Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0152 | 0.2066 | 0.4424 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0026 | 0.0067 | 0.0143 |
Echinococcus granulosus | c src tyrosine kinase | 0.0026 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.089 | 0.1906 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0398 | 0.0853 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.089 | 0.1906 |
Brugia malayi | Protein kinase domain containing protein | 0.005 | 0.0458 | 0.0981 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.2267 | 0.4855 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0201 | 0.043 |
Schistosoma mansoni | nephrin | 0.0049 | 0.0442 | 0.0946 |
Entamoeba histolytica | hypothetical protein | 0.0034 | 0.0201 | 0.4278 |
Echinococcus multilocularis | hypothetical protein | 0.0078 | 0.089 | 0.1906 |
Echinococcus granulosus | cyclin dependent kinase 5 | 0.005 | 0.0458 | 0.0458 |
Schistosoma mansoni | tyrosine kinase | 0.0026 | 0.0067 | 0.0143 |
Trypanosoma brucei | cdc2-related kinase 3 | 0.005 | 0.0458 | 0.5 |
Echinococcus granulosus | Immunoglobulin | 0.0047 | 0.0398 | 0.0398 |
Echinococcus granulosus | transcription factor collier | 0.0034 | 0.0201 | 0.0201 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0152 | 0.2066 | 0.4424 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0026 | 0.0067 | 0.0067 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0026 | 0.0067 | 0.0143 |
Entamoeba histolytica | hypothetical protein | 0.0034 | 0.0201 | 0.4278 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0497 | 0.1064 |
Schistosoma mansoni | tyrosine kinase | 0.0023 | 0.003 | 0.0064 |
Echinococcus granulosus | neuroglian | 0.0049 | 0.0442 | 0.0442 |
Echinococcus granulosus | insulin receptor | 0.0317 | 0.467 | 0.467 |
Schistosoma mansoni | tyrosine kinase | 0.0135 | 0.1797 | 0.3849 |
Echinococcus multilocularis | plexin a4 | 0.022 | 0.3138 | 0.672 |
Schistosoma mansoni | tyrosine kinase | 0.0152 | 0.2066 | 0.4424 |
Brugia malayi | SRC-1 | 0.0026 | 0.0067 | 0.0143 |
Schistosoma mansoni | tyrosine kinase | 0.0152 | 0.2066 | 0.4424 |
Brugia malayi | IPT/TIG domain containing protein | 0.0034 | 0.0201 | 0.043 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0051 | 0.0469 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0398 | 0.0853 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.005 | 0.0458 | 0.0981 |
Echinococcus multilocularis | cyclin dependent kinase 5 | 0.005 | 0.0458 | 0.0981 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.089 | 0.1906 |
Plasmodium vivax | protein kinase Crk2 | 0.005 | 0.0458 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0201 | 0.043 |
Schistosoma mansoni | semaphorin 5-related | 0.0078 | 0.089 | 0.1906 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0047 | 0.0398 | 0.0853 |
Leishmania major | cell division protein kinase 2,cdc2-related kinase | 0.005 | 0.0458 | 0.5 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.005 | 0.0458 | 0.5 |
Plasmodium falciparum | protein kinase 5 | 0.005 | 0.0458 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.0458 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0317 | 0.467 | 1 |
Loa Loa (eye worm) | plexin A | 0.022 | 0.3138 | 0.672 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0026 | 0.0067 | 0.0067 |
Echinococcus granulosus | MAP kinase activated protein kinase 2 | 0.0208 | 0.2956 | 0.2956 |
Trypanosoma brucei | cdc2-related kinase 1 | 0.005 | 0.0458 | 0.5 |
Echinococcus granulosus | cyclin dependent kinase | 0.005 | 0.0458 | 0.0458 |
Echinococcus granulosus | semaphorin 1A | 0.0078 | 0.089 | 0.089 |
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | 0.0208 | 0.2956 | 0.633 |
Entamoeba histolytica | hypothetical protein | 0.0034 | 0.0201 | 0.4278 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0201 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.089 | 0.1906 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0051 | 0.0469 | 1 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0152 | 0.2066 | 0.2066 |
Echinococcus granulosus | plexin a4 | 0.022 | 0.3138 | 0.3138 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.005 | 0.0458 | 0.977 |
Echinococcus granulosus | twitchin | 0.005 | 0.0458 | 0.0458 |
