TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 363.453 | Formula: C22H25N3O2
H donors: 0 H acceptors: 2 LogP: 3.32 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)Cc1nc2c(n1C1CCN(CC1)C(=O)C)cccc2
InChi: 1S/C22H25N3O2/c1-16(26)24-13-11-18(12-14-24)25-21-6-4-3-5-20(21)23-22(25)15-17-7-9-19(27-2)10-8-17/h3-10,18H,11-15H2,1-2H3
InChiKey: JMGOTKQRCDOMQT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	serotonin receptor	0.0025	0.0012	0.0021
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0025	0.0012	0.047
Brugia malayi	neuropeptide F receptor	0.0025	0.0012	0.047
Echinococcus granulosus	lamin	0.0054	0.0032	0.0099
Brugia malayi	hypothetical protein	0.0025	0.0012	0.047
Loa Loa (eye worm)	intermediate filament protein	0.0054	0.0032	0.221
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0012	0.0038
Echinococcus granulosus	neuropeptide receptor	0.0025	0.0012	0.0021
Echinococcus multilocularis	neuropeptide receptor	0.0025	0.0012	0.0021
Mycobacterium ulcerans	epimerase	0.0023	0.001	0.0001
Mycobacterium leprae	PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE)	0.0086	0.0055	0.0045
Echinococcus granulosus	neuropeptide s receptor	0.0025	0.0012	0.0021
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0025	0.0012	0.0021
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.0037	0.002	0.2894
Schistosoma mansoni	adenoreceptor	0.0025	0.0012	0.0038
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0012	0.0021
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0012	0.0021
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0012	0.0021
Schistosoma mansoni	myosin xvIII	0.0025	0.0012	0.0038
Brugia malayi	neuropeptide F receptor	0.0025	0.0012	0.047
Echinococcus multilocularis	sex peptide receptor	0.0025	0.0012	0.0021
Mycobacterium ulcerans	hypothetical protein	0.0023	0.001	0.0001
Echinococcus multilocularis	allatostatin A receptor	0.0025	0.0012	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0025	0.0012	0.047
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.0009	0.5
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0025	0.0012	0.0021
Echinococcus granulosus	neuropeptides capa receptor	0.0025	0.0012	0.0021
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0025	0.0012	0.0021
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0025	0.0012	0.0021
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0025	0.0012	0.047
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0018	0.0006	0.1117
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0012	0.0021
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0025	0.0012	0.0021
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0012	0.0038
Toxoplasma gondii	endonuclease IV APN	0.0086	0.0055	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0025	0.0012	0.0038
Brugia malayi	hypothetical protein	0.0025	0.0012	0.047
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0025	0.0012	0.0021
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0012	0.0021
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0012	0.0021
Brugia malayi	hypothetical protein	0.0025	0.0012	0.047
Brugia malayi	Pre-SET motif family protein	0.0026	0.0012	0.0516
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0025	0.0012	0.0038
Echinococcus multilocularis	G protein coupled receptor 139	0.0025	0.0012	0.0021
Mycobacterium ulcerans	sugar phosphate isomerases/epimerases	0.0023	0.001	0.0001
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0025	0.0012	0.0021
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0012	0.0038
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0012	0.0038
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0025	0.0012	0.047
Onchocerca volvulus		0.0025	0.0012	0.0143
Onchocerca volvulus		0.0025	0.0012	0.0143
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0025	0.0012	0.0021
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0054	0.0032	0.221
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0025	0.0012	0.0021
Echinococcus granulosus	allatostatin A receptor	0.0025	0.0012	0.0021
Onchocerca volvulus		0.0025	0.0012	0.0143
Echinococcus granulosus	histone lysine methyltransferase setb	0.0026	0.0012	0.0023
Mycobacterium tuberculosis	Probable histidinol dehydrogenase HisD (HDH)	1.396	1	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0025	0.0012	0.0038
Echinococcus granulosus	G protein coupled receptor 139	0.0025	0.0012	0.0021
Echinococcus multilocularis	conserved hypothetical protein	0.3666	0.2621	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Trichomonas vaginalis	DNA helicase recq, putative	0.0043	0.0024	0.1157
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0028	0.0014	0.2527
Schistosoma mansoni	neuropeptide F-like receptor	0.0025	0.0012	0.0038
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0025	0.0012	0.0038
Schistosoma mansoni	amine GPCR	0.0025	0.0012	0.0038
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0026	0.0012	0.0042
Brugia malayi	Serotonin receptor	0.0025	0.0012	0.047
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0012	0.0038
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0012	0.0038
Trichomonas vaginalis	DNA helicase recq1, putative	0.0043	0.0024	0.1157
