TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 473.542 | Formula: C23H27N3O6S
H donors: 2 H acceptors: 4 LogP: 2.99 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: CCOC(=O)c1c(NC(=O)NC(C(=O)OC)Cc2ccccc2)sc2c1CCN(C2)C(=O)C
InChi: 1S/C23H27N3O6S/c1-4-32-22(29)19-16-10-11-26(14(2)27)13-18(16)33-20(19)25-23(30)24-17(21(28)31-3)12-15-8-6-5-7-9-15/h5-9,17H,4,10-13H2,1-3H3,(H2,24,25,30)
InChiKey: VYIARGVYAVKIQJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	myo-inositol transporter, putative	0.0045	0.0278	0.0183
Trypanosoma cruzi	hexose transporter, putative	0.01	0.0921	1
Brugia malayi	Major Facilitator Superfamily protein	0.0045	0.0278	0.0345
Plasmodium falciparum	lysine--tRNA ligase	0.0046	0.0283	0.0006
Echinococcus multilocularis	General substrate transporter	0.0276	0.3007	0.842
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0072	0.0589	0.4835
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Echinococcus granulosus	solute carrier family 22	0.0045	0.0278	0.0345
Plasmodium falciparum	proline--tRNA ligase	0.0072	0.0589	0.032
Trichomonas vaginalis	glucose transporter, putative	0.0045	0.0278	0.0183
Toxoplasma gondii	facilitative glucose transporter GT1	0.0321	0.3541	0.5185
Schistosoma mansoni	sugar transporter	0.0045	0.0278	0.0345
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0063	0.0484	0.1264
Brugia malayi	Major Facilitator Superfamily protein	0.0045	0.0278	0.0345
Trichomonas vaginalis	sugar transporter, putative	0.01	0.0921	0.212
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0045	0.0278	1
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0868	1	1
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0046	0.0283	0.02
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0046	0.0283	0.0085
Toxoplasma gondii	lysine-tRNA ligase	0.0046	0.0283	0.0009
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0061	0.0469	0.0758
Echinococcus granulosus	lysyl tRNA synthetase	0.0046	0.0283	0.0362
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0321	0.3541	1
Trypanosoma brucei	glucose transporter, putative	0.01	0.0921	1
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Brugia malayi	hypothetical protein	0.0045	0.0278	0.0345
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0045	0.0278	0.5
Plasmodium falciparum	mitogen-activated protein kinase 2	0.033	0.3649	0.3467
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0072	0.0589	0.4835
Mycobacterium ulcerans	integral membrane transport protein	0.0045	0.0278	0.9806
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0278	0.0675
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Trichomonas vaginalis	sugar transporter, putative	0.01	0.0921	0.212
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0278	0.0183
Onchocerca volvulus		0.0045	0.0278	0.5
Onchocerca volvulus		0.0045	0.0278	0.5
Entamoeba histolytica	hypothetical protein	0.0046	0.0283	0.3786
Echinococcus granulosus	synaptic vesicle 2 protein	0.0045	0.0278	0.0345
Onchocerca volvulus		0.0045	0.0278	0.5
Echinococcus multilocularis	solute carrier family 22	0.0045	0.0278	0.0345
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0278	0.0183
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0045	0.0278	0.9806
Loa Loa (eye worm)	sugar transporter	0.0045	0.0278	0.0675
Onchocerca volvulus		0.0045	0.0278	0.5
Plasmodium vivax	hexose transporter	0.0321	0.3541	0.3356
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0063	0.0484	0.0212
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Schistosoma mansoni	glucose transporter	0.0045	0.0278	0.0345
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Trypanosoma cruzi	hexose transporter	0.01	0.0921	1
Echinococcus multilocularis	solute carrier family 22	0.0045	0.0278	0.0345
Leishmania major	lysyl-tRNA synthetase, putative	0.0046	0.0283	0.0085
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0063	0.0484	0.0955
Trichomonas vaginalis	conserved hypothetical protein	0.01	0.0921	0.212
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0063	0.0484	0.0328
Trypanosoma cruzi	hexose transporter, putative	0.01	0.0921	1
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0063	0.0484	0.0212
Treponema pallidum	prolyl-tRNA synthetase	0.0022	0	0.5
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0321	0.3541	1
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0072	0.0589	0.4835
Trypanosoma cruzi	hexose transporter, putative	0.0054	0.0388	0.1706
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0063	0.0484	0.0212
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0063	0.0484	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0278	0.0675
Loa Loa (eye worm)	hypothetical protein	0.005	0.0333	0.0833
Onchocerca volvulus		0.0045	0.0278	0.5
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0061	0.0469	0.0911
Schistosoma mansoni	protein kinase	0.0063	0.0484	0.0955
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0061	0.0469	0.9536
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0045	0.0278	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0278	0.0675
Giardia lamblia	Lysyl-tRNA synthetase	0.0046	0.0283	0.0288
Trichomonas vaginalis	glucose transporter, putative	0.01	0.0921	0.212
