Detailed information for compound 790683

Basic information

Technical information
  • TDR Targets ID: 790683
  • Name: N-(4-ethoxyphenyl)-1-thiophen-2-ylsulfonylpip eridine-3-carboxamide
  • MW: 394.508 | Formula: C18H22N2O4S2
  • H donors: 1 H acceptors: 3 LogP: 2.75 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)NC(=O)C1CCCN(C1)S(=O)(=O)c1cccs1
  • InChi: 1S/C18H22N2O4S2/c1-2-24-16-9-7-15(8-10-16)19-18(21)14-5-3-11-20(13-14)26(22,23)17-6-4-12-25-17/h4,6-10,12,14H,2-3,5,11,13H2,1H3,(H,19,21)
  • InChiKey: DQTSTPJXWXFJQI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-ethoxyphenyl)-1-(2-thienylsulfonyl)piperidine-3-carboxamide
  • N-(4-ethoxyphenyl)-1-(2-thienylsulfonyl)-3-piperidinecarboxamide
  • N-(4-ethoxyphenyl)-1-(2-thienylsulfonyl)nipecotamide
  • N-(4-ethoxyphenyl)-1-thiophen-2-ylsulfonyl-piperidine-3-carboxamide
  • EU-0057824

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0181 0.7409 1
Loa Loa (eye worm) hypothetical protein 0.0061 0.1593 0.1555
Brugia malayi Fli-1 protein 0.0217 0.9182 0.9215
Echinococcus granulosus geminin 0.0164 0.6588 0.6614
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1014 0.097
Schistosoma mansoni hypothetical protein 0.0034 0.0256 0.0222
Echinococcus multilocularis muscleblind protein 1 0.0147 0.5783 0.5784
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.2098 0.2064
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1014 0.097
Treponema pallidum hypothetical protein 0.0037 0.0432 0.5
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0181 0.7409 0.7314
Toxoplasma gondii CAAX amino terminal protease family protein 0.0037 0.0432 1
Schistosoma mansoni alpha-glucosidase 0.0138 0.5345 0.5797
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0352 0.0354
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.2098 0.2106
Brugia malayi Glycosyl hydrolases family 31 protein 0.0161 0.6433 0.644
Brugia malayi Pre-SET motif family protein 0.0206 0.8618 0.8645
Trypanosoma brucei CAAX amino terminal protease, putative 0.0181 0.7409 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0352 0.7898
Brugia malayi Ets-domain containing protein 0.0072 0.2098 0.2064
Brugia malayi Muscleblind-like protein 0.0147 0.5783 0.5784
Brugia malayi hypothetical protein 0.0233 0.9961 1
Mycobacterium ulcerans hypothetical protein 0.0037 0.0432 0.5
Loa Loa (eye worm) hypothetical protein 0.0147 0.5783 0.5784
Chlamydia trachomatis hypothetical protein 0.0037 0.0432 0.5
Schistosoma mansoni survival motor neuron protein 0.0048 0.0932 0.0963
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0161 0.6433 0.644
Schistosoma mansoni hypothetical protein 0.0164 0.6588 0.7158
Echinococcus multilocularis muscleblind protein 0.0147 0.5783 0.5784
Loa Loa (eye worm) hypothetical protein 0.0233 0.9961 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0352 0.0302
Onchocerca volvulus 0.0093 0.3138 0.3102
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.9961 1
Schistosoma mansoni ets-related 0.0217 0.9182 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1014 0.097
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.9961 1
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0037 0.0432 0.5
Toxoplasma gondii hypothetical protein 0.0037 0.0432 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.8618 0.8645
Giardia lamblia Hypothetical protein 0.0181 0.7409 0.5
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.2098 0.2064
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0181 0.7409 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.6433 0.644
Schistosoma mansoni alpha glucosidase 0.0036 0.0352 0.0328
Plasmodium vivax protease, putative 0.0037 0.0432 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0161 0.6433 0.644
Schistosoma mansoni hypothetical protein 0.0164 0.6588 0.7158
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0181 0.7409 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0352 0.0302
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0181 0.7409 0.8057
Mycobacterium ulcerans hypothetical protein 0.0037 0.0432 0.5
Echinococcus granulosus muscleblind protein 0.0147 0.5783 0.5806
Echinococcus granulosus lysosomal alpha glucosidase 0.0161 0.6433 0.6458
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0256 0.0205
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.0432 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.4355 0.4342
Toxoplasma gondii hypothetical protein 0.0037 0.0432 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0932 0.0887
Mycobacterium tuberculosis Probable conserved integral membrane protein 0.0037 0.0432 0.5
Entamoeba histolytica CAAX amino terminal protease family 0.0037 0.0432 0.0113
Loa Loa (eye worm) hypothetical protein 0.0181 0.7409 0.7424
Entamoeba histolytica CAAX prenyl protease family 0.0181 0.7409 1
Schistosoma mansoni gabp alpha 0.0072 0.2098 0.224
Echinococcus multilocularis CAAX prenyl protease 2 0.0181 0.7409 0.7424
Brugia malayi Ets-domain containing protein 0.0072 0.2098 0.2064
Onchocerca volvulus 0.0048 0.0932 0.0884
Loa Loa (eye worm) hypothetical protein 0.0147 0.5783 0.5784
Trichomonas vaginalis set domain proteins, putative 0.0234 1 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.1014 0.097
Entamoeba histolytica CAAX amino terminal protease family 0.0037 0.0432 0.0113
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0053 0.0053
Schistosoma mansoni alpha-glucosidase 0.0138 0.5345 0.5797
Echinococcus multilocularis geminin 0.0164 0.6588 0.6596
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.4355 0.4342
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0352 0.0302
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0181 0.7409 0.8057
Echinococcus granulosus CAAX prenyl protease 2 0.0181 0.7409 0.7438
Loa Loa (eye worm) hypothetical protein 0.0034 0.0256 0.0205
Loa Loa (eye worm) fli-1 protein 0.0217 0.9182 0.9215
Brugia malayi CAAX amino terminal protease family protein 0.0181 0.7409 0.7424
Plasmodium falciparum protease, putative 0.0037 0.0432 0.5
Mycobacterium ulcerans integral membrane protein 0.0037 0.0432 0.5
Mycobacterium tuberculosis Probable integral membrane protein 0.0037 0.0432 0.5
Brugia malayi MH2 domain containing protein 0.0118 0.4355 0.4342
Schistosoma mansoni hypothetical protein 0.0048 0.0932 0.0963

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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