Detailed information for compound 784153

Basic information

Technical information
  • TDR Targets ID: 784153
  • Name: 5-(3-methylphenyl)-1H-1,2,4-triazol-3-amine
  • MW: 174.202 | Formula: C9H10N4
  • H donors: 2 H acceptors: 2 LogP: 0.97 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)c1n[nH]c(n1)N
  • InChi: 1S/C9H10N4/c1-6-3-2-4-7(5-6)8-11-9(10)13-12-8/h2-5H,1H3,(H3,10,11,12,13)
  • InChiKey: DTWHVCOHVMHZSC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [5-(3-methylphenyl)-1H-1,2,4-triazol-3-yl]amine
  • A0593/0027418
  • EU-0017406
  • ZINC00050234

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0141 0.0124
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0802 0.9015 0.9014
Echinococcus granulosus aldo keto reductase family 1 member B4 0.019 0.184 0.1826
Loa Loa (eye worm) hypothetical protein 0.0148 0.1348 0.1333
Mycobacterium ulcerans hypothetical protein 0.0055 0.0261 0.0526
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.019 0.0173
Plasmodium vivax aldehyde reductase, putative 0.0055 0.0261 0.0244
Plasmodium falciparum aldo-keto reductase, putative 0.0055 0.0261 0.0244
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0141 0.0124
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.019 0.184 0.1826
Plasmodium falciparum protein-S-isoprenylcysteine O-methyltransferase, putative 0.0886 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.019 0.184 0.1826
Echinococcus multilocularis tumor protein p63 0.0334 0.3533 0.3522
Trichomonas vaginalis aldo-keto reductase, putative 0.019 0.184 0.1826
Entamoeba histolytica aldose reductase, putative 0.019 0.184 0.1826
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.019 0.184 0.1826
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0387 0.415 1
Trichomonas vaginalis aldo-keto reductase, putative 0.019 0.184 0.1826
Echinococcus granulosus aldo keto reductase family 1 member B4 0.019 0.184 0.1826
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.019 0.184 0.1826
Mycobacterium ulcerans oxidoreductase 0.019 0.184 0.4374
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0141 0.0124
Brugia malayi NADH-dependent xylose reductase 0.0055 0.0261 0.0244
Mycobacterium leprae Conserved hypothetical protein 0.0135 0.1196 0.65
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0512 0.5
Trichomonas vaginalis aldo-keto reductase, putative 0.0055 0.0261 0.0244
Mycobacterium ulcerans hypothetical protein 0.0387 0.415 1
Trypanosoma brucei aldo/keto reductase, putative 0.0055 0.0261 0.0244
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0045 0.0028
Echinococcus multilocularis neuropeptide receptor A26 0.0457 0.4977 0.4968
Echinococcus granulosus aldehyde reductase 0.0135 0.1196 0.1181
Trichomonas vaginalis aldo-keto reductase, putative 0.019 0.184 0.1826
Trichomonas vaginalis aldo-keto reductase, putative 0.019 0.184 0.1826
Onchocerca volvulus 0.019 0.184 1
Echinococcus granulosus tumor protein p63 0.0334 0.3533 0.3522
Echinococcus granulosus muscleblind protein 0.0148 0.1348 0.1333
Brugia malayi Muscleblind-like protein 0.0148 0.1348 0.1333
Echinococcus multilocularis aldo keto reductase 0.019 0.184 0.1826
Leishmania major aldo-keto reductase-like protein 0.019 0.184 0.1826
Onchocerca volvulus 0.0095 0.0728 0.3261
Brugia malayi Inositol-1 0.0037 0.0045 0.0028
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0045 0.0028
Loa Loa (eye worm) oxidoreductase 0.019 0.184 0.1826
Onchocerca volvulus 0.019 0.184 1
Entamoeba histolytica aldose reductase, putative 0.019 0.184 0.1826
Echinococcus granulosus aldo keto reductase 0.019 0.184 0.1826
Onchocerca volvulus 0.019 0.184 1
Echinococcus multilocularis voltage gated potassium channel subunit 0.0055 0.0261 0.0244
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0204 0.0187
Echinococcus granulosus aldo keto reductase family 1 member B4 0.019 0.184 0.1826
Trichomonas vaginalis aldo-keto reductase, putative 0.019 0.184 0.1826
Echinococcus granulosus aldo keto reductase family 1 member B4 0.019 0.184 0.1826
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0141 0.0124
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.019 0.184 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.019 0.184 0.1826
Trypanosoma brucei aldo-keto reductase, putative 0.019 0.184 0.1826
Schistosoma mansoni hypothetical protein 0.0095 0.0728 0.0712
Trichomonas vaginalis aldo-keto reductase, putative 0.0055 0.0261 0.0244
Trichomonas vaginalis aldo-keto reductase, putative 0.019 0.184 0.1826
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0204 0.1108
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0321 0.0672
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0141 0.0124
Brugia malayi Probable ClpP-like protease 0.0076 0.0512 0.0496
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.019 0.184 0.1826
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0512 0.0496
Echinococcus multilocularis microtubule associated protein 2 0.0675 0.7521 0.7516
Loa Loa (eye worm) hypothetical protein 0.0148 0.1348 0.1333
