Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0648 | 1 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0142 | 0.1724 | 0.5626 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0648 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0224 | 0.3064 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0648 | 1 | 0.5 |
Schistosoma mansoni | patched 1 | 0.0043 | 0.0103 | 0.0337 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.026 | 0.0529 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0648 | 1 | 0.5 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0099 | 0.1028 | 1 |
Echinococcus granulosus | geminin | 0.0171 | 0.2197 | 0.7171 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.0224 | 0.3064 | 1 |
Echinococcus multilocularis | protein dispatched 1 | 0.0049 | 0.0202 | 0.0658 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0043 | 0.0103 | 0.0337 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0043 | 0.0103 | 0.0337 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0078 | 0.0255 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.0224 | 0.3064 | 1 |
Echinococcus granulosus | sterol O acyltransferase 1 | 0.0224 | 0.3064 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0043 | 0.0103 | 0.0337 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0078 | 0.0255 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0099 | 0.1028 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0142 | 0.1724 | 0.5626 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0078 | 0.0255 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0101 | 0.1054 | 0.3438 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0648 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0084 | 0.0783 | 0.7617 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2707 | 0.8794 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0078 | 0.0255 |
Echinococcus multilocularis | geminin | 0.0171 | 0.2197 | 0.7171 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0099 | 0.1028 | 0.3357 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.2197 | 0.7171 |
Brugia malayi | CHE-14 protein | 0.0043 | 0.0103 | 0.1004 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0084 | 0.0783 | 0.7617 |
Echinococcus multilocularis | expressed conserved protein | 0.0093 | 0.093 | 0.3036 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0084 | 0.0783 | 0.7617 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0648 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0084 | 0.0783 | 0.7617 |
Echinococcus multilocularis | protein patched | 0.0043 | 0.0103 | 0.0337 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.1028 | 0.3125 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.0103 | 0.5 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0648 | 1 | 0.5 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0084 | 0.0783 | 0.7617 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.2197 | 0.7171 |
Echinococcus granulosus | expressed conserved protein | 0.0093 | 0.093 | 0.3036 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0099 | 0.1028 | 0.3357 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.