Detailed information for compound 792696

Basic information

Technical information
  • TDR Targets ID: 792696
  • Name: 2,5-diethoxy-N-(1H-indazol-6-yl)benzenesulfon amide
  • MW: 361.415 | Formula: C17H19N3O4S
  • H donors: 2 H acceptors: 3 LogP: 2.06 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1S(=O)(=O)Nc1ccc2c(c1)n[nH]c2)OCC
  • InChi: 1S/C17H19N3O4S/c1-3-23-14-7-8-16(24-4-2)17(10-14)25(21,22)20-13-6-5-12-11-18-19-15(12)9-13/h5-11,20H,3-4H2,1-2H3,(H,18,19)
  • InChiKey: QVPJMBNJLWJIBL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC04625522
  • A3855/0163688

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0027 0.0274 0.0274
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0274 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0274 1
Onchocerca volvulus 0.0021 0.0156 0.2075
Brugia malayi PAN domain containing protein 0.0033 0.0389 0.0389
Schistosoma mansoni hypothetical protein 0.0051 0.0751 0.076
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0389 0.0389
Brugia malayi PAN domain containing protein 0.0033 0.0389 0.0389
Toxoplasma gondii microneme protein MIC17A 0.0033 0.0389 0.0519
Brugia malayi SH2 domain containing protein 0.0021 0.0156 0.0156
Echinococcus multilocularis protein tyrosine kinase 0.0501 0.9881 1
Onchocerca volvulus 0.0027 0.0274 0.3641
Mycobacterium ulcerans hypothetical protein 0.0027 0.0274 1
Schistosoma mansoni tyrosine kinase 0.0024 0.0204 0.0206
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0274 1
Onchocerca volvulus 0.0033 0.0389 0.5179
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0024 0.0204 0.0206
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0017 0.0067 0.0067
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0015 0.0022 0.0022
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0274 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0024 0.0204 0.0206
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0022
Onchocerca volvulus 0.0033 0.0389 0.5179
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0274 0.3015
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0274 0.3015
Brugia malayi Variant SH3 domain containing protein 0.0133 0.2417 0.2417
Schistosoma mansoni tyrosine kinase 0.0021 0.0156 0.0158
Brugia malayi Phosphatidylinositol-specific phospholipase C, X domain containing protein 0.0018 0.0088 0.0088
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0274 0.0274
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0135 0.5
Plasmodium falciparum cysteine repeat modular protein 1 0.0051 0.0751 1
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0135 0.0992
Echinococcus granulosus tyrosine protein kinase Src42A 0.0024 0.0204 0.0206
Brugia malayi PAN domain containing protein 0.0033 0.0389 0.0389
Brugia malayi PAN domain containing protein 0.0033 0.0389 0.0389
Brugia malayi PAN domain containing protein 0.0033 0.0389 0.0389
Brugia malayi 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta 4 0.0017 0.0067 0.0067
Echinococcus granulosus tyrosine protein kinase Srms 0.0021 0.0156 0.0158
Echinococcus granulosus tyrosine protein kinase Fyn 0.0024 0.0204 0.0206
Leishmania major phospholipase c-like protein 0.0018 0.0088 0.03
Toxoplasma gondii kringle domain-containing protein 0.0051 0.0751 0.1143
Loa Loa (eye worm) hypothetical protein 0.0018 0.0088 0.0088
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0024 0.0204 0.0206
Loa Loa (eye worm) hypothetical protein 0.0033 0.0389 0.0389
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0024 0.0204 0.0206
Echinococcus granulosus tissue type plasminogen activator 0.0051 0.0751 0.076
Echinococcus multilocularis tyrosine kinase 0.0021 0.0156 0.0158
Echinococcus granulosus tyrosine protein kinase Fyn 0.0024 0.0204 0.0206
Echinococcus multilocularis c src tyrosine kinase 0.0024 0.0204 0.0206
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0156 0.0156
Echinococcus multilocularis tyrosine protein kinase Blk 0.0021 0.0156 0.0158
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0024 0.0204 0.0206
Echinococcus granulosus tyrosine protein kinase Blk 0.0021 0.0156 0.0158
Schistosoma mansoni nck2/grb4 0.0015 0.0022 0.0023
Schistosoma mansoni tyrosine kinase 0.0024 0.0204 0.0206
Trypanosoma brucei phosphoinositide-specific phospholipase C 0.0018 0.0088 0.5
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0274 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0135 0.0135
Echinococcus granulosus tyrosine kinase 0.0021 0.0156 0.0158
Loa Loa (eye worm) hypothetical protein 0.0033 0.0389 0.0389
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0389 0.0519
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0024 0.0204 0.0206
