Detailed information for compound 807531

Basic information

Technical information
  • TDR Targets ID: 807531
  • Name: (5E)-5-[[3-[2-(3-methoxyphenoxy)ethoxy]phenyl ]methylidene]-2-sulfanylidene-1,3-thiazolidin -4-one
  • MW: 387.473 | Formula: C19H17NO4S2
  • H donors: 1 H acceptors: 1 LogP: 4.4 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)OCCOc1cccc(c1)/C=C\1/SC(=S)NC1=O
  • InChi: 1S/C19H17NO4S2/c1-22-14-5-3-7-16(12-14)24-9-8-23-15-6-2-4-13(10-15)11-17-18(21)20-19(25)26-17/h2-7,10-12H,8-9H2,1H3,(H,20,21,25)/b17-11+
  • InChiKey: ANDCOMOYJGXFSD-GZTJUZNOSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (5E)-5-[[3-[2-(3-methoxyphenoxy)ethoxy]phenyl]methylene]-2-thioxo-thiazolidin-4-one
  • (5E)-5-[[3-[2-(3-methoxyphenoxy)ethoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone
  • (5E)-5-[3-[2-(3-methoxyphenoxy)ethoxy]benzylidene]-2-thioxo-thiazolidin-4-one
  • AIDS-345503
  • AIDS345503
  • BIM-0009965.P001
  • ZINC02961441
  • 4-Thiazolidinone, 5-[[3-[2-(3-methoxyphenoxy)ethoxy]phenyl]methylene]-2-thioxo-, (5E)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans glutaminase 0.0297 0.3511 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0051 0.0093
Plasmodium vivax macrophage migration inhibitory factor, putative 0.0347 0.4143 0.5
Leishmania major macrophage migration inhibitory factor-like protein 0.0347 0.4143 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.5
Trichomonas vaginalis macrophage migration inhibitory factor, mif, putative 0.0347 0.4143 1
Trichomonas vaginalis conserved hypothetical protein 0.0347 0.4143 1
Schistosoma mansoni intermediate filament proteins 0.0029 0.017 0.0343
Echinococcus multilocularis survival motor neuron protein 1 0.0242 0.283 0.2793
Echinococcus granulosus geminin 0.0171 0.1935 0.6778
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.017 0.031
Loa Loa (eye worm) macrophage migration inhibitory factor 0.0347 0.4143 0.7571
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0051 0.0093
Schistosoma mansoni hypothetical protein 0.0171 0.1935 0.5444
Trypanosoma brucei unspecified product 0.002 0.0051 0.5
Echinococcus multilocularis Protein lozenge 0.0057 0.0515 0.0466
Loa Loa (eye worm) runx1 0.0057 0.0515 0.0941
Echinococcus multilocularis musashi 0.0029 0.017 0.0119
Schistosoma mansoni glutaminase 0.0297 0.3511 1
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0051 0.5
Trichomonas vaginalis glutaminase, putative 0.0297 0.3511 0.8456
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0148 0.1655 0.3024
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.5
Onchocerca volvulus 0.0049 0.0421 0.0474
Schistosoma mansoni lozenge 0.0057 0.0515 0.1341
Schistosoma mansoni lamin 0.0029 0.017 0.0343
Echinococcus granulosus intermediate filament protein 0.0029 0.017 0.0427
Leishmania major macrophage migration inhibitory factor-like protein 0.0347 0.4143 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.5
Schistosoma mansoni hypothetical protein 0.0171 0.1935 0.5444
Echinococcus multilocularis lamin dm0 0.0029 0.017 0.0119
Schistosoma mansoni survival motor neuron protein 0.0049 0.0421 0.107
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.5
Brugia malayi Bm-MIF-1, identical 0.0347 0.4143 0.7571
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0051 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.5
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0051 0.5
Entamoeba histolytica macrophage migration inhibitory factor-like protein 0.0347 0.4143 1
Loa Loa (eye worm) glutaminase 0.0297 0.3511 0.6416
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0051 0.5
Brugia malayi hypothetical protein 0.0454 0.5472 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0051 0.5
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0051 0.5
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0051 0.5
Loa Loa (eye worm) hypothetical protein 0.0454 0.5472 1
Echinococcus granulosus lamin 0.0029 0.017 0.0427
Loa Loa (eye worm) hypothetical protein 0.0454 0.5472 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.5
Brugia malayi glutaminase DH11.1 0.0297 0.3511 0.6416
Echinococcus multilocularis lamin 0.0029 0.017 0.0119
Schistosoma mansoni hypothetical protein 0.0049 0.0421 0.107
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0051 0.0093
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0051 0.5
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0051 0.5
Giardia lamblia Macrophage migration inhibitory factor 0.0347 0.4143 1
Onchocerca volvulus 0.0454 0.5472 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0051 0.5
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0051 0.5
Loa Loa (eye worm) hypothetical protein 0.0242 0.283 0.5172
Echinococcus granulosus lamin dm0 0.0029 0.017 0.0427
Schistosoma mansoni lamin 0.0029 0.017 0.0343
Brugia malayi hypothetical protein 0.0242 0.283 0.5172
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.5
Echinococcus multilocularis geminin 0.0171 0.1935 0.1893
Plasmodium falciparum macrophage migration inhibitory factor 0.0347 0.4143 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.017 0.031
Loa Loa (eye worm) macrophage migration inhibitory factor 2 0.0148 0.1655 0.3024
Brugia malayi intermediate filament protein 0.0029 0.017 0.031
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0051 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0051 0.5
Loa Loa (eye worm) intermediate filament protein 0.0029 0.017 0.031
Echinococcus granulosus survival motor neuron protein 1 0.0242 0.283 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0163 0.0298
Loa Loa (eye worm) glutaminase 2 0.0297 0.3511 0.6416
Toxoplasma gondii macrophage migration inhibitory factor, putative 0.0347 0.4143 0.5
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.017 0.031
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0421 0.077

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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