Detailed information for compound 817022

Basic information

Technical information
  • TDR Targets ID: 817022
  • Name: (2E)-2-[(4-methoxyphenyl)methylidene]-1-benzo thiophen-3-one
  • MW: 268.33 | Formula: C16H12O2S
  • H donors: 0 H acceptors: 1 LogP: 4.11 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)/C=C\1/Sc2c(C1=O)cccc2
  • InChi: 1S/C16H12O2S/c1-18-12-8-6-11(7-9-12)10-15-16(17)13-4-2-3-5-14(13)19-15/h2-10H,1H3/b15-10+
  • InChiKey: DTKZJSCQDPXIJP-XNTDXEJSSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2E)-2-[(4-methoxyphenyl)methylene]benzothiophen-3-one
  • (2E)-2-[(4-methoxyphenyl)methylene]-3-benzothiophenone
  • (2E)-2-(4-methoxybenzylidene)benzothiophen-3-one
  • 5376-36-3
  • BIM-0007544.P001
  • ZINC00126468

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major glucose transporter, lmgt1 0.0031 0.0345 0.6871
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.003 0.0335 0.6561
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0044 0.0664 0.0804
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0044 0.0664 0.0804
Schistosoma mansoni hypothetical protein 0.0099 0.2038 0.2879
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Schistosoma mansoni gliotactin 0.0049 0.0795 0.1002
Schistosoma mansoni glucose transport protein 0.0099 0.2038 0.2879
Echinococcus multilocularis sex peptide receptor 0.0044 0.0664 0.0804
Plasmodium falciparum calcium-dependent protein kinase 2 0.003 0.0336 0.0207
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0664 0.0804
Schistosoma mansoni neuropeptide receptor 0.0044 0.0664 0.0804
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0044 0.0664 0.0804
Echinococcus granulosus neuropeptides capa receptor 0.0044 0.0664 0.0804
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0099 0.2038 0.2879
Echinococcus granulosus neuropeptide Y receptor 0.0044 0.0664 0.0804
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.003 0.0335 0.0308
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.003 0.0336 0.032
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0049 0.0795 0.1002
Plasmodium falciparum calcium-dependent protein kinase 4 0.003 0.0336 0.0207
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0044 0.0664 0.0804
Echinococcus multilocularis G protein coupled receptor 139 0.0044 0.0664 0.0804
Brugia malayi Tachykinin-like peptides receptor 99D 0.0044 0.0664 0.0786
Schistosoma mansoni neuropeptide receptor 0.0044 0.0664 0.0804
Schistosoma mansoni glucose transport protein 0.0099 0.2038 0.2879
Echinococcus granulosus allatostatin A receptor 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0049 0.0795 0.1002
Trypanosoma brucei glucose transporter, putative 0.0031 0.0345 0.6871
Echinococcus multilocularis carboxylesterase 5A 0.029 0.6753 1
Echinococcus multilocularis neuropeptide Y receptor 0.0044 0.0664 0.0804
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0345 0.1423
Loa Loa (eye worm) hypothetical protein 0.0233 0.5355 0.7889
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.003 0.0336 0.032
Echinococcus granulosus g protein coupled receptor 0.0044 0.0664 0.0804
Brugia malayi larval opioid receptor 0.0044 0.0664 0.0786
Trichomonas vaginalis spcc417.12 protein, putative 0.0049 0.0795 0.3704
Echinococcus granulosus neuropeptide receptor 0.0044 0.0664 0.0804
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0345 0.7803
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0044 0.0664 0.0804
Brugia malayi Dopamine receptor protein 1 0.0044 0.0664 0.0786
Echinococcus multilocularis g protein coupled receptor 0.0044 0.0664 0.0804
Loa Loa (eye worm) G-protein coupled receptor 0.0044 0.0664 0.0804
Schistosoma mansoni glucose transport protein 0.0099 0.2038 0.2879
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0345 0.1423
Echinococcus granulosus carboxylesterase 5A 0.029 0.6753 1
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0345 0.7803
Brugia malayi Carboxylesterase family protein 0.0049 0.0795 0.0979
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0345 0.6871
Brugia malayi ORL1-like opioid receptor 0.0044 0.0664 0.0786
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0345 0.6871
Onchocerca volvulus 0.0049 0.0795 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.003 0.0336 0.0207
