TDR Targets

Basic information

Technical information

TDR Targets ID: 792696
Name: 2,5-diethoxy-N-(1H-indazol-6-yl)benzenesulfon amide
MW: 361.415 | Formula: C17H19N3O4S
H donors: 2 H acceptors: 3 LogP: 2.06 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1S(=O)(=O)Nc1ccc2c(c1)n[nH]c2)OCC
InChi: 1S/C17H19N3O4S/c1-3-23-14-7-8-16(24-4-2)17(10-14)25(21,22)20-13-6-5-12-11-18-19-15(12)9-13/h5-11,20H,3-4H2,1-2H3,(H,18,19)
InChiKey: QVPJMBNJLWJIBL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ZINC04625522
A3855/0163688

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0021	0.0156	0.0158
Onchocerca volvulus		0.0021	0.0156	0.2075
Brugia malayi	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4	0.0017	0.0067	0.0067
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0274	0.3015
Echinococcus granulosus	tyrosine protein kinase Blk	0.0021	0.0156	0.0158
Toxoplasma gondii	PAN domain-containing protein	0.0033	0.0389	0.0519
Brugia malayi	PAN domain containing protein	0.0033	0.0389	0.0389
Echinococcus multilocularis	tyrosine protein kinase shark	0.0021	0.0156	0.0158
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0156	0.0156
Plasmodium falciparum	cysteine repeat modular protein 1	0.0051	0.0751	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0389	0.0389
Schistosoma mansoni	growth factor receptor-bound protein	0.0015	0.0022	0.0023
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0021	0.0156	0.0158
Onchocerca volvulus		0.0033	0.0389	0.5179
Toxoplasma gondii	PAN domain-containing protein	0.0033	0.0389	0.0519
Toxoplasma gondii	PAN domain-containing protein	0.0033	0.0389	0.0519
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0088	0.0088
Brugia malayi	PAN domain containing protein	0.0033	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0751	0.0751
Echinococcus multilocularis	tissue type plasminogen activator	0.0051	0.0751	0.076
Plasmodium vivax	acyl-CoA synthetase, putative	0.002	0.0135	0.0992
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0024	0.0204	0.0206
Schistosoma mansoni	nck2/grb4	0.0015	0.0022	0.0023
Brugia malayi	SRC-1	0.0024	0.0204	0.0204
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0274	1
Echinococcus granulosus	NCK adaptor protein	0.0015	0.0022	0.0023
Echinococcus granulosus	c src tyrosine kinase	0.0024	0.0204	0.0206
Onchocerca volvulus		0.0021	0.0156	0.2075
Schistosoma mansoni	tyrosine kinase	0.0021	0.0156	0.0158
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0024	0.0204	0.0206
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.002	0.0135	0.4943
Trypanosoma cruzi	hypothetical protein, conserved	0.0051	0.0751	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.006	0.0933	0.0933
Loa Loa (eye worm)	Plcb4 protein	0.0017	0.0067	0.0067
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0027	0.0274	1
Brugia malayi	PAN domain containing protein	0.0033	0.0389	0.0389
Brugia malayi	Protein kinase domain containing protein	0.006	0.0933	0.0933
Entamoeba histolytica	acyl-coA synthetase, putative	0.0027	0.0274	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0024	0.0204	0.0206
Loa Loa (eye worm)	hypothetical protein	0.002	0.0135	0.0135
Echinococcus multilocularis	1 phosphatidylinositol 4,5 bisphosphate	0.0018	0.0088	0.0089
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.0017	0.0067	0.0067
Toxoplasma gondii	kringle domain-containing protein	0.0051	0.0751	0.1143
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.0274	0.5
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0027	0.0274	1
Toxoplasma gondii	microneme protein, putative	0.0033	0.0389	0.0519
Onchocerca volvulus		0.0033	0.0389	0.5179
Brugia malayi	Sex muscle abnormal protein 5	0.0015	0.0022	0.0022
Toxoplasma gondii	microneme protein MIC17C	0.0033	0.0389	0.0519
Brugia malayi	Variant SH3 domain containing protein	0.0015	0.0022	0.0022
Echinococcus multilocularis	NCK adaptor protein	0.0015	0.0022	0.0023
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.0274	0.5
Toxoplasma gondii	subtilisin SUB12	0.0033	0.0389	0.0519
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0156	0.0156
Onchocerca volvulus		0.0021	0.0156	0.2075
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0024	0.0204	0.0206
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0274	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0024	0.0204	0.0206
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0015	0.0022	0.0022
Brugia malayi	Tyrosine-protein kinase abl-1	0.0024	0.0204	0.0204
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0024	0.0204	0.0206
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0156	0.0156
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0133	0.2417	0.2417
