TDR Targets

Basic information

Technical information

TDR Targets ID: 827030
Name: N-(1,1-dioxothiolan-3-yl)-N-[(5-methylfuran-2 -yl)methyl]-2-(4-methylphenoxy)acetamide
MW: 377.455 | Formula: C19H23NO5S
H donors: 0 H acceptors: 3 LogP: 2.35 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: Cc1ccc(cc1)OCC(=O)N(C1CCS(=O)(=O)C1)Cc1ccc(o1)C
InChi: 1S/C19H23NO5S/c1-14-3-6-17(7-4-14)24-12-19(21)20(11-18-8-5-15(2)25-18)16-9-10-26(22,23)13-16/h3-8,16H,9-13H2,1-2H3
InChiKey: UPPQVNRBXIRCJA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(1,1-dioxothiolan-3-yl)-N-[(5-methyl-2-furyl)methyl]-2-(4-methylphenoxy)acetamide
N-(1,1-dioxo-3-thiolanyl)-N-[(5-methyl-2-furyl)methyl]-2-(4-methylphenoxy)acetamide
N-(1,1-diketothiolan-3-yl)-N-[(5-methyl-2-furyl)methyl]-2-(4-methylphenoxy)acetamide
N-(1,1-dioxothiolan-3-yl)-N-[(5-methylfuran-2-yl)methyl]-2-(4-methylphenoxy)ethanamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	vitamin D (1,25- dihydroxyvitamin D3) receptor	Starlite/ChEMBL	No references
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Homo sapiens	lysine (K)-specific demethylase 4A	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	jmjC domain-containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	Probable JmjC domain-containing histone demethylation protein 3B, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127917	All targets in OG5_127917
Brugia malayi	jmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	Transcription factor JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma mansoni	jumonji domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	Get druggable targets OG5_127917	All targets in OG5_127917
Schistosoma japonicum	JmjC domain-containing histone demethylation protein 3C, putative	Get druggable targets OG5_127917	All targets in OG5_127917
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Candida albicans	one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp	Get druggable targets OG5_127917	All targets in OG5_127917

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	steroid hormone receptor	vitamin D (1,25- dihydroxyvitamin D3) receptor	427 aa	416 aa	24.5 %
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.3045	0.3045
Schistosoma mansoni	adenoreceptor	0.0046	0.2301	0.2301
Schistosoma mansoni	biogenic amine receptor	0.0046	0.2301	0.2301
Schistosoma mansoni	neuropeptide receptor	0.0046	0.2301	0.2301
Echinococcus granulosus	serotonin receptor	0.0046	0.2301	0.2301
Schistosoma mansoni	cathepsin F (C01 family)	0.003	0.099	0.099
Schistosoma mansoni	growth hormone secretagogue receptor	0.0046	0.2301	0.2301
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0046	0.2301	0.205
Echinococcus granulosus	orexin receptor type 2	0.0046	0.2301	0.2301
Brugia malayi	Bromodomain containing protein	0.0035	0.144	0.144
Plasmodium vivax	vivapain-2	0.003	0.099	0.6878
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.003	0.099	0.377
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.2301	0.2301
Echinococcus granulosus	7tm_1 domain containing protein	0.0046	0.2301	0.2301
Echinococcus granulosus	somatostatin receptor	0.0046	0.2301	0.2301
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.2301	0.2301
Echinococcus granulosus	cathepsin L cysteine proteinase	0.003	0.099	0.099
Echinococcus granulosus	G protein coupled receptor 139	0.0046	0.2301	0.2301
Onchocerca volvulus	Cathepsin F homolog	0.003	0.099	0.34
Echinococcus multilocularis	fmrfamide receptor	0.0046	0.2301	0.2301
Giardia lamblia	Cathepsin B precursor	0.005	0.2626	1
Brugia malayi	RE15519p	0.0046	0.2301	0.2301
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.003	0.099	0.6878
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.003	0.099	0.377
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0046	0.2301	0.2301
Echinococcus granulosus	neuropeptide Y receptor	0.0046	0.2301	0.2301
Brugia malayi	Cathepsin L-like precursor	0.003	0.099	0.099
Schistosoma mansoni	cathepsin F (C01 family)	0.003	0.099	0.099
Loa Loa (eye worm)	neuropeptide F receptor	0.0046	0.2301	0.205
Brugia malayi	G-protein coupled receptor	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.003	0.099	0.377
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.3045	0.3045
Schistosoma mansoni	neuropeptide receptor	0.0046	0.2301	0.2301
Echinococcus multilocularis	neuropeptides capa receptor	0.0046	0.2301	0.2301
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.2033	0.2033
Trypanosoma cruzi	cysteine peptidase, putative	0.003	0.099	0.099
Echinococcus granulosus	cathepsin b	0.0142	1	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0046	0.2301	0.2301
Schistosoma mansoni	neuropeptide receptor	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Onchocerca volvulus		0.0046	0.2301	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0046	0.2301	0.2301
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.2301	0.2301
Onchocerca volvulus	Alhambra homolog	0.0035	0.144	0.5664
Echinococcus multilocularis	cathepsin L cysteine protease	0.003	0.099	0.099
Plasmodium falciparum	phd finger protein, putative	0.0035	0.144	1
Echinococcus multilocularis	cathepsin b	0.0142	1	1
