinase homolog	0.0034	0.0214	0.1779
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0246	1
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1201	0.1337
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0063	0.007
Plasmodium vivax	pyruvate kinase, putative	0.0034	0.0214	0.8693
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0246	0.0565
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0246	0.0758
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0001	0.5
Plasmodium vivax	ataxin-2 like protein, putative	0.0024	0.0063	0.2517
Trypanosoma brucei	pyruvate kinase 1	0.0034	0.0214	0.0491
Echinococcus granulosus	transcription factor Dp 1	0.0037	0.026	0.026
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0034	0.0214	0.0659
Mycobacterium ulcerans	hypothetical protein	0.0161	0.2136	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0246	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0246	0.0273
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0034	0.0214	0.0238
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0043	0.0345	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0611	0.8983	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0246	0.0273
Echinococcus multilocularis	tar DNA binding protein	0.0255	0.3575	0.3575
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0001	0.0001
Brugia malayi	hypothetical protein	0.0024	0.0063	0.007
Brugia malayi	RNA binding protein	0.0255	0.3575	0.398
Brugia malayi	RNA recognition motif domain containing protein	0.0255	0.3575	0.398
Brugia malayi	Muscleblind-like protein	0.0611	0.8983	1
Brugia malayi	beta-lactamase family protein	0.0036	0.0246	0.0273
Schistosoma mansoni	tar DNA-binding protein	0.0255	0.3575	0.4622
Schistosoma mansoni	hypothetical protein	0.0529	0.7735	1
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.0065	0.0673	0.1552
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0246	0.0758
Schistosoma mansoni	cellular tumor antigen P53	0.0099	0.1201	0.1553
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0246	0.0246
Loa Loa (eye worm)	TAR-binding protein	0.0255	0.3575	0.398
Onchocerca volvulus		0.0099	0.1201	1
Onchocerca volvulus		0.0036	0.0246	0.2045
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0144	0.1888	0.4357
Entamoeba histolytica	hypothetical protein	0.0074	0.0813	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0246	0.0273
Entamoeba histolytica	pyruvate kinase, putative	0.0024	0.0056	0.0675
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0246	0.0565
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0246	0.0565
Echinococcus multilocularis	pyruvate kinase	0.0034	0.0214	0.0214
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0246	1
Brugia malayi	TAR-binding protein	0.0255	0.3575	0.398
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0246	0.0758
Schistosoma mansoni	tar DNA-binding protein	0.0255	0.3575	0.4622
Plasmodium falciparum	pyruvate kinase	0.0034	0.0214	1
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0435	0.0485
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0246	0.0318
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0246	0.0758
Toxoplasma gondii	hypothetical protein	0.0049	0.0441	1
Echinococcus granulosus	pyruvate kinase	0.0034	0.0214	0.0214
Schistosoma mansoni	hypothetical protein	0.0529	0.7735	1
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.0065	0.0673	0.828
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0305	0.4332	1
Schistosoma mansoni	hypothetical protein	0.0033	0.02	0.0259
Loa Loa (eye worm)	hypothetical protein	0.0033	0.02	0.0223
Schistosoma mansoni	ap endonuclease	0.002	0.0001	0.0002
Echinococcus multilocularis	tumor protein p63	0.0678	1	1
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0246	0.0758
Toxoplasma gondii	pyruvate kinase PyK1	0.0034	0.0214	0.4833
Entamoeba histolytica	hypothetical protein	0.0074	0.0813	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0246	0.1145
Echinococcus multilocularis	muscleblind protein	0.0611	0.8983	0.8983
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0149	0.1953	0.2174
Loa Loa (eye worm)	pyruvate kinase	0.0034	0.0214	0.0238
Echinococcus multilocularis	pyruvate kinase	0.0034	0.0214	0.0214
Loa Loa (eye worm)	RNA binding protein	0.0255	0.3575	0.398
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0001	0.0001
Schistosoma mansoni	transcription factor LCR-F1	0.0074	0.0813	0.1051
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0034	0.0214	0.0491
Schistosoma mansoni	pyruvate kinase	0.0034	0.0214	0.0276
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0246	0.0758
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.0065	0.0673	0.0673
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0063	0.0142
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0001	0.0001
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0305	0.4332	1
Brugia malayi	beta-lactamase family protein	0.0036	0.0246	0.0273
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0246	0.1145
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.0065	0.0673	0.075
Onchocerca volvulus	Pyruvate kinase homolog	0.0034	0.0214	0.1779
Schistosoma mansoni	hypothetical protein	0.0074	0.0813	0.1051
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0063	0.2896
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0149	0.1953	0.2525
Schistosoma mansoni	pyruvate kinase	0.0034	0.0214	0.0276
Trypanosoma brucei	pyruvate kinase 1, putative	0.0034	0.0214	0.0491
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.0065	0.0673	0.1552
Echinococcus multilocularis	muscleblind protein 1	0.0611	0.8983	0.8983
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0149	0.1953	0.2525
Onchocerca volvulus		0.0036	0.0246	0.2045
Toxoplasma gondii	ABC1 family protein	0.0036	0.0246	0.556
Echinococcus multilocularis	pyruvate kinase	0.0027	0.0104	0.0104
Brugia malayi	MH2 domain containing protein	0.0116	0.146	0.1626
Mycobacterium ulcerans	pyruvate kinase	0.0034	0.0214	0.0995
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.146	0.1626
Schistosoma mansoni	tar DNA-binding protein	0.0255	0.3575	0.4622
Entamoeba histolytica	hypothetical protein	0.0074	0.0813	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0063	0.2896
Schistosoma mansoni	ap endonuclease	0.002	0.0001	0.0002
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0246	0.0246
Echinococcus granulosus	tar DNA binding protein	0.0255	0.3575	0.3575
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0052	0.0488	0.1123
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0001	0.5
Echinococcus granulosus	muscleblind protein	0.0611	0.8983	0.8983
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0149	0.1953	0.1953
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0246	0.0273
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.0246	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0214	0.0238
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0161	0.2136	0.6621
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0063	0.0142
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0246	0.0758
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0056	0.0062
Schistosoma mansoni	tar DNA-binding protein	0.0255	0.3575	0.4622
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0001	0.0001
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.0246	1
Brugia malayi	hypothetical protein	0.0074	0.0813	0.0905
Loa Loa (eye worm)	pyruvate kinase-PB	0.0024	0.0056	0.0062
Echinococcus granulosus	geminin	0.0529	0.7735	0.7735
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.0065	0.0673	0.0673
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0144	0.1888	0.4357
Onchocerca volvulus	Pyruvate kinase homolog	0.0034	0.0214	0.1779
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.02	0.0223
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0246	0.0273
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.0065	0.0673	0.0871
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.0065	0.0673	0.075

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 763345