Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosine kinase | 0.0022 | 0.007 | 0.0549 |
Echinococcus multilocularis | NCK adaptor protein | 0.0031 | 0.0213 | 0.0999 |
Echinococcus granulosus | c src tyrosine kinase | 0.0037 | 0.0311 | 0.153 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0031 | 0.0213 | 0.0386 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0037 | 0.0311 | 0.153 |
Schistosoma mansoni | vesicular amine transporter | 0.0019 | 0.0031 | 0.0242 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0315 | 0.4759 | 1 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0037 | 0.0311 | 0.153 |
Trypanosoma brucei | wee1-like protein kinase | 0.0644 | 1 | 1 |
Brugia malayi | Variant SH3 domain containing protein | 0.0031 | 0.0213 | 0.0386 |
Loa Loa (eye worm) | TK protein kinase | 0.0082 | 0.1027 | 0.2107 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0082 | 0.1027 | 0.5445 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0097 | 0.1268 | 0.6762 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0097 | 0.1268 | 0.6762 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0213 | 0.0386 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0097 | 0.1268 | 0.6762 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0075 | 0.093 | 0.4914 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0031 | 0.0213 | 0.0999 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0097 | 0.1268 | 0.6762 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0082 | 0.1027 | 0.5445 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0082 | 0.1027 | 0.5445 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0022 | 0.007 | 0.0212 |
Echinococcus granulosus | NCK adaptor protein | 0.0031 | 0.0213 | 0.0999 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0022 | 0.007 | 0.0082 |
Echinococcus granulosus | tyrosine kinase | 0.0022 | 0.007 | 0.0212 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0097 | 0.1268 | 0.6762 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0025 | 0.013 | 0.0544 |
Onchocerca volvulus | 0.0022 | 0.007 | 0.0029 | |
Echinococcus multilocularis | tyrosine kinase | 0.0022 | 0.007 | 0.0212 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0097 | 0.1268 | 0.6762 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0031 | 0.0213 | 0.0386 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0208 | 0.0376 |
Brugia malayi | SH2 domain containing protein | 0.0022 | 0.007 | 0.0082 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0022 | 0.007 | 0.0082 |
Onchocerca volvulus | 0.0284 | 0.4257 | 0.96 | |
Onchocerca volvulus | 0.0022 | 0.007 | 0.0029 | |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0134 | 0.186 | 1 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0644 | 1 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0295 | 0.4432 | 1 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0644 | 1 | 1 |
Brugia malayi | Variant SH3 domain containing protein | 0.0031 | 0.0213 | 0.0386 |
Brugia malayi | Protein kinase domain containing protein | 0.0022 | 0.007 | 0.0082 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0037 | 0.0311 | 0.153 |
Echinococcus granulosus | neuroglian | 0.0024 | 0.0109 | 0.0426 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0097 | 0.1268 | 0.6762 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0022 | 0.007 | 0.0082 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0097 | 0.1268 | 0.6762 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0097 | 0.1268 | 0.6762 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0644 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0082 | 0.1027 | 0.5445 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.1268 | 1 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0644 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.0082 | 0.1027 | 0.5445 |
Schistosoma mansoni | nephrin | 0.0024 | 0.0109 | 0.0858 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0031 | 0.0213 | 0.0386 |
Onchocerca volvulus | 0.0022 | 0.007 | 0.0029 | |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0097 | 0.1268 | 0.6762 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0134 | 0.186 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0102 | 0.1359 | 0.7257 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0097 | 0.1268 | 0.6762 |
Brugia malayi | hypothetical protein | 0.0022 | 0.007 | 0.0082 |
Loa Loa (eye worm) | TK protein kinase | 0.0066 | 0.078 | 0.1584 |
Echinococcus granulosus | twitchin | 0.003 | 0.0199 | 0.0922 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0022 | 0.007 | 0.0082 |
Brugia malayi | SH2 domain containing protein | 0.0022 | 0.007 | 0.0082 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.0066 | 0.078 | 0.4094 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0097 | 0.1268 | 0.6762 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0022 | 0.007 | 0.0212 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0134 | 0.186 | 1 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0019 | 0.0031 | 0.0242 |
Brugia malayi | protein-tyrosine kinase | 0.0082 | 0.1027 | 0.2107 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0022 | 0.007 | 0.0091 |
Schistosoma mansoni | tyrosine kinase | 0.0022 | 0.007 | 0.0549 |
Schistosoma mansoni | cell adhesion molecule | 0.0025 | 0.013 | 0.1028 |
Brugia malayi | Protein kinase domain containing protein | 0.0022 | 0.007 | 0.0082 |
Brugia malayi | SRC-1 | 0.0097 | 0.1268 | 0.2617 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0022 | 0.007 | 0.0082 |
Echinococcus multilocularis | neuroglian | 0.0024 | 0.0109 | 0.0426 |
Schistosoma mansoni | tyrosine kinase | 0.0037 | 0.0311 | 0.245 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0097 | 0.1268 | 0.6762 |
Echinococcus granulosus | roundabout 2 | 0.003 | 0.0208 | 0.0971 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0022 | 0.007 | 0.0082 |
Onchocerca volvulus | 0.0022 | 0.007 | 0.0029 | |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0134 | 0.186 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0022 | 0.007 | 0.0082 |
Schistosoma mansoni | nck2/grb4 | 0.0031 | 0.0213 | 0.1683 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0037 | 0.0311 | 0.245 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0022 | 0.007 | 0.0082 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0208 | 0.0376 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0134 | 0.186 | 0.387 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0022 | 0.007 | 0.0212 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0022 | 0.007 | 0.0212 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0037 | 0.0311 | 0.0592 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0097 | 0.1268 | 0.6762 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0022 | 0.007 | 0.0082 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0097 | 0.1268 | 0.6762 |
Brugia malayi | P38 map kinase family protein 2 | 0.0134 | 0.186 | 0.387 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0022 | 0.007 | 0.0082 |
Onchocerca volvulus | 0.0022 | 0.007 | 0.0029 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0021 | 0.0063 | 0.05 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0134 | 0.186 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0022 | 0.007 | 0.0082 |
Entamoeba histolytica | protein kinase, putative | 0.0066 | 0.078 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.007 | 0.0082 |
Loa Loa (eye worm) | SRC-1 | 0.0097 | 0.1268 | 0.2617 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0037 | 0.0311 | 0.153 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0031 | 0.0213 | 0.1683 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0031 | 0.0213 | 0.1683 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0019 | 0.0031 | 0.0242 |
Brugia malayi | Protein kinase domain containing protein | 0.0022 | 0.007 | 0.0082 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0031 | 0.0213 | 0.0999 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0022 | 0.007 | 0.0212 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.1268 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.003 | 0.0208 | 0.0971 |
Brugia malayi | Protein kinase domain containing protein | 0.0022 | 0.007 | 0.0082 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0022 | 0.007 | 0.0212 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0031 | 0.0213 | 0.1683 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0082 | 0.1027 | 0.5445 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.013 | 0.0211 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0097 | 0.1268 | 0.6762 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0022 | 0.007 | 0.0212 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0075 | 0.093 | 0.4914 |
Schistosoma mansoni | tyrosine kinase | 0.0037 | 0.0311 | 0.245 |
Schistosoma mansoni | adapter molecule crk | 0.0031 | 0.0213 | 0.1683 |
Brugia malayi | Protein kinase domain containing protein | 0.0022 | 0.007 | 0.0082 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0134 | 0.186 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0315 | 0.4759 | 1 |
Onchocerca volvulus | 0.0022 | 0.007 | 0.0029 | |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.0066 | 0.078 | 0.4094 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.