Loa Loa (eye worm) hypothetical protein 0.0021 0.0156 0.0156
Echinococcus granulosus tyrosine protein kinase ABL1 0.0021 0.0156 0.0158
Schistosoma mansoni phospholipase C beta 0.0017 0.0067 0.0068
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0274 1
Toxoplasma gondii PAN domain-containing protein 0.0305 0.5894 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.002 0.0135 0.0135
Schistosoma mansoni growth factor receptor-bound protein 0.0015 0.0022 0.0023
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0024 0.0204 0.0206
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0015 0.0022 0.0023
Onchocerca volvulus 0.0033 0.0389 0.5179
Toxoplasma gondii PAN/Apple domain-containing protein 0.0033 0.0389 0.0519
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0021 0.0156 0.0158
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0389 0.0389
Trypanosoma cruzi hypothetical protein, conserved 0.0051 0.0751 1
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0022 0.0022
Echinococcus granulosus protein tyrosine kinase 0.0501 0.9881 1
Toxoplasma gondii microneme protein, putative 0.0033 0.0389 0.0519
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0156 0.0156
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0021 0.0156 0.0158
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0274 0.3015
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0156 0.0156
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0274 1
Echinococcus granulosus c src tyrosine kinase 0.0024 0.0204 0.0206
Loa Loa (eye worm) hypothetical protein 0.0051 0.0751 0.0751
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0389 0.0519
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0389 0.0389
Brugia malayi PAN domain containing protein 0.0033 0.0389 0.0389
Brugia malayi hypothetical protein 0.0021 0.0156 0.0156
Onchocerca volvulus 0.0033 0.0389 0.5179
Brugia malayi PAN domain containing protein 0.0033 0.0389 0.0389
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0024 0.0204 0.0206
Schistosoma mansoni tyrosine kinase 0.0024 0.0204 0.0206
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0024 0.0204 0.0206
Echinococcus multilocularis NCK adaptor protein 0.0015 0.0022 0.0023
Brugia malayi Sex muscle abnormal protein 5 0.0015 0.0022 0.0022
Onchocerca volvulus 0.0021 0.0156 0.2075
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0156 0.0156
Onchocerca volvulus 0.0033 0.0389 0.5179
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0021 0.0156 0.0158
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0156 0.0156
Loa Loa (eye worm) TK protein kinase 0.0021 0.0156 0.0156
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0389 0.0519
Toxoplasma gondii hypothetical protein 0.0033 0.0389 0.0519
Loa Loa (eye worm) TK/FAK protein kinase 0.0507 1 1
Echinococcus granulosus tyrosine protein kinase shark 0.0021 0.0156 0.0158
Brugia malayi SH2 domain containing protein 0.0021 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0027 0.0274 0.0274
Brugia malayi Protein kinase domain containing protein 0.0021 0.0156 0.0156
Echinococcus multilocularis tyrosine protein kinase shark 0.0021 0.0156 0.0158
Echinococcus multilocularis tyrosine protein kinase Abl 0.0024 0.0204 0.0206
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0018 0.0088 0.0088
Loa Loa (eye worm) TK/ROR protein kinase 0.006 0.0933 0.0933
Loa Loa (eye worm) Plcb4 protein 0.0017 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0033 0.0389 0.0389
Toxoplasma gondii PAN domain-containing protein 0.0305 0.5894 1
Schistosoma mansoni tyrosine kinase 0.0501 0.9881 1
Onchocerca volvulus 0.0033 0.0389 0.5179
Echinococcus granulosus tyrosine protein kinase Lyn 0.0024 0.0204 0.0206
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0024 0.0204 0.0206
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0033 0.0389 0.0519
Onchocerca volvulus 0.0021 0.0156 0.2075
Brugia malayi protein-tyrosine kinase 0.0021 0.0156 0.0156
Onchocerca volvulus 0.0033 0.0389 0.5179
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0024 0.0204 0.0206
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0021 0.0156 0.0158
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0156 0.0156
Brugia malayi Variant SH3 domain containing protein 0.0015 0.0022 0.0022
Onchocerca volvulus 0.0033 0.0389 0.5179
Brugia malayi Protein kinase domain containing protein 0.0021 0.0156 0.0156
Echinococcus multilocularis tissue type plasminogen activator 0.0051 0.0751 0.076
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0024 0.0204 0.0206
Brugia malayi PAN domain containing protein 0.0033 0.0389 0.0389
