Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hexokinase type 2 | 0.0889 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0558 | 0.6105 | 0.6084 |
Onchocerca volvulus | Hexokinase homolog | 0.0558 | 0.6105 | 0.6073 |
Schistosoma mansoni | chromobox protein | 0.0081 | 0.0502 | 0.0464 |
Loa Loa (eye worm) | hexokinase | 0.0275 | 0.2781 | 0.2743 |
Brugia malayi | chromobox protein homolog 3 | 0.0046 | 0.0082 | 0.0042 |
Schistosoma mansoni | chromobox protein | 0.0081 | 0.0502 | 0.0464 |
Leishmania major | hexokinase, putative | 0.0889 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0049 | 0.0123 | 0.1553 |
Trypanosoma cruzi | hexokinase, putative | 0.0889 | 1 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0039 | 0 | 0.5 |
Echinococcus multilocularis | chromobox protein 1 | 0.0081 | 0.0502 | 0.0464 |
Trichomonas vaginalis | chromobox protein, putative | 0.0049 | 0.0123 | 0.1553 |
Echinococcus multilocularis | chromobox protein 1 | 0.0081 | 0.0502 | 0.0464 |
Trypanosoma brucei | hexokinase | 0.0889 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.287 | 0.2832 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0043 | 0.0053 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.0379 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0071 | 0.0379 | 0.0328 |
Onchocerca volvulus | 0.0889 | 1 | 1 | |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0071 | 0.0379 | 0.034 |
Brugia malayi | Hexokinase family protein | 0.0889 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0276 | 0.2787 | 0.2758 |
Echinococcus multilocularis | hexokinase type 2 | 0.0889 | 1 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0071 | 0.0379 | 0.034 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0046 | 0.0082 | 0.0647 |
Echinococcus multilocularis | hexokinase | 0.0889 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0889 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.0889 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0889 | 1 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.0208 | 0.0169 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0043 | 0.0053 | 0.0013 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.027 | 0.272 | 0.2682 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.0379 | 0.034 |
Brugia malayi | Hexokinase family protein | 0.0558 | 0.6105 | 0.6089 |
Brugia malayi | Hexokinase family protein | 0.0275 | 0.2781 | 0.2752 |
Entamoeba histolytica | hexokinase 2 | 0.0889 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0889 | 1 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0889 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.2787 | 0.2749 |
Trichomonas vaginalis | chromobox protein, putative | 0.0081 | 0.0502 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.0208 | 0.0169 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0043 | 0.0053 | 0.0013 |
Plasmodium vivax | hexokinase, putative | 0.0889 | 1 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.0081 | 0.0502 | 0.0464 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.0379 | 0.034 |
Brugia malayi | follicle stimulating hormone receptor | 0.027 | 0.272 | 0.2691 |
Echinococcus multilocularis | hexokinase | 0.0889 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0081 | 0.0502 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0276 | 0.2787 | 0.2758 |
Trypanosoma cruzi | hexokinase, putative | 0.0889 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0606 | 0.6677 | 0.6659 |
Onchocerca volvulus | 0.0056 | 0.0208 | 0.0127 | |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0043 | 0.0053 | 0.0013 |
Echinococcus granulosus | hexokinase | 0.0889 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0071 | 0.0379 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0208 | 0.0169 |
Onchocerca volvulus | 0.0889 | 1 | 1 | |
Onchocerca volvulus | 0.0889 | 1 | 1 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.0379 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.287 | 0.2832 |
Leishmania major | hexokinase, putative | 0.0889 | 1 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0276 | 0.2787 | 0.2758 |
Brugia malayi | Heterochromatin protein 1 | 0.0081 | 0.0502 | 0.0464 |
Plasmodium falciparum | hexokinase | 0.0889 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0046 | 0.0082 | 0.0647 |
Brugia malayi | Inositol-1 | 0.0043 | 0.0053 | 0.0013 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.0053 | 0.0013 |
Onchocerca volvulus | 0.0558 | 0.6105 | 0.6073 | |
Echinococcus granulosus | chromobox protein 1 | 0.0081 | 0.0502 | 0.0464 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0071 | 0.0379 | 0.0328 |
Treponema pallidum | hexokinase (hxk) | 0.0889 | 1 | 0.5 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0081 | 0.0502 | 0.0451 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.0053 | 0.0013 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0049 | 0.0123 | 0.0041 |
Trypanosoma brucei | hexokinase | 0.0889 | 1 | 1 |
Brugia malayi | hexokinase type II | 0.0283 | 0.287 | 0.2842 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0082 | 0.0029 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.0379 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.0889 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0889 | 1 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.0889 | 1 | 1 |
Schistosoma mansoni | hexokinase | 0.0889 | 1 | 1 |
Toxoplasma gondii | hexokinase | 0.0889 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.