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0278	0.0675
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0063	0.0484	0.0328
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0278	0.0183
Onchocerca volvulus	Putative transporter	0.0045	0.0278	0.5
Giardia lamblia	Prolyl-tRNA synthetase	0.0061	0.0469	1
Brugia malayi	major facilitator superfamily protein	0.0045	0.0278	0.0345
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Trypanosoma brucei	glucose transporter 2A	0.01	0.0921	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0278	0.0675
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0063	0.0484	0.0212
Brugia malayi	Major Facilitator Superfamily protein	0.0045	0.0278	0.0345
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0045	0.0278	0.0345
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0046	0.0283	1
Schistosoma mansoni	sugar transporter	0.0045	0.0278	0.0345
Leishmania major	glucose transporter, lmgt1	0.01	0.0921	1
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0278	0.0675
Schistosoma mansoni	protein kinase	0.0063	0.0484	0.0955
Onchocerca volvulus		0.0045	0.0278	0.5
Echinococcus multilocularis	solute carrier family 22	0.0045	0.0278	0.0345
Trypanosoma brucei	THT1 - hexose transporter, putative	0.01	0.0921	1
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0061	0.0469	0.0911
Trypanosoma brucei	THT1 - hexose transporter, putative	0.01	0.0921	1
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0278	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0278	0.0675
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0072	0.0589	0.4835
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Schistosoma mansoni	sugar transporter	0.0045	0.0278	0.0345
Brugia malayi	hypothetical protein	0.0045	0.0278	0.0345
Schistosoma mansoni	lysyl-tRNA synthetase	0.0046	0.0283	0.0362
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0063	0.0484	0.0955
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0278	0.0675
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0045	0.0278	0.9806
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Schistosoma mansoni	sugar transporter	0.0045	0.0278	0.0345
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0045	0.0278	0.0345
Brugia malayi	Sugar transporter family protein	0.0045	0.0278	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0469	0.1221
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Onchocerca volvulus		0.0045	0.0278	0.5
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0063	0.0484	0.0212
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0046	0.0283	1
Brugia malayi	Cam kinase protein 1	0.0063	0.0484	0.0955
Schistosoma mansoni	glucose transport protein	0.0321	0.3541	1
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0063	0.0484	0.0212
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0063	0.0484	0.0955
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0321	0.3541	1
Echinococcus granulosus	calcium dependent protein kinase	0.0059	0.0438	0.082
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0278	0.0675
Echinococcus granulosus	solute carrier family 22	0.0045	0.0278	0.0345
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0321	0.3541	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0045	0.0278	0.0675
Trypanosoma brucei	glucose transporter, putative	0.01	0.0921	1
Echinococcus granulosus	solute carrier family 22	0.0045	0.0278	0.0345
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0046	0.0283	0.3046
Chlamydia trachomatis	lysine--tRNA ligase	0.0046	0.0283	1
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Onchocerca volvulus		0.0045	0.0278	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Trypanosoma cruzi	hexose transporter, putative	0.01	0.0921	1
Trichomonas vaginalis	conserved hypothetical protein	0.0321	0.3541	1
Trichomonas vaginalis	CAMK family protein kinase	0.0063	0.0484	0.0803
Schistosoma mansoni	hypothetical protein	0.0321	0.3541	1
Schistosoma mansoni	glucose transport protein	0.0321	0.3541	1
Trypanosoma brucei	THT1 - hexose transporter, putative	0.01	0.0921	1
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Onchocerca volvulus		0.0045	0.0278	0.5
Onchocerca volvulus		0.0045	0.0278	0.5
Echinococcus granulosus	General substrate transporter	0.0276	0.3007	0.842
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0321	0.3541	1
Toxoplasma gondii	protein kinase, putative	0.0578	0.6571	1
Leishmania major	glucose transporter/membrane transporter D2, putative	0.01	0.0921	1
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Plasmodium vivax	proline--tRNA ligase, putative	0.0072	0.0589	0.032
Leishmania major	glucose transporter, lmgt2	0.01	0.0921	1
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.033	0.3649	0.5356
Echinococcus granulosus	solute carrier family 22	0.0045	0.0278	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0484	0.1264
Trypanosoma brucei	glucose transporter, putative	0.01	0.0921	1
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0045	0.0278	0.0345
Schistosoma mansoni	serine/threonine protein kinase	0.0063	0.0484	0.0955
Plasmodium falciparum	protein kinase 7	0.0578	0.6571	0.6473
Schistosoma mansoni	protein kinase	0.0063	0.0484	0.0955
