TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 346.378 | Formula: C18H22N2O5
H donors: 1 H acceptors: 3 LogP: 1.82 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CC(OCCNC(=O)c1noc(c1)COc1cccc(c1)C(=O)C)C
InChi: 1S/C18H22N2O5/c1-12(2)23-8-7-19-18(22)17-10-16(25-20-17)11-24-15-6-4-5-14(9-15)13(3)21/h4-6,9-10,12H,7-8,11H2,1-3H3,(H,19,22)
InChiKey: LQZQPXMGPJSLIP-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.003	0.0157	0.2954
Trichomonas vaginalis	CAMK family protein kinase	0.0066	0.0554	0.1927
Leishmania major	glucose transporter, lmgt2	0.0066	0.0564	0.8107
Onchocerca volvulus		0.003	0.0157	0.025
Onchocerca volvulus		0.003	0.0157	0.025
Brugia malayi	nuclear receptor RXR	0.0045	0.0324	0.0515
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0061	0.0504	0.0801
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0061	0.0504	0.2271
Loa Loa (eye worm)	hypothetical protein	0.0578	0.6293	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0061	0.0504	0.2271
Loa Loa (eye worm)	hypothetical protein	0.003	0.0157	0.025
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0048	0.0355	0.395
Loa Loa (eye worm)	hypothetical protein	0.003	0.0157	0.025
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0066	0.0564	0.8107
Plasmodium vivax	proline--tRNA ligase, putative	0.0075	0.0659	0.051
Brugia malayi	steroid hormone receptor	0.0061	0.0504	0.0801
Brugia malayi	major facilitator superfamily protein	0.003	0.0157	0.025
Schistosoma mansoni	glucose transporter	0.003	0.0157	0.0709
Schistosoma mansoni	retinoic acid receptor RXR	0.0061	0.0504	0.2271
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0061	0.0504	0.0801
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0061	0.0504	0.0801
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0064	0.054	1
Onchocerca volvulus	Putative transporter	0.003	0.0157	0.025
Brugia malayi	hypothetical protein	0.003	0.0157	0.025
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0061	0.0504	0.2271
Entamoeba histolytica	protein kinase, putative	0.0066	0.0554	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0061	0.0504	0.0801
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0214	0.2219	1
Schistosoma mansoni	protein kinase	0.0066	0.0554	0.2499
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0048	0.0355	1
Brugia malayi	hypothetical protein	0.0045	0.0324	0.0515
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0045	0.0324	0.146
Loa Loa (eye worm)	hypothetical protein	0.003	0.0157	0.025
Brugia malayi	Sugar transporter family protein	0.003	0.0157	0.025
Schistosoma mansoni	hypothetical protein	0.0214	0.2219	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0061	0.0504	0.2271
Brugia malayi	lysyl-tRNA synthetase	0.0048	0.0355	0.0565
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0061	0.0504	0.0801
Echinococcus granulosus	calcium dependent protein kinase	0.0062	0.0509	0.2294
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0214	0.2219	1
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0214	0.2219	1
Brugia malayi	hypothetical protein	0.0045	0.0324	0.0515
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0045	0.0324	0.146
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0324	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0324	0.0515
Schistosoma mansoni	nuclear hormone receptor	0.0061	0.0504	0.2271
Brugia malayi	Cam kinase protein 1	0.0066	0.0554	0.0881
Brugia malayi	Nuclear hormone receptor-like 1	0.0045	0.0324	0.0515
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0061	0.0504	0.0801
Echinococcus multilocularis	solute carrier family 22	0.003	0.0157	0.0709
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0061	0.0504	0.2271
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0045	0.0324	0.146
Loa Loa (eye worm)	sugar transporter	0.0214	0.2219	0.3525
Loa Loa (eye worm)	hypothetical protein	0.003	0.0157	0.025
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0061	0.0504	0.2271
Toxoplasma gondii	protein kinase, putative	0.0605	0.6597	1
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0564	0.8107
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0064	0.054	0.2432
Onchocerca volvulus	Protein ultraspiracle homolog	0.0061	0.0504	0.0801
Plasmodium falciparum	protein kinase 7	0.0605	0.6597	0.6542
Trypanosoma cruzi	hexose transporter	0.0066	0.0564	0.8107
Plasmodium vivax	lysine--tRNA ligase, putative	0.0048	0.0355	0.0201
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0061	0.0504	0.2271
Brugia malayi	nuclear receptor NHR-88	0.0061	0.0504	0.0801
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0066	0.0554	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0064	0.054	0.0857
Schistosoma mansoni	protein kinase	0.0066	0.0554	0.2499
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0061	0.0504	0.2271
Trichomonas vaginalis	glucose transporter, putative	0.0066	0.0564	0.1973
