Detailed information for compound 809885

Basic information

Technical information
  • TDR Targets ID: 809885
  • Name: 4-ethoxy-N-(2,4,6-trimethylphenyl)benzenesulf onamide
  • MW: 319.419 | Formula: C17H21NO3S
  • H donors: 1 H acceptors: 2 LogP: 3.88 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)S(=O)(=O)Nc1c(C)cc(cc1C)C
  • InChi: 1S/C17H21NO3S/c1-5-21-15-6-8-16(9-7-15)22(19,20)18-17-13(3)10-12(2)11-14(17)4/h6-11,18H,5H2,1-4H3
  • InChiKey: ZTDNJZBUTWTQEW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • CBMicro_008219
  • ZINC00380174
  • T5881435
  • 4-Ethoxy-N-(2,4,6-trimethyl-phenyl)-benzenesulfonamide
  • BAS 02105671
  • BIM-0008077.P001
  • AG-690/15438020

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0132 0.1134
Wolbachia endosymbiont of Brugia malayi phospho-N-acetylmuramoyl-pentapeptide-transferase 0.2848 1 0.5
Leishmania major importin beta-1 subunit, putative 0.0023 0.0052 0.0702
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0132 0.1134
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0026 0.0663
Echinococcus multilocularis UDP N acetylglucosamine dolichyl phosphate 0.012 0.0393 0.3367
Plasmodium falciparum UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.012 0.0393 1
Brugia malayi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.012 0.0393 1
Plasmodium vivax importin-beta 2, putative 0.0028 0.007 0.1207
Schistosoma mansoni ran 0.0021 0.0045 0.0381
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0132 0.13
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0045 0.0502
Echinococcus granulosus UDP N acetylglucosamine dolichyl phosphate 0.012 0.0393 0.3367
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.007 0.1207
Schistosoma mansoni hypothetical protein 0.0297 0.1019 0.8726
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0045 0.0437
Loa Loa (eye worm) hypothetical protein 0.0028 0.007 0.0691
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.012 0.0393 0.3367
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0045 0.1132
Echinococcus multilocularis snurportin 1 0.0297 0.1019 0.8726
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0132 0.1134
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0052 0.0211
Leishmania major GTP-binding protein, putative 0.0021 0.0045 0.0502
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0045 0.0502
Echinococcus granulosus geminin 0.034 0.1168 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0297 0.1019 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0026 0.0256
Brugia malayi RNA, U transporter 1 0.0079 0.0251 0.6388
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0045 0.0502
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0045 0.0502
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.0378 0.3712
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0026 0.0223
Trichomonas vaginalis glucosaminephosphotransferase, putative 0.012 0.0393 1
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.012 0.0393 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0026 0.0223
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0132 0.3369
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0026 0.0223
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0052 0.0211
Loa Loa (eye worm) hypothetical protein 0.012 0.0393 0.3858
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.0378 0.3712
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0052 0.0211
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0045 0.0381
Echinococcus granulosus importin subunit beta 1 0.0028 0.007 0.0603
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0026 0.0223
Entamoeba histolytica UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.012 0.0393 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0132 0.1134
Mycobacterium tuberculosis Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.2848 1 1
Echinococcus multilocularis importin subunit beta 1 0.0028 0.007 0.0603
Treponema pallidum phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) 0.1083 0.3784 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0132 0.1134
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0132 0.1134
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0045 0.0502
Toxoplasma gondii glycosyl transferase, group 4 family protein 0.012 0.0393 1
Schistosoma mansoni hypothetical protein 0.034 0.1168 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.007 0.1207
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.012 0.0393 1
Leishmania major UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.012 0.0393 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0045 0.0381
Chlamydia trachomatis phospho-N-acetylmuramoyl-pentapeptide-transferase 0.1083 0.3784 0.5
Mycobacterium ulcerans phospho-N-acetylmuramoyl-pentapeptide-transferase 0.2848 1 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0052 0.0702
Schistosoma mansoni hypothetical protein 0.034 0.1168 1
Schistosoma mansoni ran 0.0021 0.0045 0.0381
Brugia malayi isocitrate dehydrogenase 0.0015 0.0026 0.0663
Brugia malayi MH2 domain containing protein 0.0115 0.0378 0.9621
Plasmodium falciparum importin beta, putative 0.0028 0.007 0.1207
Entamoeba histolytica hypothetical protein 0.0023 0.0052 0.0211
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0045 0.0502
Echinococcus multilocularis geminin 0.034 0.1168 1
Giardia lamblia UDP-N-acetylglucosamine-dolichyl-phosphateN-acetylglucosaminephosphotransferase 0.012 0.0393 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.007 0.1207
Plasmodium vivax N-acetylglucosamine-1-phosphate transferase, putative 0.012 0.0393 1
Schistosoma mansoni importin beta-1 0.0028 0.007 0.0603
Echinococcus granulosus snurportin 1 0.0297 0.1019 0.8726
Onchocerca volvulus 0.012 0.0393 0.5
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0026 0.0223
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.012 0.0393 0.3367
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0132 0.1134
Trypanosoma brucei UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.012 0.0393 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0026 0.0223
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0026 0.0223
Brugia malayi Importin beta-1 subunit 0.0028 0.007 0.179

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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