Detailed information for compound 805577

Basic information

Technical information
  • TDR Targets ID: 805577
  • Name: methyl 2-amino-4-methyl-5-(phenylcarbamoyl)th iophene-3-carboxylate
  • MW: 290.338 | Formula: C14H14N2O3S
  • H donors: 2 H acceptors: 2 LogP: 3.19 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1c(N)sc(c1C)C(=O)Nc1ccccc1
  • InChi: 1S/C14H14N2O3S/c1-8-10(14(18)19-2)12(15)20-11(8)13(17)16-9-6-4-3-5-7-9/h3-7H,15H2,1-2H3,(H,16,17)
  • InChiKey: BWKPWQXMESIWDK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-4-methyl-5-[oxo-(phenylamino)methyl]-3-thiophenecarboxylic acid methyl ester
  • 2-amino-4-methyl-5-(phenylcarbamoyl)thiophene-3-carboxylic acid methyl ester
  • ST5433216
  • A3408/0144535
  • ZINC01441472

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0602 0.1876 0.3147
Loa Loa (eye worm) integrin beta-2 0.2648 1 1
Loa Loa (eye worm) norepinephrine transporter 0.0181 0.0205 0.0169
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0278 0.0588 0.0778
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0602 0.1876 0.2483
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0324 0.0773 0.0739
Echinococcus multilocularis integrin alpha ps 0.0533 0.16 0.2117
Onchocerca volvulus 0.0278 0.0588 0.154
Loa Loa (eye worm) hypothetical protein 0.0278 0.0588 0.0553
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0602 0.1876 0.2483
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0181 0.0205 0.0169
Echinococcus granulosus 7TM GPCR rhodopsin 0.0139 0.0037 0.0048
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0602 0.1876 0.1846
Echinococcus granulosus alpha 1A adrenergic receptor 0.0139 0.0037 0.0048
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0602 0.1876 0.1846
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0962 0.3303 0.559
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0324 0.0773 0.0739
Echinococcus multilocularis neuropeptide FF receptor 2 0.0139 0.0037 0.0048
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0324 0.0773 0.126
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0139 0.0037 0.0048
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.0037 0.0048
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0139 0.0037 0.0048
Loa Loa (eye worm) GABA receptor subunit 0.0324 0.0773 0.0739
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0139 0.0037 0.0048
Echinococcus granulosus integrin alpha ps 0.0255 0.0498 0.066
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0422 0.116 0.1128
Loa Loa (eye worm) solute carrier family 6 member 4 0.0181 0.0205 0.0169
Echinococcus granulosus somatostatin receptor 0.0139 0.0037 0.0048
Echinococcus multilocularis serotonin receptor 0.0139 0.0037 0.0048
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0278 0.0588 0.0778
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0602 0.1876 0.3147
Echinococcus granulosus hypothetical protein 0.0139 0.0037 0.0048
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0278 0.0588 0.0778
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.1041 0.3616 0.4786
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0602 0.1876 0.2483
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0602 0.1876 0.1846
Loa Loa (eye worm) hypothetical protein 0.0181 0.0205 0.0169
Echinococcus granulosus neuropeptide receptor 0.0139 0.0037 0.0048
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.0037 0.0048
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0324 0.0773 0.0739
Echinococcus granulosus integrin alpha 3 0.0911 0.3101 0.4104
Echinococcus multilocularis G protein coupled receptor 139 0.0139 0.0037 0.0048
Schistosoma mansoni neurotransmitter gated ion channel 0.0278 0.0588 0.0943
Echinococcus granulosus tm gpcr rhodopsin 0.0139 0.0037 0.0048
Brugia malayi hypothetical protein 0.0278 0.0588 0.0553
Brugia malayi excitatory GABA receptor EXP-1A 0.0602 0.1876 0.1846
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0278 0.0588 0.0553
Echinococcus multilocularis G-protein coupled receptor, putative 0.0139 0.0037 0.0048
Loa Loa (eye worm) hypothetical protein 0.0602 0.1876 0.1846
Loa Loa (eye worm) hypothetical protein 0.0602 0.1876 0.1846
Echinococcus multilocularis nAChR subunit 0.0324 0.0773 0.1023
Loa Loa (eye worm) hypothetical protein 0.0602 0.1876 0.1846
