Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | zinc carboxypeptidase | 0.0046 | 0.5497 | 0.9389 |
Toxoplasma gondii | zinc carboxypeptidase superfamily protein | 0.002 | 0 | 0.5 |
Toxoplasma gondii | zinc carboxypeptidase, putative | 0.002 | 0 | 0.5 |
Onchocerca volvulus | 0.0067 | 1 | 1 | |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.002 | 0 | 0.5 |
Toxoplasma gondii | zinc carboxypeptidase superfamily protein | 0.002 | 0 | 0.5 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.002 | 0 | 0.5 |
Trypanosoma cruzi | Carboxypeptidase-like protein | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.1352 | 0.231 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0046 | 0.5497 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14, putative | 0.002 | 0 | 0.5 |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.002 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.002 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14, putative | 0.002 | 0 | 0.5 |
Onchocerca volvulus | 0.0067 | 1 | 1 | |
Toxoplasma gondii | flagellar/basal body protein | 0.002 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, Clan MC, Family M14 | 0.002 | 0 | 0.5 |
Trypanosoma brucei | Carboxypeptidase-like protein | 0.002 | 0 | 0.5 |
Trypanosoma brucei | metallo-peptidase, Clan MC, Family M14, putative | 0.002 | 0 | 0.5 |
Trypanosoma brucei | metallo-peptidase, Clan MC, Family M14, putative | 0.002 | 0 | 0.5 |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | subfamily M14A unassigned peptidase | 0.0067 | 1 | 1 |
Onchocerca volvulus | 0.0067 | 1 | 1 | |
Giardia lamblia | Nuclear ATP/GTP-binding protein | 0.002 | 0 | 0.5 |
Leishmania major | zinc carboxypeptidase, putative,metallo-peptidase, Clan MC, Family M14 | 0.002 | 0 | 0.5 |
Onchocerca volvulus | Carboxypeptidase D homolog | 0.0046 | 0.5497 | 0.5497 |
Brugia malayi | Zinc carboxypeptidase family protein | 0.0046 | 0.5497 | 1 |
Brugia malayi | LD47325p | 0.0026 | 0.1352 | 0.246 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.5497 | 0.9389 |
Trypanosoma cruzi | zinc carboxypeptidase, putative | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | carboxypeptidase regulatory region-containing protein, putative | 0.0026 | 0.1352 | 1 |
Onchocerca volvulus | 0.0067 | 1 | 1 | |
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.0067 | 1 | 1 |
Schistosoma mansoni | subfamily M14A unassigned peptidase (M14 family) | 0.0067 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.5855 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5000 nM | Inhibitory activity against human gamma-secretase using SH-SY5Y cells. | ChEMBL. | 12482419 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.