Detailed information for compound 79606

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 279.376 | Formula: C19H21NO
  • H donors: 0 H acceptors: 0 LogP: 3.82 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2CC3N(C)CCc4c3c(c2cc1C)ccc4
  • InChi: 1S/C19H21NO/c1-12-9-16-14(11-18(12)21-3)10-17-19-13(7-8-20(17)2)5-4-6-15(16)19/h4-6,9,11,17H,7-8,10H2,1-3H3
  • InChiKey: JKUGXXAJYWLNAX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) BEN-1 protein 0.0584 0.3403 0.7799
Brugia malayi follicle stimulating hormone receptor 0.0737 0.4363 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0178 0.0042
Brugia malayi ORL1-like opioid receptor 0.0737 0.4363 1
Leishmania major heat shock protein 83-1 0.0069 0.0165 0.0124
Loa Loa (eye worm) hypothetical protein 0.0205 0.1023 0.2344
Leishmania major beta tubulin 0.0584 0.3403 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0737 0.4363 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0737 0.4363 0.4321
Brugia malayi Serotonin receptor 0.0737 0.4363 1
Schistosoma mansoni hypothetical protein 0.0737 0.4363 0.8688
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0873 0.2286
Schistosoma mansoni amine GPCR 0.0737 0.4363 0.8688
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0737 0.4363 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0737 0.4363 0.8688
Echinococcus granulosus sex peptide receptor 0.0737 0.4363 0.4321
Loa Loa (eye worm) hypothetical protein 0.01 0.0362 0.083
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0737 0.4363 0.8688
Mycobacterium ulcerans heat shock protein 90 0.0062 0.0124 0.5
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Echinococcus granulosus tm gpcr rhodopsin 0.0737 0.4363 0.4321
Echinococcus multilocularis serotonin receptor 0.0737 0.4363 0.4321
Echinococcus multilocularis sex peptide receptor 0.0737 0.4363 0.4321
Echinococcus multilocularis Tubulin beta 2C chain 0.0584 0.3403 0.3353
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0737 0.4363 0.4321
Loa Loa (eye worm) TYRA-2 protein 0.0737 0.4363 1
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0143 0.0631 0.1547
Plasmodium falciparum plasmepsin IV 0.0143 0.0631 0.1441
Echinococcus multilocularis tubulin beta 1 chain 0.0584 0.3403 0.3353
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0737 0.4363 1
Schistosoma mansoni hypothetical protein 0.0737 0.4363 0.8688
Echinococcus granulosus integrin alpha ps 0.0081 0.0245 0.0172
Loa Loa (eye worm) heat shock protein 90 0.0069 0.0165 0.0377
Echinococcus multilocularis heat shock protein 90 0.0069 0.0165 0.0091
Leishmania major beta tubulin 0.0584 0.3403 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0071 0.0178 0.0042
Echinococcus granulosus rhodopsin orphan GPCR 0.0737 0.4363 0.4321
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Onchocerca volvulus 0.0737 0.4363 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0071 0.0178 0.0165
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0276 0.1471 0.3371
Trypanosoma cruzi heat shock protein 85, putative 0.0069 0.0165 0.0246
Schistosoma mansoni heat shock protein 0.0069 0.0165 0.0328
Schistosoma mansoni endoplasmin 0.0069 0.0165 0.0328
Brugia malayi neuropeptide F receptor 0.0737 0.4363 1
Echinococcus multilocularis integrin alpha 3 0.0139 0.0607 0.0537
Plasmodium vivax plasmepsin IV, putative 0.0143 0.0631 0.1441
Loa Loa (eye worm) endoplasmin 0.0069 0.0165 0.0377
Toxoplasma gondii beta-1 tubulin, putative 0.0584 0.3403 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.0429 0.0983
Schistosoma mansoni hypothetical protein 0.0737 0.4363 0.8688
Toxoplasma gondii aspartyl protease ASP1 0.0143 0.0631 0.1441
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0737 0.4363 0.4321
Schistosoma mansoni growth hormone secretagogue receptor 0.0737 0.4363 0.8688
Brugia malayi G protein-coupled receptor 0.0737 0.4363 1
