Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.01 | 0.035 |
Schistosoma mansoni | protein kinase | 0.1064 | 1 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.01 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.01 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.01 | 0.01 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.01 | 1 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.1064 | 1 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.01 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.01 | 0.01 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.01 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.01 | 0.01 |
Onchocerca volvulus | 0.0035 | 0.01 | 0.5 | |
Brugia malayi | beta-lactamase | 0.0035 | 0.01 | 0.01 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.01 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1063 | 0.9985 | 1 |
Onchocerca volvulus | 0.0035 | 0.01 | 0.5 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0229 | 0.0229 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.01 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.01 | 0.01 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.01 | 0.035 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.01 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.01 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0321 | 0.2847 | 0.2852 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0229 | 0.0229 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.01 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.01 | 0.01 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.01 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.01 | 0.01 |
Schistosoma mansoni | protein kinase | 0.1064 | 1 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0322 | 0.2863 | 1 |
Loa Loa (eye worm) | STE/STE11/ASK protein kinase | 0.0322 | 0.2863 | 0.2867 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.1064 | 1 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.01 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0229 | 0.0229 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.01 | 0.0018 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.01 | 0.01 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0024 | 0 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.01 | 0.01 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.01 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0082 | 0.0082 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0322 | 0.2863 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.01 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.01 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0229 | 0.0229 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0082 | 0.0083 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.01 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.01 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0222 | 0.1903 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.01 | 0.01 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.01 | 0.01 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.01 | 1 |
Onchocerca volvulus | 0.0035 | 0.01 | 0.5 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.01 | 0.0018 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.