TDR Targets

Basic information

Technical information

TDR Targets ID: 816675
Name: 2,6-dimethoxy-N-naphthalen-2-ylbenzamide
MW: 307.343 | Formula: C19H17NO3
H donors: 1 H acceptors: 1 LogP: 3.95 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1cccc(c1C(=O)Nc1ccc2c(c1)cccc2)OC
InChi: 1S/C19H17NO3/c1-22-16-8-5-9-17(23-2)18(16)19(21)20-15-11-10-13-6-3-4-7-14(13)12-15/h3-12H,1-2H3,(H,20,21)
InChiKey: MAMDIGJDVOXEBX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2,6-dimethoxy-N-(2-naphthyl)benzamide
2,6-dimethoxy-N-naphthalen-2-yl-benzamide
BIM-0009751.P001
ZINC00341287
Oprea1_493063
CBMicro_009892
AG-670/11899291

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	serine:threonine protein kinase:endoribonuclease	0.0206	0.2808	0.2772
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0367	0.1149
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0207	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0044	0.0312
Schistosoma mansoni	cpg binding protein	0.0032	0.0391	0.0382
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0007	0.0051	0.0546
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0007	0.0051	0.0546
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0044	0.0312
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0294	1
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0294	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0044	0.0312
Brugia malayi	RNA binding protein	0.0062	0.081	0.2753
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0051	0.0546
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0571	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0207	0.0568
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0294	1
Trichomonas vaginalis	serine threonine-protein kinase, putative	0.0105	0.1406	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0019	0.0207	0.5
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0294	0.0884
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0044	0.0312
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0007	0.0051	0.0546
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0294	0.0884
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0044	0.0312
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0044	0.0312
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0294	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0193	0.6071
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0007	0.0051	0.0546
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0207	0.0568
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0044	0.0312
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0044	0.0312
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0571	0.1885
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0057	0.0742	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0294	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0044	0.0312
Schistosoma mansoni	cpg binding protein	0.0032	0.0391	0.0382
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0077	0.0096
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0051	0.0359
Schistosoma mansoni	acetyl-CoA synthetase	0.0007	0.0051	0.0041
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0053	0.0044
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0079	0.0028
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0044	0.0312
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0571	0.0523
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0207	0.0568
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.081	0.0763
Echinococcus multilocularis	microtubule associated protein 2	0.0724	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0106	0.1415	0.1407
Echinococcus granulosus	cpg binding protein	0.0032	0.0391	0.0342
Trypanosoma brucei	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0051	0.5
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0044	0.0312
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0051	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0294	0.0884
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0207	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0079	0.0028
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0571	0.0562
Trichomonas vaginalis	helicase, putative	0.0007	0.0044	0.0312
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0019	0.0207	0.6421
Brugia malayi	Ribonuclease 2-5A family protein	0.0206	0.2808	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.081	0.0801
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0053	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0294	0.0884
Echinococcus granulosus	tar DNA binding protein	0.0062	0.081	0.0763
Onchocerca volvulus		0.0025	0.0294	0.7697
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0053	0.0003
Echinococcus multilocularis	cpg binding protein	0.0032	0.0391	0.0342
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0007	0.0051	0.0546
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0044	0.0312
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0044	0.0312
Echinococcus granulosus	dnaJ subfamily B	0.0429	0.5907	0.5886
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.081	0.0801
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.081	0.0801
Brugia malayi	TAR-binding protein	0.0062	0.081	0.2753
Entamoeba histolytica	protein kinase, putative	0.0206	0.2808	1
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.0051	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0294	0.0884
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0294	1
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0007	0.0051	0.5
Trypanosoma cruzi	long-chain-fatty-acid-CoA ligase, putative	0.0007	0.0051	0.5
Loa Loa (eye worm)	IRE protein kinase	0.0206	0.2808	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0207	0.0568
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0294	0.0884
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0064	0.0836	0.0828
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.081	0.0801
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0007	0.0051	0.0546
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.081	0.2753
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0193	0.6071
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0207	0.0568
Trypanosoma brucei	acetyl-CoA synthetase, putative	0.0007	0.0051	0.5
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0193	0.6071
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0294	0.0884
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0294	0.0884
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0018	0.0193	0.6071
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0044	0.0312
Schistosoma mansoni	microtubule-associated protein tau	0.0724	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0294	1
Echinococcus multilocularis	serine:threonine protein kinase:endoribonuclease	0.0206	0.2808	0.2772
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0051	0.0546
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0571	0.0562
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.081	0.2753
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0294	1
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0053	0.0003
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0294	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0571	0.0523
Trichomonas vaginalis	conserved hypothetical protein	0.0105	0.1406	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0044	0.0312
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0079	0.0102
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0044	0.0312
Schistosoma mansoni	cpg binding protein	0.003	0.0367	0.0359
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0044	0.0312
Schistosoma mansoni	hypothetical protein	0.0429	0.5907	0.5903
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0294	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0571	0.0523
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0294	1
Loa Loa (eye worm)	RNA binding protein	0.0062	0.081	0.2753
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0571	0.1885
Echinococcus multilocularis	dnaJ subfamily B	0.0429	0.5907	0.5886
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.081	0.2753
Onchocerca volvulus		0.003	0.0367	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0294	1
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0007	0.0051	0.0546
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.081	0.0801
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0294	1
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0053	0.0003
Entamoeba histolytica	protein kinase, putative	0.0206	0.2808	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0207	0.6617
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0051	0.0546
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0571	0.0562
Trypanosoma cruzi	acetyl-CoA synthetase, putative	0.0007	0.0051	0.5
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0294	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0051	0.0546
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0294	0.0884
Brugia malayi	CXXC zinc finger family protein	0.003	0.0367	0.1149
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0294	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 816675