Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0028 | 0.0022 | 0.0045 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0081 | 0.0342 | 0.5513 |
Plasmodium falciparum | glutathione reductase | 0.0049 | 0.0149 | 0.397 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0154 | 0.041 |
Trypanosoma cruzi | glycosyl hydrolase-like protein, putative | 0.0028 | 0.0022 | 0.0045 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0028 | 0.0022 | 0.0131 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.0342 | 0.5 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0081 | 0.0342 | 0.1056 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0154 | 0.012 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0517 | 0.295 | 0.2926 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.0342 | 0.0853 |
Trypanosoma brucei | glucosidase, putative | 0.0075 | 0.0306 | 0.0568 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.0342 | 1 |
Onchocerca volvulus | 0.0157 | 0.0797 | 0.2646 | |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0517 | 0.295 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0081 | 0.0342 | 0.1056 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.006 | 0.0215 | 0.0429 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0517 | 0.295 | 0.5869 |
Leishmania major | glycosyl hydrolase-like protein | 0.0028 | 0.0022 | 0.0045 |
Onchocerca volvulus | 0.0197 | 0.1032 | 0.3448 | |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0075 | 0.0306 | 0.1794 |
Trichomonas vaginalis | glutaminase, putative | 0.0309 | 0.1706 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.006 | 0.0215 | 0.0429 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0049 | 0.0149 | 0.0395 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.0342 | 1 |
Brugia malayi | glutathione reductase | 0.0049 | 0.0149 | 0.0254 |
Schistosoma mansoni | glutaminase | 0.0309 | 0.1706 | 0.5733 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.034 | 0.1891 | 0.3745 |
Schistosoma mansoni | hypothetical protein | 0.0321 | 0.1775 | 0.5971 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0517 | 0.295 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0049 | 0.0149 | 0.0254 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.0216 | 0.0624 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.006 | 0.0215 | 0.0386 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0112 | 0.0527 | 0.8342 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0125 | 0.0602 | 1 |
Brugia malayi | Probable ClpP-like protease | 0.0081 | 0.0342 | 0.0641 |
Toxoplasma gondii | thioredoxin reductase | 0.0049 | 0.0149 | 0.397 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0125 | 0.0602 | 1 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0321 | 0.1775 | 0.3514 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0125 | 0.0602 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.006 | 0.0215 | 0.126 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0154 | 0.041 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.034 | 0.1891 | 0.6366 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.006 | 0.0215 | 0.0181 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0125 | 0.0602 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.034 | 0.1891 | 0.1863 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0053 | 0.0174 | 0.2615 |
Mycobacterium ulcerans | glutaminase | 0.0309 | 0.1706 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0049 | 0.0149 | 0.397 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.003 | 0.0034 | 0.0023 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0075 | 0.0306 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.006 | 0.0215 | 0.1449 |
Schistosoma mansoni | alpha glucosidase | 0.0075 | 0.0306 | 0.0932 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.0342 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0049 | 0.0149 | 0.397 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.034 | 0.1891 | 0.1863 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0075 | 0.0306 | 0.1794 |
Echinococcus multilocularis | geminin | 0.0177 | 0.0912 | 0.088 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0028 | 0.0022 | 0.0731 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0075 | 0.0306 | 0.0932 |
Brugia malayi | hypothetical protein | 0.0157 | 0.0797 | 0.1553 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.0216 | 0.0431 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0154 | 0.041 |
Trichomonas vaginalis | ap endonuclease, putative | 0.006 | 0.0215 | 0.126 |
Echinococcus granulosus | geminin | 0.0177 | 0.0912 | 0.3009 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 0.0154 | 0.041 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0112 | 0.0527 | 0.8342 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0075 | 0.0306 | 0.1794 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0861 | 0.5011 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0028 | 0.0022 | 0.0131 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0053 | 0.0174 | 0.014 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0075 | 0.0306 | 0.0273 |
Loa Loa (eye worm) | glutaminase 2 | 0.0309 | 0.1706 | 0.3375 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0861 | 0.5011 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0034 | 0.0023 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.0216 | 0.606 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0112 | 0.0527 | 0.8342 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.006 | 0.0215 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.0797 | 0.1553 |
