Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SUMO1/sentrin specific peptidase 7 | Starlite/ChEMBL | No references |
Homo sapiens | SUMO1/sentrin specific peptidase 6 | Starlite/ChEMBL | No references |
Homo sapiens | SUMO/sentrin specific peptidase family member 8 | Starlite/ChEMBL | No references |
Homo sapiens | caspase 3, apoptosis-related cysteine peptidase | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | sentrin-specific protease 1 | SUMO/sentrin specific peptidase family member 8 | 212 aa | 197 aa | 23.4 % |
Brugia malayi | Cell death protein 3 precursor | caspase 3, apoptosis-related cysteine peptidase | 277 aa | 253 aa | 38.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | Ulp1 protease family, C-terminal catalytic domain-containing protein | 0.0047 | 0.001 | 1 |
Echinococcus multilocularis | sentrin specific protease 8 | 0.0111 | 0.3975 | 0.3969 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.012 | 0.4498 | 0.4492 |
Loa Loa (eye worm) | acetyltransferase | 0.0158 | 0.686 | 1 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0047 | 0.001 | 0.0026 |
Echinococcus multilocularis | expressed conserved protein | 0.0163 | 0.7132 | 0.7129 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.012 | 0.4498 | 0.4498 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.8503 | 0.8502 |
Schistosoma mansoni | hypothetical protein | 0.0185 | 0.8503 | 0.8502 |
Echinococcus granulosus | expressed conserved protein | 0.0163 | 0.7132 | 0.7132 |
Entamoeba histolytica | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.021 | 1 | 1 |
Plasmodium falciparum | sentrin-specific protease 1 | 0.0047 | 0.001 | 0.5 |
Loa Loa (eye worm) | Ulp1 protease | 0.0111 | 0.3975 | 0.5788 |
Plasmodium vivax | sentrin-specific protease 1, putative | 0.0047 | 0.001 | 1 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0111 | 0.3975 | 1 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0111 | 0.3975 | 0.5788 |
Echinococcus multilocularis | sentrin specific protease 7 | 0.021 | 1 | 1 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0047 | 0.001 | 0.0026 |
Chlamydia trachomatis | deubiquitinase/deneddylase Dub1 | 0.0047 | 0.001 | 0.5 |
Trichomonas vaginalis | Sentrin-specific protease, putative | 0.0111 | 0.3975 | 1 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0047 | 0.001 | 0.0026 |
Echinococcus granulosus | sentrin specific protease 8 | 0.0111 | 0.3975 | 0.3975 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.021 | 1 | 1 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0047 | 0.001 | 0.0026 |
Echinococcus granulosus | sentrin specific protease 1 | 0.0047 | 0.001 | 0.001 |
Echinococcus multilocularis | caspase | 0.012 | 0.4498 | 0.4492 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0.001 | 0.0026 |
Toxoplasma gondii | Ulp1 protease family, C-terminal catalytic domain-containing protein | 0.0047 | 0.001 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0158 | 0.686 | 0.6857 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0111 | 0.3975 | 1 |
Onchocerca volvulus | 0.0047 | 0.001 | 0.5 | |
Echinococcus granulosus | geminin | 0.0185 | 0.8503 | 0.8503 |
Toxoplasma gondii | Ulp1 protease family, C-terminal catalytic domain-containing protein | 0.0047 | 0.001 | 1 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.012 | 0.4498 | 0.4492 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0158 | 0.686 | 1 |
Entamoeba histolytica | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0111 | 0.3975 | 0.3969 |
Plasmodium vivax | sentrin-specific protease 2, putative | 0.0047 | 0.001 | 1 |
Trichomonas vaginalis | sentrin/sumo-specific protease, senp8, putative | 0.0047 | 0.001 | 0.0026 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0111 | 0.3975 | 0.3969 |
Leishmania major | SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative | 0.0047 | 0.001 | 0.5 |
Echinococcus granulosus | caspase | 0.012 | 0.4498 | 0.4498 |
Trypanosoma brucei | SUMO1/Ulp2, putative | 0.0047 | 0.001 | 0.5 |
Chlamydia trachomatis | deubiquitinase/deneddylase Dub2 | 0.0047 | 0.001 | 0.5 |
Giardia lamblia | Sentrin specific protease, putative | 0.0047 | 0.001 | 0.5 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0158 | 0.686 | 0.6857 |
Echinococcus granulosus | caspase 3 | 0.0088 | 0.2531 | 0.2531 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0047 | 0.001 | 0.0026 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0154 | 0.6587 | 0.6587 |
Trypanosoma cruzi | hypothetical protein | 0.0111 | 0.3975 | 1 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0111 | 0.3975 | 1 |
Echinococcus multilocularis | geminin | 0.0185 | 0.8503 | 0.8502 |
Echinococcus multilocularis | caspase 3 | 0.0088 | 0.2531 | 0.2524 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.012 | 0.4498 | 0.4492 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0047 | 0.001 | 0.0026 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.4 uM | PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific protease 7 (SENP7) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID434973, AID434986] | ChEMBL. | No reference |
IC50 (functional) | = 1.44 uM | PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2575] | ChEMBL. | No reference |
IC50 (functional) | = 1.5 uM | PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific protease 6 (SENP6) using a Luminescent assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2582, AID2599] | ChEMBL. | No reference |
IC50 (functional) | = 1.57 uM | PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2599, AID434973, AID489001] | ChEMBL. | No reference |
IC50 (functional) | = 2.08 uM | PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific protease 7 (SENP7) using a Luminescent assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID434973, AID434986] | ChEMBL. | No reference |
IC50 (functional) | = 3.7 uM | PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2599, AID434973, AID489001] | ChEMBL. | No reference |
IC50 (functional) | > 99 uM | PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific protease 6 (SENP6) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2582, AID2599] | ChEMBL. | No reference |
IC50 (functional) | > 99 uM | PUBCHEM_BIOASSAY: SAR Analysis of small molecule inhibitors of Sentrin-specific protease 8 (SENP8) using a Luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2540, AID2575] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.