Loa Loa (eye worm)	hypothetical protein	0.002	0.0135	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0389	0.0389
Onchocerca volvulus		0.0033	0.0389	0.5179
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0033	0.0389	0.0519
Echinococcus granulosus	1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4	0.0018	0.0088	0.0089
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0024	0.0204	0.0206
Onchocerca volvulus		0.0018	0.0088	0.1169
Leishmania major	phospholipase c-like protein	0.0018	0.0088	0.03
Onchocerca volvulus		0.0033	0.0389	0.5179
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0274	0.3015
Onchocerca volvulus		0.0033	0.0389	0.5179
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0274	0.0274
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0022	0.0022
Schistosoma mansoni	phospholipase C beta	0.0017	0.0067	0.0068
Onchocerca volvulus		0.0021	0.0156	0.2075
Echinococcus granulosus	tyrosine kinase	0.0021	0.0156	0.0158
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0156	0.0156
Echinococcus multilocularis	protein tyrosine kinase	0.0501	0.9881	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0024	0.0204	0.0206
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.002	0.0135	0.5
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0033	0.0389	0.0519
Brugia malayi	PAN domain containing protein	0.0033	0.0389	0.0389
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0274	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0024	0.0204	0.0206
Loa Loa (eye worm)	TK/ABL protein kinase	0.0021	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.002	0.0135	0.0135
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0024	0.0204	0.0206
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0156	0.0156
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0156	0.0156
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0389	0.0389
Schistosoma mansoni	hypothetical protein	0.0051	0.0751	0.076
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0024	0.0204	0.0206
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0021	0.0156	0.0158
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0156	0.0156
Echinococcus multilocularis	c src tyrosine kinase	0.0024	0.0204	0.0206
Loa Loa (eye worm)	PAN domain-containing protein	0.0033	0.0389	0.0389
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0274	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0024	0.0204	0.0206
Loa Loa (eye worm)	PAN domain-containing protein	0.0033	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0389	0.0389
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0015	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0389	0.0389
Schistosoma mansoni	tyrosine kinase	0.0021	0.0156	0.0158
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0021	0.0156	0.0158
Echinococcus granulosus	protein tyrosine kinase	0.0501	0.9881	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0021	0.0156	0.0158
Brugia malayi	PAN domain containing protein	0.0033	0.0389	0.0389
Brugia malayi	Variant SH3 domain containing protein	0.0133	0.2417	0.2417
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0274	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0156	0.0156
Toxoplasma gondii	microneme protein MIC17A	0.0033	0.0389	0.0519
Toxoplasma gondii	hypothetical protein	0.0033	0.0389	0.0519
Onchocerca volvulus		0.0021	0.0156	0.2075
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0156	0.0156
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0024	0.0204	0.0206
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0024	0.0204	0.0206
Brugia malayi	PAN domain containing protein	0.0033	0.0389	0.0389
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0021	0.0156	0.0158
Toxoplasma gondii	PAN domain-containing protein	0.0305	0.5894	1
Echinococcus multilocularis	tyrosine kinase	0.0021	0.0156	0.0158
Trypanosoma brucei	phosphoinositide-specific phospholipase C	0.0018	0.0088	0.5
Loa Loa (eye worm)	TK protein kinase	0.0021	0.0156	0.0156
Brugia malayi	protein-tyrosine kinase	0.0021	0.0156	0.0156
Brugia malayi	Kringle domain containing protein	0.0051	0.0751	0.0751
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0027	0.0274	1
Echinococcus granulosus	growth factor receptor bound protein 2	0.0015	0.0022	0.0023
Onchocerca volvulus		0.0033	0.0389	0.5179
Leishmania major	hypothetical protein, conserved	0.0051	0.0751	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0027	0.0274	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0033	0.0389	0.0389
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0156	0.0156
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0156	0.0156