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0066	0.0555	0.0404
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0346	0.3696	0.3595
Trichomonas vaginalis	conserved hypothetical protein	0.0214	0.2219	1
Schistosoma mansoni	sugar transporter	0.003	0.0157	0.0709
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0564	0.8107
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0214	0.2219	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0061	0.0504	0.2271
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0064	0.054	0.2432
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0061	0.0504	0.2271
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0066	0.0555	0.0617
Leishmania major	glucose transporter, lmgt3	0.0066	0.0564	0.8107
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0066	0.0554	0.2499
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.003	0.0157	0.2954
Onchocerca volvulus		0.003	0.0157	0.025
Echinococcus granulosus	solute carrier family 22	0.003	0.0157	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0355	0.0565
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0061	0.0504	0.2271
Brugia malayi	Major Facilitator Superfamily protein	0.003	0.0157	0.025
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0061	0.0504	0.0801
Plasmodium falciparum	proline--tRNA ligase	0.0075	0.0659	0.051
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0048	0.0355	0.395
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0061	0.0504	0.0801
Onchocerca volvulus		0.003	0.0157	0.025
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0405	0.0643
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0066	0.0555	0.0404
Brugia malayi	Nuclear hormone receptor-like 1	0.0061	0.0504	0.0801
Brugia malayi	ecdysteroid receptor	0.0578	0.6293	1
Echinococcus multilocularis	lysyl tRNA synthetase	0.0048	0.0355	0.1602
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0564	0.8107
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0061	0.0504	0.0801
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.003	0.0157	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0554	0.0881
Schistosoma mansoni	serine/threonine protein kinase	0.0066	0.0554	0.2499
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0061	0.0504	0.0801
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0075	0.0659	1
Schistosoma mansoni	glucose transport protein	0.0214	0.2219	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0061	0.0504	0.2271
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0048	0.0355	0.0961
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0504	0.0801
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0061	0.0504	0.0801
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0061	0.0504	0.2271
Echinococcus granulosus	synaptic vesicle 2 protein	0.003	0.0157	0.0709
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0061	0.0504	0.0801
Toxoplasma gondii	lysine-tRNA ligase	0.0048	0.0355	0.0308
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0066	0.0554	0.2499
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0061	0.0504	0.2271
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0064	0.054	0.2432
Brugia malayi	Sugar transporter family protein	0.0214	0.2219	0.3525
Loa Loa (eye worm)	hypothetical protein	0.003	0.0157	0.025
Brugia malayi	Major Facilitator Superfamily protein	0.003	0.0157	0.025
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0214	0.2219	1
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0564	0.8107
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0564	0.8107
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0061	0.0504	0.2271
Brugia malayi	nuclear hormone receptor	0.0061	0.0504	0.0801
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0564	0.1973
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0504	0.0801
Plasmodium falciparum	hexose transporter	0.0214	0.2219	0.2094
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0066	0.0555	0.0404
Echinococcus multilocularis	synaptic vesicle 2 protein	0.003	0.0157	0.0709
Trypanosoma cruzi	hexose transporter, putative	0.0036	0.0227	0.1383
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0041	0.0275	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0045	0.0324	0.146
Leishmania major	protein kinase, putative	0.0066	0.0554	0.7919
Brugia malayi	photoreceptor-specific nuclear receptor	0.0061	0.0504	0.0801
Onchocerca volvulus		0.003	0.0157	0.025
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0066	0.0555	0.0404
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0048	0.0355	0.3046
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0064	0.054	0.0857
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0504	0.0801
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0064	0.054	0.2432
Onchocerca volvulus		0.003	0.0157	0.025
Loa Loa (eye worm)	steroid hormone receptor	0.0061	0.0504	0.0801