Echinococcus multilocularis aldo keto reductase 0.019 0.184 0.1826
Loa Loa (eye worm) oxidoreductase 0.019 0.184 0.1826
Loa Loa (eye worm) hypothetical protein 0.019 0.184 0.1826
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.019 0.184 0.1826
Schistosoma mansoni potassium channel beta 0.0055 0.0261 0.0244
Echinococcus multilocularis neuropeptide s receptor 0.0457 0.4977 0.4968
Onchocerca volvulus 0.0055 0.0261 0.0429
Echinococcus granulosus voltage gated potassium channel subunit 0.0055 0.0261 0.0244
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0045 0.0028
Echinococcus multilocularis geminin 0.0333 0.3522 0.351
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.0886 1 1
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0055 0.0261 0.0244
Schistosoma mansoni inositol monophosphatase 0.0037 0.0045 0.0028
Echinococcus multilocularis muscleblind protein 1 0.0148 0.1348 0.1333
Mycobacterium leprae Possible oxidoreductase 0.0055 0.0261 0.1417
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0512 0.0496
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.019 0.184 0.1826
Echinococcus granulosus protein S isoprenylcysteine O methyltransferase 0.0886 1 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.019 0.0173
Trichomonas vaginalis aldo-keto reductase, putative 0.019 0.184 0.1826
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0886 1 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0045 0.0028
Loa Loa (eye worm) hypothetical protein 0.0465 0.5066 0.5057
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0512 0.0496
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0886 1 1
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.0886 1 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0512 0.0496
Schistosoma mansoni aldo-keto reductase 0.019 0.184 0.1826
Trichomonas vaginalis aldo-keto reductase, putative 0.0055 0.0261 0.0244
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.0728 0.0712
Echinococcus granulosus aldo keto reductase 0.019 0.184 0.1826
Echinococcus granulosus aldo keto reductase family 1 member B4 0.019 0.184 0.1826
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0512 0.2784
Mycobacterium tuberculosis Probable oxidoreductase 0.019 0.184 0.4435
Echinococcus granulosus neuropeptide s receptor 0.0457 0.4977 0.4968
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0055 0.0261 0.0244
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0321 0.0672
Leishmania major prostaglandin f synthase, putative 0.019 0.184 0.1826
Schistosoma mansoni microtubule-associated protein tau 0.0675 0.7521 0.7516
Brugia malayi hypothetical protein 0.0465 0.5066 0.5057
Echinococcus granulosus aldo keto reductase family 1 member B4 0.019 0.184 0.1826
Echinococcus multilocularis aldehyde reductase 0.0135 0.1196 0.1181
Toxoplasma gondii isoprenylcysteine carboxyl methyltransferase (icmt) family protein 0.0886 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.019 0.184 0.1826
Echinococcus granulosus aldo keto reductase family 1 member B4 0.019 0.184 0.1826
Echinococcus granulosus aldo keto reductase family 1 member B4 0.019 0.184 0.1826
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0321 0.0304
Echinococcus granulosus aldo keto reductase 0.019 0.184 0.1826
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.019 0.184 0.1826
Schistosoma mansoni survival motor neuron protein 0.0095 0.0728 0.0712
Plasmodium vivax protein-S-isoprenylcysteine O-methyltransferase, putative 0.0886 1 1
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0321 0.0304
Echinococcus granulosus survival motor neuron protein 1 0.0465 0.5066 0.5057
Loa Loa (eye worm) inositol-1 0.0037 0.0045 0.0028
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0045 0.0028
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0321 0.0304
Schistosoma mansoni hypothetical protein 0.0333 0.3522 0.351
Echinococcus granulosus geminin 0.0333 0.3522 0.351
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0321 0.0772
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0512 0.5
Trypanosoma brucei prenyl protein specific carboxyl methyltransferase 0.0886 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.019 0.184 0.1826
Trichomonas vaginalis aldo/keto reductase, putative 0.019 0.184 0.1826
Toxoplasma gondii aldo-keto reductase 0.0055 0.0261 0.0244
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.019 0.184 0.1826
Trypanosoma cruzi aldo-keto reductase 0.019 0.184 0.1826
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.019 0.184 0.1826
Onchocerca volvulus 0.019 0.184 1
Trichomonas vaginalis aldo-keto reductase, putative 0.019 0.184 0.1826
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0045 0.0028
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0045 0.0028
Echinococcus granulosus aldo keto reductase family 1 member B4 0.019 0.184 0.1826
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0055 0.0261 0.0244
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0321 0.0304