Onchocerca volvulus		0.0046	0.2301	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.2301	0.2301
Brugia malayi	Cathepsin L-like precursor	0.0021	0.0315	0.0315
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0046	0.2301	0.2301
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	1	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0046	0.2301	0.2301
Loa Loa (eye worm)	cysteine protease	0.003	0.099	0.0697
Brugia malayi	Cathepsin L-like precursor	0.003	0.099	0.099
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.2301	0.2301
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.2301	0.2301
Echinococcus granulosus	neuropeptide s receptor	0.0046	0.2301	0.2301
Onchocerca volvulus		0.003	0.099	0.34
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Brugia malayi	putative neuropeptide receptor	0.0046	0.2301	0.2301
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.2301	0.2301
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.006	0.3456	0.3243
Loa Loa (eye worm)	TYRA-2 protein	0.0046	0.2301	0.205
Brugia malayi	Cathepsin L-like precursor	0.003	0.099	0.099
Echinococcus granulosus	neuropeptide receptor A26	0.0046	0.2301	0.2301
Onchocerca volvulus		0.0046	0.2301	1
Echinococcus granulosus	cathepsin b	0.0142	1	1
Brugia malayi	Cathepsin L-like precursor	0.0021	0.0315	0.0315
Brugia malayi	hypothetical protein	0.0046	0.2301	0.2301
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.005	0.2626	1
Brugia malayi	neuropeptide F receptor	0.0046	0.2301	0.2301
Echinococcus multilocularis	jumonji domain containing protein	0.0049	0.2545	0.2545
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.2301	0.2301
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Echinococcus multilocularis	dro:myosuppressin receptor	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Echinococcus granulosus	g protein coupled receptor	0.0046	0.2301	0.2301
Plasmodium falciparum	cysteine proteinase falcipain 3	0.003	0.099	0.6878
Schistosoma mansoni	hypothetical protein	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.2301	0.2301
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.3045	0.3045
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.2301	0.2301
Schistosoma mansoni	hypothetical protein	0.0046	0.2301	0.2301
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Brugia malayi	jmjC domain containing protein	0.0115	0.786	0.786
Echinococcus granulosus	lysine specific demethylase 5A	0.0043	0.2033	0.2033
Brugia malayi	ORL1-like opioid receptor	0.0046	0.2301	0.2301
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0046	0.2301	0.2301
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0046	0.2301	0.2301
Schistosoma mansoni	biogenic amine receptor	0.0046	0.2301	0.2301
Echinococcus multilocularis	fmrfamide receptor	0.0046	0.2301	0.2301
Brugia malayi	Cathepsin L-like precursor	0.003	0.099	0.099
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0046	0.2301	0.2301
Plasmodium vivax	vivapain-2	0.003	0.099	0.6878
Loa Loa (eye worm)	hypothetical protein	0.003	0.099	0.0697
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.2301	0.2301
Schistosoma mansoni	biogenic amine receptor	0.0046	0.2301	0.2301
Brugia malayi	jmjC domain containing protein	0.0043	0.2033	0.2033
Echinococcus multilocularis	g-protein coupled receptor	0.0046	0.2301	0.2301
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.003	0.099	0.377
Onchocerca volvulus		0.0046	0.2301	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0046	0.2301	0.2301
Onchocerca volvulus		0.0046	0.2301	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.3045	0.3045
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Schistosoma mansoni	amine GPCR	0.0046	0.2301	0.2301
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.003	0.099	0.377
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Schistosoma mansoni	opsin-like receptor	0.0046	0.2301	0.2301
Trypanosoma cruzi	cysteine peptidase, putative	0.003	0.099	0.099
Loa Loa (eye worm)	cathepsin B	0.005	0.2626	0.2387
Brugia malayi	PHD-finger family protein	0.0035	0.144	0.144
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0046	0.2301	0.2301
Echinococcus multilocularis	somatostatin receptor	0.0046	0.2301	0.2301
Echinococcus granulosus	neuropeptide receptor	0.0046	0.2301	0.2301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.003	0.099	0.377
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.003	0.099	0.377
Brugia malayi	follicle stimulating hormone receptor	0.0046	0.2301	0.2301
Schistosoma mansoni	amine GPCR	0.0046	0.2301	0.2301
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0142	1	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0046	0.2301	0.205
Echinococcus granulosus	biogenic amine 5HT receptor	0.0046	0.2301	0.2301
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0046	0.2301	1
Brugia malayi	G-protein coupled receptor	0.0046	0.2301	0.2301
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.003	0.099	0.377
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0046	0.2301	0.2301
Echinococcus granulosus	sex peptide receptor	0.0046	0.2301	0.2301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.003	0.099	0.377
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.2301	0.2301
