TDR Targets

Basic information

Technical information

TDR Targets ID: 792069
Name: 1-ethyl-3-(4-methoxyphenyl)-1-[4-(4-methylphe nyl)-1,3-thiazol-2-yl]urea
MW: 367.465 | Formula: C20H21N3O2S
H donors: 1 H acceptors: 2 LogP: 4.4 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCN(c1scc(n1)c1ccc(cc1)C)C(=O)Nc1ccc(cc1)OC
InChi: 1S/C20H21N3O2S/c1-4-23(19(24)21-16-9-11-17(25-3)12-10-16)20-22-18(13-26-20)15-7-5-14(2)6-8-15/h5-13H,4H2,1-3H3,(H,21,24)
InChiKey: DCYSXQRAXZQYNC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-ethyl-3-(4-methoxyphenyl)-1-[4-(4-methylphenyl)thiazol-2-yl]urea
1-ethyl-3-(4-methoxyphenyl)-1-[4-(4-methylphenyl)-2-thiazolyl]urea

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0044	0.0111
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0038	0.0374	0.0358
Brugia malayi	exodeoxyribonuclease III family protein	0.0038	0.0374	0.1247
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0038	0.0374	0.2987
Schistosoma mansoni	hypothetical protein	0.0043	0.0436	0.106
Loa Loa (eye worm)	CYP4Cod1	0.0012	0.0044	0.0111
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0017	0.0043
Mycobacterium ulcerans	bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein	0.0303	0.3709	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0017	0.0043
Loa Loa (eye worm)	heterotrimeric G protein alpha subunit	0.001	0.0019	0.0049
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.001	0.0019	0.0002
Schistosoma mansoni	hypothetical protein	0.0043	0.0436	0.106
Schistosoma mansoni	hypothetical protein	0.0323	0.3968	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0019	0.0049
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0038	0.0374	0.0199
Brugia malayi	Niemann-Pick C1 protein precursor	0.0104	0.1208	0.4157
Loa Loa (eye worm)	hypothetical protein	0.0188	0.2264	0.5705
Trichomonas vaginalis	conserved hypothetical protein	0.0183	0.2199	1
Echinococcus multilocularis	expressed conserved protein	0.0098	0.1128	0.1113
Echinococcus multilocularis	guanine nucleotide binding protein subunit	0.001	0.0019	0.0002
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0038	0.0374	0.0904
Schistosoma mansoni	hypothetical protein	0.0172	0.2059	0.5168
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0374	0.0572
Echinococcus multilocularis	protein patched	0.0045	0.0456	0.044
Brugia malayi	guanine nucleotide-binding protein G-o protein alpha subunit	0.001	0.0019	0.0008
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0237	0.2882	0.7252
Echinococcus granulosus	sterol regulatory element binding protein	0.0045	0.0456	0.1111
Echinococcus granulosus	expressed protein	0.001	0.0019	0.0006
Brugia malayi	RNA, U transporter 1	0.0086	0.0977	0.335
Loa Loa (eye worm)	hypothetical protein	0.003	0.0273	0.0687
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0017	0.0043
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0038	0.0374	1
Trichomonas vaginalis	ran, putative	0.0022	0.0172	0.07
Echinococcus multilocularis	muscleblind protein	0.0148	0.1757	0.1743
Brugia malayi	guanine nucleotide-binding protein alpha-3 subunit, putative	0.001	0.0019	0.0008
Leishmania major	GTP-binding protein, putative	0.0022	0.0172	0.3869
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0355	0.9428
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0273	0.4981
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0172	0.0392
Brugia malayi	Muscleblind-like protein	0.0148	0.1757	0.6072
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0038	0.0374	1
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0374	0.1629
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.001	0.0019	0.0006
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0022	0.0172	0.3869
Brugia malayi	Guanine nucleotide-binding protein alpha-12 subunit, putative	0.001	0.0019	0.0008
Entamoeba histolytica	Ran family GTPase	0.0022	0.0172	0.1284
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-12 subunit	0.001	0.0019	0.0049
Plasmodium falciparum	nicotinamide/nicotinic acid mononucleotide adenylyltransferase	0.0303	0.3709	1
Plasmodium falciparum	importin beta, putative	0.003	0.0273	0.0285
Schistosoma mansoni	GTP-binding protein alpha subunit	0.001	0.0019	0.0006
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0237	0.2882	1
Echinococcus granulosus	snurportin 1	0.0323	0.3968	1
Treponema pallidum	hypothetical protein	0.0303	0.3709	1
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.001	0.0019	0.0006
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0323	0.3968	1
Schistosoma mansoni	ap endonuclease	0.0038	0.0374	0.0904
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0022	0.0172	0.054
