Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | 6-phosphogluconolactonase | 0.0125 | 0.3064 | 0.31 |
Brugia malayi | glucose phosphate isomerase a | 0.0048 | 0.0643 | 0.0302 |
Schistosoma mansoni | fructose 16-bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0346 | 1 | 1 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0346 | 1 | 1 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0323 | 0.9266 | 1 |
Mycobacterium leprae | Probable 6-phosphogluconolactonase DevB (6PGL) | 0.0125 | 0.3064 | 0.661 |
Echinococcus granulosus | glucose 6 phosphate isomerase | 0.0048 | 0.0643 | 0.0302 |
Mycobacterium ulcerans | 6-phosphogluconolactonase | 0.0125 | 0.3064 | 0.661 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.004 | 0.0375 | 0.0101 |
Loa Loa (eye worm) | 6-phosphogluconolactonase | 0.0125 | 0.3064 | 0.3306 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0346 | 1 | 1 |
Leishmania major | 6-phosphogluconolactonase | 0.0125 | 0.3064 | 0.31 |
Toxoplasma gondii | fructose-bisphosphate aldolase, putative | 0.0323 | 0.9266 | 1 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0323 | 0.9266 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.004 | 0.0375 | 0.0109 |
Plasmodium falciparum | glucose-6-phosphate isomerase | 0.0048 | 0.0643 | 0.0408 |
Echinococcus granulosus | fructose bisphosphate aldolase class I | 0.0323 | 0.9266 | 1 |
Leishmania major | pyruvate kinase | 0.004 | 0.0375 | 0.0109 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Plasmodium vivax | pyruvate kinase, putative | 0.004 | 0.0375 | 0.0109 |
Echinococcus multilocularis | glucose 6 phosphate isomerase | 0.0048 | 0.0643 | 0.0579 |
Loa Loa (eye worm) | phosphoglucose isomerase | 0.0048 | 0.0643 | 0.0694 |
Loa Loa (eye worm) | fructose-bisphosphate aldolase 1 | 0.0323 | 0.9266 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 0.0375 | 0.0405 |
Leishmania major | glucose-6-phosphate isomerase | 0.0048 | 0.0643 | 0.0408 |
Schistosoma mansoni | pyruvate kinase | 0.004 | 0.0375 | 0.0109 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0346 | 1 | 1 |
Entamoeba histolytica | glucose-6-phosphate isomerase, putative | 0.0048 | 0.0643 | 0.0643 |
Brugia malayi | 6-phosphogluconolactonase family protein | 0.0125 | 0.3064 | 0.3024 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Mycobacterium ulcerans | glucose-6-phosphate isomerase | 0.0048 | 0.0643 | 0.0659 |
Leishmania major | pyruvate kinase | 0.004 | 0.0375 | 0.0109 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0169 | 0.4443 | 1 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.004 | 0.0375 | 0.0109 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.004 | 0.0375 | 0.5 |
Trypanosoma cruzi | glucose-6-phosphate isomerase, glycosomal, putative | 0.0048 | 0.0643 | 0.0408 |
Entamoeba histolytica | glucosamine-6-phosphate isomerase, putative | 0.0036 | 0.0277 | 0.0277 |
Mycobacterium tuberculosis | Probable 6-phosphogluconolactonase DevB (6PGL) | 0.0089 | 0.1922 | 0.3803 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0346 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0346 | 1 | 1 |
Chlamydia trachomatis | glucose-6-phosphate isomerase | 0.0048 | 0.0643 | 0.0998 |
Trypanosoma cruzi | glucose-6-phosphate isomerase, glycosomal, putative | 0.0048 | 0.0643 | 0.0408 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.004 | 0.0375 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.004 | 0.0375 | 0.0285 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate isomerase Pgi (GPI) (phosphoglucose isomerase) (phosphohexose isomerase) (phi) | 0.0048 | 0.0643 | 0.0659 |
Loa Loa (eye worm) | fructose-bisphosphate aldolase 2 | 0.0323 | 0.9266 | 1 |
Trypanosoma cruzi | 6-phosphogluconolactonase, putative | 0.0125 | 0.3064 | 0.31 |
Plasmodium falciparum | pyruvate kinase | 0.004 | 0.0375 | 0.0109 |
Echinococcus multilocularis | 6 phosphogluconolactonase | 0.0125 | 0.3064 | 0.3223 |
Schistosoma mansoni | glucose-6-phosphate isomerase | 0.0048 | 0.0643 | 0.0408 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Brugia malayi | fructose-bisphosphate aldolase 1 | 0.0323 | 0.9266 | 1 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0323 | 0.9266 | 1 |
