TDR Targets

Basic information

Technical information

TDR Targets ID: 794394
Name: 8-(2-nitrophenyl)-7,8-dihydro-5H-[1,3]dioxolo [4,5-g]quinolin-6-one
MW: 312.277 | Formula: C16H12N2O5
H donors: 1 H acceptors: 3 LogP: 2.16 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O=C1Nc2cc3OCOc3cc2C(C1)c1ccccc1[N+](=O)[O-]
InChi: 1S/C16H12N2O5/c19-16-6-10(9-3-1-2-4-13(9)18(20)21)11-5-14-15(23-8-22-14)7-12(11)17-16/h1-5,7,10H,6,8H2,(H,17,19)
InChiKey: TVXUVYGQVVDYDM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

A2913/0122803

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0115	0.011
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0017	0.0115	0.011
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0009	0.0005	0.0005
Leishmania major	hypothetical protein, conserved	0.0026	0.025	0.0245
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0538	0.0865
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0107	0.148	0.1478
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0109	0.1514	0.8837
Echinococcus granulosus	GPCR family 2	0.0034	0.0376	0.0606
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0009	0.0005	0.0005
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0209	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0005	0.0003
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0804	0.1296
Leishmania major	GTP-binding protein, putative	0.0021	0.0177	0.0172
Treponema pallidum	bacterioferrin (TpF1)	0.0017	0.0127	1
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0038	0.0058
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0025	0.0247	0.0245
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0115	0.011
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0009	0.0005	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0673	1	1
Schistosoma mansoni	hypothetical protein	0.0034	0.0376	0.0601
Schistosoma mansoni	hypothetical protein	0.0418	0.6172	1
Mycobacterium tuberculosis	Probable reductase	0.0109	0.1514	0.8837
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0017	0.0115	0.0184
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0376	0.0376
Brugia malayi	hypothetical protein	0.0017	0.0114	0.0114
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.0404	0.595	1
Echinococcus multilocularis	snurportin 1	0.0301	0.4396	0.7122
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0289	0.0176
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0099	0.1355	0.1355
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0209	0.0204
Mycobacterium ulcerans	bacterioferritin BfrB	0.0017	0.0127	1
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0017	0.0115	0.011
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0177	0.131
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0122	0.1699	0.2752
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0009	0.0005	0.0005
Brugia malayi	hypothetical protein	0.0026	0.025	0.025
Schistosoma mansoni	hypothetical protein	0.0034	0.0376	0.0601
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0009	0.0005	0.0005
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0376	0.0606
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0538	0.0869
Onchocerca volvulus	Poor gastrulation protein homolog	0.0016	0.0107	0.0171
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0009	0.0005	0.0003
Loa Loa (eye worm)	thioredoxin reductase	0.0048	0.0588	0.0586
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0012	0.0049	0.0049
Echinococcus granulosus	ferritin	0.0017	0.0127	0.0203
Echinococcus granulosus	glutamate receptor 2	0.0009	0.0005	0.0005
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0009	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0005	0.0003
Echinococcus granulosus	nmda type glutamate receptor	0.0009	0.0005	0.0005
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0009	0.0005	0.0005
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0009	0.0005	0.0005
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0009	0.0005	0.0005
Trichomonas vaginalis	ran, putative	0.0021	0.0177	0.6607
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0005	0.0003
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0301	0.4396	0.4395
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0109	0.1514	0.8829
Schistosoma mansoni	hypothetical protein	0.0016	0.0107	0.0165
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0538	0.0869
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1699	0.1698
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0177	0.0177
Echinococcus granulosus	cpg binding protein	0.0031	0.0333	0.0537
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0038	0.0058
Brugia malayi	hypothetical protein	0.0009	0.0005	0.0005
Schistosoma mansoni	hypothetical protein	0.0301	0.4396	0.7121
Echinococcus granulosus	snurportin 1	0.0301	0.4396	0.7122
Schistosoma mansoni	ran	0.0021	0.0177	0.0279
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0112	0.1559	0.2521
Loa Loa (eye worm)	glutathione reductase	0.0048	0.0588	0.0586
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0017	0.0115	0.011
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0289	0.2956
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0289	0.0176