Echinococcus multilocularis | Immunoglobulin | 0.0047 | 0.0398 | 0.0853 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0441 | 0.0945 |
Echinococcus granulosus | exocyst complex component 2 | 0.0034 | 0.0201 | 0.0201 |
Brugia malayi | Protein kinase domain containing protein | 0.0182 | 0.2535 | 0.5429 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0317 | 0.467 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0026 | 0.0067 | 0.0143 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0152 | 0.2066 | 0.4424 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0179 | 0.2492 | 0.9584 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0152 | 0.2066 | 0.4424 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.26 | 0.5568 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0027 | 0.0084 | 0.0084 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0026 | 0.0067 | 0.0143 |
Trypanosoma cruzi | cdc2-related kinase 1 | 0.005 | 0.0458 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0152 | 0.2066 | 0.4424 |
Echinococcus multilocularis | cyclin dependent kinase 1 | 0.005 | 0.0458 | 0.0981 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0026 | 0.0067 | 0.0067 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0026 | 0.0067 | 0.0143 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0047 | 0.0398 | 0.0853 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0078 | 0.089 | 0.1906 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0201 | 0.043 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.089 | 0.1906 |
Echinococcus multilocularis | roundabout 2 | 0.0053 | 0.0497 | 0.1064 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.089 | 0.1906 |
Schistosoma mansoni | tyrosine kinase | 0.0135 | 0.1797 | 0.3849 |
Schistosoma mansoni | vesicular amine transporter | 0.0047 | 0.0398 | 0.0853 |
Brugia malayi | cell division control protein 2 homolog | 0.005 | 0.0458 | 0.0981 |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.0458 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.005 | 0.0458 | 0.0981 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0026 | 0.0067 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0398 | 0.0853 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0047 | 0.0398 | 0.0853 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.005 | 0.0458 | 0.5 |
Echinococcus multilocularis | 0.0039 | 0.0287 | 0.0615 | |
Onchocerca volvulus | 0.0159 | 0.218 | 0.8385 | |
Echinococcus granulosus | 5'partial|cyclin dependent kinase 1 | 0.005 | 0.0458 | 0.0458 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0047 | 0.0398 | 0.0853 |
Schistosoma mansoni | tyrosine kinase | 0.0026 | 0.0067 | 0.0143 |
Onchocerca volvulus | 0.0186 | 0.26 | 1 | |
Trichomonas vaginalis | CMGC family protein kinase | 0.005 | 0.0458 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0026 | 0.0067 | 0.0067 |
Schistosoma mansoni | tyrosine kinase | 0.0135 | 0.1797 | 0.3849 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0497 | 0.1064 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0026 | 0.0067 | 0.0143 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0026 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0454 | 0.0971 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0201 | 0.043 |
Brugia malayi | Plexin repeat family protein | 0.0186 | 0.26 | 0.5568 |
Toxoplasma gondii | cell-cycle-associated protein kinase CDK, putative | 0.005 | 0.0458 | 0.5 |
Leishmania major | cell division related protein kinase 2,cdc2-related kinase | 0.005 | 0.0458 | 0.5 |
Echinococcus granulosus | semaphorin 5B | 0.0078 | 0.089 | 0.089 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0026 | 0.0067 | 0.0143 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.005 | 0.0454 | 0.0454 |
Entamoeba histolytica | cell surface protease gp63, putative | 0.0034 | 0.0201 | 0.4278 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.005 | 0.0458 | 0.0981 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0078 | 0.089 | 0.1906 |
Brugia malayi | hypothetical protein | 0.0078 | 0.089 | 0.1906 |
Loa Loa (eye worm) | SRC-1 | 0.0026 | 0.0067 | 0.0143 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0317 | 0.467 | 0.467 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0152 | 0.2066 | 0.2066 |