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Echinococcus granulosus G protein coupled receptor 139 0.0737 0.4363 0.4321
Echinococcus granulosus tubulin subunit beta 0.0584 0.3403 0.3353
Echinococcus granulosus rhodopsin orphan GPCR 0.0737 0.4363 0.4321
Schistosoma mansoni neuropeptide receptor 0.0737 0.4363 0.8688
Leishmania major heat shock protein 83-1 0.0069 0.0165 0.0124
Echinococcus granulosus GPCR family 2 0.0111 0.0429 0.0357
Echinococcus granulosus tubulin beta 4A class IVa 0.0584 0.3403 0.3353
Echinococcus multilocularis neuropeptide receptor A26 0.0737 0.4363 0.4321
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0737 0.4363 0.8688
Brugia malayi larval opioid receptor 0.0737 0.4363 1
Leishmania major heat shock protein 83-1 0.0069 0.0165 0.0124
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0677 0.3989 0.3944
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Schistosoma mansoni amine GPCR 0.0737 0.4363 0.8688
Echinococcus multilocularis rhodopsin orphan GPCR 0.0737 0.4363 0.4321
Schistosoma mansoni hypothetical protein 0.0102 0.0375 0.0746
Brugia malayi hypothetical protein 0.0737 0.4363 1
Trypanosoma cruzi beta tubulin, putative 0.0584 0.3403 1
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0873 0.2286
Echinococcus granulosus orexin receptor type 2 0.0737 0.4363 0.4321
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0737 0.4363 0.4321
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0737 0.4363 0.8688
Trypanosoma brucei beta tubulin 0.0584 0.3403 1
Onchocerca volvulus 0.0737 0.4363 1
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Schistosoma mansoni cathepsin D (A01 family) 0.0421 0.2379 0.4737
Schistosoma mansoni tubulin subunit beta 0.0584 0.3403 0.6776
Echinococcus granulosus Tubulin beta 2C chain 0.0584 0.3403 0.3353
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Leishmania major beta tubulin 0.0584 0.3403 1
Brugia malayi putative neuropeptide receptor 0.0737 0.4363 1
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Schistosoma mansoni neuropeptide receptor 0.0737 0.4363 0.8688
Echinococcus granulosus rhodopsin orphan GPCR 0.0737 0.4363 0.4321
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Brugia malayi Endoplasmin precursor 0.0069 0.0165 0.0211
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0737 0.4363 0.8688
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0154 0.0703 0.1664
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.1471 0.4107
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Trypanosoma brucei beta tubulin 0.0584 0.3403 1
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0873 0.2286
Leishmania major heat shock protein 83-1 0.0069 0.0165 0.0124
Echinococcus granulosus neuropeptide Y receptor 0.0737 0.4363 0.4321
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0737 0.4363 0.8688
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0737 0.4363 0.8688
Loa Loa (eye worm) G-protein coupled receptor 0.0737 0.4363 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.041 0.2309 0.2251
Schistosoma mansoni amine GPCR 0.0737 0.4363 0.8688
Loa Loa (eye worm) latrophilin receptor protein 2 0.0111 0.0429 0.0983
Echinococcus granulosus beta tubulin 0.0584 0.3403 0.3353
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0316 0.1717 0.3936
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0062 0.0124 0.5
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Brugia malayi putative neuropeptide receptor NPR1 0.0737 0.4363 1
Schistosoma mansoni heat shock protein 0.0069 0.0165 0.0328
Onchocerca volvulus 0.0737 0.4363 1
Schistosoma mansoni adenoreceptor 0.0737 0.4363 0.8688
Schistosoma mansoni hypothetical protein 0.0737 0.4363 0.8688
Echinococcus granulosus Tubulin beta 2C chain 0.0584 0.3403 0.3353
Leishmania major heat shock protein 83-1 0.0069 0.0165 0.0124