Mycobacterium ulcerans	bacterioferritin BfrA	0.0017	0.0127	1
Echinococcus multilocularis	dnaJ subfamily B	0.0418	0.6172	1
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0016	0.0107	0.0107
Schistosoma mansoni	metabotropic glutamate receptor	0.0083	0.1113	0.1797
Brugia malayi	RNA, U transporter 1	0.008	0.1072	0.1072
Echinococcus granulosus	expressed protein	0.0017	0.0127	0.0203
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.0177	0.1052
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.009	0.1215	0.1215
Trypanosoma cruzi	trypanothione reductase, putative	0.0048	0.0588	0.0583
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0308	0.0308
Loa Loa (eye worm)	glutamate receptor	0.0099	0.1355	0.1354
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0122	0.1699	0.2752
Entamoeba histolytica	Ran family GTPase	0.0021	0.0177	0.8442
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.0177	0.0063
Toxoplasma gondii	thioredoxin reductase	0.0048	0.0588	0.8027
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0017	0.0115	0.0179
Echinococcus multilocularis	GPCR, family 3, C terminal	0.0016	0.0107	0.017
Schistosoma mansoni	ferritin	0.0017	0.0127	0.0198
Plasmodium vivax	thioredoxin reductase, putative	0.0048	0.0588	1
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0017	0.0115	0.011
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0009	0.0005	0.0005
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0376	0.0606
Echinococcus multilocularis	vesicular acetylcholine transporter	0.0404	0.595	0.9641
Schistosoma mansoni	metabotropic glutamate receptor	0.0048	0.0591	0.0951
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0009	0.0005	0.0003
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0209	0.0204
Plasmodium vivax	glutathione reductase, putative	0.0048	0.0588	1
Loa Loa (eye worm)	hypothetical protein	0.0107	0.148	0.1478
Trypanosoma brucei	trypanothione reductase	0.0048	0.0588	0.0478
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0289	0.0466
Brugia malayi	Receptor family ligand binding region containing protein	0.0009	0.0005	0.0005
Leishmania major	trypanothione reductase	0.0048	0.0588	0.0583
Echinococcus multilocularis	glutamate receptor 2	0.0009	0.0005	0.0005
Echinococcus granulosus	dnaJ subfamily B	0.0418	0.6172	1
Brugia malayi	vesicular acetylcholine transporter unc-17	0.0404	0.595	0.595
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0009	0.0005	0.0005
Schistosoma mansoni	hypothetical protein	0.0034	0.0376	0.0601
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0109	0.1514	0.8837
Schistosoma mansoni	ferritin light chain	0.0017	0.0127	0.0198
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0673	1	1
Plasmodium vivax	importin-beta 2, putative	0.0028	0.0289	0.3683
Brugia malayi	metabotropic glutamate receptor type 2	0.0048	0.0591	0.0591
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0107	0.0105
Schistosoma mansoni	ferritin	0.0017	0.0127	0.0198
Echinococcus multilocularis	nmda type glutamate receptor	0.0009	0.0005	0.0005
Echinococcus multilocularis	expressed protein	0.0017	0.0127	0.0203
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0538	0.0538
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0005	0.0003
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0017	0.0115	0.0184
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0177	0.0284
Echinococcus granulosus	vesicular acetylcholine transporter	0.0404	0.595	0.9641
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0177	0.131
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0376	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0344	0.5045	0.5044
Echinococcus granulosus	receptor type guanylyl cyclase	0.0009	0.0005	0.0005
Brugia malayi	Guanylyl cyclase protein 23	0.0009	0.0005	0.0005
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0209	1
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0177	0.0284
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0538	0.0865
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0109	0.1514	0.8837
Brugia malayi	Importin beta-1 subunit	0.0028	0.0289	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0005	0.0003
Brugia malayi	Receptor family ligand binding region containing protein	0.0025	0.0247	0.0247
Schistosoma mansoni	cpg binding protein	0.0031	0.0333	0.0532
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0376	0.0606
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0308	0.0306
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0122	0.1698	1
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0376	0.0376
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0017	0.0127	1
Schistosoma mansoni	apoferritin-2	0.0017	0.0127	0.0198
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0969	0.0967
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0177	0.0172
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0083	0.1113	0.1801
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0048	0.0588	0.2985
Schistosoma mansoni	apoferritin-2	0.0017	0.0127	0.0198
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0107	0.148	0.148
Mycobacterium tuberculosis	Probable oxidoreductase	0.0122	0.1698	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.0048	0.0588	0.095
