Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.0105 | 0.0363 | 0.0583 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0363 | 0.0583 |
Onchocerca volvulus | 0.0105 | 0.0363 | 0.3006 | |
Toxoplasma gondii | hypothetical protein | 0.0516 | 0.2791 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0363 | 0.0363 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0095 | 0.0095 |
Onchocerca volvulus | 0.007 | 0.0154 | 0.0668 | |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0363 | 0.0363 |
Echinococcus granulosus | carbonic anhydrase | 0.0516 | 0.2791 | 0.4478 |
Onchocerca volvulus | Peroxidase homolog | 0.0105 | 0.0363 | 0.3006 |
Plasmodium vivax | conserved Plasmodium protein, unknown function | 0.0208 | 0.0973 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0105 | 0.0363 | 0.3006 |
Wolbachia endosymbiont of Brugia malayi | cytochrome c oxidase, subunit 2 | 0.0299 | 0.1506 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0105 | 0.0363 | 0.0363 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1259 | 0.7177 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1099 | 0.6231 | 1 |
Schistosoma mansoni | peroxidasin | 0.0105 | 0.0363 | 0.0506 |
Onchocerca volvulus | Putative sulfate transporter | 0.0211 | 0.0987 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.0094 | 0.0295 | 0.0295 |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0243 | 0.118 | 0.1571 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1099 | 0.6231 | 1 |
Echinococcus granulosus | dynactin 5 p25 | 0.0073 | 0.0171 | 0.0274 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0516 | 0.2791 | 0.2791 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0363 | 0.0363 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.0951 | 0.0951 |
Onchocerca volvulus | Dual oxidase homolog | 0.0105 | 0.0363 | 0.3006 |
Trichomonas vaginalis | maltose O-acetyltransferase, putative | 0.007 | 0.0154 | 0.0184 |
Schistosoma mansoni | cytochrome-c oxidase | 0.009 | 0.0275 | 0.0384 |
Onchocerca volvulus | 0.0105 | 0.0363 | 0.3006 | |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0363 | 0.0363 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.006 | 0.0095 | 0.0132 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0105 | 0.0363 | 0.0363 |
Brugia malayi | Blistered cuticle protein 3 | 0.0105 | 0.0363 | 0.0583 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0516 | 0.2791 | 0.4478 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0363 | 0.0363 |
Echinococcus multilocularis | WD repeat containing protein 48 | 0.0205 | 0.0951 | 0.1527 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0094 | 0.0295 | 0.0411 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0363 | 0.0363 |
Brugia malayi | Animal haem peroxidase family protein | 0.0105 | 0.0363 | 0.0583 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1099 | 0.6231 | 1 |
Onchocerca volvulus | 0.0105 | 0.0363 | 0.3006 | |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.0904 | 0.1451 |
Onchocerca volvulus | 0.0094 | 0.0295 | 0.2241 | |
Echinococcus multilocularis | carbonic anhydrase | 0.0516 | 0.2791 | 0.4478 |
Onchocerca volvulus | Cytochrome c oxidase subunit 2 homolog | 0.009 | 0.0275 | 0.2025 |
Brugia malayi | Animal haem peroxidase family protein | 0.0105 | 0.0363 | 0.0583 |
Brugia malayi | Peroxidasin | 0.0105 | 0.0363 | 0.0583 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1099 | 0.6231 | 0.6231 |
Schistosoma mansoni | carbonic anhydrase | 0.0516 | 0.2791 | 0.3888 |
Mycobacterium ulcerans | transmembrane cytochrome C oxidase (subunit II) CtaC | 0.009 | 0.0275 | 0.0147 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1099 | 0.6231 | 0.8682 |
Echinococcus granulosus | peroxidasin | 0.0105 | 0.0363 | 0.0583 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0516 | 0.2791 | 0.4478 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0363 | 0.0363 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0094 | 0.0295 | 0.0473 |
Onchocerca volvulus | 0.009 | 0.0275 | 0.2025 | |
Plasmodium falciparum | carbonic anhydrase | 0.0516 | 0.2791 | 1 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0094 | 0.0295 | 0.0411 |
Echinococcus multilocularis | peroxidasin | 0.0105 | 0.0363 | 0.0583 |
Echinococcus granulosus | carbonic anhydrase | 0.0516 | 0.2791 | 0.4478 |
Onchocerca volvulus | 0.0211 | 0.0987 | 1 | |
Onchocerca volvulus | Peroxidasin homolog | 0.0105 | 0.0363 | 0.3006 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0295 | 0.0295 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0094 | 0.0295 | 0.0295 |
Schistosoma mansoni | hypothetical protein | 0.0088 | 0.0262 | 0.0365 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1099 | 0.6231 | 0.8682 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0363 | 0.0363 |
Loa Loa (eye worm) | hypothetical protein | 0.0516 | 0.2791 | 0.2791 |
Echinococcus granulosus | carbonic anhydrase II | 0.1099 | 0.6231 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.007 | 0.0154 | 0.0184 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1099 | 0.6231 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0363 | 0.0363 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1099 | 0.6231 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0105 | 0.0363 | 0.3006 |
