Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1727 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0023 | 0.1727 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.1727 | 0.1727 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.1727 | 0.1727 |
Echinococcus multilocularis | dna polymerase eta | 0.0023 | 0.1727 | 0.1727 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.1727 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.1727 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1727 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1727 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.1727 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.1727 | 0.1727 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1727 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.1727 | 0.1727 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.1727 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1727 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.1727 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.1727 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1727 | 0.1727 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1727 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0023 | 0.1727 | 0.1727 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0.1727 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1727 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.1727 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.1727 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.1727 | 0.1727 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.1727 | 0.1727 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.1727 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1727 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.1727 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1727 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.1727 | 0.1727 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1727 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1727 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.1727 | 0.5 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.1727 | 0.1727 |
Leishmania major | DNA polymerase eta, putative | 0.0023 | 0.1727 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.1727 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.1727 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 0.1727 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 0.1727 | 0.5 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.1727 | 0.1727 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.1727 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0023 | 0.1727 | 0.1727 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.1727 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 3.5481 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 7.9433 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.