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Brugia malayi Serotonin receptor 0.0044 0.0664 0.0786
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0044 0.0664 0.0786
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.032 0.0285
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Echinococcus granulosus neuropeptide receptor A26 0.0044 0.0664 0.0804
Echinococcus multilocularis neuropeptide FF receptor 2 0.0044 0.0664 0.0804
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.003 0.032 0.0278
Brugia malayi G protein-coupled receptor F59B2.13 0.0044 0.0664 0.0786
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0289 0.0237
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0044 0.0664 0.0804
Entamoeba histolytica protein kinase, putative 0.003 0.0335 1
Echinococcus multilocularis neuropeptides capa receptor 0.0044 0.0664 0.0804
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.003 0.0335 0.0308
Leishmania major protein kinase, putative 0.003 0.0335 0.6561
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0044 0.0664 0.0804
Plasmodium falciparum mitogen-activated protein kinase 2 0.016 0.355 0.3464
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.2038 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0044 0.0664 0.0804
Echinococcus multilocularis acetylcholinesterase 0.029 0.6753 1
Mycobacterium tuberculosis Carboxylesterase LipT 0.0049 0.0795 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Brugia malayi Carboxylesterase family protein 0.029 0.6753 0.9772
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0664 0.0804
Echinococcus multilocularis neuropeptide receptor A26 0.0044 0.0664 0.0804
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0035 0.0442 0.0486
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0099 0.2038 0.2879
Echinococcus granulosus tachykinin peptides receptor 99D 0.0044 0.0664 0.0804
Echinococcus granulosus neuroligin 0.0049 0.0795 0.1002
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0049 0.0795 0.1002
Loa Loa (eye worm) hypothetical protein 0.0049 0.0795 0.1002
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Echinococcus multilocularis neuropeptide receptor 0.0044 0.0664 0.0804
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.003 0.0335 0.0308
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0044 0.0664 0.0804
Echinococcus granulosus orexin receptor type 2 0.0044 0.0664 0.0804
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0442 1
Schistosoma mansoni opsin-like receptor 0.0044 0.0664 0.0804
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0345 0.1423
Echinococcus granulosus G protein coupled receptor 139 0.0044 0.0664 0.0804
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0044 0.0664 0.0804
Echinococcus multilocularis g protein coupled receptor 0.0044 0.0664 0.0804
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.003 0.0335 0.0308
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.003 0.0335 0.0308
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0345 0.1423
Loa Loa (eye worm) hypothetical protein 0.003 0.032 0.0285
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Echinococcus granulosus somatostatin receptor 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0049 0.0795 0.1002
Echinococcus multilocularis allatostatin A receptor 0.0044 0.0664 0.0804
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0044 0.0664 0.0804
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0044 0.0664 0.0804
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Echinococcus granulosus tm gpcr rhodopsin 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0024 0.0182 0.0076
Echinococcus multilocularis serotonin receptor 0.0044 0.0664 0.0804
Onchocerca volvulus 0.0049 0.0795 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0664 0.0804
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0664 0.0804
Echinococcus granulosus serotonin receptor 0.0044 0.0664 0.0804
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0099 0.2038 0.2879
Schistosoma mansoni hypothetical protein 0.0044 0.0664 0.0804
Echinococcus multilocularis serotonin receptor 0.0044 0.0664 0.0804
Echinococcus granulosus biogenic amine 5HT receptor 0.0044 0.0664 0.0804
