TDR Targets

Basic information

Technical information

TDR Targets ID: 804088
Name: 5-amino-1-[(4-methylphenyl)methyl]-N-(phenylm ethyl)triazole-4-carboxamide
MW: 321.376 | Formula: C18H19N5O
H donors: 2 H acceptors: 3 LogP: 2.96 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)Cn1nnc(c1N)C(=O)NCc1ccccc1
InChi: 1S/C18H19N5O/c1-13-7-9-15(10-8-13)12-23-17(19)16(21-22-23)18(24)20-11-14-5-3-2-4-6-14/h2-10H,11-12,19H2,1H3,(H,20,24)
InChiKey: FZYVRDMGQSPKPN-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

5-amino-1-[(4-methylphenyl)methyl]-N-(phenylmethyl)-4-triazolecarboxamide
5-amino-N-(benzyl)-1-(4-methylbenzyl)triazole-4-carboxamide
5-amino-1-[(4-methylphenyl)methyl]-N-(phenylmethyl)-1,2,3-triazole-4-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	PHD-finger family protein	0.003	0.1608	0.2002
Entamoeba histolytica	zinc finger protein, putative	0.0022	0.1143	0.5
Loa Loa (eye worm)	jmjC domain-containing protein	0.001	0.0427	0.0532
Schistosoma mansoni	lar interacting protein (lip)-related protein	0.0013	0.0657	0.024
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.1143	1
Trichomonas vaginalis	c2h2 zinc finger protein, putative	0.0013	0.0657	0.5745
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0097	0.5576	0.5378
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.1143	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0657	0.0817
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0022	0.1143	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.001	0.0427	0.0532
Toxoplasma gondii	PHD-finger domain-containing protein	0.001	0.0434	0.006
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.26	0.227
Plasmodium vivax	hypothetical protein, conserved	0.003	0.1608	1
Echinococcus granulosus	tankyrase	0.0152	0.8816	0.8763
Entamoeba histolytica	hypothetical protein	0.0022	0.1143	0.5
Schistosoma mansoni	hypothetical protein	0.0013	0.0657	0.024
Brugia malayi	coiled-coil like protein 1	0.0013	0.0657	0.0277
Schistosoma mansoni	hypothetical protein	0.0172	1	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0061	0.3465	0.4313
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0022	0.1143	1
Loa Loa (eye worm)	tnks protein	0.0139	0.8035	1
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0022	0.1143	0.0748
Plasmodium falciparum	protein kinase, putative	0.0013	0.0657	0.1942
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.1143	1
Brugia malayi	hypothetical protein	0.0013	0.0657	0.0277
Loa Loa (eye worm)	hypothetical protein	0.001	0.0434	0.0541
Onchocerca volvulus		0.0013	0.0657	0.00000011832
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.26	0.3237
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.26	0.2625
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0657	0.5745
Plasmodium vivax	hypothetical protein, conserved	0.001	0.0434	0.006
Echinococcus granulosus	liprin alpha 2	0.0013	0.0657	0.024
Echinococcus granulosus	liprin beta 1	0.0013	0.0657	0.024
Brugia malayi	hypothetical protein	0.0013	0.0657	0.0277
Echinococcus multilocularis	poly (ADP ribose) polymerase	0.0022	0.1143	0.1143
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.1608	1
Echinococcus multilocularis	sterile alpha and tir motif containing protein	0.0013	0.0657	0.0657
Echinococcus multilocularis	PHD finger protein rhinoceros	0.003	0.1608	0.1608
Loa Loa (eye worm)	hypothetical protein	0.0051	0.2854	0.3552
Brugia malayi	PHD-finger family protein	0.001	0.0434	0.0009
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.003	0.1608	0.1234
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.1143	1
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.001	0.0427	0.0427
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0097	0.5576	0.5576
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.26	0.227
Brugia malayi	AF-10 protein	0.001	0.0434	0.0009
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.26	0.227
Echinococcus multilocularis	geminin	0.0172	1	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.26	0.26
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.1143	1
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.1143	1
Schistosoma mansoni	sarm1	0.0013	0.0657	0.024
Schistosoma mansoni	hypothetical protein	0.001	0.0434	0.0007
Plasmodium falciparum	phd finger protein, putative	0.003	0.1608	1
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.1143	1
Loa Loa (eye worm)	hypothetical protein	0.0115	0.6635	0.8257
Entamoeba histolytica	hypothetical protein	0.0022	0.1143	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0013	0.0657	0.1942
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.26	0.26
Plasmodium falciparum	conserved Plasmodium membrane protein, unknown function	0.001	0.0434	0.006
Echinococcus granulosus	lysine specific demethylase 5A	0.0036	0.1975	0.1617
Plasmodium falciparum	tyrosine kinase-like protein	0.0013	0.0657	0.1942
Echinococcus multilocularis	stromal interaction molecule 1	0.0013	0.0657	0.0657
Loa Loa (eye worm)	hypothetical protein	0.003	0.1608	0.2002
Schistosoma mansoni	tankyrase	0.0152	0.8828	0.8776
Echinococcus multilocularis	poly (adp ribose) polymerase 2	0.0022	0.1143	0.1143