Echinococcus multilocularis neuropeptide receptor 0.0139 0.0037 0.0048
Echinococcus multilocularis serotonin transporter 0.0181 0.0205 0.0271
Echinococcus multilocularis g protein coupled receptor 0.0139 0.0037 0.0048
Echinococcus granulosus g protein coupled receptor 0.0139 0.0037 0.0048
Loa Loa (eye worm) hypothetical protein 0.031 0.0717 0.0683
Brugia malayi Cation transporter family protein 0.0602 0.1876 0.1846
Echinococcus multilocularis neuropeptide Y receptor 0.0139 0.0037 0.0048
Loa Loa (eye worm) hypothetical protein 0.0602 0.1876 0.1846
Brugia malayi Cation transporter family protein 0.0962 0.3303 0.3279
Loa Loa (eye worm) hypothetical protein 0.0278 0.0588 0.0553
Loa Loa (eye worm) serotonin transporter b 0.0181 0.0205 0.0169
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0139 0.0037 0.0048
Loa Loa (eye worm) hypothetical protein 0.0278 0.0588 0.0553
Brugia malayi hypothetical protein 0.0278 0.0588 0.0553
Schistosoma mansoni nAChR subunit 0.0602 0.1876 0.3147
Echinococcus multilocularis integrin alpha ps 0.0255 0.0498 0.066
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0602 0.1876 0.1846
Schistosoma mansoni nAChR subunit 0.0602 0.1876 0.3147
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.1041 0.3616 0.4786
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.1041 0.3616 0.4786
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0602 0.1876 0.1846
Loa Loa (eye worm) hypothetical protein 0.0278 0.0588 0.0553
Echinococcus granulosus integrin alpha ps 0.0533 0.16 0.2117
Brugia malayi hypothetical protein 0.0278 0.0588 0.0553
Loa Loa (eye worm) hypothetical protein 0.0278 0.0588 0.0553
Loa Loa (eye worm) hypothetical protein 0.0602 0.1876 0.1846
Schistosoma mansoni sodium/chloride dependent transporter 0.0181 0.0205 0.0288
Echinococcus multilocularis g protein coupled receptor 0.0139 0.0037 0.0048
Echinococcus granulosus tachykinin peptides receptor 99D 0.0139 0.0037 0.0048
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0278 0.0588 0.0553
Echinococcus multilocularis fmrfamide receptor 0.0139 0.0037 0.0048
Loa Loa (eye worm) hypothetical protein 0.0602 0.1876 0.1846
Onchocerca volvulus 0.0962 0.3303 0.9126
Schistosoma mansoni nAChR subunit 0.0602 0.1876 0.3147
Loa Loa (eye worm) hypothetical protein 0.0324 0.0773 0.0739
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0139 0.0037 0.0048
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0602 0.1876 0.2483
Echinococcus granulosus biogenic amine 5HT receptor 0.0139 0.0037 0.0048
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0139 0.0037 0.0048
Echinococcus multilocularis glycine receptor subunit beta 0.0602 0.1876 0.2483
Echinococcus multilocularis integrin beta 2 0.2033 0.7556 1
Loa Loa (eye worm) hypothetical protein 0.0602 0.1876 0.1846
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0278 0.0588 0.0553
Schistosoma mansoni hypothetical protein 0.0255 0.0498 0.0791
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0139 0.0037 0.0048
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0602 0.1876 0.3147
Brugia malayi Integrin alpha pat-2 precursor 0.1188 0.4202 0.4181
Brugia malayi hypothetical protein 0.0278 0.0588 0.0553
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.0037 0.0048
Echinococcus granulosus allatostatin A receptor 0.0139 0.0037 0.0048
Loa Loa (eye worm) acetylcholine receptor protein 0.0278 0.0588 0.0553
Echinococcus multilocularis neuropeptides capa receptor 0.0139 0.0037 0.0048
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.1041 0.3616 0.4786
Echinococcus granulosus tm gpcr rhodopsin 0.0139 0.0037 0.0048
Echinococcus granulosus rhodopsin orphan GPCR 0.0139 0.0037 0.0048
Echinococcus granulosus glycine receptor subunit alpha 1 0.0602 0.1876 0.2483
Loa Loa (eye worm) hypothetical protein 0.0602 0.1876 0.1846
Loa Loa (eye worm) hypothetical protein 0.0278 0.059 0.0556
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.059 0.1828 0.3065
Loa Loa (eye worm) hypothetical protein 0.0962 0.3303 0.3279
Schistosoma mansoni nAChR subunit 0.0602 0.1876 0.3147
Echinococcus multilocularis orexin receptor type 2 0.0139 0.0037 0.0048
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0602 0.1876 0.1846
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0602 0.1876 0.3147