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0061	0.0504	0.0801
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0214	0.2219	1
Trichomonas vaginalis	sugar transporter, putative	0.0066	0.0564	0.1973
Loa Loa (eye worm)	hypothetical protein	0.003	0.0157	0.025
Onchocerca volvulus		0.003	0.0157	0.025
Echinococcus multilocularis	solute carrier family 22	0.003	0.0157	0.0709
Onchocerca volvulus		0.003	0.0157	0.025
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0061	0.0504	0.2271
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0504	0.0801
Schistosoma mansoni	thyroid hormone receptor	0.0061	0.0504	0.2271
Trypanosoma cruzi	hexose transporter, putative	0.0066	0.0564	0.8107
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0075	0.0659	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0066	0.0564	0.8107
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0066	0.0554	0.2499
Trypanosoma cruzi	hexose transporter, putative	0.0066	0.0564	0.8107
Loa Loa (eye worm)	major facilitator superfamily transporter	0.003	0.0157	0.025
Chlamydia trachomatis	lysine--tRNA ligase	0.0048	0.0355	1
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0026	0.0115	0.0183
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0061	0.0504	0.2271
Trypanosoma cruzi	hexose transporter, putative	0.0066	0.0564	0.8107
Schistosoma mansoni	glucose transport protein	0.0214	0.2219	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0061	0.0504	0.2271
Schistosoma mansoni	sugar transporter	0.003	0.0157	0.0709
Loa Loa (eye worm)	hypothetical protein	0.003	0.0157	0.025
Schistosoma mansoni	protein kinase	0.0066	0.0554	0.2499
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0066	0.0555	0.0617
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0066	0.0555	0.0404
Trichomonas vaginalis	sugar transporter, putative	0.0066	0.0564	0.1973
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0075	0.0659	0.0779
Echinococcus granulosus	General substrate transporter	0.0184	0.1881	0.848
Treponema pallidum	prolyl-tRNA synthetase	0.0023	0.0074	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0061	0.0504	0.2271
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0066	0.0554	0.2499
Schistosoma mansoni	lysyl-tRNA synthetase	0.0048	0.0355	0.1602
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0324	0.0515
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0064	0.054	0.0857
Onchocerca volvulus		0.003	0.0157	0.025
Trypanosoma brucei	glucose transporter 1E	0.0066	0.0564	0.8107
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0042	0.0289	0.0641
Echinococcus granulosus	FTZ F1 alpha	0.0061	0.0504	0.2271
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0061	0.0504	0.0801
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0061	0.0504	0.0801
Onchocerca volvulus		0.003	0.0157	0.025
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0214	0.2219	1
Giardia lamblia	Prolyl-tRNA synthetase	0.0064	0.054	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0066	0.0564	0.8107
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0061	0.0504	0.0801
Mycobacterium ulcerans	sugar transporter	0.003	0.0157	0.2954
Entamoeba histolytica	protein kinase, putative	0.0066	0.0554	1
Leishmania major	lysyl-tRNA synthetase, putative	0.0048	0.0355	0.395
Onchocerca volvulus		0.003	0.0157	0.025
Trichomonas vaginalis	sugar transporter, putative	0.0066	0.0564	0.1973
Onchocerca volvulus		0.003	0.0157	0.025
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0061	0.0504	0.2271
Mycobacterium ulcerans	integral membrane transport protein	0.003	0.0157	0.2954
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0909	1	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.003	0.0157	0.025
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0504	0.0801
Onchocerca volvulus		0.003	0.0157	0.025
Plasmodium vivax	hexose transporter	0.0214	0.2219	0.2094
Echinococcus multilocularis	ecdysone induced protein 78C	0.0061	0.0504	0.2271
Schistosoma mansoni	lysyl-tRNA synthetase	0.0048	0.0355	0.1602
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0324	0.0515
Onchocerca volvulus		0.003	0.0157	0.025
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0061	0.0504	0.0801
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0048	0.0355	1
Brugia malayi	hypothetical protein	0.003	0.0157	0.025
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0061	0.0504	0.0801
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0066	0.0555	0.0404
Trypanosoma brucei	glucose transporter 2A	0.0066	0.0564	0.8107
Schistosoma mansoni	sugar transporter	0.003	0.0157	0.0709
Brugia malayi	Major Facilitator Superfamily protein	0.003	0.0157	0.025
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0564	0.8107
Schistosoma mansoni	thyroid hormone receptor	0.0061	0.0504	0.2271
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0066	0.0554	0.0881