Plasmodium falciparum calcium-dependent protein kinase 5 0.003 0.0336 0.0207
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0099 0.2038 0.2879
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0664 0.0804
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.003 0.032 0.0285
Schistosoma mansoni amine GPCR 0.0044 0.0664 0.0804
Trypanosoma cruzi hexose transporter 0.0031 0.0345 0.7803
Trichomonas vaginalis CAMK family protein kinase 0.003 0.0335 0.1374
Schistosoma mansoni neuropeptide F-like receptor 0.0044 0.0664 0.0804
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.003 0.032 0.1297
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0044 0.0664 0.0804
Echinococcus multilocularis orexin receptor type 2 0.0044 0.0664 0.0804
Brugia malayi follicle stimulating hormone receptor 0.0044 0.0664 0.0786
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0044 0.0664 0.0804
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.003 0.0335 0.0308
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0044 0.0664 0.0786
Loa Loa (eye worm) carboxylesterase 0.029 0.6753 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0044 0.0664 0.0804
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0044 0.0664 0.0804
Brugia malayi hypothetical protein 0.0044 0.0664 0.0786
Brugia malayi putative neuropeptide receptor 0.0044 0.0664 0.0786
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0049 0.0795 0.3704
Echinococcus granulosus para nitrobenzyl esterase 0.0049 0.0795 0.1002
Trypanosoma brucei glucose transporter 2A 0.0031 0.0345 0.6871
Echinococcus granulosus sex peptide receptor 0.0044 0.0664 0.0804
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0044 0.0664 0.0804
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.003 0.0335 0.0308
Schistosoma mansoni amine GPCR 0.0044 0.0664 0.0804
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0289 0.0237
Schistosoma mansoni neuroligin 3 (S09 family) 0.0049 0.0795 0.1002
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Brugia malayi G-protein coupled receptor 0.0044 0.0664 0.0786
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0044 0.0664 0.0786
Toxoplasma gondii protein kinase, putative 0.028 0.6518 1
Schistosoma mansoni amine GPCR 0.0044 0.0664 0.0804
Echinococcus granulosus tm gpcr rhodopsin 0.0044 0.0664 0.0804
Brugia malayi Carboxylesterase family protein 0.029 0.6753 0.9772
Schistosoma mansoni myosin xvIII 0.0044 0.0664 0.0804
Schistosoma mansoni neuropeptide receptor 0.0044 0.0664 0.0804
Brugia malayi hypothetical protein 0.0044 0.0664 0.0786
Loa Loa (eye worm) G-protein coupled receptor 0.0044 0.0664 0.0804
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.003 0.0335 0.0308
Brugia malayi Sugar transporter family protein 0.0099 0.2038 0.2813
Plasmodium vivax CDK-related protein kinase 6, putative 0.0421 1 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0099 0.2038 0.2879
Schistosoma mansoni acetylcholinesterase 0.0049 0.0795 0.1002
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.003 0.0336 0.032
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Giardia lamblia Prolyl-tRNA synthetase 0.003 0.032 1
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0345 0.1423
Echinococcus granulosus acetylcholinesterase 0.029 0.6753 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0044 0.0664 0.0804
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0664 0.0804
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0345 0.1423
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0044 0.0664 0.0804
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0664 0.0804
Brugia malayi Dopamine receptor 0.0044 0.0664 0.0786
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.003 0.0335 0.0301
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Echinococcus granulosus hypothetical protein 0.0044 0.0664 0.0804
Schistosoma mansoni hypothetical protein 0.0044 0.0664 0.0804
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0044 0.0664 0.0804
Onchocerca volvulus 0.0049 0.0795 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Plasmodium vivax hexose transporter 0.0099 0.2038 0.1932
Mycobacterium ulcerans carboxylesterase, LipT 0.0049 0.0795 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0664 0.0804