Echinococcus granulosus	7tm_1 domain containing protein	0.0025	0.0012	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0023	0.001	0.0309
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0012	0.0021
Brugia malayi	follicle stimulating hormone receptor	0.0025	0.0012	0.047
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Brugia malayi	hypothetical protein	0.0025	0.0012	0.047
Echinococcus granulosus	bloom syndrome protein	0.0043	0.0024	0.0068
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0023	0.001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Echinococcus granulosus	sex peptide receptor	0.0025	0.0012	0.0021
Echinococcus granulosus	neuropeptide Y receptor	0.0025	0.0012	0.0021
Brugia malayi	hypothetical protein	0.0025	0.0012	0.047
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0026	0.0012	0.0042
Onchocerca volvulus		0.0025	0.0012	0.0143
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0012	0.0021
Plasmodium vivax	SET domain protein, putative	0.0026	0.0012	0.0756
Brugia malayi	G protein-coupled receptor F59B2.13	0.0025	0.0012	0.047
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0012	0.0038
Schistosoma mansoni	hypothetical protein	0.0025	0.0012	0.0038
Brugia malayi	Bloom's syndrome protein homolog	0.0043	0.0024	0.1525
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0018	0.0006	0.1117
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0012	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0032	0.221
Mycobacterium ulcerans	histidinol dehydrogenase	1.396	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0012	0.0021
Onchocerca volvulus		0.0025	0.0012	0.0143
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0025	0.0012	0.0038
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0025	0.0012	0.0021
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0021	0.0009	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0025	0.0012	0.0021
Onchocerca volvulus		0.0025	0.0012	0.0143
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0181	0.0124	1
Echinococcus granulosus	hypothetical protein	0.3691	0.2639	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0025	0.0012	0.0021
Onchocerca volvulus		0.0025	0.0012	0.0143
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0026	0.0012	0.2214
Echinococcus granulosus	g-protein coupled receptor	0.0025	0.0012	0.0021
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0009	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Echinococcus multilocularis	fmrfamide receptor	0.0025	0.0012	0.0021
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0029	0.0014	0.0686
Brugia malayi	G-protein coupled receptor	0.0025	0.0012	0.047
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0026	0.0012	0.0023
Plasmodium falciparum	apurinic/apyrimidinic endonuclease Apn1, putative	0.0086	0.0055	1
Brugia malayi	Intermediate filament tail domain containing protein	0.0054	0.0032	0.221
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0025	0.0012	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0026	0.0012	0.0023
Echinococcus multilocularis	serotonin receptor	0.0025	0.0012	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0012	0.0021
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0025	0.0012	0.0038
Echinococcus multilocularis	lamin dm0	0.0054	0.0032	0.0099
Brugia malayi	ORL1-like opioid receptor	0.0025	0.0012	0.047
Schistosoma mansoni	amine GPCR	0.0025	0.0012	0.0038
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0012	0.0021
Brugia malayi	G protein-coupled receptor	0.0025	0.0012	0.047
Brugia malayi	Melatonin receptor type 1A	0.0025	0.0012	0.047
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Brugia malayi	putative neuropeptide receptor	0.0025	0.0012	0.047
Schistosoma mansoni	opsin-like receptor	0.0025	0.0012	0.0038
Brugia malayi	DNA-(Apurinic or apyrimidinic site) lyase	0.0086	0.0055	0.418
Loa Loa (eye worm)	RecQ helicase	0.0043	0.0024	0.1525
Schistosoma mansoni	amine GPCR	0.0025	0.0012	0.0038
Brugia malayi	hypothetical protein	0.0025	0.0012	0.047
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0012	0.0038
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0012	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0012	0.0516
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0012	0.0021
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0025	0.0012	0.0021
Schistosoma mansoni	lamin	0.0054	0.0032	0.018
Onchocerca volvulus		0.0025	0.0012	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Trichomonas vaginalis	DNA helicase recq, putative	0.0023	0.001	0.0087
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0025	0.0012	0.047
Brugia malayi	Hypothetical 29.7 kDa protein C05D11.5 in chromosome III	0.0023	0.001	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Loa Loa (eye worm)	neuropeptide F receptor	0.0025	0.0012	0.047
Onchocerca volvulus		0.0025	0.0012	0.0143
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0012	0.0021
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0025	0.0012	0.047
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0025	0.0012	0.047
Loa Loa (eye worm)	TYRA-2 protein	0.0025	0.0012	0.047
Echinococcus multilocularis	neuropeptide Y receptor	0.0025	0.0012	0.0021
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0012	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0018	0.0999