Schistosoma mansoni | cytochrome c oxidase subunit II | 0.0245 | 0.1186 | 0.1653 |
Schistosoma mansoni | hypothetical protein | 0.0088 | 0.0262 | 0.0365 |
Echinococcus granulosus | serotonin transporter | 0.0094 | 0.0295 | 0.0473 |
Onchocerca volvulus | Cytochrome c oxidase subunit 2 homolog | 0.009 | 0.0275 | 0.2025 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0516 | 0.2791 | 0.3888 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0243 | 0.118 | 0.1835 |
Brugia malayi | Animal haem peroxidase family protein | 0.0105 | 0.0363 | 0.0583 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0363 | 0.0363 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1099 | 0.6231 | 1 |
Entamoeba histolytica | acetyltransferase, putative | 0.0073 | 0.0171 | 0.0238 |
Echinococcus multilocularis | serotonin transporter | 0.0094 | 0.0295 | 0.0473 |
Leishmania major | carbonic anhydrase-like protein | 0.1099 | 0.6231 | 0.8682 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1259 | 0.7177 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0197 | 0.0904 | 0.1451 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1259 | 0.7177 | 0.8543 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1462 | 0.8374 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0295 | 0.0295 |
Echinococcus multilocularis | carbonic anhydrase | 0.0516 | 0.2791 | 0.4478 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0105 | 0.0363 | 0.0363 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0197 | 0.0904 | 0.1451 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0516 | 0.2791 | 0.4478 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1462 | 0.8374 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0105 | 0.0363 | 0.0363 |
Echinococcus granulosus | carbonic anhydrase | 0.0516 | 0.2791 | 0.4478 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0516 | 0.2791 | 0.3888 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0363 | 0.0363 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0516 | 0.2791 | 0.3888 |
Echinococcus multilocularis | tumor protein p63 | 0.0408 | 0.2152 | 0.3453 |
Schistosoma mansoni | carbonic anhydrase | 0.1259 | 0.7177 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0105 | 0.0363 | 0.0583 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0197 | 0.0904 | 0.1451 |
Schistosoma mansoni | hypothetical protein | 0.0516 | 0.2791 | 0.3888 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0105 | 0.0363 | 0.0363 |
Schistosoma mansoni | peroxidasin | 0.0105 | 0.0363 | 0.0506 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0295 | 0.0295 |
Onchocerca volvulus | Peroxidasin homolog | 0.0105 | 0.0363 | 0.3006 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0094 | 0.0295 | 0.0295 |
Loa Loa (eye worm) | hypothetical protein | 0.0516 | 0.2791 | 0.2791 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0094 | 0.0295 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0363 | 0.0363 |
Echinococcus multilocularis | carbonic anhydrase | 0.0516 | 0.2791 | 0.4478 |
Onchocerca volvulus | Cytochrome c oxidase subunit 2 homolog | 0.009 | 0.0275 | 0.2025 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0363 | 0.0363 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0363 | 0.0363 |
Onchocerca volvulus | Cytochrome c oxidase subunit 2 homolog | 0.009 | 0.0275 | 0.2025 |
Schistosoma mansoni | hypothetical protein | 0.0117 | 0.0432 | 0.0601 |
Toxoplasma gondii | cytochrome C oxidase subunit IIb, putative | 0.009 | 0.0275 | 0.0987 |
Echinococcus granulosus | WD repeat containing protein 48 | 0.0205 | 0.0951 | 0.1527 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.0742 | 0.1034 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0197 | 0.0904 | 0.0904 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1259 | 0.7177 | 1 |
Entamoeba histolytica | ankyrin, putative | 0.0073 | 0.0171 | 0.0238 |
Mycobacterium tuberculosis | Probable transmembrane cytochrome C oxidase (subunit II) CtaC | 0.009 | 0.0275 | 0.019 |
Mycobacterium leprae | PROBABLE TRANSFERASE | 0.007 | 0.0154 | 0.013 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1462 | 0.8374 | 1 |
Brugia malayi | Hypothetical WD-repeat protein F35G12.4 in chromosome III | 0.0205 | 0.0951 | 0.1527 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0801 | 0.4473 | 0.7823 |
Loa Loa (eye worm) | cytochrome oxidase subunit 2 | 0.0054 | 0.0062 | 0.0062 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1004 | 0.5671 | 1 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0516 | 0.2791 | 0.4478 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0516 | 0.2791 | 0.4478 |
Toxoplasma gondii | hypothetical protein | 0.0117 | 0.0432 | 0.1546 |
Schistosoma mansoni | alpha-glucosidase | 0.0169 | 0.0742 | 0.1034 |
Echinococcus granulosus | tumor protein p63 | 0.0408 | 0.2152 | 0.3453 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1099 | 0.6231 | 0.6231 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0701 | 0.3884 | 0.675 |
Echinococcus granulosus | cytochrome c oxidase subunit II | 0.0299 | 0.1506 | 0.2417 |
Onchocerca volvulus | 0.0114 | 0.0414 | 0.3579 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.