Echinococcus granulosus	lysyl tRNA synthetase	0.0048	0.0355	0.1602
Echinococcus multilocularis	solute carrier family 22	0.003	0.0157	0.0709
Echinococcus granulosus	Sugar transporter ERD6 protein	0.003	0.0157	0.0709
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0064	0.054	0.9253
Echinococcus multilocularis	General substrate transporter	0.0184	0.1881	0.848
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0061	0.0504	0.2271
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0564	0.8107
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0066	0.0554	0.2499
Schistosoma mansoni	sugar transporter	0.003	0.0157	0.0709
Loa Loa (eye worm)	hypothetical protein	0.003	0.0157	0.025
Trypanosoma brucei	glucose transporter, putative	0.0066	0.0564	0.8107
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0504	0.0801
Brugia malayi	hypothetical protein	0.003	0.0157	0.025
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0214	0.2219	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0157	0.025
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0041	0.0275	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0061	0.0504	0.0801
Echinococcus granulosus	solute carrier family 22	0.003	0.0157	0.0709
Echinococcus multilocularis	calcium dependent protein kinase	0.0062	0.0509	0.2294
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0066	0.0554	0.0881
Toxoplasma gondii	facilitative glucose transporter GT1	0.0214	0.2219	0.3201
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0066	0.0554	0.2499
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0075	0.0659	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0061	0.0504	0.2271
Trichomonas vaginalis	glucose transporter, putative	0.0066	0.0564	0.1973
Plasmodium falciparum	lysine--tRNA ligase	0.0048	0.0355	0.0201
Schistosoma mansoni	RAR-like nuclear receptor	0.0061	0.0504	0.2271
Giardia lamblia	Lysyl-tRNA synthetase	0.0048	0.0355	0.5182
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0346	0.3696	0.5495
Leishmania major	glucose transporter, lmgt1	0.0066	0.0564	0.8107
Loa Loa (eye worm)	hypothetical protein	0.003	0.0157	0.025
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0066	0.0555	0.0617
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.003	0.0157	0.5
Brugia malayi	major facilitator superfamily protein	0.003	0.0157	0.025
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0066	0.0555	0.0404
Loa Loa (eye worm)	hypothetical protein	0.003	0.0157	0.025
Loa Loa (eye worm)	hypothetical protein	0.0064	0.054	0.0857
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0061	0.0504	0.0801
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0075	0.0659	1
Schistosoma mansoni	glucose transport protein	0.0214	0.2219	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0066	0.0554	0.2499
Loa Loa (eye worm)	hypothetical protein	0.003	0.0157	0.025
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0061	0.0504	0.0801
Echinococcus granulosus	solute carrier family 22	0.003	0.0157	0.0709
Loa Loa (eye worm)	sugar transporter	0.003	0.0157	0.025
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0066	0.0554	0.2499
Schistosoma mansoni	coup transcription factor	0.0061	0.0504	0.2271
Onchocerca volvulus		0.003	0.0157	0.025
Trichomonas vaginalis	conserved hypothetical protein	0.0066	0.0564	0.1973
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0064	0.054	0.1855
Echinococcus multilocularis	solute carrier family 22	0.003	0.0157	0.0709
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0066	0.0554	0.7919
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0346	0.3696	0.3595
Brugia malayi	Nuclear hormone receptor-like 1	0.0045	0.0324	0.0515
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0075	0.0659	1
Brugia malayi	Steroid receptor seven-up type 2	0.0061	0.0504	0.0801
Onchocerca volvulus		0.003	0.0157	0.025
Loa Loa (eye worm)	hypothetical protein	0.003	0.0157	0.025
Brugia malayi	Sugar transporter family protein	0.003	0.0157	0.025
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.003	0.0157	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0324	0.0515
Loa Loa (eye worm)	hypothetical protein	0.003	0.0157	0.025
Onchocerca volvulus		0.0061	0.0504	0.0801
Echinococcus granulosus	solute carrier family 22	0.003	0.0157	0.0709
Onchocerca volvulus	Bile acid receptor homolog	0.0578	0.6293	1
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0045	0.0324	0.0515
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0066	0.0555	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0504	0.0801
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0066	0.0555	0.0404
Loa Loa (eye worm)	hypothetical protein	0.003	0.0157	0.025
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0066	0.0564	0.8107
Echinococcus multilocularis	FTZ F1 alpha	0.0061	0.0504	0.2271

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 763717