Plasmodium falciparum	importin beta, putative	0.0028	0.0289	0.3683
Onchocerca volvulus	Metabotropic glutamate receptor homolog	0.0016	0.0107	0.0171
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0122	0.1698	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0115	0.011
Echinococcus multilocularis	glutamate receptor 2	0.0009	0.0005	0.0005
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0115	0.011
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0009	0.0005	0.0005
Schistosoma mansoni	hypothetical protein	0.0034	0.0376	0.0601
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0048	0.0588	0.095
Leishmania major	C-8 sterol isomerase-like protein	0.0673	1	1
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0673	1	1
Schistosoma mansoni	vesicular acetylcholine transporter	0.0404	0.595	0.9641
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0115	0.011
Echinococcus granulosus	glutamate receptor 2	0.0009	0.0005	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0005	0.0003
Schistosoma mansoni	importin beta-1	0.0028	0.0289	0.0461
Brugia malayi	latrophilin 2 splice variant baaae	0.0073	0.0969	0.0969
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0083	0.1113	0.1801
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0012	0.0049	0.0049
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0209	1
Echinococcus granulosus	tyrosine kinase	0.0009	0.0005	0.0005
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.0017	0.0127	0.0072
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.025	0.0245
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0025	0.0247	0.0245
Echinococcus granulosus	GPCR family 3 C terminal	0.0016	0.0107	0.017
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0376	0.0606
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.0704	1
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0115	0.011
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0177	0.0175
Schistosoma mansoni	cpg binding protein	0.0029	0.0308	0.0491
Plasmodium falciparum	glutathione reductase	0.0048	0.0588	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.025	0.0248
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.025	0.2292
Schistosoma mansoni	ferritin	0.0017	0.0127	0.0198
Loa Loa (eye worm)	glutamate receptor	0.0039	0.0451	0.0449
Schistosoma mansoni	ran	0.0021	0.0177	0.0279
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0177	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0289	0.0287
Trypanosoma cruzi	trypanothione reductase, putative	0.0017	0.0115	0.011
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0538	0.0536
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0122	0.1698	1
Entamoeba histolytica	hypothetical protein	0.0023	0.0209	1
Schistosoma mansoni	cpg binding protein	0.0031	0.0333	0.0532
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0538	0.0869
Schistosoma mansoni	hypothetical protein	0.0011	0.0038	0.0053
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.025	0.2855
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0017	0.0115	0.0115
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0005	0.0003
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.025	0.0136
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.0177	0.0172
Schistosoma mansoni	hypothetical protein	0.0073	0.0969	0.1563
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.025	0.0245
Echinococcus multilocularis	ferritin	0.0017	0.0127	0.0203
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0538	0.0865
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0289	0.0466
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0017	0.0115	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0107	0.148	0.148
Onchocerca volvulus		0.0029	0.0308	0.0509
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0017	0.0115	0.011
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0376	0.0606
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.0017	0.0127	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0376	0.0374
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0538	0.0869
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.025	0.2855
Schistosoma mansoni	ferritin light chain	0.0017	0.0127	0.0198
Brugia malayi	Thioredoxin reductase	0.0048	0.0588	0.0588
Trichomonas vaginalis	ferritin, putative	0.0017	0.0127	0.1222
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0009	0.0005	0.0005
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.025	0.2855
Echinococcus multilocularis	tyrosine kinase	0.0009	0.0005	0.0005
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0109	0.1514	0.8837
Brugia malayi	glutathione reductase	0.0048	0.0588	0.0588
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0247	0.0245
Plasmodium falciparum	thioredoxin reductase	0.0048	0.0588	1
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0009	0.0005	0.0003
Schistosoma mansoni	ferritin	0.0017	0.0127	0.0198
Mycobacterium tuberculosis	Probable dehydrogenase	0.0109	0.1514	0.8837
Echinococcus multilocularis	cpg binding protein	0.0031	0.0333	0.0537
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.0404	0.595	0.5949
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0017	0.0115	0.011

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 794394