Plasmodium falciparum | fructose-bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Chlamydia trachomatis | 6-phosphogluconolactonase | 0.0125 | 0.3064 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.004 | 0.0375 | 0.5 |
Mycobacterium leprae | Probable glucose-6-phosphate isomerase Pgi (phosphoglucose isomerase) (phosphohexose isomerase) (PHI) | 0.0048 | 0.0643 | 0.0659 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0346 | 1 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0169 | 0.4443 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0643 | 0.0694 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0346 | 1 | 1 |
Giardia lamblia | Glucose-6-phosphate isomerase | 0.0048 | 0.0643 | 0.0377 |
Echinococcus multilocularis | fructose bisphosphate aldolase class I | 0.0323 | 0.9266 | 1 |
Trypanosoma cruzi | 6-phosphogluconolactonase, putative | 0.0125 | 0.3064 | 0.31 |
Brugia malayi | fructose-bisphosphate aldolase 2 | 0.0323 | 0.9266 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0375 | 0.0405 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.004 | 0.0375 | 0.0101 |
Giardia lamblia | Pyruvate kinase | 0.004 | 0.0375 | 0.0101 |
Trypanosoma brucei | pyruvate kinase 1 | 0.004 | 0.0375 | 0.0109 |
Echinococcus granulosus | 6 phosphogluconolactonase | 0.0125 | 0.3064 | 0.3024 |
Schistosoma mansoni | 6-phosphogluconolactonase | 0.0125 | 0.3064 | 0.31 |
Plasmodium vivax | fructose 1,6-bisphosphate aldolase, putative | 0.0323 | 0.9266 | 1 |
Trypanosoma brucei | 6-phosphogluconolactonase | 0.0125 | 0.3064 | 0.31 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0346 | 1 | 1 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0169 | 0.4443 | 1 |
Trypanosoma brucei | glucose-6-phosphate isomerase, glycosomal | 0.0048 | 0.0643 | 0.0408 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Leishmania major | fructose-1,6-bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.004 | 0.0375 | 0.0109 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0346 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 0.0375 | 0.0405 |
Trypanosoma brucei | fructose-bisphosphate aldolase, glycosomal, putative | 0.0323 | 0.9266 | 1 |
Trichomonas vaginalis | glucose-6-phosphate isomerase, putative | 0.0048 | 0.0643 | 0.0377 |
Schistosoma mansoni | fructose 16-bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.004 | 0.0375 | 0.0285 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.004 | 0.0375 | 0.0109 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0346 | 1 | 1 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0323 | 0.9266 | 1 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0125 | 0.3064 | 0.2587 |
Trichomonas vaginalis | glucose-6-phosphate isomerase, putative | 0.0048 | 0.0643 | 0.0377 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.004 | 0.0375 | 0.0109 |
Toxoplasma gondii | glucose-6-phosphate isomerase GPI | 0.0048 | 0.0643 | 0.0408 |
Plasmodium vivax | glucose-6-phosphate isomerase, putative | 0.0048 | 0.0643 | 0.0408 |
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 0.0375 | 0.0405 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.13 ug ml-1 | In vitro antibacterial activity of the compound was tested against Haemophilus influenzae Q1 | ChEMBL. | 10406653 |
MIC (functional) | = 0.25 ug ml-1 | In vitro antibacterial activity of the compound was tested against Streptococcus pneumoniae PU7 | ChEMBL. | 10406653 |
MIC (functional) | = 0.5 ug ml-1 | In vitro antibacterial activity of the compound was tested against Streptococcus pyogenes CN10 | ChEMBL. | 10406653 |
MIC (functional) | = 1 ug ml-1 | In vitro antibacterial activity of the compound was tested against Staphylococcus aureus Oxford | ChEMBL. | 10406653 |
MIC (functional) | = 2 ug ml-1 | In vitro antibacterial activity of the compound was tested against Moraxella catarrhalis 1502 | ChEMBL. | 10406653 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.