Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, gamma | Starlite/ChEMBL | References |
Rattus norvegicus | Protein kinase C (PKC) | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, delta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, epsilon | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, eta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, beta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, alpha | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, iota | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Protein kinase C (PKC) | 671 aa | 653 aa | 65.4 % | |
Brugia malayi | Protein kinase c protein 2 | Protein kinase C (PKC) | 671 aa | 652 aa | 65.8 % |
Schistosoma mansoni | serine/threonine protein kinase | Protein kinase C (PKC) | 671 aa | 651 aa | 61.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0294 | 0.8265 | 0.8265 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.3264 | 0.3548 |
Trichomonas vaginalis | AGC family protein kinase | 0.0083 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0318 | 0.9199 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0083 | 0 | 0.5 |
Brugia malayi | protein kinase C3,putative | 0.0243 | 0.6272 | 0.6818 |
Trichomonas vaginalis | AGC family protein kinase | 0.0083 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.3264 | 0.3548 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0235 | 0.5951 | 0.6281 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.4645 | 0.5049 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0168 | 0.3335 | 0.352 |
Trichomonas vaginalis | AGC family protein kinase | 0.0083 | 0 | 0.5 |
Echinococcus granulosus | protein kinase C gamma type | 0.0235 | 0.5951 | 0.6281 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0294 | 0.8265 | 0.8265 |
Trichomonas vaginalis | AGC family protein kinase | 0.0083 | 0 | 0.5 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0083 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0318 | 0.9199 | 0.9199 |
Onchocerca volvulus | 0.0167 | 0.3264 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0167 | 0.3264 | 0.3548 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.233 | 0.2533 |
Brugia malayi | Protein kinase c protein 2 | 0.0213 | 0.5062 | 0.5503 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0294 | 0.8265 | 0.8724 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0257 | 0.6797 | 0.7389 |
Echinococcus multilocularis | protein kinase c iota type | 0.0325 | 0.9474 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0318 | 0.9199 | 0.971 |
Trichomonas vaginalis | AGC family protein kinase | 0.0083 | 0 | 0.5 |
Toxoplasma gondii | AGC kinase | 0.0083 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0083 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0083 | 0 | 0.5 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0143 | 0.233 | 0.246 |
Loa Loa (eye worm) | hypothetical protein | 0.025 | 0.6538 | 0.7107 |
Trichomonas vaginalis | AGC family protein kinase | 0.0083 | 0 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0154 | 0.2748 | 0.2987 |
Brugia malayi | protein kinase C II. | 0.0318 | 0.9199 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0083 | 0 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.025 | 0.6538 | 0.69 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.5579 | 0.6064 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0143 | 0.233 | 0.246 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0294 | 0.8265 | 0.8724 |
Echinococcus granulosus | protein kinase c iota type | 0.0325 | 0.9474 | 1 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0318 | 0.9199 | 0.971 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0143 | 0.233 | 0.246 |
Trichomonas vaginalis | AGC family protein kinase | 0.0083 | 0 | 0.5 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0168 | 0.3335 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.01 uM | Inhibition of Protein kinase C beta 2 | ChEMBL. | 12749884 |
IC50 (binding) | = 0.01 uM | Inhibition of Protein kinase C beta 2 | ChEMBL. | 12749884 |
IC50 (binding) | = 0.03 uM | Inhibition of Protein kinase C beta 1 | ChEMBL. | 12749884 |
IC50 (binding) | = 0.03 uM | Inhibition of Protein kinase C beta 1 | ChEMBL. | 12749884 |
IC50 (binding) | = 0.05 uM | Inhibition of Protein kinase C eta | ChEMBL. | 12749884 |
IC50 (binding) | = 0.05 uM | Inhibition of Protein kinase C eta | ChEMBL. | 12749884 |
IC50 (binding) | = 0.3 uM | Inhibition of Protein kinase C alpha | ChEMBL. | 12749884 |
IC50 (binding) | = 0.3 uM | Inhibition of purified rat brain protein kinase C (RB-PKC) | ChEMBL. | 12749884 |
IC50 (binding) | = 0.3 uM | Inhibition of Protein kinase C alpha | ChEMBL. | 12749884 |
IC50 (binding) | = 0.3 uM | Inhibition of purified rat brain protein kinase C (RB-PKC) | ChEMBL. | 12749884 |
IC50 (binding) | = 0.4 uM | Inhibition of Protein kinase C gamma | ChEMBL. | 12749884 |
IC50 (binding) | = 0.4 uM | Inhibition of Protein kinase C delta | ChEMBL. | 12749884 |
IC50 (binding) | = 0.4 uM | Inhibition of Protein kinase C gamma | ChEMBL. | 12749884 |
IC50 (binding) | = 0.4 uM | Inhibition of Protein kinase C delta | ChEMBL. | 12749884 |
IC50 (binding) | = 0.9 uM | Inhibition of Protein kinase C epsilon | ChEMBL. | 12749884 |
IC50 (binding) | = 0.9 uM | Inhibition of Protein kinase C epsilon | ChEMBL. | 12749884 |
IC50 (binding) | = 9 uM | Inhibition of Protein kinase C zeta | ChEMBL. | 12749884 |
IC50 (binding) | = 9 uM | Inhibition of Protein kinase C zeta | ChEMBL. | 12749884 |
IC50 (binding) | = 25 uM | Inhibition of purified mammalian brain [Ca2+]/Calmodulin dependent kinase | ChEMBL. | 12749884 |
IC50 (binding) | = 25 uM | Inhibition of purified mammalian brain [Ca2+]/Calmodulin dependent kinase | ChEMBL. | 12749884 |
IC50 (binding) | = 68 uM | Inhibition of Src protein tryrosine kinase | ChEMBL. | 12749884 |
IC50 (binding) | = 68 uM | Inhibition of Src protein tryrosine kinase | ChEMBL. | 12749884 |
IC50 (binding) | > 100 uM | Inhibition of cAMP dependent protein kinase catalytic subunit of bovine heart | ChEMBL. | 12749884 |
IC50 (binding) | > 100 uM | Inhibition of purified rat brain casein kinase II | ChEMBL. | 12749884 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.