Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0353 | 0.0321 |
Leishmania major | hypothetical protein, conserved | 0.0053 | 0.0228 | 0.5 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0063 | 0.0353 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.1425 | 0.3072 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0151 | 0.1425 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.0151 | 0.1425 | 0.1112 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0063 | 0.0353 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0151 | 0.1425 | 0.3072 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0063 | 0.0353 | 0.5 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0053 | 0.0228 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.025 | 0.2626 | 0.6152 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0373 | 0.4127 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0373 | 0.4127 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0353 | 0.0321 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0151 | 0.1425 | 0.2842 |
Brugia malayi | Carboxylesterase family protein | 0.0063 | 0.0353 | 0.0855 |
Brugia malayi | Carboxylesterase family protein | 0.0063 | 0.0353 | 0.0855 |
Loa Loa (eye worm) | hypothetical protein | 0.0373 | 0.4127 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0063 | 0.0353 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0151 | 0.1425 | 0.3072 |
Echinococcus multilocularis | acetylcholinesterase | 0.0373 | 0.4127 | 0.3912 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0373 | 0.4127 | 0.3912 |
Echinococcus granulosus | acetylcholinesterase | 0.0373 | 0.4127 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.1425 | 0.3072 |
Echinococcus granulosus | acetylcholinesterase | 0.0373 | 0.4127 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0151 | 0.1425 | 0.3454 |
Echinococcus granulosus | serotonin transporter | 0.0151 | 0.1425 | 0.2842 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0353 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0353 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0353 | 0.0321 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.0228 | 0.5 |
Brugia malayi | hypothetical protein | 0.0063 | 0.0353 | 0.0855 |
Loa Loa (eye worm) | hypothetical protein | 0.0373 | 0.4127 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0353 | 0.0321 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.025 | 0.2626 | 0.6152 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0151 | 0.1425 | 0.2842 |
Brugia malayi | Carboxylesterase family protein | 0.0373 | 0.4127 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0063 | 0.0353 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0063 | 0.0353 | 0.0321 |
Loa Loa (eye worm) | serotonin transporter b | 0.0151 | 0.1425 | 0.3072 |
Echinococcus multilocularis | acetylcholinesterase | 0.0373 | 0.4127 | 0.3912 |
Brugia malayi | Carboxylesterase family protein | 0.0063 | 0.0353 | 0.0855 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0353 | 0.0321 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0053 | 0.0228 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.1425 | 0.3072 |
Brugia malayi | Carboxylesterase family protein | 0.0063 | 0.0353 | 0.0855 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0053 | 0.0228 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0063 | 0.0353 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.0228 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0373 | 0.4127 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0373 | 0.4127 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0373 | 0.4127 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0053 | 0.0228 | 0.5 |
Brugia malayi | hypothetical protein | 0.0053 | 0.0228 | 0.0551 |
Loa Loa (eye worm) | carboxylesterase | 0.0063 | 0.0353 | 0.0321 |
Brugia malayi | MH2 domain containing protein | 0.025 | 0.2626 | 0.6364 |
Onchocerca volvulus | 0.0151 | 0.1425 | 1 | |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0053 | 0.0228 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.