Echinococcus multilocularis neuropeptide receptor 0.0139 0.0037 0.0048
Onchocerca volvulus Putative nachr subunit 0.1041 0.3616 1
Loa Loa (eye worm) hypothetical protein 0.0324 0.0773 0.0739
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0602 0.1876 0.1846
Entamoeba histolytica hypothetical protein 0.0324 0.0773 0.5
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0581 0.179 0.3
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0139 0.0037 0.0048
Brugia malayi hypothetical protein 0.0278 0.0588 0.0553
Echinococcus granulosus nAChR subunit 0.0602 0.1876 0.2483
Schistosoma mansoni nAChR subunit 0.0602 0.1876 0.3147
Echinococcus multilocularis g-protein coupled receptor 0.0139 0.0037 0.0048
Schistosoma mansoni nAChR subunit 0.0602 0.1876 0.3147
Echinococcus granulosus g protein coupled receptor 0.0139 0.0037 0.0048
Treponema pallidum sodium- and chloride- dependent transporter 0.0181 0.0205 0.5
Loa Loa (eye worm) hypothetical protein 0.0255 0.0498 0.0464
Echinococcus granulosus rhodopsin orphan GPCR 0.0139 0.0037 0.0048
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0139 0.0037 0.0048
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0139 0.0037 0.0048
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0674 0.2161 0.2132
Echinococcus granulosus rhodopsin orphan GPCR 0.0139 0.0037 0.0048
Echinococcus granulosus glycine receptor subunit alpha 1 0.0602 0.1876 0.2483
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0602 0.1876 0.2483
Echinococcus granulosus tm gpcr rhodopsin 0.0139 0.0037 0.0048
Echinococcus granulosus neuropeptide Y receptor 0.0139 0.0037 0.0048
Echinococcus granulosus rhodopsin orphan GPCR 0.0139 0.0037 0.0048
Echinococcus granulosus integrin beta 2 0.2033 0.7556 1
Brugia malayi solute carrier family 40, member 1 0.0196 0.0263 0.0227
Echinococcus granulosus small conductance calcium activated potassium 0.0839 0.2817 0.3728
Schistosoma mansoni integrin alpha-ps 0.0533 0.16 0.2675
Loa Loa (eye worm) hypothetical protein 0.0324 0.0773 0.0739
Brugia malayi Cation transporter family protein 0.0602 0.1876 0.1846
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0602 0.1876 0.1846
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0602 0.1876 0.1846
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.1041 0.3616 0.3593
Schistosoma mansoni calcium-activated potassium channel 0.0839 0.2817 0.4757
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0602 0.1876 0.2483
Loa Loa (eye worm) ACC-1 protein 0.0602 0.1876 0.1846
Loa Loa (eye worm) hypothetical protein 0.0181 0.0205 0.0169
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0602 0.1876 0.1846
Loa Loa (eye worm) hypothetical protein 0.022 0.0359 0.0324
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0602 0.1876 0.1846
Brugia malayi hypothetical protein 0.0422 0.116 0.1128
Loa Loa (eye worm) hypothetical protein 0.0324 0.0773 0.0739
Loa Loa (eye worm) hypothetical protein 0.1041 0.3616 0.3593
Schistosoma mansoni integrin alpha 0.1188 0.4202 0.7128
Echinococcus granulosus dro:myosuppressin receptor 0.0139 0.0037 0.0048
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0139 0.0037 0.0048
Echinococcus multilocularis neuropeptide s receptor 0.0139 0.0037 0.0048
Schistosoma mansoni integrin beta subunit 0.1611 0.588 1
Loa Loa (eye worm) hypothetical protein 0.0684 0.22 0.2172
Onchocerca volvulus 0.0602 0.1876 0.5138
Schistosoma mansoni calcium-activated potassium channel 0.0589 0.1823 0.3056
Schistosoma mansoni acetylcholine receptor-related 0.0278 0.0588 0.0943
Echinococcus granulosus G protein coupled receptor 139 0.0139 0.0037 0.0048
Echinococcus granulosus g-protein coupled receptor 0.0139 0.0037 0.0048
Echinococcus multilocularis nAChR subunit 0.0602 0.1876 0.2483
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0602 0.1876 0.1846
Onchocerca volvulus 0.0962 0.3303 0.9126
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.0037 0.0048
Loa Loa (eye worm) hypothetical protein 0.0602 0.1876 0.1846
Onchocerca volvulus 0.0196 0.0263 0.0633
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0602 0.1876 0.1846
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0139 0.0037 0.0048
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0962 0.3303 0.559
Onchocerca volvulus 0.0602 0.1876 0.5138
