Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0108 | 0.0616 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0108 | 0.0616 | 0.0616 |
Giardia lamblia | Ceramide glucosyltransferase | 0.0369 | 0.3783 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0881 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0158 | 0.1226 | 0.1226 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0881 | 1 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0127 | 0.0841 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0108 | 0.0616 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0578 | 0.6322 | 0.6081 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0158 | 0.1226 | 0.1226 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0108 | 0.0616 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0609 | 0.67 | 0.6483 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0127 | 0.0841 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0578 | 0.6322 | 0.6081 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0609 | 0.67 | 0.6483 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0881 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0108 | 0.0618 | 0.0673 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.1226 | 0.1226 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0578 | 0.6322 | 0.6081 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0108 | 0.0616 | 0.5 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.0814 | 0.9183 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0108 | 0.0616 | 0.067 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.071 | 0.7925 | 0.8629 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0158 | 0.1226 | 0.1226 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.0814 | 0.9183 | 0.9183 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0108 | 0.0616 | 0.067 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.071 | 0.7925 | 0.8629 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0814 | 0.9183 | 1 |
Echinococcus granulosus | bile acid beta glucosidase | 0.071 | 0.7925 | 0.8629 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0108 | 0.0616 | 0.067 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0108 | 0.0616 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0127 | 0.0841 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0578 | 0.6322 | 0.6081 |
Brugia malayi | Ceramide glucosyltransferase | 0.0814 | 0.9183 | 0.9183 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0108 | 0.0616 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0881 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0881 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0881 | 1 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0198 | 0.1713 | 0.1865 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.0814 | 0.9183 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0108 | 0.0616 | 0.5 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0108 | 0.0616 | 0.5 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0198 | 0.1713 | 0.1865 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.0618 | 0.0618 |
Schistosoma mansoni | hypothetical protein | 0.0306 | 0.302 | 0.3289 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.071 | 0.7925 | 0.8629 |
Trypanosoma brucei | protein kinase, putative | 0.0108 | 0.0616 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0578 | 0.6322 | 0.6081 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0881 | 1 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.0814 | 0.9183 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0578 | 0.6322 | 0.6081 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0108 | 0.0618 | 0.0618 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0578 | 0.6322 | 0.6081 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.0814 | 0.9183 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0108 | 0.0616 | 0.067 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.071 | 0.7925 | 0.8629 |
Brugia malayi | MAP kinase sur-1 | 0.0108 | 0.0616 | 0.0616 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.071 | 0.7925 | 0.8629 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0127 | 0.0841 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0479 | 0.5123 | 0.5123 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0108 | 0.0616 | 0.067 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.