Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/FER protein kinase | 0.0023 | 0.0112 | 0.0082 |
Brugia malayi | Variant SH3 domain containing protein | 0.0032 | 0.0345 | 0.0386 |
Schistosoma mansoni | nck2/grb4 | 0.0032 | 0.0345 | 0.1683 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0101 | 0.2049 | 0.6874 |
Echinococcus granulosus | tyrosine kinase | 0.0023 | 0.0112 | 0.0216 |
Echinococcus multilocularis | tyrosine kinase | 0.0023 | 0.0112 | 0.0216 |
Schistosoma mansoni | cell adhesion molecule | 0.0027 | 0.0211 | 0.1028 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0023 | 0.0112 | 0.0082 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0101 | 0.2049 | 0.6874 |
Brugia malayi | Protein kinase domain containing protein | 0.0023 | 0.0112 | 0.0082 |
Schistosoma mansoni | adapter molecule crk | 0.0032 | 0.0345 | 0.1683 |
Brugia malayi | Protein kinase domain containing protein | 0.0023 | 0.0112 | 0.0082 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0085 | 0.1659 | 0.5535 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0101 | 0.2049 | 0.6874 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0085 | 0.1659 | 0.5535 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0101 | 0.2049 | 0.6874 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0345 | 0.0386 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0079 | 0.1502 | 0.4995 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0337 | 0.0376 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0085 | 0.1659 | 0.5535 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0101 | 0.2049 | 0.6874 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0101 | 0.2049 | 0.6874 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0337 | 0.0376 |
Loa Loa (eye worm) | TK protein kinase | 0.0085 | 0.1659 | 0.2107 |
Trypanosoma brucei | wee1-like protein kinase | 0.0423 | 1 | 1 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0038 | 0.0502 | 0.0592 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0329 | 0.7689 | 1 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.002 | 0.005 | 0.0242 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0038 | 0.0502 | 0.1555 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0032 | 0.0345 | 0.0386 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0038 | 0.0502 | 0.1555 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0032 | 0.0345 | 0.0386 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0023 | 0.0112 | 0.0082 |
Onchocerca volvulus | 0.0023 | 0.0112 | 0.0099 | |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0101 | 0.2049 | 0.6874 |
Entamoeba histolytica | protein kinase, putative | 0.0069 | 0.126 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0023 | 0.0112 | 0.0082 |
Brugia malayi | SH2 domain containing protein | 0.0023 | 0.0112 | 0.0082 |
Echinococcus granulosus | roundabout 2 | 0.0032 | 0.0337 | 0.0987 |
Echinococcus multilocularis | tyrosine protein kinase HCK | 0.0069 | 0.126 | 0.4162 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0101 | 0.2049 | 0.6874 |
Brugia malayi | Protein kinase domain containing protein | 0.0023 | 0.0112 | 0.0082 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0105 | 0.2145 | 0.7206 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0101 | 0.2049 | 0.6874 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0138 | 0.2958 | 1 |
Echinococcus multilocularis | roundabout 2 | 0.0032 | 0.0337 | 0.0987 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0023 | 0.0112 | 0.0216 |
Schistosoma mansoni | nephrin | 0.0025 | 0.0176 | 0.0858 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0423 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0101 | 0.2049 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0085 | 0.1659 | 0.5535 |
Echinococcus granulosus | tyrosine kinase | 0.0085 | 0.1659 | 0.5535 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0101 | 0.2049 | 0.6874 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0101 | 0.2049 | 0.6874 |
Onchocerca volvulus | 0.0023 | 0.0112 | 0.0099 | |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0423 | 1 | 1 |
Echinococcus granulosus | neuroglian | 0.0025 | 0.0176 | 0.0433 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0101 | 0.2049 | 0.6874 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0038 | 0.0502 | 0.1555 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0023 | 0.0112 | 0.0216 |
Brugia malayi | Variant SH3 domain containing protein | 0.0032 | 0.0345 | 0.0386 |
Trypanosoma cruzi | Wee1-like protein kinase, putative | 0.0423 | 1 | 1 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.0423 | 1 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0308 | 0.7161 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0138 | 0.2958 | 1 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0023 | 0.0112 | 0.0216 |