Loa Loa (eye worm) hypothetical protein 0.0196 0.0263 0.0227
Loa Loa (eye worm) hypothetical protein 0.0962 0.3303 0.3279
Loa Loa (eye worm) hypothetical protein 0.0324 0.0773 0.0739
Loa Loa (eye worm) hypothetical protein 0.0278 0.0588 0.0553
Schistosoma mansoni neurotransmitter gated ion channel 0.0278 0.0588 0.0943
Loa Loa (eye worm) hypothetical protein 0.0278 0.0588 0.0553
Echinococcus granulosus rhodopsin orphan GPCR 0.0139 0.0037 0.0048
Echinococcus multilocularis neuropeptides capa receptor 0.0139 0.0037 0.0048
Echinococcus granulosus glycine receptor subunit beta 0.0602 0.1876 0.2483
Echinococcus multilocularis dro:myosuppressin receptor 0.0139 0.0037 0.0048
Echinococcus granulosus neuropeptide Y receptor 0.0139 0.0037 0.0048
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0602 0.1876 0.1846
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0181 0.0205 0.0288
Echinococcus granulosus neuropeptides capa receptor 0.0139 0.0037 0.0048
Loa Loa (eye worm) hypothetical protein 0.0278 0.0588 0.0553
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.1041 0.3616 0.4786
Loa Loa (eye worm) hypothetical protein 0.0602 0.1876 0.1846
Echinococcus multilocularis integrin alpha 3 0.0911 0.3101 0.4104
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0139 0.0037 0.0048
Echinococcus granulosus neuropeptide s receptor 0.0139 0.0037 0.0048
Echinococcus granulosus rhodopsin orphan GPCR 0.0139 0.0037 0.0048
Loa Loa (eye worm) hypothetical protein 0.0933 0.3189 0.3164
Echinococcus granulosus neuropeptide receptor A26 0.0139 0.0037 0.0048
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0602 0.1876 0.2483
Loa Loa (eye worm) hypothetical protein 0.0324 0.0773 0.0739
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0324 0.0773 0.0739
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0602 0.1876 0.1846
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.0037 0.0048
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0324 0.0773 0.126
Loa Loa (eye worm) hypothetical protein 0.0839 0.2817 0.279
Loa Loa (eye worm) hypothetical protein 0.0602 0.1876 0.1846
Echinococcus multilocularis fmrfamide receptor 0.0139 0.0037 0.0048
Onchocerca volvulus 0.0324 0.0773 0.2057
Loa Loa (eye worm) ACC-1 protein 0.0602 0.1876 0.1846
Loa Loa (eye worm) LGC-31 protein 0.0602 0.1876 0.1846
Schistosoma mansoni integrin alpha-ps 0.0277 0.0586 0.094
Loa Loa (eye worm) hypothetical protein 0.0181 0.0205 0.0169
Echinococcus granulosus neuropeptide FF receptor 2 0.0139 0.0037 0.0048
Echinococcus granulosus fmrfamide receptor 0.0139 0.0037 0.0048
Loa Loa (eye worm) hypothetical protein 0.0324 0.0773 0.0739
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0139 0.0037 0.0048
Echinococcus granulosus nAChR subunit 0.0324 0.0773 0.1023
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0602 0.1876 0.1846
Onchocerca volvulus 0.0278 0.0588 0.154
Echinococcus granulosus serotonin transporter 0.0181 0.0205 0.0271
Echinococcus granulosus glycine receptor subunit alpha 1 0.0602 0.1876 0.2483
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0602 0.1876 0.2483
Echinococcus multilocularis serotonin receptor 0.0139 0.0037 0.0048
Echinococcus multilocularis integrin alpha ps 0.0533 0.16 0.2117
Echinococcus multilocularis allatostatin A receptor 0.0139 0.0037 0.0048
Loa Loa (eye worm) hypothetical protein 0.0674 0.2161 0.2132
Loa Loa (eye worm) hypothetical protein 0.0602 0.1876 0.1846
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.1041 0.3616 0.3593
Onchocerca volvulus 0.0962 0.3303 0.9126
Brugia malayi Kelch motif family protein 0.0422 0.116 0.1128
Loa Loa (eye worm) hypothetical protein 0.0602 0.1876 0.1846
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0602 0.1876 0.1846
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0602 0.1876 0.2483
Loa Loa (eye worm) hypothetical protein 0.0656 0.2087 0.2058
Onchocerca volvulus 0.0581 0.179 0.4897
Echinococcus granulosus g protein coupled receptor 0.0139 0.0037 0.0048
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0139 0.0037 0.0048
Brugia malayi Trypsin family protein 0.0581 0.179 0.1759
Loa Loa (eye worm) hypothetical protein 0.0278 0.0588 0.0553
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0602 0.1876 0.2483
Loa Loa (eye worm) hypothetical protein 0.0602 0.1876 0.1846