Echinococcus multilocularis	expressed protein	0.001	0.0019	0.0002
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0038	0.0374	1
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.001	0.0019	0.0006
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0037	0.0355	0.085
Echinococcus granulosus	gtp binding protein I alpha 1subunit	0.001	0.0019	0.0006
Echinococcus multilocularis	muscleblind protein 1	0.0148	0.1757	0.1743
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0355	0.0856
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0106	0.1229	0.3066
Echinococcus multilocularis	geminin	0.0172	0.2059	0.2046
Echinococcus multilocularis	snurportin 1	0.0323	0.3968	0.3958
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0583	0.147
Echinococcus multilocularis	protein dispatched 1	0.0051	0.0536	0.052
Loa Loa (eye worm)	hypothetical protein	0.0104	0.1208	0.3044
Plasmodium vivax	nicotinate-nucleotide adenylyltransferase, putative	0.0303	0.3709	1
Echinococcus granulosus	inositol monophosphatase 1	0.0037	0.0355	0.0856
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0017	0.0043
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0038	0.0374	0.0901
Brugia malayi	Importin beta-1 subunit	0.003	0.0273	0.0892
Brugia malayi	GTP-binding regulatory protein alpha chain - starfish, putative	0.001	0.0019	0.0008
Mycobacterium tuberculosis	Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic	0.0303	0.3709	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0149	0.1773	0.1759
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0237	0.2882	0.287
Schistosoma mansoni	GTP-binding protein (I) alpha-1subunit gnai1	0.001	0.0019	0.0006
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0188	0.2264	0.7841
Schistosoma mansoni	inositol monophosphatase	0.0037	0.0355	0.0856
Loa Loa (eye worm)	guanine nucleotide-binding protein alpha-6 subunit	0.001	0.0019	0.0049
Loa Loa (eye worm)	hypothetical protein	0.001	0.0017	0.0043
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0037	0.0355	0.2828
Echinococcus granulosus	Protein patched homolog 1	0.0045	0.0456	0.1111
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0044	0.0095
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0172	0.0155
Loa Loa (eye worm)	hypothetical protein	0.001	0.0017	0.0043
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.001	0.0019	0.0006
Schistosoma mansoni	GTP-binding protein alpha subunit	0.001	0.0019	0.0006
Schistosoma mansoni	GTP-binding protein alpha subunit gna	0.001	0.0019	0.0006
Schistosoma mansoni	patched 1	0.0045	0.0456	0.1111
Loa Loa (eye worm)	hypothetical protein	0.001	0.0017	0.0043
Schistosoma mansoni	hypothetical protein	0.0172	0.2059	0.5168
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0355	0.9428
Loa Loa (eye worm)	hypothetical protein	0.001	0.0017	0.0043
Loa Loa (eye worm)	hypothetical protein	0.001	0.0019	0.0049
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0237	0.2882	0.287
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0017	0.0043
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.001	0.0019	0.0006
Echinococcus granulosus	expressed conserved protein	0.0098	0.1128	0.2812
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0273	0.0256
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0172	0.3869
Trichomonas vaginalis	inositol monophosphatase, putative	0.0037	0.0355	0.1542
Brugia malayi	Guanine nucleotide-binding protein alpha-6 subunit, putative	0.001	0.0019	0.0008
Echinococcus granulosus	Niemann Pick C1 protein	0.0104	0.1208	0.3014
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0025	0.02	0.4735
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.001	0.0019	0.0002
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0044	0.0111
Brugia malayi	CHE-14 protein	0.0045	0.0456	0.1532
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0355	0.9428
Onchocerca volvulus		0.001	0.0019	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0149	0.1773	0.4445
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.001	0.0019	0.0006
Trichomonas vaginalis	ap endonuclease, putative	0.0038	0.0374	0.1629
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0172	0.0433
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.001	0.0019	0.0006
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.02	0.0831
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0237	0.2882	0.7252
Loa Loa (eye worm)	hypothetical protein	0.001	0.0019	0.0049
Loa Loa (eye worm)	hypothetical protein	0.001	0.0019	0.0049
Schistosoma mansoni	ran	0.0022	0.0172	0.0392
Toxoplasma gondii	exonuclease III APE	0.0038	0.0374	1
Brugia malayi	guanine nucleotide-binding protein alpha-7 subunit, putative	0.001	0.0019	0.0008
