TDR Targets

Basic information

Technical information

TDR Targets ID: 765087
Name: 3-(5-chloro-2-hydroxyphenyl)-3-phenylpropanoi c acid
MW: 276.715 | Formula: C15H13ClO3
H donors: 2 H acceptors: 3 LogP: 3.41 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CC(c1cc(Cl)ccc1O)c1ccccc1
InChi: 1S/C15H13ClO3/c16-11-6-7-14(17)13(8-11)12(9-15(18)19)10-4-2-1-3-5-10/h1-8,12,17H,9H2,(H,18,19)
InChiKey: MXZMXRGCRQAVJR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(5-chloro-2-hydroxy-phenyl)-3-phenyl-propanoic acid
3-(5-chloro-2-hydroxy-phenyl)-3-phenyl-propionic acid
ChemDiv3_006418
IDI1_024328

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0751	0.174
Brugia malayi	hypothetical protein	0.0065	0.0293	0.068
Echinococcus multilocularis	sodium bile acid cotransporter	0.0476	0.4315	0.4315
Leishmania major	hypothetical protein, conserved	0.0101	0.0645	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0112	0.0751	0.174
Schistosoma mansoni	tar DNA-binding protein	0.0261	0.2214	0.513
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0459	0.1063
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0035	0.5
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0044	0.0084	0.0196
Trypanosoma brucei	PAB1-binding protein , putative	0.0101	0.0645	1
Schistosoma mansoni	intermediate filament proteins	0.0082	0.0459	0.1063
Echinococcus granulosus	lamin	0.0082	0.0459	0.0459
Echinococcus multilocularis	tumor protein p63	0.1056	1	1
Entamoeba histolytica	hypothetical protein	0.0112	0.0755	0.5
Loa Loa (eye worm)	TAR-binding protein	0.0261	0.2214	0.513
Plasmodium vivax	ataxin-2 like protein, putative	0.0101	0.0645	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0101	0.0645	0.5
Loa Loa (eye worm)	intermediate filament protein	0.0082	0.0459	0.1063
Trypanosoma cruzi	PAB1-binding protein , putative	0.0101	0.0645	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0035	0.0082
Loa Loa (eye worm)	transcription factor SMAD2	0.0249	0.2093	0.4851
Brugia malayi	MH2 domain containing protein	0.0249	0.2093	0.4851
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0035	0.0082
Brugia malayi	RNA binding protein	0.0261	0.2214	0.513
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0027	0.0062
Echinococcus granulosus	intermediate filament protein	0.0082	0.0459	0.0459
Mycobacterium leprae	Probable lipase LipE	0.0039	0.0035	0.5
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0035	0.0035
Schistosoma mansoni	sodium-bile acid cotransporter related	0.0193	0.1543	0.3576
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0035	0.0082
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0112	0.0755	0.0755
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.004	0.0042	0.0042
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0045	0.0098	0.0098
Mycobacterium ulcerans	beta-lactamase	0.0039	0.0035	0.5
Brugia malayi	TAR-binding protein	0.0261	0.2214	0.513
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0035	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0035	0.0082
Schistosoma mansoni	hypothetical protein	0.0045	0.0098	0.0226
Loa Loa (eye worm)	RNA binding protein	0.0261	0.2214	0.513
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0035	0.0082
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0035	0.5
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0082	0.0459	0.1063
Schistosoma mansoni	sodium-bile acid cotransporter	0.0283	0.2425	0.5619
Plasmodium falciparum	ataxin-2 like protein, putative	0.0101	0.0645	0.5
Trichomonas vaginalis	esterase, putative	0.0039	0.0035	0.5
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.0035	0.5
Schistosoma mansoni	sodium-bile acid cotransporter related	0.0476	0.4315	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0035	0.0082
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0261	0.2214	0.513
Loa Loa (eye worm)	hypothetical protein	0.0154	0.1167	0.2704
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.004	0.0042	0.0042
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0035	0.5
Echinococcus multilocularis	lamin	0.0082	0.0459	0.0459