Leishmania major beta tubulin 0.0584 0.3403 1
Brugia malayi hypothetical protein 0.0737 0.4363 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0737 0.4363 1
Leishmania major beta tubulin 0.0584 0.3403 1
Giardia lamblia Rab geranylgeranyltransferase 0.0154 0.0703 0.1767
Schistosoma mansoni hypothetical protein 0.0111 0.0429 0.0854
Echinococcus multilocularis rhodopsin orphan GPCR 0.0737 0.4363 0.4321
Echinococcus multilocularis G protein coupled receptor 139 0.0842 0.5022 0.4984
Trypanosoma cruzi heat shock protein 85, putative 0.0062 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Schistosoma mansoni neuropeptide F-like receptor 0.0737 0.4363 0.8688
Leishmania major beta tubulin 0.0584 0.3403 1
Leishmania major heat shock protein 83-1 0.0069 0.0165 0.0124
Echinococcus multilocularis G-protein coupled receptor, putative 0.0737 0.4363 0.4321
Brugia malayi Integrin alpha pat-2 precursor 0.0181 0.0872 0.1862
Onchocerca volvulus 0.0737 0.4363 1
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0677 0.3989 0.3944
Brugia malayi heat shock protein 90 0.0069 0.0165 0.0211
Schistosoma mansoni tubulin subunit beta 0.0584 0.3403 0.6776
Leishmania major beta tubulin 0.0584 0.3403 1
Schistosoma mansoni opsin-like receptor 0.0737 0.4363 0.8688
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0071 0.0178 0.0355
Brugia malayi hypothetical protein 0.0737 0.4363 1
Loa Loa (eye worm) neuropeptide F receptor 0.0737 0.4363 1
Echinococcus granulosus tubulin beta 1 chain 0.0584 0.3403 0.3353
Schistosoma mansoni hypothetical protein 0.0054 0.0074 0.0147
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0737 0.4363 1
Echinococcus multilocularis neuropeptide receptor 0.0737 0.4363 0.4321
Brugia malayi G protein-coupled receptor F59B2.13 0.0737 0.4363 1
Brugia malayi Tubulin beta-1 chain 0.0584 0.3403 0.7761
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0143 0.0631 0.0561
Trypanosoma brucei beta tubulin 0.0584 0.3403 1
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Leishmania major heat shock protein 83-1 0.0069 0.0165 0.0124
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0737 0.4363 0.8688
Leishmania major beta tubulin 0.0584 0.3403 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0737 0.4363 0.8688
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0737 0.4363 0.4321
Schistosoma mansoni tubulin subunit beta 0.0584 0.3403 0.6776
Brugia malayi hypothetical protein 0.0737 0.4363 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0737 0.4363 0.4321
Trichomonas vaginalis heat shock protein, putative 0.0069 0.0165 0.0124
Schistosoma mansoni opsin-like receptor 0.0737 0.4363 0.8688
Echinococcus granulosus rhodopsin orphan GPCR 0.0737 0.4363 0.4321
Brugia malayi hypothetical protein 0.0737 0.4363 1
Echinococcus multilocularis neuropeptide Y receptor 0.0737 0.4363 0.4321
Leishmania major heat shock protein 83-1 0.0069 0.0165 0.0124
Trypanosoma cruzi heat shock protein 90, putative 0.0062 0.0124 0.0124
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0737 0.4363 0.4321
Brugia malayi beta-tubulin, identical 0.0584 0.3403 0.7761
Echinococcus granulosus allatostatin A receptor 0.0737 0.4363 0.4321
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0737 0.4363 0.8688
Onchocerca volvulus 0.0737 0.4363 1
Leishmania major beta tubulin 0.0584 0.3403 1
Echinococcus granulosus somatostatin receptor 0.0737 0.4363 0.4321
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0154 0.0703 0.1467
Brugia malayi RE15519p 0.0737 0.4363 1
Toxoplasma gondii beta tubulin 0.0584 0.3403 1
Schistosoma mansoni neuropeptide F-like receptor 0.0737 0.4363 0.8688
Echinococcus multilocularis rhodopsin orphan GPCR 0.0737 0.4363 0.4321
Echinococcus multilocularis endoplasmin 0.0062 0.0124 0.005
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0584 0.3403 0.3353