Plasmodium falciparum | importin beta, putative | 0.003 | 0.0034 | 0.037 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0216 | 0.0008 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0075 | 0.0306 | 0.1794 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0075 | 0.0306 | 0.0611 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0075 | 0.0306 | 0.8871 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.0216 | 0.1475 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0075 | 0.0306 | 0.1794 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.003 | 0.0034 | 0.0023 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.0342 | 0.0853 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0028 | 0.0022 | 0.0131 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0342 | 0.0641 |
Schistosoma mansoni | alpha-glucosidase | 0.0293 | 0.1607 | 0.5394 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.0216 | 0.0183 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0028 | 0.0022 | 0.0131 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0081 | 0.0342 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0051 | 0.0158 | 0.0273 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0028 | 0.0022 | 0.0131 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0517 | 0.295 | 1 |
Schistosoma mansoni | ap endonuclease | 0.006 | 0.0215 | 0.062 |
Schistosoma mansoni | alpha-glucosidase | 0.0293 | 0.1607 | 0.5394 |
Brugia malayi | RNA, U transporter 1 | 0.0085 | 0.0366 | 0.0689 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.006 | 0.0215 | 0.0386 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0053 | 0.0174 | 0.048 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.006 | 0.0215 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0049 | 0.0149 | 0.397 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0081 | 0.0342 | 0.0309 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0216 | 0.0008 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0053 | 0.0174 | 0.0546 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.006 | 0.0215 | 0.062 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0075 | 0.0306 | 0.0568 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0028 | 0.0022 | 0.0131 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0075 | 0.0306 | 0.1794 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.006 | 0.0215 | 0.7023 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0049 | 0.0149 | 0.0116 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.005 | 0.0154 | 0.0263 |
Toxoplasma gondii | exonuclease III APE | 0.006 | 0.0215 | 0.6024 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.0216 | 0.0008 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0075 | 0.0306 | 0.1794 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 0.0154 | 0.041 |
Echinococcus multilocularis | snurportin 1 | 0.0321 | 0.1775 | 0.1747 |
Leishmania major | trypanothione reductase | 0.0049 | 0.0149 | 0.0298 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0053 | 0.0174 | 0.0546 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0112 | 0.0527 | 0.8342 |
Loa Loa (eye worm) | glutaminase | 0.0309 | 0.1706 | 0.3375 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.0912 | 0.3009 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0112 | 0.0527 | 0.8705 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0081 | 0.0342 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0028 | 0.0022 | 0.0131 |
Trypanosoma brucei | trypanothione reductase | 0.0049 | 0.0149 | 0.0254 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.006 | 0.0215 | 0.6024 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0081 | 0.0342 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.0309 | 0.1706 | 0.3375 |
Loa Loa (eye worm) | hypothetical protein | 0.0861 | 0.5011 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0861 | 0.5011 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0075 | 0.0306 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0216 | 0.0624 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0112 | 0.0527 | 0.8342 |
Mycobacterium tuberculosis | Probable reductase | 0.0112 | 0.0527 | 0.8342 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.006 | 0.0215 | 0.6024 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 0.249 | 0.4946 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 0.0154 | 0.0263 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0081 | 0.0342 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.006 | 0.0215 | 0.0386 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0861 | 0.5011 | 1 |
Brugia malayi | Importin beta-1 subunit | 0.003 | 0.0034 | 0.0023 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0075 | 0.0306 | 0.1794 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.003 | 0.0034 | 0.037 |
Brugia malayi | Thioredoxin reductase | 0.0049 | 0.0149 | 0.0254 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0517 | 0.295 | 0.5869 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0049 | 0.0149 | 0.0298 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 0.0154 | 0.012 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.034 | 0.1891 | 0.3745 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0075 | 0.0306 | 0.0568 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0051 | 0.0158 | 0.0273 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.0216 | 0.0624 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.0912 | 0.3009 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0075 | 0.0306 | 0.1794 |
Loa Loa (eye worm) | glutathione reductase | 0.0049 | 0.0149 | 0.0254 |
Schistosoma mansoni | ap endonuclease | 0.006 | 0.0215 | 0.062 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0075 | 0.0306 | 0.0611 |
Plasmodium vivax | importin-beta 2, putative | 0.003 | 0.0034 | 0.037 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0028 | 0.0022 | 0.0131 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0075 | 0.0306 | 0.0611 |
Echinococcus granulosus | snurportin 1 | 0.0321 | 0.1775 | 0.5971 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.006 | 0.0215 | 0.6024 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.