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0055 0.0261 0.0244
Trypanosoma cruzi aldo/keto reductase, putative 0.0055 0.0261 0.0244
Echinococcus multilocularis muscleblind protein 0.0148 0.1348 0.1333
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.019 0.184 0.1826
Loa Loa (eye worm) protein-S isoprenylcysteine O-methyltransferase 0.0886 1 1
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0055 0.0261 0.0244
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0055 0.0261 0.0244
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0141 0.0124
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0204 0.0491
Echinococcus granulosus microtubule associated protein 2 0.0675 0.7521 0.7516
Schistosoma mansoni inositol monophosphatase 0.0037 0.0045 0.0028
Echinococcus multilocularis aldo keto reductase 0.019 0.184 0.1826
Entamoeba histolytica alcohol dehydrogenase, putative 0.0055 0.0261 0.0244
Echinococcus granulosus hypothetical protein 0.019 0.184 0.1826
Entamoeba histolytica aldose reductase, putative 0.019 0.184 0.1826
Mycobacterium tuberculosis Conserved protein 0.0055 0.0261 0.0629
Giardia lamblia Isoprenylcysteine carboxyl methyltransferase 0.0886 1 1
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0512 0.0496
Toxoplasma gondii aldose reductase, putative 0.019 0.184 0.1826
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0512 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0512 0.5
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0045 0.0028
Trichomonas vaginalis aldo-keto reductase, putative 0.019 0.184 0.1826
Echinococcus multilocularis aldo keto reductase 0.019 0.184 0.1826
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.019 0.184 0.1826
Loa Loa (eye worm) oxidoreductase 0.019 0.184 0.1826
Onchocerca volvulus 0.019 0.184 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0512 0.0496
Schistosoma mansoni pol-related 0.019 0.184 0.1826
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.019 0.184 0.1826
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0141 0.0124
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0204 0.0491
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0512 0.1139
Schistosoma mansoni aldo-keto reductase 0.019 0.184 0.1826
Leishmania major prenyl protein specific carboxyl methyltransferase, putative 0.0886 1 1
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0045 0.0028
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.019 0.184 0.1826
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.019 0.184 0.1826
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.019 0.184 0.1826
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0055 0.0261 0.0244
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0141 0.0124
Trichomonas vaginalis aldo-keto reductase, putative 0.019 0.184 0.1826
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0141 0.0124
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0321 0.0304
Echinococcus granulosus neuropeptide receptor A26 0.0457 0.4977 0.4968
Trypanosoma cruzi aldo/keto reductase, putative 0.019 0.184 0.1826
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0045 0.0028
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0045 0.0028
Trichomonas vaginalis aldo/keto reductase, putative 0.019 0.184 0.1826
Onchocerca volvulus 0.019 0.184 1
Trichomonas vaginalis aldo/keto reductase, putative 0.019 0.184 0.1826
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.0886 1 1
Loa Loa (eye worm) oxidoreductase 0.019 0.184 0.1826
Schistosoma mansoni hypothetical protein 0.0333 0.3522 0.351
Echinococcus multilocularis survival motor neuron protein 1 0.0465 0.5066 0.5057
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0512 0.0496
Loa Loa (eye worm) oxidoreductase 0.019 0.184 0.1826
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0321 0.0304
Trichomonas vaginalis aldo-keto reductase, putative 0.019 0.184 0.1826
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0512 0.1139
Schistosoma mansoni protein-s-isoprenylcysteine o-methyltransferase 0.0886 1 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.0055 0.0261 0.0244
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0886 1 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0512 0.0496
Trypanosoma brucei prostaglandin f synthase 0.019 0.184 0.1826
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.0886 1 1
Plasmodium falciparum aldehyde reductase, putative 0.0055 0.0261 0.0244
Trichomonas vaginalis aldo-keto reductase, putative 0.019 0.184 0.1826
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0321 0.0672
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.019 0.184 0.1826
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0055 0.0261 0.0244
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0204 0.0187
Echinococcus multilocularis 0.0886 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0261 0.0244

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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