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.003 0.032 0.0278
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.003 0.0336 0.0207
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Trypanosoma brucei glucose transporter, putative 0.0031 0.0345 0.6871
Echinococcus granulosus neuropeptide FF receptor 2 0.0044 0.0664 0.0804
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0108 0.2254 0.3206
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.003 0.032 0.0285
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0442 1
Echinococcus multilocularis neuroligin 0.0049 0.0795 0.1002
Schistosoma mansoni protein kinase 0.003 0.0335 0.0308
Trypanosoma brucei glucose transporter, putative 0.0031 0.0345 0.6871
Loa Loa (eye worm) neuropeptide F receptor 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0664 0.0804
Trypanosoma brucei glucose transporter, putative 0.0031 0.0345 0.6871
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0099 0.2038 0.2879
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0044 0.0664 0.0804
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0345 0.7803
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.003 0.0335 0.0308
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0044 0.0664 0.0804
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.003 0.0336 0.0207
Schistosoma mansoni opsin-like receptor 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Echinococcus granulosus neuropeptides capa receptor 0.0044 0.0664 0.0804
Schistosoma mansoni histamine h1 receptor 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0044 0.0664 0.0804
Loa Loa (eye worm) carboxylesterase 0.0049 0.0795 0.1002
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.016 0.355 0.5352
Plasmodium falciparum proline--tRNA ligase 0.0035 0.0442 0.0315
Echinococcus granulosus fmrfamide receptor 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0125 0.2685 0.3855
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0044 0.0664 0.0804
Schistosoma mansoni opsin-like receptor 0.0044 0.0664 0.0804
Schistosoma mansoni alpha-1 adrenergic receptor 0.0044 0.0664 0.0804
Onchocerca volvulus 0.0049 0.0795 1
Echinococcus granulosus acetylcholinesterase 0.029 0.6753 1
Trypanosoma brucei glucose transporter, putative 0.0031 0.0345 0.6871
Echinococcus granulosus biogenic amine 5HT receptor 0.0044 0.0664 0.0804
Trypanosoma brucei glucose transporter, putative 0.0031 0.0345 0.6871
Schistosoma mansoni neuropeptide F-like receptor 0.0044 0.0664 0.0804
Brugia malayi GnHR receptor homolog 0.0044 0.0664 0.0786
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0044 0.0664 0.0786
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0664 0.0804
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Brugia malayi sulfakinin receptor protein 0.0044 0.0664 0.0786
Brugia malayi hypothetical protein 0.0049 0.0795 0.0979
Chlamydia trachomatis lysine--tRNA ligase 0.0022 0.0132 0.5
Echinococcus multilocularis g protein coupled receptor 0.0044 0.0664 0.0804
Brugia malayi hypothetical protein 0.0044 0.0664 0.0786
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0442 1
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0049 0.0795 1
Loa Loa (eye worm) acetylcholinesterase 1 0.029 0.6753 1
Brugia malayi Carboxylesterase family protein 0.0049 0.0795 0.0979
Brugia malayi hypothetical protein 0.0044 0.0664 0.0786
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.003 0.032 1
Echinococcus multilocularis neuropeptide Y receptor 0.0044 0.0664 0.0804
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.032 0.0285
Loa Loa (eye worm) hypothetical protein 0.0049 0.0795 0.1002
Brugia malayi Cam kinase protein 1 0.003 0.0335 0.0301
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.003 0.032 0.0285
Echinococcus multilocularis BC026374 protein (S09 family) 0.0049 0.0795 0.1002
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0044 0.0664 0.0804
Echinococcus multilocularis fmrfamide receptor 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.029 0.6753 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0044 0.0664 0.0804
Plasmodium falciparum calcium-dependent protein kinase 3 0.003 0.0336 0.0207