Echinococcus granulosus neuropeptide s receptor 0.0737 0.4363 0.4321
Schistosoma mansoni apoptosis regulator bax 0.0054 0.0074 0.0147
Schistosoma mansoni hypothetical protein 0.0111 0.0429 0.0854
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0737 0.4363 0.8688
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0062 0.0124 0.5
Loa Loa (eye worm) neuropeptide F receptor 0.0737 0.4363 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0069 0.0165 0.0246
Echinococcus multilocularis serotonin receptor 0.0737 0.4363 0.4321
Trypanosoma cruzi heat shock protein 90, putative 0.0069 0.0165 0.0246
Giardia lamblia Heat shock protein HSP 90-alpha 0.0069 0.0165 0.0124
Brugia malayi Dopamine receptor 0.0737 0.4363 1
Echinococcus granulosus heat shock protein 0.0069 0.0165 0.0091
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0154 0.0703 0.1767
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0071 0.0178 0.0105
Loa Loa (eye worm) hypothetical protein 0.0154 0.0703 0.1612
Schistosoma mansoni amine GPCR 0.0737 0.4363 0.8688
Echinococcus granulosus neuropeptide receptor 0.0842 0.5022 0.4984
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0071 0.0178 0.0105
Echinococcus granulosus biogenic amine 5HT receptor 0.0737 0.4363 0.4321
Echinococcus multilocularis beta tubulin 0.0584 0.3403 0.3353
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0276 0.1471 0.3256
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0154 0.0703 0.1767
Giardia lamblia Beta tubulin 0.0584 0.3403 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0737 0.4363 1
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0737 0.4363 0.8688
Giardia lamblia Beta tubulin 0.0584 0.3403 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0737 0.4363 0.4321
Schistosoma mansoni endoplasmin 0.0069 0.0165 0.0328
Schistosoma mansoni hypothetical protein 0.0111 0.0429 0.0854
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0154 0.0703 0.1664
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.1471 0.4107
Echinococcus granulosus Tubulin beta 2C chain 0.0584 0.3403 0.3353
Trichomonas vaginalis tubulin epsilon chain, putative 0.0584 0.3403 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0737 0.4363 1
Leishmania major heat shock protein 83-1 0.0069 0.0165 0.0124
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0143 0.0631 0.0561
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0737 0.4363 0.8688
Entamoeba histolytica tubulin family protein 0.0584 0.3403 1
Plasmodium vivax aspartyl proteinase, putative 0.0143 0.0631 0.1441
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Onchocerca volvulus 0.0737 0.4363 1
Brugia malayi sulfakinin receptor protein 0.0737 0.4363 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0114 0.0452 0.1001
Echinococcus multilocularis rhodopsin orphan GPCR 0.0737 0.4363 0.4321
Echinococcus granulosus neuropeptides capa receptor 0.0737 0.4363 0.4321
Echinococcus granulosus rhodopsin orphan GPCR 0.0737 0.4363 0.4321
Schistosoma mansoni integrin alpha-ps 0.0081 0.0245 0.0487
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0737 0.4363 0.4321
Echinococcus multilocularis Tubulin beta 2C chain 0.0584 0.3403 0.3353
Brugia malayi Serotonin receptor 0.0737 0.4363 1
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Brugia malayi hypothetical protein 0.0737 0.4363 1
Echinococcus multilocularis integrin alpha ps 0.0081 0.0245 0.0172
Brugia malayi hypothetical protein 0.0737 0.4363 1
Brugia malayi Dopamine receptor protein 1 0.0737 0.4363 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0737 0.4363 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0737 0.4363 0.8688
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0154 0.0703 0.0634
Echinococcus multilocularis neuropeptide FF receptor 2 0.0737 0.4363 0.4321
Echinococcus granulosus fmrfamide receptor 0.0737 0.4363 0.4321