Echinococcus multilocularis	fmrfamide receptor	0.0025	0.0012	0.0021
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0025	0.0012	0.0143
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0025	0.0012	0.0021
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0025	0.0012	0.0021
Onchocerca volvulus		0.0025	0.0012	0.0143
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.2025	0.1445	0.5502
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0023	0.001	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0012	0.0038
Echinococcus granulosus	neuropeptide FF receptor 2	0.0025	0.0012	0.0021
Echinococcus granulosus	neuropeptide receptor A26	0.0025	0.0012	0.0021
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0025	0.0012	0.0038
Brugia malayi	Dopamine receptor	0.0025	0.0012	0.047
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0012	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Echinococcus multilocularis	neuropeptides capa receptor	0.0025	0.0012	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0012	0.0512
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0025	0.0012	0.0021
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0025	0.0012	0.0038
Brugia malayi	AKH receptor	0.0025	0.0012	0.047
Chlamydia trachomatis	endonuclease IV	0.0086	0.0055	0.5
Entamoeba histolytica	recQ family helicase, putative	0.0023	0.001	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0025	0.0012	0.047
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0012	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Brugia malayi	intermediate filament protein	0.0054	0.0032	0.221
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0025	0.0012	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Echinococcus multilocularis	musashi	0.0054	0.0032	0.0099
Echinococcus multilocularis	neuropeptide receptor	0.0025	0.0012	0.0021
Echinococcus multilocularis	serotonin receptor	0.0025	0.0012	0.0021
Onchocerca volvulus		0.0206	0.0142	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0009	0.0216
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0026	0.0012	0.0023
Echinococcus multilocularis	neuropeptide s receptor	0.0025	0.0012	0.0021
Brugia malayi	G-protein coupled receptor	0.0025	0.0012	0.047
Loa Loa (eye worm)	G-protein coupled receptor	0.0025	0.0012	0.047
Loa Loa (eye worm)	G-protein coupled receptor	0.0025	0.0012	0.047
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0026	0.0012	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Brugia malayi	Pre-SET motif family protein	0.0181	0.0124	1
Echinococcus granulosus	neuropeptides capa receptor	0.0025	0.0012	0.0021
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0012	0.0021
Trichomonas vaginalis	set domain proteins, putative	0.0206	0.0142	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0025	0.0012	0.0021
Loa Loa (eye worm)	neuropeptide F receptor	0.0025	0.0012	0.047
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Loa Loa (eye worm)	melatonin receptor type 1A	0.0025	0.0012	0.047
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Onchocerca volvulus		0.0025	0.0012	0.0143
Brugia malayi	putative neuropeptide receptor NPR1	0.0025	0.0012	0.047
Schistosoma mansoni	opsin-like receptor	0.0025	0.0012	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0025	0.0012	0.0021
Schistosoma mansoni	intermediate filament proteins	0.0054	0.0032	0.018
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0025	0.0012	0.0038
Brugia malayi	Serotonin receptor	0.0025	0.0012	0.047
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0012	0.0021
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0012	0.0021
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0029	0.0014	0.118
Brugia malayi	hypothetical protein	0.0025	0.0012	0.047
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Echinococcus multilocularis	neuropeptides capa receptor	0.0025	0.0012	0.0021
Brugia malayi	hypothetical protein	0.0025	0.0012	0.047
Echinococcus multilocularis	neuropeptide Y receptor	0.0025	0.0012	0.0021
Onchocerca volvulus		0.0026	0.0012	0.0184
Echinococcus multilocularis	dro:myosuppressin receptor	0.0025	0.0012	0.0021
Brugia malayi	GnHR receptor homolog	0.0025	0.0012	0.047
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0011	0.0452
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0012	0.0021
Brugia malayi	larval opioid receptor	0.0025	0.0012	0.047
Brugia malayi	Dopamine receptor protein 2	0.0025	0.0012	0.047
Echinococcus granulosus	biogenic amine 5HT receptor	0.2025	0.1445	0.5464
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0025	0.0012	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0025	0.0012	0.002
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Echinococcus granulosus	neuropeptide Y receptor	0.0025	0.0012	0.0021
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0023	0.001	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Echinococcus granulosus	lamin dm0	0.0054	0.0032	0.0099
Brugia malayi	Dopamine receptor protein 1	0.0025	0.0012	0.047
Onchocerca volvulus		0.0025	0.0012	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0055	0.418
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Schistosoma mansoni	blooms syndrome DNA helicase	0.0034	0.0018	0.008
