Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0008 | 0.0023 | 0.0023 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0281 | 0.0426 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0639 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Onchocerca volvulus | 0.0016 | 0.015 | 0.0087 | |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0212 | 0.0312 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0011 | 0.0065 | 0.0065 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0063 | 0.0882 | 0.1417 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0639 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0011 | 0.0063 | 0.2127 |
Schistosoma mansoni | cpg binding protein | 0.0028 | 0.0336 | 0.0336 |
Leishmania major | cathepsin L-like protease | 0.0063 | 0.0882 | 0.1234 |
Onchocerca volvulus | 0.0016 | 0.015 | 0.0087 | |
Echinococcus multilocularis | cysteine protease | 0.0016 | 0.015 | 0.015 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0212 | 0.0106 |
Leishmania major | cathepsin L-like protease | 0.0063 | 0.0882 | 0.1234 |
Brugia malayi | Cathepsin L-like precursor | 0.0011 | 0.0063 | 0.004 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0016 | 0.015 | 0.015 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0049 | 0.0669 | 0.1066 |
Brugia malayi | Cathepsin L-like precursor | 0.0011 | 0.0063 | 0.004 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.015 | 0.0127 |
Onchocerca volvulus | Huntingtin homolog | 0.0133 | 0.1995 | 0.1944 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0008 | 0.0023 | 0.0023 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0281 | 0.0426 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0882 | 0.1417 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0016 | 0.015 | 0.015 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0882 | 0.1417 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.1995 | 0.1973 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0212 | 0.0212 |
Loa Loa (eye worm) | hypothetical protein | 0.0392 | 0.6084 | 0.6073 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Onchocerca volvulus | Cathepsin L homolog | 0.0016 | 0.015 | 0.0087 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1005 | 0.0981 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0016 | 0.015 | 0.0127 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0016 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0063 | 0.0036 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0281 | 0.0259 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0212 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0281 | 1 |
Echinococcus granulosus | cathepsin L | 0.0008 | 0.0023 | 0.0023 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0406 | 0.0406 |
Echinococcus granulosus | cathepsin l1 | 0.0011 | 0.0063 | 0.0063 |
Schistosoma mansoni | hypothetical protein | 0.0403 | 0.6256 | 0.6256 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0016 | 0.015 | 0.015 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0212 | 0.0212 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0882 | 0.1417 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0882 | 0.1417 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0027 | 0.0027 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.0406 | 0.0383 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0882 | 0.1417 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0016 | 0.015 | 0.4896 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0016 | 0.015 | 0.4896 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0103 | 0.1522 | 0.1502 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0882 | 0.1417 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0212 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0103 | 0.1522 | 0.1499 |
Echinococcus multilocularis | cathepsin L | 0.0008 | 0.0023 | 0.0023 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.0212 | 0.5 |
Echinococcus granulosus | cathepsin l1 | 0.0016 | 0.015 | 0.015 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0063 | 0.0036 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.0406 | 0.0379 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0016 | 0.015 | 0.015 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.1005 | 0.1005 |
Onchocerca volvulus | Huntingtin homolog | 0.0133 | 0.1995 | 0.1944 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.1995 | 0.1973 |
Echinococcus granulosus | dnaJ subfamily B | 0.0403 | 0.6256 | 0.6256 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0406 | 0.0406 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0212 | 0.0312 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0392 | 0.6084 | 0.6075 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0281 | 0.0222 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0063 | 0.0882 | 0.1417 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0009 | 0.0025 | 0.0002 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0406 | 0.0406 |
Plasmodium vivax | vivapain-2 | 0.0016 | 0.015 | 0.4896 |
Echinococcus multilocularis | cysteine protease | 0.0016 | 0.015 | 0.015 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0008 | 0.0023 | 0.0023 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.0406 | 0.0383 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Loa Loa (eye worm) | ctsf protein | 0.0016 | 0.015 | 0.0123 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.0406 | 0.0406 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0406 | 0.0406 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0392 | 0.6084 | 1 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0212 | 0.0212 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0406 | 0.0406 |
Leishmania major | cathepsin L-like protease | 0.0063 | 0.0882 | 0.1234 |