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0099 0.2038 0.2879
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0664 0.0804
Echinococcus granulosus 7TM GPCR rhodopsin 0.0044 0.0664 0.0804
Schistosoma mansoni biogenic amine (5HT) receptor 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Brugia malayi Dopamine receptor protein 2 0.0044 0.0664 0.0786
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0442 1
Trypanosoma brucei glucose transporter 1E 0.0031 0.0345 0.6871
Brugia malayi Carboxylesterase family protein 0.0049 0.0795 0.0979
Loa Loa (eye worm) hypothetical protein 0.029 0.6753 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Schistosoma mansoni protein kinase 0.003 0.0335 0.0308
Brugia malayi hypothetical protein 0.0044 0.0664 0.0786
Echinococcus multilocularis para nitrobenzyl esterase 0.0049 0.0795 0.1002
Echinococcus multilocularis acetylcholinesterase 0.029 0.6753 1
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0296 0.6908 1
Trypanosoma brucei glucose transporter, putative 0.0031 0.0345 0.6871
Loa Loa (eye worm) carboxylesterase 0.0049 0.0795 0.1002
Loa Loa (eye worm) hypothetical protein 0.0049 0.0795 0.1002
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Leishmania major glucose transporter/membrane transporter D2, putative 0.0031 0.0345 0.6871
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.029 0.6753 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.016 0.355 0.3464
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0044 0.0664 0.0804
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0049 0.0795 0.1002
Loa Loa (eye worm) sugar transporter 0.0099 0.2038 0.2879
Plasmodium falciparum hexose transporter 0.0099 0.2038 0.1932
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0044 0.0664 0.0804
Brugia malayi neuropeptide F receptor 0.0044 0.0664 0.0786
Brugia malayi hypothetical protein 0.0044 0.0664 0.0786
Trypanosoma brucei glucose transporter, putative 0.0031 0.0345 0.6871
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0345 0.1423
Schistosoma mansoni amine GPCR 0.0044 0.0664 0.0804
Echinococcus granulosus dro:myosuppressin receptor 0.0044 0.0664 0.0804
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0044 0.0664 0.0804
Schistosoma mansoni biogenic amine receptor 0.0044 0.0664 0.0804
Plasmodium vivax calcium-dependent protein kinase, putative 0.003 0.0336 0.0207
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0664 0.0804
Brugia malayi putative neuropeptide receptor NPR1 0.0044 0.0664 0.0786
Loa Loa (eye worm) hypothetical protein 0.0063 0.1132 0.1511
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0044 0.0664 0.0804
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0022 0.0132 0.0342
Brugia malayi Carboxylesterase family protein 0.0049 0.0795 0.0979
Schistosoma mansoni neuropeptide f receptor 76f 0.0044 0.0664 0.0804
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0044 0.0664 0.0804
Brugia malayi hypothetical protein 0.0044 0.0664 0.0786
Leishmania major glucose transporter, lmgt3 0.0031 0.0345 0.6871
Schistosoma mansoni protein kinase 0.003 0.0335 0.0308
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0044 0.0664 0.0786
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0664 0.0804
Schistosoma mansoni hypothetical protein 0.0044 0.0664 0.0804
Echinococcus granulosus BC026374 protein S09 family 0.0049 0.0795 0.1002
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0664 0.0804
Plasmodium falciparum protein kinase 7 0.028 0.6518 0.6471
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Loa Loa (eye worm) neuropeptide F receptor 0.0044 0.0664 0.0804
Schistosoma mansoni adenoreceptor 0.0044 0.0664 0.0804
Echinococcus multilocularis dro:myosuppressin receptor 0.0044 0.0664 0.0804
Echinococcus multilocularis somatostatin receptor 0.0044 0.0664 0.0804
Echinococcus granulosus neuropeptide receptor 0.0044 0.0664 0.0804
Brugia malayi G-protein coupled receptor 0.0044 0.0664 0.0786
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Echinococcus granulosus peptide allatostatin:somatostatin 0.0044 0.0664 0.0804
Schistosoma mansoni serine/threonine protein kinase 0.003 0.0335 0.0308
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0022 0.0132 0.3046
