Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | angiotensin I converting enzyme | Starlite/ChEMBL | References |
Oryctolagus cuniculus | Neprilysin | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma japonicum | Endothelin-converting enzyme 2, putative | Neprilysin | 750 aa | 787 aa | 21.2 % |
Onchocerca volvulus | Neprilysin | 750 aa | 682 aa | 31.4 % | |
Onchocerca volvulus | Neprilysin | 750 aa | 713 aa | 33.7 % | |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | Neprilysin | 750 aa | 773 aa | 20.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | p25-alpha family protein | 0.038 | 0.4851 | 0.4851 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0209 | 0.0209 |
Echinococcus multilocularis | geminin | 0.0176 | 0.2002 | 1 |
Onchocerca volvulus | TPPP family protein homolog | 0.038 | 0.4851 | 1 |
Brugia malayi | hypothetical protein | 0.0314 | 0.3927 | 0.3927 |
Echinococcus granulosus | geminin | 0.0176 | 0.2002 | 1 |
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0114 | 0.1138 | 0.5685 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0209 | 0.1044 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0114 | 0.1138 | 0.5685 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.1138 | 0.1138 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.075 | 0.075 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0527 | 0.2632 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0209 | 0.1044 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0723 | 0.0723 |
Loa Loa (eye worm) | hypothetical protein | 0.0314 | 0.3927 | 0.3927 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0058 | 0.0349 | 0.1745 |
Brugia malayi | Peptidase family M13 containing protein | 0.0114 | 0.1138 | 0.1138 |
Schistosoma mansoni | neprilysin-2 (M13 family) | 0.0058 | 0.0349 | 0.1745 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.2002 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0723 | 0.0723 |
Mycobacterium leprae | probable zinc metalloprotease | 0.0114 | 0.1138 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0058 | 0.0349 | 0.1745 |
Loa Loa (eye worm) | angiotensin-converting enzyme family protein | 0.0749 | 1 | 1 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.0723 | 0.0723 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.075 | 0.075 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0209 | 0.1044 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0103 | 0.0981 | 0.0981 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0723 | 0.0723 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0723 | 0.0723 |
Brugia malayi | p25-alpha family protein | 0.038 | 0.4851 | 0.4851 |
Schistosoma mansoni | family M13 non-peptidase homologue (M13 family) | 0.0058 | 0.0349 | 0.1745 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.007 | 0.0527 | 0.0527 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0981 | 0.0981 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0114 | 0.1138 | 0.5685 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0114 | 0.1138 | 0.1138 |
Toxoplasma gondii | peptidase family M13 protein | 0.0114 | 0.1138 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0527 | 0.0527 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.075 | 0.075 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0209 | 0.1044 |
Schistosoma mansoni | Nep2 peptidase (M13 family) | 0.0058 | 0.0349 | 0.1745 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.2002 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.075 | 0.075 |
Mycobacterium ulcerans | zinc metalloprotease | 0.0114 | 0.1138 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0209 | 0.0209 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.1138 | 0.1138 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0209 | 0.1044 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.075 | 0.075 |
Onchocerca volvulus | 0.0314 | 0.3927 | 0.7954 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0103 | 0.0981 | 0.0981 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0103 | 0.0981 | 0.0981 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.1138 | 0.1138 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0209 | 0.1044 |
Loa Loa (eye worm) | hypothetical protein | 0.0086 | 0.075 | 0.075 |
Mycobacterium tuberculosis | Probable zinc metalloprotease Zmp1 | 0.0114 | 0.1138 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0335 | 0.0335 |
Loa Loa (eye worm) | peptidase family M13 containing protein | 0.0084 | 0.0723 | 0.0723 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0209 | 0.1044 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.22 uM | Tested for inhibitory potency against neutral endopeptidase (NEP) | ChEMBL. | 8021926 |
IC50 (binding) | = 0.22 uM | Tested for inhibitory potency against neutral endopeptidase (NEP) | ChEMBL. | 8021926 |
IC50 (binding) | = 0.8 uM | Tested for inhibitory potency against Angiotensin I Converting Enzyme | ChEMBL. | 8021926 |
IC50 (binding) | = 0.8 uM | Tested for inhibitory potency against Angiotensin I Converting Enzyme | ChEMBL. | 8021926 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.