Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.1308 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.0074 | 0.0564 |
Brugia malayi | hypothetical protein | 0.0277 | 0.1308 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0199 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.0074 | 0.0564 |
Schistosoma mansoni | survival motor neuron protein | 0.0056 | 0.0199 | 1 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.2004 | 1 | 1 |
Mycobacterium ulcerans | thymidine phosphorylase | 0.2004 | 1 | 1 |
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.0566 | 0.2762 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0277 | 0.1308 | 0.1243 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0277 | 0.1308 | 0.1243 |
Echinococcus multilocularis | thymidine phosphorylase | 0.2004 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0074 | 0.0564 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0056 | 0.0199 | 0.1522 |
Onchocerca volvulus | 0.0056 | 0.0199 | 1 | |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0032 | 0.0074 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0071 | 0.0542 |
Brugia malayi | intermediate filament protein | 0.0032 | 0.0074 | 0.0564 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.