Loa Loa (eye worm)	neuropeptide F receptor	0.0046	0.2301	0.205
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0046	0.2301	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0046	0.2301	0.205
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.003	0.099	0.377
Brugia malayi	hypothetical protein	0.0046	0.2301	0.2301
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0046	0.2301	0.2301
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0046	0.2301	0.2301
Schistosoma mansoni	neuropeptide F-like receptor	0.0046	0.2301	0.2301
Onchocerca volvulus		0.003	0.099	0.34
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0046	0.2301	0.205
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.2301	0.2301
Echinococcus multilocularis	allatostatin A receptor	0.0046	0.2301	0.2301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.003	0.099	0.377
Echinococcus multilocularis	neuropeptide Y receptor	0.0046	0.2301	0.2301
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Schistosoma mansoni	jumonji domain containing protein	0.0092	0.596	0.596
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.005	0.2626	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.2301	0.2301
Schistosoma mansoni	neuropeptide f receptor 76f	0.0046	0.2301	0.2301
Onchocerca volvulus		0.0046	0.2301	1
Onchocerca volvulus		0.0046	0.2301	1
Schistosoma mansoni	histamine h1 receptor	0.0046	0.2301	0.2301
Brugia malayi	AKH receptor	0.0046	0.2301	0.2301
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.2301	0.2301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.003	0.099	0.377
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.003	0.099	0.377
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0046	0.2301	0.2301
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.003	0.099	0.377
Loa Loa (eye worm)	jmjC domain-containing protein	0.0043	0.2033	0.1774
Echinococcus granulosus	g protein coupled receptor	0.0046	0.2301	0.2301
Echinococcus granulosus	g-protein coupled receptor	0.0046	0.2301	0.2301
Schistosoma mansoni	neuropeptide receptor	0.0046	0.2301	0.2301
Onchocerca volvulus		0.003	0.099	0.34
Brugia malayi	sulfakinin receptor protein	0.0046	0.2301	0.2301
Echinococcus multilocularis	G protein coupled receptor 139	0.0046	0.2301	0.2301
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.005	0.2626	0.2626
Echinococcus granulosus	peregrin	0.0035	0.144	0.144
Brugia malayi	Dopamine receptor protein 2	0.0046	0.2301	0.2301
Brugia malayi	hypothetical protein	0.0046	0.2301	0.2301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.003	0.099	0.377
Onchocerca volvulus		0.0046	0.2301	1
Echinococcus multilocularis	neuropeptide receptor	0.0046	0.2301	0.2301
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.003	0.099	0.377
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0046	0.2301	0.2301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.003	0.099	0.377
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.2301	0.2301
Echinococcus granulosus	7TM GPCR rhodopsin	0.0046	0.2301	0.2301
Schistosoma mansoni	neuropeptide F-like receptor	0.0046	0.2301	0.2301
Echinococcus granulosus	dro:myosuppressin receptor	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Echinococcus granulosus	biogenic amine 5HT receptor	0.0046	0.2301	0.2301
Echinococcus granulosus	neuropeptide FF receptor 2	0.0046	0.2301	0.2301
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0046	0.2301	0.2301
Brugia malayi	hypothetical protein	0.0046	0.2301	0.2301
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0046	0.2301	0.2301
Echinococcus multilocularis	sex peptide receptor	0.0046	0.2301	0.2301
Echinococcus granulosus	allatostatin A receptor	0.0046	0.2301	0.2301
Brugia malayi	Melatonin receptor type 1A	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0046	0.2301	0.2301
Brugia malayi	Serotonin receptor	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Loa Loa (eye worm)	G-protein coupled receptor	0.0046	0.2301	0.205
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.003	0.099	0.099
Onchocerca volvulus		0.0046	0.2301	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Echinococcus granulosus	neuropeptide receptor	0.0046	0.2301	0.2301
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0046	0.2301	0.2301
Brugia malayi	hypothetical protein	0.0046	0.2301	0.2301
Loa Loa (eye worm)	PHD-finger family protein	0.0035	0.144	0.1161
Brugia malayi	Papain family cysteine protease containing protein	0.003	0.099	0.099
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.2301	0.2301
Brugia malayi	Dopamine receptor	0.0046	0.2301	0.2301
Brugia malayi	G protein-coupled receptor	0.0046	0.2301	0.2301
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0046	0.2301	0.2301
Echinococcus granulosus	PHD finger protein rhinoceros	0.0035	0.144	0.144
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0046	0.2301	0.2301
Echinococcus granulosus	cathepsin l1	0.0021	0.0315	0.0315
Brugia malayi	GnHR receptor homolog	0.0046	0.2301	0.2301
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0046	0.2301	0.2301
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.144	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.2301	0.2301