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0035	0.0035
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0035	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0645	0.1495
Echinococcus granulosus	sodium bile acid cotransporter	0.0476	0.4315	0.4315
Loa Loa (eye worm)	MH2 domain-containing protein	0.0249	0.2093	0.4851
Brugia malayi	beta-lactamase family protein	0.0039	0.0035	0.0082
Schistosoma mansoni	hypothetical protein	0.0112	0.0755	0.175
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0035	0.0082
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0112	0.0751	0.174
Brugia malayi	hypothetical protein	0.0112	0.0755	0.175
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0112	0.0751	0.174
Echinococcus multilocularis	tar DNA binding protein	0.0261	0.2214	0.2214
Entamoeba histolytica	hypothetical protein	0.0112	0.0755	0.5
Brugia malayi	Intermediate filament tail domain containing protein	0.0082	0.0459	0.1063
Schistosoma mansoni	hypothetical protein	0.0077	0.0403	0.0934
Onchocerca volvulus		0.0476	0.4315	1
Mycobacterium ulcerans	lipase LipD	0.0039	0.0035	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.0042	0.0096
Brugia malayi	latrophilin 2 splice variant baaae	0.0077	0.0403	0.0934
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0035	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0261	0.2214	0.513
Schistosoma mansoni	tar DNA-binding protein	0.0261	0.2214	0.513
Toxoplasma gondii	LsmAD domain-containing protein	0.0101	0.0645	1
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0045	0.0098	0.0098
Schistosoma mansoni	cellular tumor antigen P53	0.0154	0.1167	0.2704
Echinococcus multilocularis	sodium bile acid cotransporter	0.0476	0.4315	0.4315
Trypanosoma cruzi	PAB1-binding protein , putative	0.0101	0.0645	1
Brugia malayi	Sodium Bile acid symporter family protein	0.0476	0.4315	1
Schistosoma mansoni	tar DNA-binding protein	0.0261	0.2214	0.513
Onchocerca volvulus		0.0154	0.1167	0.2644
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.025	0.2099	1
Onchocerca volvulus		0.0082	0.0459	0.0989
Brugia malayi	beta-lactamase	0.0039	0.0035	0.0082
Entamoeba histolytica	hypothetical protein	0.0112	0.0755	0.5
Echinococcus multilocularis	lamin dm0	0.0082	0.0459	0.0459
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0035	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0261	0.2214	0.513
Echinococcus granulosus	lamin dm0	0.0082	0.0459	0.0459
Schistosoma mansoni	lamin	0.0082	0.0459	0.1063
Loa Loa (eye worm)	hypothetical protein	0.0476	0.4315	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0035	0.0082
Onchocerca volvulus		0.0082	0.0459	0.0989
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0027	0.0062
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.0035	0.5
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0444	0.1029
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0112	0.0755	0.0755
Entamoeba histolytica	hypothetical protein	0.0112	0.0755	0.5
Brugia malayi	intermediate filament protein	0.0082	0.0459	0.1063
Loa Loa (eye worm)	hypothetical protein	0.0077	0.0403	0.0934
Echinococcus granulosus	sodium bile acid cotransporter	0.0476	0.4315	0.4315
Echinococcus multilocularis	sodium bile acid cotransporter	0.0476	0.4315	0.4315
Echinococcus multilocularis	musashi	0.0082	0.0459	0.0459
Brugia malayi	cytoplasmic intermediate filament protein	0.0044	0.0084	0.0196
Echinococcus granulosus	sodium bile acid cotransporter	0.0476	0.4315	0.4315
Brugia malayi	RNA recognition motif domain containing protein	0.0261	0.2214	0.513
Brugia malayi	beta-lactamase family protein	0.0039	0.0035	0.0082
Brugia malayi	hypothetical protein	0.0101	0.0645	0.1495
Schistosoma mansoni	transcription factor LCR-F1	0.0112	0.0755	0.175
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0035	0.5
Schistosoma mansoni	lamin	0.0082	0.0459	0.1063
Echinococcus granulosus	tar DNA binding protein	0.0261	0.2214	0.2214
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0035	0.0082
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0035	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 765087