Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0454 | 0.385 | 0.385 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0046 | 0.0234 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0046 | 0.0234 | 0.0391 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0037 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0158 | 0.6787 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.0158 | 0.6787 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.0158 | 0.6787 |
Trypanosoma cruzi | NEK family Serine/threonine-protein kinase, putative | 0.0694 | 0.5977 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.0158 | 0.6787 |
Brugia malayi | SWIRM domain containing protein | 0.0046 | 0.0234 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0037 | 0.0158 | 0.0158 |
Trypanosoma cruzi | NEK family Serine/threonine-protein kinase, putative | 0.0694 | 0.5977 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0046 | 0.0234 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.0046 | 0.0234 | 0.0234 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0158 | 0.6787 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0046 | 0.0234 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0158 | 1 |
Schistosoma mansoni | amine oxidase | 0.0046 | 0.0234 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0046 | 0.0234 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0652 | 0.5603 | 0.5603 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0158 | 0.6787 |
Echinococcus multilocularis | 0.0046 | 0.0234 | 1 | |
Mycobacterium tuberculosis | Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) | 0.1149 | 1 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0158 | 0.6787 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.0158 | 0.6787 |
Mycobacterium ulcerans | dehydrogenase | 0.0046 | 0.0234 | 0.0234 |
Trypanosoma cruzi | NEK family Serine/threonine-protein kinase, putative | 0.0694 | 0.5977 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.0158 | 0.0158 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0158 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.0158 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0046 | 0.0234 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0046 | 0.0234 | 0.0234 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0037 | 0.0158 | 0.0158 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0046 | 0.0234 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0046 | 0.0234 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0158 | 0.0158 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.0158 | 1 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0046 | 0.0234 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0234 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0046 | 0.0234 | 1 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0454 | 0.385 | 0.385 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0158 | 0.6787 |
Mycobacterium ulcerans | monoamine oxidase | 0.0046 | 0.0234 | 0.0234 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0158 | 0.0265 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0158 | 0.6787 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0046 | 0.0234 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0234 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0158 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0234 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.0158 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0158 | 0.0158 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0046 | 0.0234 | 0.0391 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0037 | 0.0158 | 0.0158 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.0158 | 0.0158 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0239 | 0.1946 | 0.1946 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.0158 | 0.0265 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0046 | 0.0234 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0234 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0454 | 0.385 | 0.3751 |
Brugia malayi | beta-lactamase | 0.0037 | 0.0158 | 0.6787 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0652 | 0.5603 | 0.5603 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0046 | 0.0234 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.0158 | 0.0158 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0234 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0158 | 0.6787 |
Onchocerca volvulus | 0.0046 | 0.0234 | 1 | |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.0158 | 0.6787 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.0454 | 0.385 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0037 | 0.0158 | 0.0158 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.0158 | 0.6787 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0046 | 0.0234 | 1 |
Mycobacterium ulcerans | serine/threonine-protein kinase B PknB | 0.1149 | 1 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0046 | 0.0234 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0046 | 0.0234 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0158 | 0.6787 |
Brugia malayi | hypothetical protein | 0.0046 | 0.0234 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0046 | 0.0234 | 0.0234 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0606 | 0.5197 | 0.5197 |
Treponema pallidum | hypothetical protein | 0.0454 | 0.385 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.0158 | 0.6787 |
Trypanosoma cruzi | NEK family Serine/threonine-protein kinase, putative | 0.0694 | 0.5977 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.0158 | 0.0158 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.0158 | 0.6787 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0046 | 0.0234 | 1 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0046 | 0.0234 | 0.0234 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0046 | 0.0234 | 0.0076 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.0158 | 0.0158 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0046 | 0.0234 | 1 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0046 | 0.0234 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.0158 | 0.6787 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0037 | 0.0158 | 0.0158 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0037 | 0.0158 | 0.0158 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.0158 | 0.6787 |
Schistosoma mansoni | amine oxidase | 0.0046 | 0.0234 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0234 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.0158 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.