Detailed information for compound 807291

Basic information

Technical information
  • TDR Targets ID: 807291
  • Name: 4-chloro-N-(1-phenylethyl)benzenesulfonamide
  • MW: 295.784 | Formula: C14H14ClNO2S
  • H donors: 1 H acceptors: 2 LogP: 3.41 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)S(=O)(=O)NC(c1ccccc1)C
  • InChi: 1S/C14H14ClNO2S/c1-11(12-5-3-2-4-6-12)16-19(17,18)14-9-7-13(15)8-10-14/h2-11,16H,1H3
  • InChiKey: PISRQXFFYFWCDQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • ST042459
  • 4-Chloro-N-(1-phenyl-ethyl)-benzenesulfonamide
  • BAS 00407353
  • BIM-0006514.P001
  • AG-690/10418022
  • Oprea1_139533
  • CBMicro_006620

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0191 0.0219
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.025 0.0873
Toxoplasma gondii Erv1 / Alr family protein 0.0073 0.2862 1
Echinococcus granulosus sulfhydryl oxidase 1 0.0012 0.008 0.028
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0073 0.2862 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0871 0.4472
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0012 0.008 0.008
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0384 0.0439
Schistosoma mansoni intermediate filament proteins 0.0026 0.0744 0.3819
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0384 0.1091
Schistosoma mansoni lamin 0.0026 0.0744 0.3819
Echinococcus granulosus GPCR family 2 0.0015 0.025 0.0873
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.025 0.0286
Loa Loa (eye worm) hypothetical protein 0.0026 0.0744 0.0852
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0871 0.3043
Schistosoma mansoni hypothetical protein 0.0015 0.025 0.1283
Schistosoma mansoni ap endonuclease 0.0018 0.0384 0.197
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0384 0.1341
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0012 0.008 0.008
Onchocerca volvulus 0.0029 0.0871 0.0871
Brugia malayi Latrophilin receptor protein 2 0.0015 0.025 0.0286
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.1057 0.1211
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0871 0.4472
Brugia malayi Pre-SET motif family protein 0.0204 0.8732 1
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0073 0.2862 1
Brugia malayi Erv1 / Alr family protein 0.0012 0.008 0.0092
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0384 0.1091
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.1947 0.223
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0384 0.5
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0871 0.3043
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0384 0.1091
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0128 0.0448
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0871 0.3043
Brugia malayi intermediate filament protein 0.0026 0.0744 0.0852
Schistosoma mansoni hypothetical protein 0.0015 0.025 0.1283
Echinococcus multilocularis GPCR, family 2 0.0015 0.025 0.0873
Brugia malayi quiescin Q6 0.0012 0.008 0.0092
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1947 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.025 0.0873
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1753 0.2007
Echinococcus granulosus lamin 0.0026 0.0744 0.2598
Loa Loa (eye worm) hypothetical protein 0.0049 0.1753 0.2007
Loa Loa (eye worm) hypothetical protein 0.0015 0.025 0.0286
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0871 0.4472
Loa Loa (eye worm) Erv1/Alr family protein 0.0012 0.008 0.0092
Schistosoma mansoni lamin 0.0026 0.0744 0.3819
Plasmodium vivax SET domain protein, putative 0.0029 0.0871 0.2842
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0073 0.2862 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0744 0.0852
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.025 0.0873
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.025 0.0873
Schistosoma mansoni hypothetical protein 0.0015 0.025 0.1283
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.025 0.0286
Loa Loa (eye worm) hypothetical protein 0.0029 0.0871 0.0997
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0822 0.2874
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0384 0.5
Echinococcus granulosus intermediate filament protein 0.0026 0.0744 0.2598
Loa Loa (eye worm) hypothetical protein 0.0012 0.0106 0.0122
Echinococcus granulosus lamin dm0 0.0026 0.0744 0.2598
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0744 0.0852
Loa Loa (eye worm) hypothetical protein 0.0013 0.0128 0.0147
Loa Loa (eye worm) hepatopoietin HPO2 0.0073 0.2862 0.3277
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0073 0.2862 1
Toxoplasma gondii Erv1 / Alr family protein 0.0073 0.2862 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1753 0.2007
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.8732 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0384 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1753 0.2007
Echinococcus multilocularis lamin 0.0026 0.0744 0.2598
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0191 0.0219
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0128 0.0448
Echinococcus multilocularis musashi 0.0026 0.0744 0.2598
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.1947 0.6804
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0073 0.2862 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0871 0.4472
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1947 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.1947 0.223
Loa Loa (eye worm) hypothetical protein 0.0033 0.1057 0.1211
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0384 0.5
Brugia malayi Augmenter of liver regeneration 0.0073 0.2862 0.3277
Trichomonas vaginalis set domain proteins, putative 0.0232 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0384 0.1341
Echinococcus multilocularis sulfhydryl oxidase 1 0.0012 0.008 0.028
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.1947 0.6804
Loa Loa (eye worm) hypothetical protein 0.0012 0.008 0.0092
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1947 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.1947 0.6804
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0384 0.1091
Leishmania major hypothetical protein, conserved 0.0073 0.2862 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0384 0.5
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0871 0.2842
Brugia malayi Pre-SET motif family protein 0.0029 0.0871 0.0997
Schistosoma mansoni hypothetical protein 0.0033 0.1057 0.5429
Schistosoma mansoni ap endonuclease 0.0018 0.0384 0.197
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0384 0.5
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0073 0.2862 1
Echinococcus multilocularis lamin dm0 0.0026 0.0744 0.2598
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0384 0.0439
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0073 0.2862 1
Toxoplasma gondii exonuclease III APE 0.0018 0.0384 0.1091
Onchocerca volvulus 0.0026 0.0744 0.0744
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0384 0.1091
Onchocerca volvulus Sulfhydryl oxidase homolog 0.0012 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0106 0.0122
Schistosoma mansoni hypothetical protein 0.0015 0.025 0.1283
Onchocerca volvulus 0.0026 0.0744 0.0744
Loa Loa (eye worm) quiescin Q6 0.0012 0.008 0.0092
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0744 0.0852
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.1947 0.6804
Loa Loa (eye worm) hypothetical protein 0.0012 0.008 0.0092
Schistosoma mansoni quiescin q6-related sulfhydryl oxidase 0.0012 0.008 0.0411
Loa Loa (eye worm) hypothetical protein 0.0026 0.0722 0.0827
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0073 0.2862 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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