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Echinococcus multilocularis heat shock protein 90 0.0062 0.0124 0.005
Echinococcus multilocularis beta tubulin 0.0584 0.3403 0.3353
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Schistosoma mansoni hypothetical protein 0.0054 0.0074 0.0147
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0143 0.0631 0.1447
Plasmodium falciparum plasmepsin VI 0.0143 0.0631 0.1441
Onchocerca volvulus 0.0737 0.4363 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0737 0.4363 0.4321
Trichomonas vaginalis tubulin gamma chain, putative 0.0584 0.3403 1
Loa Loa (eye worm) beta-tubulin 0.0584 0.3403 0.7799
Leishmania major beta tubulin 0.0584 0.3403 1
Onchocerca volvulus 0.0737 0.4363 1
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0584 0.3403 0.3353
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0584 0.3403 1
Schistosoma mansoni biogenic amine receptor 0.0737 0.4363 0.8688
Leishmania major beta tubulin 0.0584 0.3403 1
Loa Loa (eye worm) G-protein coupled receptor 0.0737 0.4363 1
Schistosoma mansoni hypothetical protein 0.0205 0.1023 0.2037
Onchocerca volvulus 0.0737 0.4363 1
Brugia malayi neuropeptide F receptor 0.0737 0.4363 1
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Leishmania major heat shock protein 83-1 0.0069 0.0165 0.0124
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0737 0.4363 0.4321
Loa Loa (eye worm) hypothetical protein 0.0143 0.0631 0.1447
Leishmania major beta tubulin 0.0584 0.3403 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0737 0.4363 0.8688
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0143 0.0631 0.1257
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0737 0.4363 0.8688
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.1471 0.4107
Echinococcus multilocularis neuropeptide s receptor 0.0737 0.4363 0.4321
Echinococcus multilocularis rhodopsin orphan GPCR 0.0737 0.4363 0.4321
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0154 0.0703 0.0634
Echinococcus multilocularis somatostatin receptor 0.0737 0.4363 0.4321
Brugia malayi hypothetical protein 0.0737 0.4363 1
Echinococcus granulosus neuropeptide receptor A26 0.0737 0.4363 0.4321
Echinococcus multilocularis neuropeptides capa receptor 0.0737 0.4363 0.4321
Onchocerca volvulus 0.0737 0.4363 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0737 0.4363 0.4321
Leishmania major heat shock protein 83-1 0.0069 0.0165 0.0124
Onchocerca volvulus 0.0737 0.4363 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0737 0.4363 0.4321
Echinococcus granulosus heat shock protein 90 0.0069 0.0165 0.0091
Echinococcus multilocularis heat shock protein 0.0069 0.0165 0.0091
Schistosoma mansoni tubulin subunit beta 0.0584 0.3403 0.6776
Loa Loa (eye worm) BEN-1 protein 0.0584 0.3403 0.7799
Schistosoma mansoni myosin xvIII 0.0737 0.4363 0.8688
Echinococcus multilocularis Tubulin beta 2C chain 0.0584 0.3403 0.3353
Echinococcus granulosus g protein coupled receptor 0.0737 0.4363 0.4321
Brugia malayi latrophilin 2 splice variant baaae 0.0205 0.1023 0.2212
Trypanosoma cruzi heat shock protein 85, putative 0.0069 0.0165 0.0246
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0154 0.0703 0.1767
Echinococcus granulosus endoplasmin 0.0062 0.0124 0.005
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0873 0.2286
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0615 0.3597 0.8214
Loa Loa (eye worm) hypothetical protein 0.0615 0.3597 0.8245
Echinococcus granulosus integrin alpha 3 0.0139 0.0607 0.0537
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0737 0.4363 0.8688
Brugia malayi hypothetical protein 0.0737 0.4363 1
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0737 0.4363 0.8688
Brugia malayi hypothetical protein 0.0737 0.4363 1
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0154 0.0703 0.1612