Schistosoma mansoni	growth factor receptor-bound protein	0.0015	0.0022	0.0023
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0274	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0021	0.0156	0.0158
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0274	0.0274
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.002	0.0135	0.139
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0021	0.0156	0.0158
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0156	0.0156
Toxoplasma gondii	PAN domain-containing protein	0.0305	0.5894	1
Echinococcus granulosus	tyrosine kinase	0.0021	0.0156	0.0158
Toxoplasma gondii	microneme protein MIC4	0.0033	0.0389	0.0519
Schistosoma mansoni	tyrosine kinase	0.0024	0.0204	0.0206
Loa Loa (eye worm)	PAN domain-containing protein	0.0033	0.0389	0.0389
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0389	0.0389
Schistosoma mansoni	tyrosine kinase	0.0024	0.0204	0.0206
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0015	0.0022	0.0023
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0274	0.0274
Toxoplasma gondii	PAN domain-containing protein	0.0033	0.0389	0.0519
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0024	0.0204	0.0206
Schistosoma mansoni	adapter molecule crk	0.0015	0.0022	0.0023
Echinococcus granulosus	tissue type plasminogen activator	0.0051	0.0751	0.076
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0021	0.0156	0.0158
Brugia malayi	Phosphatidylinositol-specific phospholipase C, X domain containing protein	0.0018	0.0088	0.0088
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0274	0.3015
Onchocerca volvulus		0.0018	0.0088	0.1169
Onchocerca volvulus		0.0033	0.0389	0.5179
Brugia malayi	Variant SH3 domain containing protein	0.0015	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0088	0.0088
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0274	0.0274
Onchocerca volvulus		0.0021	0.0156	0.2075
Loa Loa (eye worm)	SRC-1	0.0024	0.0204	0.0204
Schistosoma mansoni	tyrosine kinase	0.0024	0.0204	0.0206
Loa Loa (eye worm)	TK/FER protein kinase	0.0021	0.0156	0.0156
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0156	0.0156
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0274	0.0274
Onchocerca volvulus		0.0033	0.0389	0.5179
Schistosoma mansoni	tyrosine kinase	0.0024	0.0204	0.0206
Onchocerca volvulus		0.0051	0.0751	1
Plasmodium falciparum	acyl-CoA synthetase	0.002	0.0135	0.0992
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0067	0.0067
Toxoplasma gondii	hypothetical protein	0.0033	0.0389	0.0519
Brugia malayi	Protein kinase domain containing protein	0.0021	0.0156	0.0156
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0024	0.0204	0.0206
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0024	0.0204	0.0206
Loa Loa (eye worm)	PAN domain-containing protein	0.0033	0.0389	0.0389
Onchocerca volvulus		0.0033	0.0389	0.5179
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0389	0.0389
Onchocerca volvulus		0.0033	0.0389	0.5179
Brugia malayi	PAN domain containing protein	0.0033	0.0389	0.0389
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0051	0.0751	1
Brugia malayi	SH2 domain containing protein	0.0021	0.0156	0.0156
Brugia malayi	SH2 domain containing protein	0.0021	0.0156	0.0156
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0027	0.0274	1
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0024	0.0204	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0156	0.0156
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0024	0.0204	0.0206
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0027	0.0274	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0015	0.0022	0.0023
Loa Loa (eye worm)	TK/FAK protein kinase	0.0507	1	1
Brugia malayi	hypothetical protein	0.0021	0.0156	0.0156
Brugia malayi	PAN domain containing protein	0.0033	0.0389	0.0389
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0024	0.0204	0.0206
Loa Loa (eye worm)	hypothetical protein	0.002	0.0135	0.0135
Brugia malayi	PAN domain containing protein	0.0033	0.0389	0.0389
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0024	0.0204	0.0206
Echinococcus granulosus	tyrosine protein kinase Srms	0.0021	0.0156	0.0158
Toxoplasma gondii	microneme protein MIC17B	0.0033	0.0389	0.0519
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0274	0.0274
Schistosoma mansoni	tyrosine kinase	0.0501	0.9881	1
Onchocerca volvulus		0.0033	0.0389	0.5179
Onchocerca volvulus		0.0027	0.0274	0.3641
Brugia malayi	PAN domain containing protein	0.0033	0.0389	0.0389
Loa Loa (eye worm)	phosphatidylinositol-specific phospholipase C	0.0018	0.0088	0.0088

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 792696