Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | replicative DNA helicase | 0.1948 | 0.6868 | 1 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.2736 | 1 | 1 |
Echinococcus granulosus | Receptor type tyrosine protein phosphatase O | 0.0595 | 0.1495 | 0.1495 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.115 | 0.37 | 0.5 |
Mycobacterium tuberculosis | Probable replicative DNA helicase DnaB | 0.1948 | 0.6868 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.115 | 0.37 | 0.5 |
Mycobacterium ulcerans | replicative DNA helicase DnaB | 0.1948 | 0.6868 | 1 |
Schistosoma mansoni | Replicative DNA helicase | 0.1948 | 0.6868 | 1 |
Mycobacterium leprae | PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase | 0.1948 | 0.6868 | 1 |
Wolbachia endosymbiont of Brugia malayi | replicative DNA helicase | 0.1948 | 0.6868 | 1 |
Loa Loa (eye worm) | twinkle helicase | 0.0556 | 0.1342 | 1 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.115 | 0.37 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.115 | 0.37 | 0.5 |
Treponema pallidum | replicative DNA helicase (dnaB) | 0.1948 | 0.6868 | 0.5 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0218 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.