Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Trypanosoma brucei | beta tubulin | 0.0062 | 0.6619 | 0.5 |
Leishmania major | beta tubulin | 0.0062 | 0.6619 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0062 | 0.6619 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0062 | 0.6619 | 0.6619 |
Trypanosoma brucei | beta tubulin | 0.0062 | 0.6619 | 0.5 |
Leishmania major | beta tubulin | 0.0062 | 0.6619 | 0.5 |
Leishmania major | beta tubulin | 0.0062 | 0.6619 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 1 | 1 |
Leishmania major | beta tubulin | 0.0062 | 0.6619 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 1 | 1 |
Leishmania major | beta tubulin | 0.0062 | 0.6619 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 1 | 1 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0062 | 0.6619 | 0.5 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0062 | 0.6619 | 0.6619 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0062 | 0.6619 | 0.5 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 1 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.0062 | 0.6619 | 0.5 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Loa Loa (eye worm) | beta-tubulin | 0.0062 | 0.6619 | 0.6619 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0062 | 0.6619 | 0.6619 |
Leishmania major | beta tubulin | 0.0062 | 0.6619 | 0.5 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0062 | 0.6619 | 0.5 |
Leishmania major | beta tubulin | 0.0062 | 0.6619 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0062 | 0.6619 | 0.5 |
Loa Loa (eye worm) | tubulin beta chain | 0.0062 | 0.6619 | 0.6619 |
Leishmania major | beta tubulin | 0.0062 | 0.6619 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0062 | 0.6619 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0062 | 0.6619 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Leishmania major | beta tubulin | 0.0062 | 0.6619 | 0.5 |
Leishmania major | beta tubulin | 0.0062 | 0.6619 | 0.5 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Brugia malayi | TAR-binding protein | 0.0076 | 1 | 1 |
Leishmania major | beta tubulin | 0.0062 | 0.6619 | 0.5 |
Plasmodium vivax | tubulin beta chain, putative | 0.0062 | 0.6619 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0062 | 0.6619 | 0.5 |
Plasmodium falciparum | tubulin beta chain | 0.0062 | 0.6619 | 0.5 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Toxoplasma gondii | beta-tubulin, putative | 0.0062 | 0.6619 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0062 | 0.6619 | 0.5 |
Leishmania major | beta tubulin | 0.0062 | 0.6619 | 0.5 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0062 | 0.6619 | 0.6619 |
Leishmania major | beta tubulin | 0.0062 | 0.6619 | 0.5 |
Leishmania major | beta tubulin | 0.0062 | 0.6619 | 0.5 |
Leishmania major | beta tubulin | 0.0062 | 0.6619 | 0.5 |
Leishmania major | beta tubulin | 0.0062 | 0.6619 | 0.5 |
Toxoplasma gondii | beta tubulin | 0.0062 | 0.6619 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0062 | 0.6619 | 0.5 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0062 | 0.6619 | 0.5 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0062 | 0.6619 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 1 | 1 |
Leishmania major | beta tubulin | 0.0062 | 0.6619 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0062 | 0.6619 | 0.5 |
Onchocerca volvulus | 0.0033 | 0 | 0.5 | |
Leishmania major | beta tubulin | 0.0062 | 0.6619 | 0.5 |
Trypanosoma cruzi | beta tubulin, putative | 0.0062 | 0.6619 | 0.5 |
Brugia malayi | Tubulin beta-1 chain | 0.0062 | 0.6619 | 0.6619 |
Loa Loa (eye worm) | BEN-1 protein | 0.0062 | 0.6619 | 0.6619 |
Brugia malayi | beta-tubulin, identical | 0.0062 | 0.6619 | 0.6619 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.