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0046	0.2301	0.2301
Brugia malayi	hypothetical protein	0.0046	0.2301	0.2301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.003	0.099	0.377
Brugia malayi	hypothetical protein	0.0046	0.2301	0.2301
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.2301	0.2301
Toxoplasma gondii	cathepsin B	0.005	0.2626	1
Trypanosoma cruzi	cruzipain precursor, putative	0.003	0.099	0.099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.003	0.099	0.377
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.003	0.099	0.377
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.003	0.099	0.377
Echinococcus multilocularis	cathepsin b	0.0142	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.003	0.099	0.377
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.003	0.099	0.6878
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.2301	0.2301
Schistosoma mansoni	cathepsin F (C01 family)	0.0021	0.0315	0.0315
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Echinococcus granulosus	cathepsin l cysteine peptidase	0.003	0.099	0.099
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0046	0.2301	0.2301
Entamoeba histolytica	cysteine proteinase, putative	0.0021	0.0315	0.3182
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.003	0.099	0.0697
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0115	0.786	0.786
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0046	0.2301	0.2301
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.3045	0.3045
Onchocerca volvulus		0.0046	0.2301	1
Brugia malayi	hypothetical protein	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0046	0.2301	0.2301
Onchocerca volvulus		0.003	0.099	0.34
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.2301	0.2301
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.003	0.099	0.377
Echinococcus multilocularis	cathepsin L cysteine protease	0.003	0.099	0.099
Echinococcus granulosus	cathepsin l1	0.003	0.099	0.099
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.3045	0.3045
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0021	0.0315	0.0315
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.144	0.2747
Brugia malayi	Cathepsin L-like precursor	0.003	0.099	0.099
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.003	0.099	0.377
Loa Loa (eye worm)	ctsf protein	0.003	0.099	0.0697
Loa Loa (eye worm)	G-protein coupled receptor	0.0046	0.2301	0.205
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.003	0.099	0.377
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.2301	0.2301
Echinococcus granulosus	hypothetical protein	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.003	0.099	0.377
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.003	0.099	0.377
Onchocerca volvulus	Cathepsin L homolog	0.003	0.099	0.34
Echinococcus multilocularis	neuropeptide receptor	0.0046	0.2301	0.2301
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0046	0.2301	0.2301
Brugia malayi	hypothetical protein	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Echinococcus multilocularis	neuropeptide Y receptor	0.0046	0.2301	0.2301
Onchocerca volvulus		0.003	0.099	0.34
Schistosoma mansoni	hypothetical protein	0.0046	0.2301	0.2301
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0046	0.2301	0.2301
Echinococcus granulosus	neuropeptides capa receptor	0.0046	0.2301	0.2301
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.003	0.099	0.0697
Brugia malayi	cathepsin L-like precursor	0.0021	0.0315	0.0315
Brugia malayi	Dopamine receptor protein 1	0.0046	0.2301	0.2301
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.2301	0.2301
Trypanosoma cruzi	cysteine peptidase, putative	0.003	0.099	0.099
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.003	0.099	0.377
Echinococcus granulosus	neuropeptide Y receptor	0.0046	0.2301	0.2301
Echinococcus multilocularis	serotonin receptor	0.0046	0.2301	0.2301
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.2301	0.2301
Onchocerca volvulus		0.0046	0.2301	1
Onchocerca volvulus		0.0046	0.2301	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0115	0.786	0.786
Onchocerca volvulus		0.003	0.099	0.34
Brugia malayi	Serotonin receptor	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Schistosoma mansoni	opsin-like receptor	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Brugia malayi	larval opioid receptor	0.0046	0.2301	0.2301
Entamoeba histolytica	cysteine protease, putative	0.003	0.099	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Onchocerca volvulus		0.0046	0.2301	1
Entamoeba histolytica	cysteine proteinase, putative	0.003	0.099	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.144	0.1161
Echinococcus granulosus	neuropeptides capa receptor	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Echinococcus multilocularis	lysine specific demethylase 5A	0.0043	0.2033	0.2033
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Brugia malayi	hypothetical protein	0.0046	0.2301	0.2301
Echinococcus multilocularis	neuropeptide s receptor	0.0046	0.2301	0.2301
Echinococcus multilocularis	g protein coupled receptor	0.0046	0.2301	0.2301