Echinococcus multilocularis | transcription factor collier | 0.0034 | 0.0201 | 0.043 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0026 | 0.0067 | 0.0067 |
Echinococcus granulosus | defective proboscis extension response | 0.0047 | 0.0398 | 0.0398 |
Trypanosoma cruzi | cdc2-related kinase 3 | 0.005 | 0.0458 | 0.5 |
Brugia malayi | hypothetical protein | 0.0078 | 0.089 | 0.1906 |
Brugia malayi | Sema domain containing protein | 0.0078 | 0.089 | 0.1906 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.005 | 0.0458 | 0.0981 |
Schistosoma mansoni | cell adhesion molecule | 0.005 | 0.0454 | 0.0971 |
Giardia lamblia | Kinase, CMGC CDK | 0.005 | 0.0458 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0034 | 0.0201 | 0.4278 |
Brugia malayi | Sema domain containing protein | 0.0078 | 0.089 | 0.1906 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0398 | 0.0853 |
Schistosoma mansoni | tyrosine kinase | 0.0026 | 0.0067 | 0.0143 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0226 | 0.3239 | 0.6937 |
Schistosoma mansoni | tyrosine kinase | 0.0026 | 0.0067 | 0.0143 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0026 | 0.0067 | 0.0067 |
Echinococcus granulosus | roundabout 2 | 0.0053 | 0.0497 | 0.0497 |
Schistosoma mansoni | fibrocystin l | 0.0034 | 0.0201 | 0.043 |
Brugia malayi | hypothetical protein | 0.0047 | 0.0398 | 0.0853 |
Entamoeba histolytica | cell division protein kinase 2, putative | 0.005 | 0.0458 | 0.977 |
Echinococcus multilocularis | Immunoglobulin | 0.0047 | 0.0398 | 0.0853 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.1373 | 0.294 |
Schistosoma mansoni | hypothetical protein | 0.0108 | 0.1373 | 0.294 |
Giardia lamblia | Kinase, CMGC CDK | 0.005 | 0.0458 | 0.5 |
Brugia malayi | map kinase activated protein kinase protein 2 | 0.0208 | 0.2956 | 0.633 |
Echinococcus multilocularis | MAP kinase activated protein kinase 2 | 0.0208 | 0.2956 | 0.633 |
Echinococcus multilocularis | neuroglian | 0.0049 | 0.0442 | 0.0946 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0026 | 0.0067 | 0.0143 |
Schistosoma mansoni | tyrosine kinase | 0.0317 | 0.467 | 1 |
Echinococcus multilocularis | cyclin dependent kinase | 0.005 | 0.0458 | 0.0981 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0317 | 0.467 | 1 |
Schistosoma mansoni | plexin | 0.0186 | 0.26 | 0.5568 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0026 | 0.0067 | 0.0143 |
Onchocerca volvulus | 0.0078 | 0.089 | 0.3424 | |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0201 | 0.043 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.0458 | 0.0981 |
Brugia malayi | DNA-binding protein LAG-1 | 0.0034 | 0.0201 | 0.043 |
Brugia malayi | Probable exocyst complex component Sec5 | 0.0034 | 0.0201 | 0.043 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0026 | 0.0067 | 0.0143 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.089 | 0.1906 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0398 | 0.0853 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0398 | 0.0853 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0152 | 0.2066 | 0.2066 |
Brugia malayi | Protein kinase domain containing protein | 0.0317 | 0.467 | 1 |
Echinococcus multilocularis | exocyst complex component 2 | 0.0034 | 0.0201 | 0.043 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0026 | 0.0067 | 0.0143 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0026 | 0.0067 | 0.0067 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0226 | 0.3239 | 0.6937 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0047 | 0.0398 | 0.0853 |
Schistosoma mansoni | tyrosine kinase | 0.0317 | 0.467 | 1 |
Brugia malayi | plexin A | 0.022 | 0.3138 | 0.672 |
Echinococcus multilocularis | semaphorin 5B | 0.0078 | 0.089 | 0.1906 |
Schistosoma mansoni | serine/threonine protein kinase | 0.005 | 0.0458 | 0.0981 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0026 | 0.0067 | 0.0143 |
Echinococcus granulosus | cyclin dependent kinase 1 | 0.005 | 0.0458 | 0.0458 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0026 | 0.0067 | 0.0143 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0208 | 0.2956 | 0.633 |
Schistosoma mansoni | plexin | 0.0108 | 0.1373 | 0.294 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.089 | 0.1906 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.