Schistosoma mansoni neuropeptide receptor 0.0737 0.4363 0.8688
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0111 0.0429 0.0827
Echinococcus granulosus Tubulin beta 2C chain 0.0584 0.3403 0.3353
Schistosoma mansoni biogenic amine (5HT) receptor 0.0737 0.4363 0.8688
Echinococcus multilocularis orexin receptor type 2 0.0737 0.4363 0.4321
Leishmania major beta tubulin 0.0584 0.3403 1
Trypanosoma cruzi heat shock protein 85, putative 0.0069 0.0165 0.0246
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0737 0.4363 0.4321
Leishmania major beta tubulin 0.0584 0.3403 1
Echinococcus granulosus g-protein coupled receptor 0.0737 0.4363 0.4321
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Brugia malayi Latrophilin receptor protein 2 0.0111 0.0429 0.0827
Toxoplasma gondii beta-tubulin, putative 0.0584 0.3403 1
Onchocerca volvulus 0.0737 0.4363 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0111 0.0429 0.0357
Giardia lamblia Beta tubulin 0.0584 0.3403 1
Brugia malayi GnHR receptor homolog 0.0737 0.4363 1
Echinococcus multilocularis neuropeptide Y receptor 0.0737 0.4363 0.4321
Trypanosoma brucei RNA helicase, putative 0.0102 0.0375 0.0649
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0071 0.0178 0.0243
Echinococcus granulosus hypothetical protein 0.0737 0.4363 0.4321
Echinococcus granulosus Tubulin beta 2C chain 0.0584 0.3403 0.3353
Echinococcus multilocularis g-protein coupled receptor 0.0737 0.4363 0.4321
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0074 0.017
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.0935 0.2473
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Onchocerca volvulus 0.0737 0.4363 1
Schistosoma mansoni biogenic amine receptor 0.0737 0.4363 0.8688
Brugia malayi Protein kinase domain containing protein 0.0167 0.0784 0.1655
Loa Loa (eye worm) tubulin beta-1 chain 0.0584 0.3403 0.7799
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.1471 0.4107
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0071 0.0178 0.0408
Brugia malayi Tachykinin-like peptides receptor 99D 0.0737 0.4363 1
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Brugia malayi G-protein coupled receptor 0.0737 0.4363 1
Loa Loa (eye worm) tubulin beta-2A chain 0.0584 0.3403 0.7799
Echinococcus multilocularis integrin alpha ps 0.0081 0.0245 0.0172
Leishmania major beta tubulin 0.0584 0.3403 1
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.1471 0.4107
Echinococcus multilocularis allatostatin A receptor 0.0737 0.4363 0.4321
Echinococcus granulosus serotonin receptor 0.0737 0.4363 0.4321
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0737 0.4363 1
Loa Loa (eye worm) integrin alpha pat-2 0.0279 0.1489 0.3412
Echinococcus multilocularis fmrfamide receptor 0.0737 0.4363 0.4321
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0737 0.4363 0.4321
Leishmania major heat shock protein 83-1 0.0069 0.0165 0.0124
Echinococcus multilocularis tubulin subunit beta 0.0584 0.3403 0.3353
Leishmania major heat shock protein 83-1 0.0069 0.0165 0.0124
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0737 0.4363 0.8688
Echinococcus multilocularis tachykinin peptides receptor 99D 0.1634 1 1
Onchocerca volvulus 0.0737 0.4363 1
Schistosoma mansoni hypothetical protein 0.0111 0.0429 0.0854
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0737 0.4363 0.8688
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0737 0.4363 0.8688
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0737 0.4363 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0111 0.0429 0.0357
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0737 0.4363 0.4321
Loa Loa (eye worm) tubulin beta chain 0.0584 0.3403 0.7799
Loa Loa (eye worm) apoptosis regulator protein 0.0054 0.0074 0.017
Loa Loa (eye worm) hypothetical protein 0.0167 0.0784 0.1797
Plasmodium falciparum tubulin beta chain 0.0584 0.3403 1