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.003	0.099	0.377
Echinococcus granulosus	jumonji domain containing protein	0.0049	0.2545	0.2545
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0035	0.144	0.144
Echinococcus multilocularis	neuropeptides capa receptor	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.2301	0.2301
Schistosoma mansoni	myosin xvIII	0.0046	0.2301	0.2301
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.003	0.099	0.377
Onchocerca volvulus		0.0046	0.2301	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0073	0.4444	0.4264
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.3045	0.3045
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0046	0.2301	0.2301
Schistosoma mansoni	opsin-like receptor	0.0046	0.2301	0.2301
Schistosoma mansoni	hypothetical protein	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.2301	0.2301
Brugia malayi	Cathepsin L-like precursor	0.003	0.099	0.099
Loa Loa (eye worm)	hypothetical protein	0.0142	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0142	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.2301	0.2301
Onchocerca volvulus		0.0046	0.2301	1
Echinococcus multilocularis	orexin receptor type 2	0.0046	0.2301	0.2301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.003	0.099	0.377
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.3045	0.2819
Trypanosoma cruzi	cysteine peptidase, putative	0.003	0.099	0.099
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Echinococcus granulosus	rhodopsin orphan GPCR	0.0046	0.2301	0.2301
Brugia malayi	neuropeptide F receptor	0.0046	0.2301	0.2301
Giardia lamblia	Cathepsin B precursor	0.005	0.2626	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.144	0.2747
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0046	0.2301	0.2301
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0046	0.2301	0.2301
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.2301	0.2301
Schistosoma mansoni	hypothetical protein	0.0035	0.144	0.144
Echinococcus multilocularis	neuropeptide receptor A26	0.0046	0.2301	0.2301
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0046	0.2301	0.2301
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.3045	0.3045
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0046	0.2301	0.205
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.003	0.099	0.377
Schistosoma mansoni	amine GPCR	0.0046	0.2301	0.2301
Schistosoma mansoni	amine GPCR	0.0046	0.2301	0.2301
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0046	0.2301	0.2301
Loa Loa (eye worm)	fibroinase	0.003	0.099	0.0697
Onchocerca volvulus		0.003	0.099	0.34
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0046	0.2301	0.2301
Trypanosoma brucei	cysteine peptidase C (CPC)	0.005	0.2626	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0046	0.2301	0.2301
Entamoeba histolytica	cysteine proteinase, putative	0.003	0.099	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0046	0.2301	0.205
Echinococcus granulosus	fmrfamide receptor	0.0046	0.2301	0.2301
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0021	0.0315	0.0315
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.003	0.099	0.377
Echinococcus multilocularis	serotonin receptor	0.0046	0.2301	0.2301
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0043	0.2033	0.2033
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0046	0.2301	0.2301
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Giardia lamblia	Cathepsin B precursor	0.005	0.2626	1
Onchocerca volvulus		0.0046	0.2301	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.003	0.099	0.099
Schistosoma mansoni	amine GPCR	0.0046	0.2301	0.2301
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0035	0.144	0.144
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.003	0.099	0.377
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0046	0.2301	0.2301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0315	0.12
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0021	0.0315	0.12
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0046	0.2301	0.2301
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.003	0.099	0.377
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.005	0.2626	0.2626
Echinococcus granulosus	g protein coupled receptor	0.0046	0.2301	0.2301
Echinococcus multilocularis	cysteine protease	0.003	0.099	0.099
Loa Loa (eye worm)	hypothetical protein	0.0046	0.2301	0.205
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0046	0.2301	0.2301
Echinococcus multilocularis	cysteine protease	0.003	0.099	0.099
Brugia malayi	putative neuropeptide receptor NPR1	0.0046	0.2301	0.2301
Onchocerca volvulus		0.0046	0.2301	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.003	0.099	0.377
Onchocerca volvulus	Cathepsin L homolog	0.003	0.099	0.34
Echinococcus multilocularis	peregrin	0.0035	0.144	0.144

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	3.9811 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	17.7828 uM	PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855]	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	26.6795 uM	PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1706691
Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 827030