Onchocerca volvulus | 0.0016 | 0.015 | 0.0087 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0882 | 0.1417 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.015 | 0.0127 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0281 | 0.0255 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0212 | 0.0185 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0212 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0281 | 0.0426 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0103 | 0.1522 | 0.1502 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0212 | 0.7323 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0027 | 0.0027 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0361 | 0.0361 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0011 | 0.0063 | 0.004 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0639 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.015 | 0.0127 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0281 | 1 |
Plasmodium vivax | vivapain-2 | 0.0016 | 0.015 | 0.4896 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0403 | 0.6256 | 0.6256 |
Brugia malayi | hypothetical protein | 0.0016 | 0.0142 | 0.0119 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.015 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.3055 | 0.3036 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0212 | 0.5 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0011 | 0.0065 | 0.0065 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0639 | 1 | 1 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0639 | 1 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0361 | 0.0361 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0212 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0063 | 0.0882 | 0.1417 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0054 | 0.0736 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0392 | 0.6084 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Loa Loa (eye worm) | fibroinase | 0.0016 | 0.015 | 0.0123 |
Echinococcus granulosus | cysteine protease | 0.0008 | 0.0023 | 0.0023 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0057 | 0.0796 | 0.1275 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.1522 | 0.1499 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0882 | 0.1417 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0406 | 0.0379 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0882 | 0.1417 |
Entamoeba histolytica | cysteine protease, putative | 0.0016 | 0.015 | 0.6686 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0361 | 0.0361 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0063 | 0.0036 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.1005 | 0.0984 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0281 | 0.2247 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0016 | 0.015 | 0.4896 |
Brugia malayi | CXXC zinc finger family protein | 0.0028 | 0.0336 | 0.0314 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Onchocerca volvulus | 0.0016 | 0.015 | 0.0087 | |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.015 | 0.0127 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0016 | 0.015 | 0.0209 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0008 | 0.0023 | 0.0023 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0016 | 0.015 | 0.0123 |
Trichomonas vaginalis | ap endonuclease, putative | 0.002 | 0.0212 | 1 |
Onchocerca volvulus | 0.0028 | 0.0336 | 0.0274 | |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0016 | 0.015 | 0.015 |
Brugia malayi | hypothetical protein | 0.0133 | 0.1995 | 0.1976 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0016 | 0.015 | 0.6686 |
Onchocerca volvulus | Cathepsin L homolog | 0.0016 | 0.015 | 0.0087 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0406 | 0.0406 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0011 | 0.0063 | 0.0063 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0212 | 0.0312 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0065 | 0.0065 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0016 | 0.015 | 0.0123 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0011 | 0.0063 | 0.2127 |
Onchocerca volvulus | Cathepsin F homolog | 0.0016 | 0.015 | 0.0087 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.015 | 0.0127 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0406 | 0.0406 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0212 | 0.1068 |
Onchocerca volvulus | 0.0016 | 0.015 | 0.0087 | |
Onchocerca volvulus | 0.0016 | 0.015 | 0.0087 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0016 | 0.015 | 0.6686 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.0406 | 0.0406 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0406 | 0.0406 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0882 | 0.1417 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0361 | 0.0361 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0016 | 0.015 | 0.015 |
Brugia malayi | Cathepsin L-like precursor | 0.0016 | 0.015 | 0.0127 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0392 | 0.6084 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0212 | 0.0212 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0063 | 0.0882 | 0.1417 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0016 | 0.015 | 0.015 |
Onchocerca volvulus | 0.0016 | 0.015 | 0.0087 | |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.006 | 0.0837 | 0.0837 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0063 | 0.0882 | 0.1417 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0212 | 0.0189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0016 | 0.015 | 0.6686 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0028 | 0.0336 | 0.031 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0212 | 0.7323 |
Brugia malayi | cathepsin L-like precursor | 0.0011 | 0.0063 | 0.004 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0212 | 0.5 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0011 | 0.0063 | 0.2127 |
Loa Loa (eye worm) | cysteine protease | 0.0016 | 0.015 | 0.0123 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0281 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.