Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0071 | 0.0379 | 1 |
Onchocerca volvulus | 0.0889 | 1 | 1 | |
Loa Loa (eye worm) | hexokinase | 0.0558 | 0.6105 | 0.6084 |
Echinococcus multilocularis | hexokinase type 2 | 0.0889 | 1 | 1 |
Trypanosoma cruzi | hexokinase, putative | 0.0889 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0889 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0889 | 1 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0071 | 0.0379 | 0.034 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0046 | 0.0082 | 0.0647 |
Plasmodium falciparum | hexokinase | 0.0889 | 1 | 0.5 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0039 | 0 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.0889 | 1 | 0.5 |
Toxoplasma gondii | hexokinase | 0.0889 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0889 | 1 | 1 |
Schistosoma mansoni | hexokinase | 0.0889 | 1 | 1 |
Trypanosoma brucei | hexokinase | 0.0889 | 1 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.0889 | 1 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.027 | 0.272 | 0.2691 |
Echinococcus multilocularis | hexokinase | 0.0889 | 1 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0276 | 0.2787 | 0.2758 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0071 | 0.0379 | 0.0328 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.0379 | 0.034 |
Echinococcus granulosus | hexokinase | 0.0889 | 1 | 1 |
Brugia malayi | Hexokinase family protein | 0.0275 | 0.2781 | 0.2752 |
Trichomonas vaginalis | chromobox protein, putative | 0.0049 | 0.0123 | 0.1553 |
Brugia malayi | Heterochromatin protein 1 | 0.0081 | 0.0502 | 0.0464 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.0379 | 1 |
Trypanosoma brucei | hexokinase | 0.0889 | 1 | 1 |
Schistosoma mansoni | chromobox protein | 0.0081 | 0.0502 | 0.0464 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.0053 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0082 | 0.0029 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0081 | 0.0502 | 0.0451 |
Onchocerca volvulus | 0.0889 | 1 | 1 | |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0043 | 0.0053 | 0.0013 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.0379 | 1 |
Brugia malayi | hexokinase type II | 0.0283 | 0.287 | 0.2842 |
Loa Loa (eye worm) | hexokinase type II | 0.0889 | 1 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0043 | 0.0053 | 0.0013 |
Trichomonas vaginalis | chromobox protein, putative | 0.0081 | 0.0502 | 1 |
Entamoeba histolytica | hexokinase 2 | 0.0889 | 1 | 1 |
Onchocerca volvulus | 0.0056 | 0.0208 | 0.0127 | |
Brugia malayi | Hexokinase family protein | 0.0889 | 1 | 1 |
Schistosoma mansoni | chromobox protein | 0.0081 | 0.0502 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.0606 | 0.6677 | 0.6659 |
Brugia malayi | Inositol-1 | 0.0043 | 0.0053 | 0.0013 |
Leishmania major | hexokinase, putative | 0.0889 | 1 | 1 |
Onchocerca volvulus | 0.0558 | 0.6105 | 0.6073 | |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0043 | 0.0053 | 0.5 |
Echinococcus granulosus | hexokinase | 0.0889 | 1 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.027 | 0.272 | 0.2682 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0049 | 0.0123 | 0.0041 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0071 | 0.0379 | 0.034 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0208 | 0.0169 |
Brugia malayi | chromobox protein homolog 3 | 0.0046 | 0.0082 | 0.0042 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0043 | 0.0053 | 0.0013 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0046 | 0.0082 | 0.0647 |
Brugia malayi | hypothetical protein | 0.0276 | 0.2787 | 0.2758 |
Echinococcus granulosus | chromobox protein 1 | 0.0081 | 0.0502 | 0.0464 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0276 | 0.2787 | 0.2758 |
Echinococcus granulosus | hexokinase type 2 | 0.0889 | 1 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0275 | 0.2781 | 0.2743 |
Trichomonas vaginalis | chromobox protein, putative | 0.0081 | 0.0502 | 1 |
Onchocerca volvulus | 0.0889 | 1 | 1 | |
Echinococcus multilocularis | chromobox protein 1 | 0.0081 | 0.0502 | 0.0464 |
Treponema pallidum | hexokinase (hxk) | 0.0889 | 1 | 0.5 |
Trypanosoma cruzi | hexokinase, putative | 0.0889 | 1 | 1 |
Leishmania major | hexokinase, putative | 0.0889 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.0889 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0071 | 0.0379 | 0.0328 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.0208 | 0.0169 |
Onchocerca volvulus | Hexokinase homolog | 0.0558 | 0.6105 | 0.6073 |
Trypanosoma brucei | hexokinase, putative | 0.0889 | 1 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0049 | 0.0123 | 0.1553 |
Echinococcus granulosus | chromobox protein 1 | 0.0081 | 0.0502 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.287 | 0.2832 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.287 | 0.2832 |
Brugia malayi | Hexokinase family protein | 0.0558 | 0.6105 | 0.6089 |
Echinococcus granulosus | hexokinase | 0.0889 | 1 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.0208 | 0.0169 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0043 | 0.0053 | 0.0013 |
Echinococcus multilocularis | chromobox protein 1 | 0.0081 | 0.0502 | 0.0464 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0071 | 0.0379 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0276 | 0.2787 | 0.2749 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0071 | 0.0379 | 0.034 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.