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0139 0.0037 0.0048
Loa Loa (eye worm) hypothetical protein 0.0602 0.1876 0.1846
Echinococcus granulosus orexin receptor type 2 0.0139 0.0037 0.0048
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0139 0.0037 0.0048
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.0037 0.0048
Schistosoma mansoni neurotransmitter gated ion channel 0.0324 0.0773 0.126
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0602 0.1876 0.1846
Echinococcus granulosus 7tm_1 domain containing protein 0.0139 0.0037 0.0048
Loa Loa (eye worm) hypothetical protein 0.0278 0.0588 0.0553
Echinococcus multilocularis neuropeptide receptor A26 0.0139 0.0037 0.0048
Loa Loa (eye worm) hypothetical protein 0.0581 0.179 0.1759
Loa Loa (eye worm) hypothetical protein 0.0602 0.1876 0.1846
Echinococcus granulosus biogenic amine 5HT receptor 0.0139 0.0037 0.0048
Loa Loa (eye worm) hypothetical protein 0.0278 0.0588 0.0553
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0278 0.0588 0.0778
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0278 0.0588 0.0553
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.0037 0.0048
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0139 0.0037 0.0048
Echinococcus granulosus serotonin receptor 0.0139 0.0037 0.0048
Echinococcus granulosus peptide allatostatin:somatostatin 0.0139 0.0037 0.0048
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0602 0.1876 0.1846
Echinococcus granulosus neuropeptide receptor 0.0139 0.0037 0.0048
Echinococcus multilocularis g protein coupled receptor 0.0139 0.0037 0.0048
Loa Loa (eye worm) hypothetical protein 0.0422 0.116 0.1128
Echinococcus granulosus rhodopsin orphan GPCR 0.0139 0.0037 0.0048
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0278 0.0588 0.0553
Loa Loa (eye worm) hypothetical protein 0.0277 0.0586 0.0551
Echinococcus multilocularis sex peptide receptor 0.0139 0.0037 0.0048
Onchocerca volvulus 0.0602 0.1876 0.5138
Schistosoma mansoni acetylcholine receptor subunit beta 0.0278 0.0588 0.0943
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0602 0.1876 0.2483
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0278 0.0588 0.0553
Echinococcus granulosus sex peptide receptor 0.0139 0.0037 0.0048
Schistosoma mansoni hypothetical protein 0.0839 0.2817 0.4757
Echinococcus multilocularis rhodopsin orphan GPCR 0.0139 0.0037 0.0048
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0278 0.0588 0.0553
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0278 0.0588 0.0778
Loa Loa (eye worm) hypothetical protein 0.0278 0.0588 0.0553
Loa Loa (eye worm) integrin alpha pat-2 0.1607 0.5865 0.585
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0602 0.1876 0.2483
Loa Loa (eye worm) hypothetical protein 0.0278 0.0588 0.0553
Loa Loa (eye worm) hypothetical protein 0.0581 0.179 0.1759
Echinococcus granulosus neuropeptides capa receptor 0.0139 0.0037 0.0048
Echinococcus multilocularis neuropeptide Y receptor 0.0139 0.0037 0.0048
Onchocerca volvulus 0.0181 0.0205 0.047
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0139 0.0037 0.0048
Onchocerca volvulus 0.0324 0.0773 0.2057
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.1041 0.3616 0.4786
Echinococcus multilocularis somatostatin receptor 0.0139 0.0037 0.0048
Loa Loa (eye worm) hypothetical protein 0.0278 0.0588 0.0553
Echinococcus multilocularis glycine receptor subunit beta 0.0602 0.1876 0.2483
Loa Loa (eye worm) hypothetical protein 0.0324 0.0773 0.0739
Schistosoma mansoni nAChR subunit 0.0602 0.1876 0.3147
Echinococcus granulosus glycine receptor subunit beta 0.0602 0.1876 0.2483
Loa Loa (eye worm) hypothetical protein 0.0278 0.0588 0.0553
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0602 0.1876 0.1846
Onchocerca volvulus 0.0531 0.1593 0.435
Schistosoma mansoni nAChR subunit 0.0278 0.0588 0.0943
Onchocerca volvulus 0.0278 0.0588 0.154
Schistosoma mansoni nAChR subunit 0.0278 0.0588 0.0943
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0278 0.0588 0.0553
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0139 0.0037 0.0048
Echinococcus multilocularis small conductance calcium activated potassium 0.0839 0.2817 0.3728

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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