Leishmania major beta tubulin 0.0584 0.3403 1
Brugia malayi Melatonin receptor type 1A 0.0737 0.4363 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0737 0.4363 0.4321
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0154 0.0703 0.1401
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0137 0.0595 0.1215
Trichomonas vaginalis glucosylceramidase, putative 0.0276 0.1471 0.4107
Schistosoma mansoni opsin-like receptor 0.0737 0.4363 0.8688
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0178 0.0287
Echinococcus granulosus 7tm_1 domain containing protein 0.0737 0.4363 0.4321
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Echinococcus multilocularis neuropeptide receptor 0.0842 0.5022 0.4984
Echinococcus multilocularis neuropeptides capa receptor 0.0737 0.4363 0.4321
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0737 0.4363 0.4321
Trichomonas vaginalis glucosylceramidase, putative 0.0191 0.0935 0.2473
Loa Loa (eye worm) hypothetical protein 0.0142 0.0628 0.1439
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0737 0.4363 0.4321
Brugia malayi AKH receptor 0.0737 0.4363 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0737 0.4363 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0584 0.3403 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.0595 0.1364
Leishmania major heat shock protein 83-1 0.0069 0.0165 0.0124
Echinococcus granulosus tm gpcr rhodopsin 0.0737 0.4363 0.4321
Echinococcus multilocularis Tubulin beta 2C chain 0.0584 0.3403 0.3353
Treponema pallidum heat shock protein 90 0.0062 0.0124 0.5
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.041 0.2309 0.2251
Echinococcus multilocularis g protein coupled receptor 0.0737 0.4363 0.4321
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0873 0.2286
Onchocerca volvulus 0.0737 0.4363 1
Echinococcus granulosus neuropeptides capa receptor 0.0737 0.4363 0.4321
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Schistosoma mansoni neuropeptide receptor 0.0842 0.5022 1
Leishmania major heat shock protein 83-1 0.0069 0.0165 0.0124
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0873 0.2286
Echinococcus granulosus heat shock protein 90 0.0062 0.0124 0.005
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0054 0.0074 0.0147
Trypanosoma brucei beta tubulin 0.0584 0.3403 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0737 0.4363 0.4321
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.0873 0.2286
Trichomonas vaginalis tubulin beta chain, putative 0.0584 0.3403 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0737 0.4363 0.8688
Onchocerca volvulus 0.0737 0.4363 1
Echinococcus granulosus beta tubulin 0.0584 0.3403 0.3353
Brugia malayi Dopamine receptor protein 2 0.0737 0.4363 1
Schistosoma mansoni histamine h1 receptor 0.0737 0.4363 0.8688
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0737 0.4363 0.4321
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0737 0.4363 0.4321
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0154 0.0703 0.1664
Leishmania major beta tubulin 0.0584 0.3403 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0737 0.4363 0.4321
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0737 0.4363 0.8688
Leishmania major heat shock protein 83-1 0.0069 0.0165 0.0124
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0071 0.0178 0.0287
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0737 0.4363 0.8688
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0737 0.4363 0.4321
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Schistosoma mansoni biogenic amine receptor 0.0737 0.4363 0.8688
Echinococcus granulosus alpha 1A adrenergic receptor 0.0737 0.4363 0.4321
Echinococcus granulosus neuropeptide Y receptor 0.0737 0.4363 0.4321
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Toxoplasma gondii hypothetical protein 0.0114 0.0452 0.0888
