TDR Targets

Basic information

Technical information

TDR Targets ID: 770878
Name: propyl 2-phenylquinoline-4-carboxylate
MW: 291.344 | Formula: C19H17NO2
H donors: 0 H acceptors: 2 LogP: 4.6 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCCOC(=O)c1cc(nc2c1cccc2)c1ccccc1
InChi: 1S/C19H17NO2/c1-2-12-22-19(21)16-13-18(14-8-4-3-5-9-14)20-17-11-7-6-10-15(16)17/h3-11,13H,2,12H2,1H3
InChiKey: XMVYZYSRFLFCCS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-phenyl-4-quinolinecarboxylic acid propyl ester
2-phenylcinchoninic acid propyl ester
Oprea1_432162
ZINC02078542
STK253073
AK-918/12286309

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0469	0.0469
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0013	0.0027	0.0027
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0125	0.3091	0.3091
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0098	0.2364	1
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0673	0.1056
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0013	0.0027	0.0027
Plasmodium vivax	glutathione reductase, putative	0.0039	0.0725	1
Plasmodium vivax	SET domain protein, putative	0.0031	0.05	0.6773
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0673	0.0673
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0089	0.2092	0.3374
Trichomonas vaginalis	set domain proteins, putative	0.0243	0.6342	1
Brugia malayi	Pre-SET motif family protein	0.0214	0.5531	0.5531
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.05	0.05
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.0376	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0376	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0376	1	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0089	0.2092	0.3374
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0236	0.6149	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0376	1	1
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0673	0.1056
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0673	0.0673
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0673	0.1056
Brugia malayi	Thioredoxin reductase	0.0039	0.0725	0.0725
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0089	0.2092	0.8393
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0673	1
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0112	0.2749	0.2749
Trichomonas vaginalis	glutathione reductase, putative	0.0013	0.0027	0.0043
Toxoplasma gondii	ABC1 family protein	0.0037	0.0673	0.9262
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0013	0.0008	0.0008
Onchocerca volvulus		0.0243	0.6342	1
Loa Loa (eye worm)	thioredoxin reductase	0.0039	0.0725	0.0725
Mycobacterium tuberculosis	Probable reductase	0.0089	0.2092	0.3374
Onchocerca volvulus		0.0037	0.0673	0.0297
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0673	0.1056
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.05	0.05
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0013	0.0027	0.0027
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0673	0.1056
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0673	0.0673
Plasmodium vivax	thioredoxin reductase, putative	0.0039	0.0725	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0673	0.1062
Mycobacterium tuberculosis	Probable oxidoreductase	0.0098	0.2364	0.3818
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0673	0.0673
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0673	0.0673
Brugia malayi	beta-lactamase family protein	0.0037	0.0673	0.0673
Leishmania major	hypothetical protein, conserved	0.0037	0.0673	0.9262
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0039	0.0739	0.0739
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.0112	0.2749	0.2749
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0673	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0673	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0673	0.1062
Trichomonas vaginalis	mercuric reductase, putative	0.0013	0.0027	0.0043
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0673	0.9262
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.05	0.05
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0013	0.0008	0.0008
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0673	0.9262
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0013	0.0008	0.0008
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0673	0.1056
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.05	0.6773
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0112	0.2749	0.2749
Leishmania major	trypanothione reductase	0.0039	0.0725	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0673	0.1062
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0013	0.0027	0.5
Toxoplasma gondii	thioredoxin reductase	0.0039	0.0725	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.05	0.05
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0673	0.0673
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0673	0.0673
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.05	0.05
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0013	0.0027	0.5
Brugia malayi	beta-lactamase family protein	0.0037	0.0673	0.0673
Treponema pallidum	NADH oxidase	0.0013	0.0027	0.5
Onchocerca volvulus		0.0037	0.0673	0.0297
Mycobacterium ulcerans	lipase LipD	0.0037	0.0673	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0098	0.2364	0.3818
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0673	0.1056
Entamoeba histolytica	hypothetical protein	0.0012	0	0.5
Brugia malayi	Pre-SET motif family protein	0.0031	0.05	0.05
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0125	0.3091	0.3091
Brugia malayi	beta-lactamase	0.0037	0.0673	0.0673
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.05	0.05
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0039	0.0725	0.114
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0089	0.2092	0.3374
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0673	0.0673
Entamoeba histolytica	hypothetical protein	0.0012	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0673	0.0673
Plasmodium falciparum	glutathione reductase	0.0039	0.0725	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0013	0.0027	0.5
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0673	0.0673
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.05	0.05
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0673	0.0673
Trypanosoma brucei	trypanothione reductase	0.0039	0.0725	1
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.0008	0.0008
Trichomonas vaginalis	esterase, putative	0.0037	0.0673	0.1062
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0673	0.1056
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0673	0.1056
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0673	0.1056
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0673	0.1062
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0013	0.0027	0.5
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0214	0.5531	0.5531
Onchocerca volvulus		0.0037	0.0673	0.0297
Trypanosoma cruzi	trypanothione reductase, putative	0.0039	0.0725	1
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.0112	0.2749	0.2749
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0673	0.9262
Echinococcus granulosus	thioredoxin glutathione reductase	0.0039	0.0739	0.0739
Plasmodium falciparum	thioredoxin reductase	0.0039	0.0725	1
Loa Loa (eye worm)	glutathione reductase	0.0039	0.0725	0.0725
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0673	0.0673
Loa Loa (eye worm)	hypothetical protein	0.0031	0.05	0.05
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0673	1
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.0112	0.2749	0.2749
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0089	0.2092	0.3374
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0013	0.0027	0.0027
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0673	0.1062
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0098	0.2364	0.3818
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0673	0.0673
Brugia malayi	glutathione reductase	0.0039	0.0725	0.0725
Entamoeba histolytica	hypothetical protein	0.0012	0	0.5
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0089	0.2092	0.3374
Schistosoma mansoni	serine/threonine protein kinase	0.0013	0.0008	0.0008
Schistosoma mansoni	serine/threonine protein kinase	0.0125	0.3091	0.3091
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0673	0.9262

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 770878