Detailed information for compound 785135

Basic information

Technical information
  • TDR Targets ID: 785135
  • Name: N-[(4-ethoxyphenyl)methylideneamino]-1,5-di(p henyl)-1,2,4-triazole-3-carboxamide
  • MW: 411.456 | Formula: C24H21N5O2
  • H donors: 1 H acceptors: 3 LogP: 4.9 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)C=NNC(=O)c1nc(n(n1)c1ccccc1)c1ccccc1
  • InChi: 1S/C24H21N5O2/c1-2-31-21-15-13-18(14-16-21)17-25-27-24(30)22-26-23(19-9-5-3-6-10-19)29(28-22)20-11-7-4-8-12-20/h3-17H,2H2,1H3,(H,27,30)/b25-17+
  • InChiKey: YLAYRDGDAAYUNY-KOEQRZSOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(4-ethoxyphenyl)methyleneamino]-1,5-di(phenyl)-1,2,4-triazole-3-carboxamide
  • N-[(4-ethoxybenzylidene)amino]-1,5-di(phenyl)-1,2,4-triazole-3-carboxamide
  • A0988/0046188

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0099 0.3804 0.3662
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1443 0.3792
Schistosoma mansoni ap endonuclease 0.0019 0.0224 0.0588
Schistosoma mansoni ap endonuclease 0.0019 0.0224 0.0588
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0224 0.5
Toxoplasma gondii exonuclease III APE 0.0019 0.0224 0.0588
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0066 0.2328 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0066 0.2328 0.6119
Brugia malayi follicle stimulating hormone receptor 0.0235 0.9853 0.985
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1443 0.1247
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1443 0.1247
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0099 0.3804 0.3662
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1443 0.3792
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0224 0.5
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0224 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.1443 0.1247
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0099 0.3804 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0099 0.3804 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0224 0.5
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0224 0.5
Schistosoma mansoni survival motor neuron protein 0.0049 0.154 0.4049
Echinococcus granulosus survival motor neuron protein 1 0.0238 1 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.2328 0.2152
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0099 0.3804 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0224 0.5
Toxoplasma gondii melibiase subfamily protein 0.0099 0.3804 1
Onchocerca volvulus 0.0049 0.154 0.5
Echinococcus multilocularis survival motor neuron protein 1 0.0238 1 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.154 0.1347
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0066 0.2328 0.6119
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0224 0.5
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0099 0.3804 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.1443 0.1247
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0224 0.5
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0224 0.5
Brugia malayi Melibiase family protein 0.0066 0.2328 0.2152
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0235 0.9853 0.985
Loa Loa (eye worm) hypothetical protein 0.0238 1 1
Schistosoma mansoni hypothetical protein 0.0049 0.154 0.4049
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0224 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.1443 0.1247
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.1443 0.3792
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0224 0.5
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0224 0.5
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0099 0.3804 0.3662
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.1443 0.1247

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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