Schistosoma mansoni tubulin subunit beta 0.0584 0.3403 0.6776
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0143 0.0631 0.1441
Brugia malayi G-protein coupled receptor 0.0737 0.4363 1
Entamoeba histolytica tubulin family protein 0.0584 0.3403 1
Echinococcus granulosus neuropeptide receptor 0.0737 0.4363 0.4321
Schistosoma mansoni neuropeptide f receptor 76f 0.0737 0.4363 0.8688
Echinococcus granulosus neuropeptide FF receptor 2 0.0737 0.4363 0.4321
Leishmania major heat shock protein 83-1 0.0069 0.0165 0.0124
Schistosoma mansoni hypothetical protein 0.0054 0.0074 0.0147
Onchocerca volvulus 0.0737 0.4363 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0737 0.4363 1
Plasmodium falciparum plasmepsin II 0.0143 0.0631 0.1441
Trichomonas vaginalis tubulin, putative 0.0584 0.3403 1
Echinococcus granulosus g protein coupled receptor 0.0737 0.4363 0.4321
Plasmodium vivax tubulin beta chain, putative 0.0584 0.3403 1
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Echinococcus multilocularis g protein coupled receptor 0.0737 0.4363 0.4321
Mycobacterium tuberculosis Possible exported protein 0.0494 0.2835 1
Schistosoma mansoni tubulin subunit beta 0.0584 0.3403 0.6776
Echinococcus multilocularis fmrfamide receptor 0.0737 0.4363 0.4321
Loa Loa (eye worm) tubulin beta-4 chain 0.0584 0.3403 0.7799
Leishmania major beta tubulin 0.0584 0.3403 1
Echinococcus granulosus g protein coupled receptor 0.0737 0.4363 0.4321
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0737 0.4363 1
Schistosoma mansoni amine GPCR 0.0737 0.4363 0.8688
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0737 0.4363 0.4321
Echinococcus granulosus tm gpcr rhodopsin 0.0737 0.4363 0.4321
Brugia malayi Calcitonin receptor-like protein seb-1 0.0316 0.1717 0.3831
Echinococcus granulosus dro:myosuppressin receptor 0.0737 0.4363 0.4321
Echinococcus multilocularis g protein coupled receptor 0.0737 0.4363 0.4321
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0062 0.0124 0.005
Plasmodium falciparum plasmepsin I 0.0143 0.0631 0.1441
Echinococcus granulosus rhodopsin orphan GPCR 0.0737 0.4363 0.4321
Echinococcus granulosus rhodopsin orphan GPCR 0.0737 0.4363 0.4321
Loa Loa (eye worm) hypothetical protein 0.0737 0.4363 1
Echinococcus multilocularis GPCR, family 2 0.0111 0.0429 0.0357
Schistosoma mansoni integrin alpha 0.0181 0.0872 0.1737
Schistosoma mansoni cathepsin D (A01 family) 0.0421 0.2379 0.4737
Echinococcus multilocularis rhodopsin orphan GPCR 0.0737 0.4363 0.4321

Activities

Activity type Activity value Assay description Source Reference
ED50 (binding) = 2.7 uM Ability to antagonize Acetylcholine induced contractile responses in Guinea pig ileum for 5-HT1A receptor. ChEMBL. 7783115
ED50 (binding) = 2.7 uM Ability to antagonize Acetylcholine induced contractile responses in Guinea pig ileum for 5-HT1A receptor. ChEMBL. 7783115
ED50 (binding) = 5 uM Ability to antagonize electrical induced contractile responses in Guinea pig ileum for 5-HT1A receptor. ChEMBL. 7783115
ED50 (binding) = 5 uM Ability to antagonize electrical induced contractile responses in Guinea pig ileum for 5-HT1A receptor. ChEMBL. 7783115
ED50 (binding) = 5.4 uM Ability to antagonize electrical induced contractile responses in Guinea pig ileum for 5-HT1A receptor. ChEMBL. 7783115
ED50 (binding) = 5.4 uM Ability to antagonize electrical induced contractile responses in Guinea pig ileum for 5-HT1A receptor. ChEMBL. 7783115
ED50 (binding) = 24.9 uM Ability to antagonize Acetylcholine induced contractile responses in Guinea pig ileum for 5-HT1A receptor. ChEMBL. 7783115
ED50 (binding) = 24.9 uM Ability to antagonize Acetylcholine induced contractile responses in Guinea pig ileum for 5-HT1A receptor. ChEMBL. 7783115

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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