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0063	0.0484	0.0955
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0321	0.3541	1
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0063	0.0484	0.0328
Onchocerca volvulus		0.0045	0.0278	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0278	0.0675
Trichomonas vaginalis	conserved hypothetical protein	0.0045	0.0278	0.0183
Brugia malayi	lysyl-tRNA synthetase	0.0046	0.0283	0.0362
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Entamoeba histolytica	protein kinase, putative	0.0063	0.0484	1
Onchocerca volvulus		0.0045	0.0278	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Trichomonas vaginalis	conserved hypothetical protein	0.01	0.0921	0.212
Entamoeba histolytica	protein kinase, putative	0.0063	0.0484	1
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0045	0.0278	0.0675
Brugia malayi	Sugar transporter family protein	0.0045	0.0278	0.0345
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0063	0.0484	0.0212
Brugia malayi	major facilitator superfamily protein	0.0045	0.0278	0.0345
Loa Loa (eye worm)	sugar transporter	0.0321	0.3541	1
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0045	0.0278	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0278	0.0675
Onchocerca volvulus		0.0045	0.0278	0.5
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0072	0.0589	0.4835
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0061	0.0469	0.0911
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0063	0.0484	0.0955
Trypanosoma brucei	glucose transporter, putative	0.01	0.0921	1
Trichomonas vaginalis	sugar transporter, putative	0.01	0.0921	0.212
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Onchocerca volvulus		0.0045	0.0278	0.5
Trypanosoma brucei	glucose transporter, putative	0.01	0.0921	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0283	0.0691
Plasmodium falciparum	hexose transporter	0.0321	0.3541	0.3356
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.033	0.3649	0.3467
Schistosoma mansoni	glucose transport protein	0.0321	0.3541	1
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0063	0.0484	0.0955
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Brugia malayi	hypothetical protein	0.0045	0.0278	0.0345
Echinococcus multilocularis	solute carrier family 22	0.0045	0.0278	0.0345
Echinococcus multilocularis	calcium dependent protein kinase	0.0059	0.0438	0.082
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0278	0.0675
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0046	0.0283	0.0085
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0063	0.0484	0.1264
Onchocerca volvulus		0.0045	0.0278	0.5
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0278	0.0675
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0321	0.3541	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0321	0.3541	1
Leishmania major	glucose transporter, lmgt3	0.01	0.0921	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0469	0.1221
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0061	0.0469	0.0911
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0278	0.0675
Trypanosoma brucei	glucose transporter, putative	0.01	0.0921	1
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0061	0.0469	1
Trypanosoma brucei	glucose transporter, putative	0.01	0.0921	1
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0072	0.0589	0.0495
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0061	0.0469	0.0911
Echinococcus multilocularis	lysyl tRNA synthetase	0.0046	0.0283	0.0362
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0061	0.0469	0.0911
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0063	0.0484	0.0955
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0063	0.0484	0.0955
Plasmodium vivax	lysine--tRNA ligase, putative	0.0046	0.0283	0.0006
Trichomonas vaginalis	glucose transporter, putative	0.01	0.0921	0.212
Schistosoma mansoni	lysyl-tRNA synthetase	0.0046	0.0283	0.0362
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0278	0.0675
Trypanosoma brucei	glucose transporter, putative	0.01	0.0921	1
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0063	0.0484	0.0212
Trichomonas vaginalis	sugar transporter, putative	0.0045	0.0278	0.0183
Trypanosoma brucei	glucose transporter 1E	0.01	0.0921	1
Leishmania major	protein kinase, putative	0.0063	0.0484	0.3202
Onchocerca volvulus		0.0045	0.0278	0.5
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0063	0.0484	0.3202
Mycobacterium ulcerans	sugar transporter	0.0045	0.0278	0.9806
Trichomonas vaginalis	sugar transport protein, putative	0.0045	0.0278	0.0183
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0063	0.0484	0.0955
Brugia malayi	Sugar transporter family protein	0.0321	0.3541	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.9 uM	Evaluated for its ability to inhibit LPS stimulated production of TNF-alpha in rat whole blood	ChEMBL.	12113803
Inhibition (functional)	= 8.2 %	TNF-alpha inhibiting activity by in vivo inhibition of serum TNF production in rat at 50mg/kg, per oral administration.	ChEMBL.	12113803

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL54441

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 80744