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0017	0.0043
Loa Loa (eye worm)	G protein alpha subunit 3	0.001	0.0019	0.0049
Schistosoma mansoni	hypothetical protein	0.0043	0.0436	0.106
Echinococcus multilocularis	guanine nucleotide binding protein (G protein)	0.001	0.0019	0.0002
Entamoeba histolytica	hypothetical protein	0.0025	0.02	0.1524
Schistosoma mansoni	GTP-binding protein (q) alpha-11 subunit gna11	0.001	0.0019	0.0006
Loa Loa (eye worm)	hypothetical protein	0.001	0.0017	0.0043
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0037	0.0355	0.9067
Loa Loa (eye worm)	hypothetical protein	0.001	0.0017	0.0043
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0355	0.1542
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0237	0.2882	0.7252
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0037	0.0355	0.1542
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0038	0.0374	1
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1757	0.4428
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0022	0.0172	0.3869
Echinococcus granulosus	geminin	0.0172	0.2059	0.5168
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0237	0.2882	0.7252
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0273	0.6923
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0044	0.0095
Echinococcus granulosus	importin subunit beta 1	0.003	0.0273	0.0647
Onchocerca volvulus		0.001	0.0019	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0237	0.2882	0.7263
Echinococcus multilocularis	sterol regulatory element binding protein	0.0045	0.0456	0.044
Schistosoma mansoni	ran	0.0022	0.0172	0.0392
Trichomonas vaginalis	importin beta-1, putative	0.0025	0.02	0.0831
Echinococcus granulosus	guanine nucleotide binding protein subunit	0.001	0.0019	0.0006
Echinococcus granulosus	guanine nucleotide binding protein G protein	0.001	0.0019	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1757	0.4428
Schistosoma mansoni	hypothetical protein	0.0043	0.0436	0.106
Brugia malayi	hypothetical protein	0.001	0.0019	0.0008
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0017	0.0043
Schistosoma mansoni	ap endonuclease	0.0038	0.0374	0.0904
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0374	1
Loa Loa (eye worm)	GTP-binding regulatory protein alpha chain	0.001	0.0019	0.0049
Loa Loa (eye worm)	hypothetical protein	0.001	0.0017	0.0043
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0017	0.0043
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0025	0.02	0.0831
Brugia malayi	G-protein alpha subunit	0.001	0.0019	0.0008
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0038	0.0374	0.0572
Brugia malayi	Inositol-1	0.0037	0.0355	0.1181
Loa Loa (eye worm)	hypothetical protein	0.001	0.0017	0.0043
Schistosoma mansoni	GTP-binding protein (I) alpha-2 subunit gnai2	0.001	0.0019	0.0006
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0104	0.1208	1
Echinococcus multilocularis	inositol monophosphatase 1	0.0037	0.0355	0.0339
Plasmodium vivax	importin-beta 2, putative	0.003	0.0273	0.0285
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.001	0.0019	0.0008
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0037	0.0355	0.9428
Schistosoma mansoni	trimeric G-protein alpha o subunit	0.001	0.0019	0.0006
Loa Loa (eye worm)	hypothetical protein	0.001	0.0019	0.0049
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0038	0.0374	0.0943
Echinococcus multilocularis	Niemann Pick C1 protein	0.0104	0.1208	0.1193
Echinococcus multilocularis	gtp binding protein (I) alpha 1subunit	0.001	0.0019	0.0002
Loa Loa (eye worm)	inositol-1	0.0037	0.0355	0.0896
Onchocerca volvulus		0.001	0.0019	1
Echinococcus granulosus	muscleblind protein	0.0148	0.1757	0.4403
Leishmania major	importin beta-1 subunit, putative	0.0025	0.02	0.4735
Brugia malayi	Guanine nucleotide-binding protein alpha-3 subunit, putative	0.001	0.0019	0.0008
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0456	0.2004
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0038	0.0374	1
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0045	0.0456	0.1149
Schistosoma mansoni	importin beta-1	0.003	0.0273	0.0647
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0237	0.2882	0.7252
Mycobacterium leprae	PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC	0.0303	0.3709	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0273	0.6923
Brugia malayi	guanine nucleotide-binding protein G(o), alpha subunit, putative	0.001	0.0019	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0456	0.1149
Schistosoma mansoni	GTP-binding protein (I) alpha subunit gnai	0.001	0.0019	0.0006

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 792069