Echinococcus multilocularis	jumonji domain containing protein	0.0041	0.2291	0.2291
Schistosoma mansoni	hypothetical protein	0.0013	0.0657	0.024
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.0022	0.1143	0.5
Brugia malayi	Bromodomain containing protein	0.003	0.1608	0.1427
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.26	0.227
Loa Loa (eye worm)	hypothetical protein	0.001	0.0427	0.0532
Toxoplasma gondii	PHD-finger domain-containing protein	0.003	0.1608	1
Echinococcus granulosus	Sterile alpha motif SAM	0.0013	0.0657	0.024
Echinococcus multilocularis	liprin alpha 2	0.0013	0.0657	0.0657
Brugia malayi	jmjC domain containing protein	0.0036	0.1975	0.187
Echinococcus multilocularis	tankyrase	0.0152	0.8816	0.8816
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.1143	1
Brugia malayi	Neurabin protein 1	0.0013	0.0657	0.0277
Echinococcus granulosus	PHD finger protein rhinoceros	0.003	0.1608	0.1234
Toxoplasma gondii	WD domain, G-beta repeat-containing protein	0.001	0.0434	0.006
Loa Loa (eye worm)	jmjC domain-containing protein	0.001	0.0427	0.0532
Brugia malayi	PHD-finger family protein	0.003	0.1608	0.1427
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	0.0022	0.1143	0.1423
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.1975	0.1617
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0657	0.5745
Entamoeba histolytica	hypothetical protein	0.0022	0.1143	0.5
Schistosoma mansoni	hypothetical protein	0.0013	0.0657	0.024
Echinococcus granulosus	poly ADP ribose polymerase 1	0.0022	0.1143	0.0748
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0022	0.1143	0.0748
Schistosoma mansoni	jumonji domain containing protein	0.0077	0.4402	0.4152
Loa Loa (eye worm)	hypothetical protein	0.0022	0.1143	0.1423
Echinococcus granulosus	poly adp ribose polymerase 2	0.0022	0.1143	0.0748
Schistosoma mansoni	lip-related protein (liprin) alpha	0.0013	0.0657	0.024
Brugia malayi	WGR domain containing protein	0.0022	0.1143	0.0864
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0657	0.0817
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.1143	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0427	0.0532
Echinococcus multilocularis	lysine specific demethylase 6a	0.001	0.0427	0.0427
Echinococcus multilocularis	phd:f box containing protein	0.001	0.0427	0.0427
Entamoeba histolytica	hypothetical protein	0.0022	0.1143	0.5
Schistosoma mansoni	hypothetical protein	0.0013	0.0657	0.024
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0657	0.0817
Echinococcus granulosus	peregrin	0.003	0.1608	0.1234
Loa Loa (eye worm)	jmjC domain-containing protein	0.0036	0.1975	0.2458
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0013	0.0657	0.1942
Brugia malayi	Liprin-alpha 2	0.0013	0.0657	0.0277
Echinococcus multilocularis	JmjC domain containing protein 4	0.001	0.0427	0.0427
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.26	0.227
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.001	0.0434	0.0099
Trypanosoma brucei	poly(adp-ribose) polymerase	0.0022	0.1143	1
Leishmania major	hypothetical protein, conserved	0.001	0.0427	0.5
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0022	0.1143	0.606
Onchocerca volvulus	Alhambra homolog	0.003	0.1608	0.1314
Onchocerca volvulus	Tankyrase homolog	0.0137	0.7901	1
Loa Loa (eye worm)	toll and interleukin 1 receptor domain-containing protein isoform f	0.0013	0.0657	0.0817
Echinococcus granulosus	jumonji domain containing protein	0.0041	0.2291	0.1947
Brugia malayi	Tnks protein	0.015	0.8705	1
Brugia malayi	WGR domain containing protein	0.0022	0.1143	0.0864
Trypanosoma brucei	PHD-zinc-finger like domain containing protein, putative	0.001	0.0434	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0657	0.0817
Echinococcus multilocularis	lysine specific demethylase 5A	0.0036	0.1975	0.1975
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0434	0.0009
Echinococcus multilocularis	liprin beta 1	0.0013	0.0657	0.0657
Brugia malayi	sterile alpha and TIR motif containing protein 1 isoform a	0.0013	0.0657	0.0277
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0657	0.5745
Echinococcus multilocularis	peregrin	0.003	0.1608	0.1608
Echinococcus multilocularis	jumonji domain containing 1A	0.001	0.0427	0.0427
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.001	0.0434	0.0007
Giardia lamblia	PHD finger protein 15	0.003	0.1608	0.5
Echinococcus granulosus	sterile alpha and tir motif containing protein	0.0013	0.0657	0.024
Trichomonas vaginalis	conserved hypothetical protein	0.0013	0.0657	0.5745
Echinococcus multilocularis	SAM domain containing protein	0.0013	0.0657	0.0657
Echinococcus granulosus	stromal interaction molecule 1	0.0013	0.0657	0.024
Echinococcus granulosus	SAM domain containing protein	0.0013	0.0657	0.024
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0657	0.0817
Schistosoma mansoni	hypothetical protein	0.003	0.1608	0.1234
Brugia malayi	jmjC domain containing protein	0.0097	0.5576	0.622
Schistosoma mansoni	hypothetical protein	0.0172	1	1
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.0022	0.1143	0.1143
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0036	0.1975	0.1617

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 804088