Onchocerca volvulus | 0.0297 | 0.6878 | 0.9602 | |
Brugia malayi | Protein kinase domain containing protein | 0.0023 | 0.0112 | 0.0082 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0022 | 0.0102 | 0.05 |
Onchocerca volvulus | 0.0023 | 0.0112 | 0.0099 | |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0101 | 0.2049 | 0.6874 |
Onchocerca volvulus | 0.0023 | 0.0112 | 0.0099 | |
Brugia malayi | P38 map kinase family protein 2 | 0.0138 | 0.2958 | 0.3807 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0023 | 0.0112 | 0.0082 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0101 | 0.2049 | 0.6874 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0038 | 0.0502 | 0.1555 |
Brugia malayi | Protein kinase domain containing protein | 0.0023 | 0.0112 | 0.0082 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0138 | 0.2958 | 0.3807 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0023 | 0.0112 | 0.0216 |
Echinococcus granulosus | twitchin | 0.0029 | 0.0272 | 0.0766 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0023 | 0.0112 | 0.0082 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0038 | 0.0502 | 0.245 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0032 | 0.0345 | 0.1683 |
Schistosoma mansoni | tyrosine kinase | 0.0023 | 0.0112 | 0.0549 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0023 | 0.0112 | 0.0082 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0138 | 0.2958 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0023 | 0.0112 | 0.0082 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0101 | 0.2049 | 0.6874 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0032 | 0.0345 | 0.1015 |
Schistosoma mansoni | tyrosine kinase | 0.0038 | 0.0502 | 0.245 |
Echinococcus multilocularis | neuroglian | 0.0025 | 0.0176 | 0.0433 |
Schistosoma mansoni | tyrosine kinase | 0.0101 | 0.2049 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0023 | 0.0112 | 0.0082 |
Schistosoma mansoni | tyrosine kinase | 0.0023 | 0.0112 | 0.0549 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0211 | 0.0211 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0112 | 0.0082 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0112 | 0.0082 |
Brugia malayi | protein-tyrosine kinase | 0.0085 | 0.1659 | 0.2107 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0138 | 0.2958 | 1 |
Schistosoma mansoni | vesicular amine transporter | 0.002 | 0.005 | 0.0242 |
Echinococcus granulosus | tyrosine protein kinase HCK | 0.0069 | 0.126 | 0.4162 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0329 | 0.7689 | 1 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0023 | 0.0112 | 0.0216 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0023 | 0.0112 | 0.0216 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0138 | 0.2958 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0079 | 0.1502 | 0.4995 |
Echinococcus multilocularis | NCK adaptor protein | 0.0032 | 0.0345 | 0.1015 |
Schistosoma mansoni | tyrosine kinase | 0.0038 | 0.0502 | 0.245 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0023 | 0.0112 | 0.0082 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0027 | 0.0211 | 0.0553 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0101 | 0.2049 | 0.6874 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0085 | 0.1659 | 0.5535 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0032 | 0.0345 | 0.1683 |
Onchocerca volvulus | 0.0023 | 0.0112 | 0.0099 | |
Brugia malayi | SH2 domain containing protein | 0.0023 | 0.0112 | 0.0082 |
Echinococcus granulosus | NCK adaptor protein | 0.0032 | 0.0345 | 0.1015 |
Brugia malayi | SRC-1 | 0.0101 | 0.2049 | 0.2617 |
Onchocerca volvulus | 0.0023 | 0.0112 | 0.0099 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0023 | 0.0112 | 0.0082 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0032 | 0.0345 | 0.1683 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.002 | 0.005 | 0.0242 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0032 | 0.0345 | 0.1015 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0032 | 0.0345 | 0.0386 |
Echinococcus granulosus | c src tyrosine kinase | 0.0038 | 0.0502 | 0.1555 |
Loa Loa (eye worm) | SRC-1 | 0.0101 | 0.2049 | 0.2617 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0023 | 0.0112 | 0.0216 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0138 | 0.2958 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.0069 | 0.126 | 0.1584 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0023 | 0.0112 | 0.05 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.