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0012	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Echinococcus granulosus	intermediate filament protein	0.0054	0.0032	0.0099
Echinococcus multilocularis	lamin	0.0054	0.0032	0.0099
Echinococcus granulosus	orexin receptor type 2	0.0025	0.0012	0.0021
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0025	0.0012	0.0021
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0021	0.0009	0.8824
Onchocerca volvulus		0.0025	0.0012	0.0143
Echinococcus multilocularis	g-protein coupled receptor	0.0025	0.0012	0.0021
Schistosoma mansoni	biogenic amine receptor	0.0025	0.0012	0.0038
Schistosoma mansoni	hypothetical protein	0.0025	0.0012	0.0038
Brugia malayi	hypothetical protein	0.0025	0.0012	0.047
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0012	0.0038
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0025	0.0012	0.047
Brugia malayi	sulfakinin receptor protein	0.0025	0.0012	0.047
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0025	0.0012	0.0038
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0012	0.0021
Onchocerca volvulus		0.0025	0.0012	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0025	0.0012	0.0038
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.0023	0.001	1
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0009	0.0216
Brugia malayi	hypothetical protein	0.0025	0.0012	0.047
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0025	0.0012	0.047
Schistosoma mansoni	lamin	0.0054	0.0032	0.018
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0012	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Onchocerca volvulus		0.0054	0.0032	0.1695
Schistosoma mansoni	ap endonuclease	0.0021	0.0009	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0011	0.0452
Plasmodium vivax	apurinic/apyrimidinic endonuclease Apn1, putative	0.0086	0.0055	1
Schistosoma mansoni	ap endonuclease	0.0021	0.0009	0.0018
Echinococcus multilocularis	neuropeptide receptor A26	0.0025	0.0012	0.0021
Onchocerca volvulus		0.0025	0.0012	0.0143
Echinococcus multilocularis	bloom syndrome protein	0.0043	0.0024	0.0068
Echinococcus multilocularis	g protein coupled receptor	0.0025	0.0012	0.0021
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0025	0.0012	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Schistosoma mansoni	neuropeptide f receptor 76f	0.0025	0.0012	0.0038
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0025	0.0012	0.0038
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0012	0.0038
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0025	0.0012	0.0021
Onchocerca volvulus		0.0025	0.0012	0.0143
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0012	0.0021
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0025	0.0012	0.0021
Schistosoma mansoni	opsin-like receptor	0.0025	0.0012	0.0038
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0025	0.0012	0.0038
Onchocerca volvulus		0.0025	0.0012	0.0143
Schistosoma mansoni	amine GPCR	0.0025	0.0012	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Echinococcus granulosus	somatostatin receptor	0.0025	0.0012	0.0021
Schistosoma mansoni	amine GPCR	0.0025	0.0012	0.0038
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0026	0.0012	0.0042
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0012	0.0021
Schistosoma mansoni	neuropeptide receptor	0.0025	0.0012	0.0038
Toxoplasma gondii	exonuclease III APE	0.0021	0.0009	0.1577
Echinococcus multilocularis	somatostatin receptor	0.0025	0.0012	0.0021
Schistosoma mansoni	biogenic amine (5HT) receptor	0.2025	0.1445	1
Schistosoma mansoni	histamine h1 receptor	0.0025	0.0012	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Echinococcus granulosus	biogenic amine 5HT receptor	0.0025	0.0012	0.0021
Brugia malayi	RE15519p	0.0025	0.0012	0.047
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0025	0.0012	0.047
Onchocerca volvulus		0.0054	0.0032	0.1695
Echinococcus granulosus	dro:myosuppressin receptor	0.0025	0.0012	0.0021
Mycobacterium ulcerans	endonuclease IV	0.0086	0.0055	0.0047
Echinococcus granulosus	neuropeptide receptor	0.0025	0.0012	0.0021
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0012	0.0021
Mycobacterium tuberculosis	Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase)	0.0086	0.0055	0.0047
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0009	0.0518
Echinococcus multilocularis	orexin receptor type 2	0.0025	0.0012	0.0021
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0009	0.001
Schistosoma mansoni	hypothetical protein	0.0025	0.0012	0.0038
Echinococcus granulosus	7TM GPCR rhodopsin	0.0025	0.0012	0.0021
Schistosoma mansoni	hypothetical protein	0.0025	0.0012	0.0038
Echinococcus granulosus	fmrfamide receptor	0.0025	0.0012	0.0021
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0026	0.0012	0.0042
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0025	0.0012	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Brugia malayi	cytoplasmic intermediate filament protein	0.0029	0.0014	0.0686
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0031	0.215
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0012	0.047
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0025	0.0012	0.0038

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 821652