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0022 0.0132 0.2979
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0044 0.0664 0.0804
Echinococcus multilocularis rhodopsin orphan GPCR 0.0044 0.0664 0.0804
Brugia malayi AKH receptor 0.0044 0.0664 0.0786
Schistosoma mansoni biogenic amine (5HT) receptor 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Echinococcus multilocularis neuropeptide s receptor 0.0044 0.0664 0.0804
Schistosoma mansoni amine GPCR 0.0044 0.0664 0.0804
Brugia malayi hypothetical protein 0.0044 0.0664 0.0786
Entamoeba histolytica protein kinase, putative 0.003 0.0335 1
Echinococcus granulosus tm gpcr rhodopsin 0.0044 0.0664 0.0804
Echinococcus multilocularis neuropeptide receptor 0.0044 0.0664 0.0804
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.003 0.0335 0.0308
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0442 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0044 0.0664 0.0804
Brugia malayi Serotonin receptor 0.0044 0.0664 0.0786
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0049 0.0795 0.1002
Echinococcus granulosus neuropeptide Y receptor 0.0044 0.0664 0.0804
Brugia malayi Melatonin receptor type 1A 0.0044 0.0664 0.0786
Echinococcus granulosus g-protein coupled receptor 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0664 0.0804
Echinococcus granulosus g protein coupled receptor 0.0044 0.0664 0.0804
Brugia malayi hypothetical protein 0.0044 0.0664 0.0786
Schistosoma mansoni biogenic amine receptor 0.0044 0.0664 0.0804
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0049 0.0795 0.1002
Loa Loa (eye worm) TYRA-2 protein 0.0044 0.0664 0.0804
Schistosoma mansoni BC026374 protein (S09 family) 0.0049 0.0795 0.1002
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0049 0.0795 0.1002
Brugia malayi neuropeptide F receptor 0.0044 0.0664 0.0786
Echinococcus granulosus alpha 1A adrenergic receptor 0.0044 0.0664 0.0804
Echinococcus multilocularis General substrate transporter 0.0085 0.1693 0.2358
Toxoplasma gondii facilitative glucose transporter GT1 0.0099 0.2038 0.2985
Plasmodium falciparum calcium-dependent protein kinase 1 0.003 0.0336 0.0207
Schistosoma mansoni hypothetical protein 0.0044 0.0664 0.0804
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.0345 0.6871
Echinococcus multilocularis neuropeptides capa receptor 0.0044 0.0664 0.0804
Echinococcus multilocularis g-protein coupled receptor 0.0044 0.0664 0.0804
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0044 0.0664 0.0804
Onchocerca volvulus 0.0049 0.0795 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0044 0.0664 0.0804
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0044 0.0664 0.0804
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0049 0.0795 0.1002
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0049 0.0795 1
Echinococcus multilocularis fmrfamide receptor 0.0044 0.0664 0.0804
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0664 0.0804
Echinococcus granulosus neuropeptide s receptor 0.0044 0.0664 0.0804
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.003 0.0335 0.0308
Brugia malayi G protein-coupled receptor 0.0044 0.0664 0.0786
Plasmodium vivax proline--tRNA ligase, putative 0.0035 0.0442 0.0315
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Loa Loa (eye worm) hypothetical protein 0.0044 0.0664 0.0804
Loa Loa (eye worm) melatonin receptor type 1A 0.0044 0.0664 0.0804
Echinococcus granulosus General substrate transporter 0.0085 0.1693 0.2358
Brugia malayi hypothetical protein 0.0044 0.0664 0.0786
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0099 0.2038 0.2879
Schistosoma mansoni biogenic amine receptor 0.0044 0.0664 0.0804
Schistosoma mansoni neuropeptide receptor 0.0044 0.0664 0.0804
Echinococcus granulosus g protein coupled receptor 0.0044 0.0664 0.0804
Leishmania major glucose transporter, lmgt2 0.0031 0.0345 0.6871
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0664 0.0804
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.003 0.032 0.9253
Brugia malayi RE15519p 0.0044 0.0664 0.0786
Echinococcus granulosus rhodopsin orphan GPCR 0.0044 0.0664 0.0804

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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