Schistosoma mansoni growth factor receptor-bound protein 0.0015 0.0022 0.0023
Onchocerca volvulus 0.0033 0.0389 0.5179
Loa Loa (eye worm) SRC-1 0.0024 0.0204 0.0204
Echinococcus granulosus growth factor receptor bound protein 2 0.0015 0.0022 0.0023
Schistosoma mansoni tyrosine kinase 0.0024 0.0204 0.0206
Schistosoma mansoni adapter molecule crk 0.0015 0.0022 0.0023
Brugia malayi Tyrosine-protein kinase abl-1 0.0024 0.0204 0.0204
Toxoplasma gondii microneme protein MIC17B 0.0033 0.0389 0.0519
Echinococcus multilocularis tyrosine protein kinase Srms 0.0021 0.0156 0.0158
Loa Loa (eye worm) hypothetical protein 0.0017 0.0067 0.0067
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0135 0.139
Onchocerca volvulus 0.0018 0.0088 0.1169
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0133 0.2417 0.2417
Loa Loa (eye worm) hypothetical protein 0.0033 0.0389 0.0389
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0156 0.0156
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0274 0.0274
Brugia malayi Protein kinase domain containing protein 0.0021 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0033 0.0389 0.0389
Toxoplasma gondii microneme protein MIC17C 0.0033 0.0389 0.0519
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0156 0.0156
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0274 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0135 0.4943
Echinococcus granulosus NCK adaptor protein 0.0015 0.0022 0.0023
Echinococcus granulosus tyrosine protein kinase Src64B 0.0024 0.0204 0.0206
Loa Loa (eye worm) hypothetical protein 0.002 0.0135 0.0135
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0051 0.0751 1
Schistosoma mansoni tyrosine kinase 0.0021 0.0156 0.0158
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0274 1
Toxoplasma gondii microneme protein MIC4 0.0033 0.0389 0.0519
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0274 1
Onchocerca volvulus 0.0021 0.0156 0.2075
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0389 0.0389
Toxoplasma gondii PAN domain-containing protein 0.0033 0.0389 0.0519
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0274 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0389 0.0389
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0021 0.0156 0.0158
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0024 0.0204 0.0206
Onchocerca volvulus 0.0021 0.0156 0.2075
Leishmania major hypothetical protein, conserved 0.0051 0.0751 1
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.002 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0033 0.0389 0.0389
Echinococcus granulosus 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-4 0.0018 0.0088 0.0089
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0135 0.0992
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0024 0.0204 0.0206
Echinococcus multilocularis growth factor receptor bound protein 2 0.0015 0.0022 0.0023
Loa Loa (eye worm) PAN domain-containing protein 0.0033 0.0389 0.0389
Onchocerca volvulus 0.0021 0.0156 0.2075
Toxoplasma gondii subtilisin SUB12 0.0033 0.0389 0.0519
Brugia malayi PAN domain containing protein 0.0033 0.0389 0.0389
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0274 0.0274
Loa Loa (eye worm) TK/FER protein kinase 0.0021 0.0156 0.0156
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0274 1
Onchocerca volvulus 0.0033 0.0389 0.5179
Brugia malayi Kringle domain containing protein 0.0051 0.0751 0.0751
Brugia malayi Protein kinase domain containing protein 0.006 0.0933 0.0933
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0274 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0135 0.0135
Echinococcus granulosus tyrosine protein kinase Fyn 0.0024 0.0204 0.0206
Brugia malayi PAN domain containing protein 0.0033 0.0389 0.0389
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0015 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0088 0.0088
Onchocerca volvulus 0.0018 0.0088 0.1169
Brugia malayi Protein kinase domain containing protein 0.0021 0.0156 0.0156
Toxoplasma gondii hypothetical protein 0.0033 0.0389 0.0519
Echinococcus multilocularis 1 phosphatidylinositol 4,5 bisphosphate 0.0018 0.0088 0.0089
Onchocerca volvulus 0.0033 0.0389 0.5179
Onchocerca volvulus 0.0051 0.0751 1
Loa Loa (eye worm) TK/ABL protein kinase 0.0021 0.0156 0.0156
Brugia malayi SRC-1 0.0024 0.0204 0.0204
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0274 0.5
Brugia malayi Protein kinase domain containing protein 0.0021 0.0156 0.0156
Echinococcus granulosus tyrosine kinase 0.0021 0.0156 0.0158

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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