Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0476 | 0.4315 | 0.4315 |
Loa Loa (eye worm) | intermediate filament protein | 0.0082 | 0.0459 | 0.1063 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0101 | 0.0645 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0476 | 0.4315 | 0.4315 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 0.4315 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0082 | 0.0459 | 0.1063 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0645 | 0.1495 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0035 | 0.0082 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0476 | 0.4315 | 0.4315 |
Schistosoma mansoni | tar DNA-binding protein | 0.0261 | 0.2214 | 0.513 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.0035 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0249 | 0.2093 | 0.4851 |
Schistosoma mansoni | tar DNA-binding protein | 0.0261 | 0.2214 | 0.513 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0039 | 0.0035 | 0.0082 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0039 | 0.0035 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0112 | 0.0755 | 0.175 |
Brugia malayi | Sodium Bile acid symporter family protein | 0.0476 | 0.4315 | 1 |
Brugia malayi | hypothetical protein | 0.0112 | 0.0755 | 0.175 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0035 | 0.0082 |
Loa Loa (eye worm) | beta-lactamase | 0.0039 | 0.0035 | 0.0082 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.0459 | 0.1063 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.0755 | 0.5 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0154 | 0.1167 | 0.2704 |
Mycobacterium ulcerans | beta-lactamase | 0.0039 | 0.0035 | 0.5 |
Onchocerca volvulus | 0.0082 | 0.0459 | 0.0989 | |
Echinococcus granulosus | lamin | 0.0082 | 0.0459 | 0.0459 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.0755 | 0.175 |
Schistosoma mansoni | hypothetical protein | 0.0077 | 0.0403 | 0.0934 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0035 | 0.0082 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0476 | 0.4315 | 0.4315 |
Mycobacterium ulcerans | hypothetical protein | 0.0039 | 0.0035 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0261 | 0.2214 | 0.513 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.0755 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.0755 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0035 | 0.0082 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0444 | 0.1029 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0261 | 0.2214 | 0.513 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0045 | 0.0098 | 0.0098 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0101 | 0.0645 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0249 | 0.2093 | 0.4851 |
Onchocerca volvulus | 0.0476 | 0.4315 | 1 | |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0039 | 0.0035 | 0.0035 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0098 | 0.0226 |
Schistosoma mansoni | tar DNA-binding protein | 0.0261 | 0.2214 | 0.513 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.0035 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0035 | 0.0082 |
Loa Loa (eye worm) | RNA binding protein | 0.0261 | 0.2214 | 0.513 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0476 | 0.4315 | 0.4315 |
Brugia malayi | TAR-binding protein | 0.0261 | 0.2214 | 0.513 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0101 | 0.0645 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0039 | 0.0035 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0101 | 0.0645 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0039 | 0.0035 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0035 | 0.0082 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.1167 | 0.2704 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0044 | 0.0084 | 0.0196 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0101 | 0.0645 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0082 | 0.0459 | 0.0459 |
Leishmania major | hypothetical protein, conserved | 0.0101 | 0.0645 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0476 | 0.4315 | 0.4315 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.004 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0035 | 0.0082 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0082 | 0.0459 | 0.1063 |
Schistosoma mansoni | tar DNA-binding protein | 0.0261 | 0.2214 | 0.513 |
Onchocerca volvulus | 0.0082 | 0.0459 | 0.0989 | |
Mycobacterium leprae | Probable lipase LipE | 0.0039 | 0.0035 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0112 | 0.0751 | 0.174 |
Brugia malayi | intermediate filament protein | 0.0082 | 0.0459 | 0.1063 |
Echinococcus multilocularis | lamin dm0 | 0.0082 | 0.0459 | 0.0459 |
Echinococcus multilocularis | musashi | 0.0082 | 0.0459 | 0.0459 |
Trichomonas vaginalis | esterase, putative | 0.0039 | 0.0035 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0112 | 0.0755 | 0.0755 |
Loa Loa (eye worm) | TAR-binding protein | 0.0261 | 0.2214 | 0.513 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0101 | 0.0645 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0476 | 0.4315 | 1 |
Schistosoma mansoni | lamin | 0.0082 | 0.0459 | 0.1063 |
Brugia malayi | RNA binding protein | 0.0261 | 0.2214 | 0.513 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.0035 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.1056 | 1 | 1 |
Brugia malayi | beta-lactamase | 0.0039 | 0.0035 | 0.0082 |
Entamoeba histolytica | hypothetical protein | 0.0112 | 0.0755 | 0.5 |
Echinococcus multilocularis | lamin | 0.0082 | 0.0459 | 0.0459 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0045 | 0.0098 | 0.0098 |
Brugia malayi | MH2 domain containing protein | 0.0249 | 0.2093 | 0.4851 |
Echinococcus multilocularis | tar DNA binding protein | 0.0261 | 0.2214 | 0.2214 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0751 | 0.174 |
Schistosoma mansoni | tar DNA-binding protein | 0.0261 | 0.2214 | 0.513 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0112 | 0.0751 | 0.174 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0042 | 0.0096 |
Brugia malayi | hypothetical protein | 0.0101 | 0.0645 | 0.1495 |
Schistosoma mansoni | lamin | 0.0082 | 0.0459 | 0.1063 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.0035 | 0.0082 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0027 | 0.0062 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.004 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0027 | 0.0062 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0193 | 0.1543 | 0.3576 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0077 | 0.0403 | 0.0934 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0112 | 0.0755 | 0.0755 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0101 | 0.0645 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0403 | 0.0934 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0039 | 0.0035 | 0.0082 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.0035 | 0.0082 |
Onchocerca volvulus | 0.0154 | 0.1167 | 0.2644 | |
Brugia malayi | hypothetical protein | 0.0065 | 0.0293 | 0.068 |
Echinococcus granulosus | lamin dm0 | 0.0082 | 0.0459 | 0.0459 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0035 | 0.0082 |
Echinococcus granulosus | tar DNA binding protein | 0.0261 | 0.2214 | 0.2214 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0039 | 0.0035 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.025 | 0.2099 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0039 | 0.0035 | 0.5 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.0283 | 0.2425 | 0.5619 |
Mycobacterium leprae | conserved hypothetical protein | 0.0039 | 0.0035 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0039 | 0.0035 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0044 | 0.0084 | 0.0196 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0082 | 0.0459 | 0.1063 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0112 | 0.0751 | 0.174 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.